RGD Reference Report - Reduction of EphA4 receptor expression after spinal cord injury does not induce axonal regeneration or return of tcMMEP response. - Rat Genome Database

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Reduction of EphA4 receptor expression after spinal cord injury does not induce axonal regeneration or return of tcMMEP response.

Authors: Cruz-Orengo, L  Figueroa, JD  Torrado, A  Puig, A  Whittemore, SR  Miranda, JD 
Citation: Cruz-Orengo L, etal., Neurosci Lett. 2007 May 11;418(1):49-54. Epub 2007 Mar 12.
RGD ID: 5688782
Pubmed: PMID:17418490   (View Abstract at PubMed)
PMCID: PMC2570091   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neulet.2007.03.015   (Journal Full-text)

Spinal cord injury (SCI) causes an increase of inhibitory factors that may restrict axonal outgrowth after trauma. During the past decade, the Eph receptors and ephrin ligands have emerged as key repulsive cues known to be involved in neurite outgrowth, synapse formation, and axonal pathfinding during development. Given the non-permissive environment for axonal regeneration after SCI, we questioned whether enhanced-expression of the EphA4 receptor with repulsive activity for axonal outgrowth is potentially responsible for the regenerative failure. To address this possibility, we have examined the expression of EphA4 after SCI in adult rats following a contusion SCI. EphA4 expression studies demonstrated a time-dependent change for EphA4 protein without alterations in beta-actin. EphA4 was downregulated initially and upregulated 7 days after injury. Blockade of EphA4 upregulation with antisense oligonucleotides did not produce an anatomical or physiological response monitored with anterograde tracing studies or transcranial magnetic motor evoked potentials (tcMMEP), respectively. These results demonstrated that upregulation of EphA4 receptors after trauma is not related to axonal regeneration or return of nerve conduction across the injury site.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Spinal Cord Injuries  ISOEpha4 (Rattus norvegicus)5688782; 5688782 RGD 
Spinal Cord Injuries  IEP 5688782 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of axon regeneration NOTIMP 5688782 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Epha4  (Eph receptor A4)

Genes (Mus musculus)
Epha4  (Eph receptor A4)

Genes (Homo sapiens)
EPHA4  (EPH receptor A4)


Additional Information