CCR2 (C-C motif chemokine receptor 2) - Rat Genome Database

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Gene: CCR2 (C-C motif chemokine receptor 2) Sus scrofa
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Symbol: CCR2
Name: C-C motif chemokine receptor 2
RGD ID: 13876116
Description: ENCODES a protein that exhibits CCR2 chemokine receptor binding (ortholog); cytokine binding (ortholog); identical protein binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cellular calcium ion homeostasis (ortholog); cellular defense response (ortholog); ASSOCIATED WITH aggressive periodontitis (ortholog); Alcoholic Fatty Liver (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); dendrite (ortholog); INTERACTS WITH prostaglandin F2alpha; resveratrol
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-C chemokine receptor type 2; chemokine C-C motif receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,251,959 - 29,376,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,368,735 - 29,374,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,532,565 - 32,538,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
aggressive periodontitis  (ISO)
Alcoholic Fatty Liver  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Toxoplasmosis  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Periodontitis  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
demyelinating disease  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (ISO)
dry eye syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
fungal infectious disease  (ISO)
Geographic Atrophy  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Herpes Simplex Encephalitis  (ISO)
Herpesviridae Infections  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
ileitis  (ISO)
inclusion body myositis  (ISO)
intermediate uveitis  (ISO)
interstitial lung disease  (ISO)
Intervertebral Disc Disease  (ISO)
Intimal Hyperplasia  (ISO)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (ISO)
limited scleroderma  (ISO)
lipoatrophic diabetes mellitus  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
macular degeneration  (ISO)
Mouth Neoplasms  (ISO)
myeloid sarcoma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
non-alcoholic fatty liver disease  (ISO)
oral squamous cell carcinoma  (ISO)
Pain  (ISO)
Perennial Allergic Rhinitis  (ISO)
Peri-Implantitis  (ISO)
Periapical Diseases  (ISO)
periapical granuloma  (ISO)
periapical periodontitis  (ISO)
Periodontal Cyst  (ISO)
pleural tuberculosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
posterior uveitis  (ISO)
prediabetes syndrome  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
retinal degeneration  (ISO)
retinitis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
sciatic neuropathy  (ISO)
sialadenitis  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
systemic scleroderma  (ISO)
Thoracic Injuries  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
vasculitis  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (IEA,ISO)
calcium-mediated signaling  (IBA)
cell chemotaxis  (IBA)
cellular calcium ion homeostasis  (ISO)
cellular defense response  (IEA,ISO)
cellular homeostasis  (ISO)
chemokine-mediated signaling pathway  (IEA,ISO)
chemotaxis  (IEA)
cytokine-mediated signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
hemopoiesis  (IEA,ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
humoral immune response  (IEA,ISO)
immune response  (IBA,ISO)
inflammatory response  (IBA,IEA,ISO)
inflammatory response to antigenic stimulus  (ISO)
inflammatory response to wounding  (IEA)
leukocyte adhesion to vascular endothelial cell  (IEA,ISO)
macrophage migration  (IEA)
monocyte chemotaxis  (IEA,ISO)
monocyte extravasation  (IEA)
negative regulation of angiogenesis  (IEA)
negative regulation of eosinophil degranulation  (IEA)
negative regulation of type 2 immune response  (IEA)
neutrophil clearance  (IEA,ISO)
positive regulation of alpha-beta T cell proliferation  (IEA)
positive regulation of astrocyte chemotaxis  (IEA)
positive regulation of CD8-positive, alpha-beta T cell extravasation  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of hematopoietic stem cell migration  (IEA)
positive regulation of immune complex clearance by monocytes and macrophages  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interferon-gamma production  (IEA)
positive regulation of interleukin-2 production  (IEA)
positive regulation of leukocyte tethering or rolling  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IEA)
positive regulation of monocyte extravasation  (IEA)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of synaptic transmission, glutamatergic  (IEA)
positive regulation of T cell activation  (ISO)
positive regulation of T cell chemotaxis  (IEA)
positive regulation of T-helper 1 type immune response  (IEA)
positive regulation of thymocyte migration  (IEA)
positive regulation of tumor necrosis factor production  (IEA,ISO)
regulation of cell migration  (ISO)
regulation of inflammatory response  (ISO)
regulation of T cell cytokine production  (IEA)
regulation of T cell differentiation  (IEA)
regulation of vascular endothelial growth factor production  (IEA)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
sensory perception of pain  (IEA,ISO)
T-helper 17 cell chemotaxis  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:15777643   PMID:16926016  


