IL1RN (interleukin 1 receptor antagonist)

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Gene: IL1RN (interleukin 1 receptor antagonist) Sus scrofa

Analyze

Symbol:

IL1RN

Name:

interleukin 1 receptor antagonist

RGD ID:

13854425

Description:

ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); interleukin-1 type I receptor antagonist activity (ortholog); interleukin-1 type II receptor antagonist activity (ortholog); INVOLVED IN acute-phase response (ortholog); carboxylic acid metabolic process (ortholog); cellular response to norepinephrine stimulus (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH Abscess (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog); INTERACTS WITH dibromine

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

IL-1ra; IL-1RN; IL1 inhibitor; interleukin-1 receptor antagonist protein; IRAP; IRAP1

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

NCBI Annotation Information:

Genome Annotation Status: not in current annotation release

Position:

No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Abscess (ISO)

acute kidney failure (ISO)

Acute Liver Failure (ISO)

Acute Lung Injury (ISO)

acute necrotizing pancreatitis (ISO)

adult respiratory distress syndrome (ISO)

allergic conjunctivitis (ISO)

alopecia areata (ISO)

Anorexia (ISO)

anterior uveitis (ISO)

anthracosis (ISO)

anti-basement membrane glomerulonephritis (ISO)

Arsenic Poisoning (ISO)

asthma (ISO)

Atrophy (ISO)

autistic disorder (ISO)

autoimmune thrombocytopenic purpura (ISO)

autosomal dominant polycystic kidney disease (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

bacterial pneumonia (ISO)

Behcet's disease (ISO)

Brain Injuries (ISO)

brain ischemia (ISO)

Bronchial Hyperreactivity (ISO)

bronchiolitis (ISO)

bronchiolitis obliterans (ISO)

Bronchopulmonary Dysplasia (ISO)

bronchus carcinoma (ISO)

Cachexia (ISO)

calcium oxalate nephrolithiasis (ISO)

cardiovascular system disease (ISO)

Carotid Artery Injuries (ISO)

Cerebral Hemorrhage (ISO)

cerebrovascular disease (ISO)

chronic kidney disease (ISO)

chronic myeloid leukemia (ISO)

chronic obstructive pulmonary disease (ISO)

Chronic Rhinosinusitis (ISO)

Chronic Uveitis (ISO)

cicatricial pemphigoid (ISO)

Colonic Neoplasms (ISO)

common cold (ISO)

Corneal Graft Rejection (ISO)

corneal neovascularization (ISO)

COVID-19 (ISO)

crescentic glomerulonephritis (ISO)

Cryopyrin-Associated Periodic Syndromes (ISO)

cystic fibrosis (ISO)

dacryocystitis (ISO)

Deficiency of Interleukin-1 Receptor Antagonist (ISO)

diabetic angiopathy (ISO)

Diabetic Nephropathies (ISO)

diarrhea (ISO)

Drug Hypersensitivity Syndrome (ISO)

Drug-Induced Agranulocytosis (ISO)

dry eye syndrome (ISO)

encephalitis (ISO)

end stage renal disease (ISO)

endometriosis (ISO)

Endotoxemia (ISO)

Endotoxin-Induced Uveitis (ISO)

exanthem (ISO)

Experimental Arthritis (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Autoimmune Myocarditis (ISO)

Experimental Autoimmune Uveitis (ISO)

Experimental Colitis (ISO)

Experimental Diabetes Mellitus (ISO)

Extravasation of Diagnostic and Therapeutic Materials (ISO)

Eye Manifestations (ISO)

Febrile Seizures (ISO)

Fever (ISO)

fibromyalgia (ISO)

Fibrosis (ISO)

glomerulonephritis (ISO)

gout (ISO)

Graft vs Host Disease (ISO)

Graves ophthalmopathy (ISO)

hairy cell leukemia (ISO)

hemolytic-uremic syndrome (ISO)

Henoch-Schoenlein purpura (ISO)

hepatocellular carcinoma (ISO)

herpes simplex virus keratitis (ISO)

Human Influenza (ISO)

Hyperalgesia (ISO)

hyperglycemia (ISO)

hypertension (ISO)

idiopathic pulmonary fibrosis (ISO)

IgA glomerulonephritis (ISO)

Inflammation (ISO)

inflammatory bowel disease (ISO)

interstitial lung disease (ISO)

juvenile rheumatoid arthritis (ISO)

keratoconus (ISO)

kidney disease (ISO)

