IL1RN (interleukin 1 receptor antagonist) - Rat Genome Database

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Gene: IL1RN (interleukin 1 receptor antagonist) Sus scrofa
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Symbol: IL1RN
Name: interleukin 1 receptor antagonist
RGD ID: 13854425
Description: ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); interleukin-1 type I receptor antagonist activity (ortholog); interleukin-1 type II receptor antagonist activity (ortholog); INVOLVED IN acute-phase response (ortholog); carboxylic acid metabolic process (ortholog); cellular response to norepinephrine stimulus (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH Abscess (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog); INTERACTS WITH dibromine
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-1ra; IL-1RN; IL1 inhibitor; interleukin-1 receptor antagonist protein; IRAP; IRAP1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
Abscess  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
adult respiratory distress syndrome  (ISO)
allergic conjunctivitis  (ISO)
alopecia areata  (ISO)
Anorexia  (ISO)
anterior uveitis  (ISO)
anthracosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Arsenic Poisoning  (ISO)
asthma  (ISO)
Atrophy  (ISO)
autistic disorder  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis  (ISO)
bronchiolitis obliterans  (ISO)
Bronchopulmonary Dysplasia  (ISO)
bronchus carcinoma  (ISO)
Cachexia  (ISO)
calcium oxalate nephrolithiasis  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (ISO)
Cerebral Hemorrhage  (ISO)
cerebrovascular disease  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Rhinosinusitis  (ISO)
Chronic Uveitis  (ISO)
cicatricial pemphigoid  (ISO)
Colonic Neoplasms  (ISO)
common cold  (ISO)
Corneal Graft Rejection  (ISO)
corneal neovascularization  (ISO)
COVID-19  (ISO)
crescentic glomerulonephritis  (ISO)
Cryopyrin-Associated Periodic Syndromes  (ISO)
cystic fibrosis  (ISO)
dacryocystitis  (ISO)
Deficiency of Interleukin-1 Receptor Antagonist  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diarrhea  (ISO)
Drug Hypersensitivity Syndrome  (ISO)
Drug-Induced Agranulocytosis  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
encephalitis  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Endotoxin-Induced Uveitis  (ISO)
exanthem  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Extravasation of Diagnostic and Therapeutic Materials  (ISO)
Eye Manifestations  (ISO)
Febrile Seizures  (ISO)
Fever  (ISO)
fibromyalgia  (ISO)
Fibrosis  (ISO)
glomerulonephritis  (ISO)
gout  (ISO)
Graft vs Host Disease  (ISO)
Graves ophthalmopathy  (ISO)
hairy cell leukemia  (ISO)
hemolytic-uremic syndrome  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
interstitial lung disease  (ISO)
juvenile rheumatoid arthritis  (ISO)
keratoconus  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
learning disability  (ISO)
Leukocytosis  (ISO)
Lichen Sclerosus et Atrophicus  (ISO)
listeriosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Meibomian Gland Dysfunction  (ISO)
melanoma  (ISO)
mental depression  (ISO)
middle cerebral artery infarction  (ISO)
morbid obesity  (ISO)
Muckle-Wells syndrome  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myositis  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
Oligoanuria  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
periodontitis  (ISO)
pleural disease  (ISO)
pleural tuberculosis  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
pre-eclampsia  (ISO)
Proctocolitis  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
proteinuria  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
Pseudomonas Infections  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pyelonephritis  (ISO)
renal cell carcinoma  (ISO)
respiratory allergy  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Schnitzler syndrome  (ISO)
sciatic neuropathy  (ISO)
Sclerosis  (ISO)
Sepsis  (ISO)
Serositis  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
Tobacco Use Disorder  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
Urinary Calculi  (ISO)
Uveitis, Chronic Anterior  (ISO)
vascular disease  (ISO)
Venous Thrombosis  (ISO)
Ventilator-Induced Lung Injury  (ISO)
Viral Bronchiolitis  (ISO)
viral pneumonia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
dibromine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:27902420  