Genomics

Comparative Map Data
CCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,251,959 - 29,376,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,368,735 - 29,374,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,532,565 - 32,538,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl346,353,864 - 46,360,940 (+)EnsemblGRCh38hg38GRCh38
GRCh38346,354,111 - 46,360,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,395,602 - 46,402,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,370,364 - 46,377,432 (+)NCBINCBI36hg18NCBI36
Celera346,332,557 - 46,339,734 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,438,874 - 46,446,051 (+)NCBIHuRef
CHM1_1346,345,233 - 46,352,410 (+)NCBICHM1_1
Ccr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,901,954 - 123,913,594 (+)NCBIGRCm39mm39
GRCm39 Ensembl9123,901,987 - 123,913,594 (+)Ensembl
GRCm389124,101,918 - 124,109,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,101,950 - 124,113,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,016,922 - 124,023,879 (+)NCBIGRCm37mm9NCBIm37
MGSCv369123,950,982 - 123,957,349 (+)NCBImm8
Celera9124,890,502 - 124,897,441 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
Ccr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28123,734,465 - 123,742,483 (+)NCBI
RGSC_v3.48128,892,784 - 128,893,905 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,912,520 - 128,913,642 (+)NCBI
Celera8122,833,545 - 122,834,666 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ccr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542025,641,184 - 25,664,413 (-)NCBIChiLan1.0ChiLan1.0
CCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1347,361,118 - 47,368,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,361,124 - 47,368,312 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,255,725 - 46,263,285 (+)NCBIMhudiblu_PPA_v0panPan3
CCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,305,344 - 42,313,258 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,307,580 - 42,308,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,220,658 - 42,229,191 (-)NCBI
ROS_Cfam_1.02042,787,203 - 42,795,751 (-)NCBI
UMICH_Zoey_3.12042,028,417 - 42,036,962 (-)NCBI
UNSW_CanFamBas_1.02042,429,835 - 42,438,385 (-)NCBI
UU_Cfam_GSD_1.02042,710,738 - 42,719,282 (-)NCBI
CCR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,795,192 - 7,801,242 (+)NCBI
ChlSab1.1 Ensembl227,798,646 - 7,799,728 (+)Ensembl
Vero_WHO_p1.0NW_023666041159,351,063 - 159,358,108 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000022709   ⟹   ENSSSCP00000022129
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1329,251,959 - 29,286,470 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000028261   ⟹   ENSSSCP00000024949
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1329,370,930 - 29,376,346 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000030755   ⟹   ENSSSCP00000027606
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1329,252,024 - 29,286,470 (+)Ensembl
RefSeq Acc Id: NM_001001619   ⟹   NP_001001619
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11329,368,735 - 29,374,564 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001001619 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD08648 (Get FASTA)   NCBI Sequence Viewer  
  BAD08655 (Get FASTA)   NCBI Sequence Viewer  
  BAD12134 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001001619   ⟸   NM_001001619
- UniProtKB: Q6YT42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000027606   ⟸   ENSSSCT00000030755
RefSeq Acc Id: ENSSSCP00000022129   ⟸   ENSSSCT00000022709
RefSeq Acc Id: ENSSSCP00000024949   ⟸   ENSSSCT00000028261
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024311 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070007520 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000024949 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000027606 UniProtKB/TrEMBL
  ENSSSCP00070011968 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000028261 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000030755 UniProtKB/TrEMBL
  ENSSSCT00070014497 UniProtKB/TrEMBL
InterPro Chemokine_CCR2 UniProtKB/TrEMBL
  Chemokine_CCR3 UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report ssc:414372 UniProtKB/TrEMBL
NCBI Gene CCR2 ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS CCCHEMOKINER UniProtKB/TrEMBL
  CHEMOKINER2 UniProtKB/TrEMBL
  CHEMOKINER3 UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
UniProt A0A4X1T7J6_PIG UniProtKB/TrEMBL
  A0A5K1U6D8_PIG UniProtKB/TrEMBL
  Q6YT42 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:86370 ENTREZGENE