Kidney Reperfusion Injury (ISO)

learning disability (ISO)

Leukocytosis (ISO)

Lichen Sclerosus et Atrophicus (ISO)

listeriosis (ISO)

Liver Reperfusion Injury (ISO)

lung non-small cell carcinoma (ISO)

lupus nephritis (ISO)

Mammary Neoplasms, Experimental (ISO)

Meibomian Gland Dysfunction (ISO)

melanoma (ISO)

mental depression (ISO)

middle cerebral artery infarction (ISO)

morbid obesity (ISO)

Muckle-Wells syndrome (ISO)

mucositis (ISO)

multiple myeloma (ISO)

Multiple Organ Failure (ISO)

multiple sclerosis (ISO)

myocardial infarction (ISO)

Myocardial Reperfusion Injury (ISO)

myositis (ISO)

Necrosis (ISO)

Neoplasm Invasiveness (ISO)

nephrotic syndrome (ISO)

non-alcoholic fatty liver disease (ISO)

obesity (ISO)

Oligoanuria (ISO)

osteoporosis (ISO)

Pain (ISO)

periodontitis (ISO)

pleural disease (ISO)

pleural tuberculosis (ISO)

pleurisy (ISO)

pneumonia (ISO)

Postoperative Cognitive Dysfunction (ISO)

pre-eclampsia (ISO)

Proctocolitis (ISO)

Prostatic Neoplasms (ISO)

prostatitis (ISO)

proteinuria (ISO)

Pseudomonas Aeruginosa Keratitis (ISO)

Pseudomonas Infections (ISO)

pulmonary eosinophilia (ISO)

pulmonary fibrosis (ISO)

pulmonary hypertension (ISO)

pulmonary sarcoidosis (ISO)

pulmonary tuberculosis (ISO)

pyelonephritis (ISO)

renal cell carcinoma (ISO)

respiratory allergy (ISO)

rheumatoid arthritis (ISO)

rhinitis (ISO)

Schnitzler syndrome (ISO)

sciatic neuropathy (ISO)

Sclerosis (ISO)

Sepsis (ISO)

Serositis (ISO)

silicosis (ISO)

Sjogren's syndrome (ISO)

skin disease (ISO)

Spinal Cord Injuries (ISO)

status epilepticus (ISO)

stomach cancer (ISO)

Stomach Neoplasms (ISO)

Stroke (ISO)

Subarachnoid Hemorrhage (ISO)

systemic lupus erythematosus (ISO)

Tobacco Use Disorder (ISO)

toxic shock syndrome (ISO)

transient cerebral ischemia (ISO)

Transplant Rejection (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

ulcerative colitis (ISO)

ureteral obstruction (ISO)

urinary bladder cancer (ISO)

Urinary Calculi (ISO)

Uveitis, Chronic Anterior (ISO)

vascular disease (ISO)

Venous Thrombosis (ISO)

Ventilator-Induced Lung Injury (ISO)

Viral Bronchiolitis (ISO)

viral pneumonia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

dibromine (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acute-phase response (ISO)

carboxylic acid metabolic process (ISO)

cellular response to norepinephrine stimulus (ISO)

chronic inflammatory response to antigenic stimulus (ISO)

female pregnancy (ISO)

fever generation (ISO)

immune response (IEA)

inflammatory response (IBA,IEA)

inflammatory response to antigenic stimulus (IBA)

insulin secretion (ISO)

lipid metabolic process (ISO)

memory (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of cell migration (ISO)

negative regulation of glutamate secretion (ISO)

negative regulation of heterotypic cell-cell adhesion (ISO)

negative regulation of interleukin-1-mediated signaling pathway (IBA,IEA)

negative regulation of membrane potential (ISO)

positive regulation of JUN kinase activity (ISO)

response to activity (ISO)

response to glucocorticoid (ISO)

response to interleukin-1 (ISO)

response to interleukin-4 (ISO)

response to lipopolysaccharide (ISO)

response to organic cyclic compound (ISO)

response to organonitrogen compound (ISO)

response to starvation (ISO)

response to xenobiotic stimulus (ISO)

sensory perception of pain (ISO)

signal transduction (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IEA,ISO)

vesicle (ISO)

Molecular Function

cytokine activity (IEA)

interleukin-1 receptor antagonist activity (IBA,IEA)

interleukin-1 receptor binding (IEA,ISO)

interleukin-1 type I receptor antagonist activity (ISO)

interleukin-1 type II receptor antagonist activity (ISO)

interleukin-1, type I receptor binding (ISO)

interleukin-1, type II receptor binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-1 signaling pathway (ISO)

References

Additional References at PubMed

PMID:27902420

Genomics

Comparative Map Data

IL1RN
(Sus scrofa - pig)

No map positions available.