Genomics

Comparative Map Data
IL1RN
(Sus scrofa - pig)
No map positions available.
IL1RN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,099,360 - 113,134,014 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2113,099,315 - 113,134,016 (+)EnsemblGRCh38hg38GRCh38
GRCh372113,875,548 - 113,891,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,591,941 - 113,608,064 (+)NCBINCBI36hg18NCBI36
Build 342113,591,700 - 113,607,823NCBI
Celera2107,260,159 - 107,276,191 (+)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2106,329,950 - 106,345,897 (+)NCBIHuRef
CHM1_12113,879,899 - 113,896,017 (+)NCBICHM1_1
T2T-CHM13v2.02113,544,556 - 113,560,594 (+)NCBI
Il1rn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,226,872 - 24,241,503 (+)NCBIGRCm39mm39
GRCm39 Ensembl224,226,865 - 24,241,506 (+)Ensembl
GRCm38224,336,860 - 24,351,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,336,853 - 24,351,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv37224,192,380 - 24,207,011 (+)NCBIGRCm37mm9NCBIm37
MGSCv36224,158,869 - 24,173,490 (+)NCBImm8
Celera224,056,294 - 24,070,923 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.36NCBI
Il1rn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.237,111,567 - 7,127,451 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl37,111,550 - 7,127,445 (+)Ensembl
Rnor_6.031,449,778 - 1,468,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,452,644 - 1,468,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,445,598 - 1,461,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,607,800 - 2,613,216 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.132,607,803 - 2,611,842 (+)NCBI
Celera31,959,290 - 1,964,693 (+)NCBICelera
Cytogenetic Map3p13NCBI
Il1rn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,144,810 - 1,159,471 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,145,022 - 1,159,413 (-)NCBIChiLan1.0ChiLan1.0
LOC100991079
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A114,061,182 - 114,077,048 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A114,061,182 - 114,078,839 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A88,991,646 - 89,008,013 (-)NCBIMhudiblu_PPA_v0panPan3
IL1RN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,236,690 - 37,250,424 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,212,751 - 37,249,329 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,014,575 - 37,019,617 (+)NCBI
ROS_Cfam_1.01738,014,380 - 38,028,164 (+)NCBI
ROS_Cfam_1.0 Ensembl1738,014,324 - 38,027,492 (+)Ensembl
UMICH_Zoey_3.11737,157,832 - 37,162,873 (+)NCBI
UNSW_CanFamBas_1.01737,214,332 - 37,219,374 (+)NCBI
UU_Cfam_GSD_1.01737,426,795 - 37,431,843 (+)NCBI
Il1rn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,552,650 - 82,571,860 (+)NCBI
SpeTri2.0NW_0049367831,447,158 - 1,466,331 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1RN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,136,667 - 16,152,451 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1416,146,333 - 16,151,326 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660803,528,175 - 3,543,946 (-)NCBIVero_WHO_p1.0
Il1rn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474913,210,476 - 13,225,890 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474913,210,365 - 13,224,471 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Protein Sequences
Protein RefSeqs NP_999427 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA99424 (Get FASTA)   NCBI Sequence Viewer  
  AAT00592 (Get FASTA)   NCBI Sequence Viewer  
  Q29056 (Get FASTA)   NCBI Sequence Viewer  


Additional Information

Database Acc Id Source(s)
InterPro IL-1_CS UniProtKB/Swiss-Prot
  IL-1_fam UniProtKB/Swiss-Prot
  IL-1RA/IL-36 UniProtKB/Swiss-Prot
  IL1/FGF UniProtKB/Swiss-Prot
  IL1RA UniProtKB/Swiss-Prot
NCBI Gene IL1RN ENTREZGENE
PANTHER PTHR10078 UniProtKB/Swiss-Prot
  PTHR10078:SF28 UniProtKB/Swiss-Prot
Pfam IL1 UniProtKB/Swiss-Prot
PRINTS INTERLEUKIN1 UniProtKB/Swiss-Prot
  INTRLEUKIN1X UniProtKB/Swiss-Prot
PROSITE INTERLEUKIN_1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot
UniProt IL1RA_PIG UniProtKB/Swiss-Prot, ENTREZGENE