IL1RN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	113,099,360 - 113,134,014 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	113,099,315 - 113,134,016 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	113,875,548 - 113,891,591 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	113,591,941 - 113,608,064 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	113,591,700 - 113,607,823	NCBI
Celera	2	107,260,159 - 107,276,191 (+)	NCBI
Cytogenetic Map	2	q14.1	NCBI
HuRef	2	106,329,950 - 106,345,897 (+)	NCBI		HuRef
CHM1_1	2	113,879,899 - 113,896,017 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	113,544,556 - 113,560,594 (+)	NCBI

Il1rn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	24,226,872 - 24,241,503 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	2	24,226,865 - 24,241,506 (+)	Ensembl
GRCm38	2	24,336,860 - 24,351,491 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	24,336,853 - 24,351,494 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	24,192,380 - 24,207,011 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	24,158,869 - 24,173,490 (+)	NCBI			mm8
Celera	2	24,056,294 - 24,070,923 (+)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	16.36	NCBI

Il1rn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	7,111,567 - 7,127,451 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	3	7,111,550 - 7,127,445 (+)	Ensembl
Rnor_6.0	3	1,449,778 - 1,468,624 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	1,452,644 - 1,468,614 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	1,445,598 - 1,461,452 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	2,607,800 - 2,613,216 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	2,607,803 - 2,611,842 (+)	NCBI
Celera	3	1,959,290 - 1,964,693 (+)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

Il1rn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	1,144,810 - 1,159,471 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	1,145,022 - 1,159,413 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100991079
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	114,061,182 - 114,077,048 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	114,061,182 - 114,078,839 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	88,991,646 - 89,008,013 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

IL1RN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	37,236,690 - 37,250,424 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	37,212,751 - 37,249,329 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	37,014,575 - 37,019,617 (+)	NCBI
ROS_Cfam_1.0	17	38,014,380 - 38,028,164 (+)	NCBI
ROS_Cfam_1.0 Ensembl	17	38,014,324 - 38,027,492 (+)	Ensembl
UMICH_Zoey_3.1	17	37,157,832 - 37,162,873 (+)	NCBI
UNSW_CanFamBas_1.0	17	37,214,332 - 37,219,374 (+)	NCBI
UU_Cfam_GSD_1.0	17	37,426,795 - 37,431,843 (+)	NCBI

Il1rn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	82,552,650 - 82,571,860 (+)	NCBI
SpeTri2.0	NW_004936783	1,447,158 - 1,466,331 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IL1RN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	16,136,667 - 16,152,451 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	14	16,146,333 - 16,151,326 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666080	3,528,175 - 3,543,946 (-)	NCBI	Vero_WHO_p1.0

Il1rn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	13,210,476 - 13,225,890 (+)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624749	13,210,365 - 13,224,471 (+)	NCBI	HetGla_female_1.0		hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_214262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY577820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L38849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Protein Sequences


Protein RefSeqs	NP_999427	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA99424	(Get FASTA)	NCBI Sequence Viewer
	AAT00592	(Get FASTA)	NCBI Sequence Viewer
	Q29056	(Get FASTA)	NCBI Sequence Viewer

Additional Information

External Database Links

Database	Acc Id	Source(s)
InterPro	IL-1_CS	UniProtKB/Swiss-Prot
	IL-1_fam	UniProtKB/Swiss-Prot
	IL-1RA/IL-36	UniProtKB/Swiss-Prot
	IL1/FGF	UniProtKB/Swiss-Prot
	IL1RA	UniProtKB/Swiss-Prot
NCBI Gene	IL1RN	ENTREZGENE
PANTHER	PTHR10078	UniProtKB/Swiss-Prot
	PTHR10078:SF28	UniProtKB/Swiss-Prot
Pfam	IL1	UniProtKB/Swiss-Prot
PRINTS	INTERLEUKIN1	UniProtKB/Swiss-Prot
	INTRLEUKIN1X	UniProtKB/Swiss-Prot
PROSITE	INTERLEUKIN_1	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50353	UniProtKB/Swiss-Prot
UniProt	IL1RA_PIG	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)