ID1 (inhibitor of DNA binding 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: ID1 (inhibitor of DNA binding 1) Sus scrofa
Analyze
Symbol: ID1
Name: inhibitor of DNA binding 1
RGD ID: 14254536
Description: ENCODES a protein that exhibits identical protein binding (ortholog); proteasome binding (ortholog); transcription factor binding (ortholog); INVOLVED IN apoptotic process (ortholog); BMP signaling pathway (ortholog); cell-abiotic substrate adhesion (ortholog); PARTICIPATES IN interleukin-3 signaling pathway; ASSOCIATED WITH cholestasis (ortholog); disease of cellular proliferation (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN centrosome (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA-binding protein inhibitor ID-1; inhibitor of DNA binding 1, HLH protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,316,514 - 35,317,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,316,518 - 35,317,742 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,187,160 - 40,188,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
BMP signaling pathway  (ISO)
cell differentiation  (IBA,IEA)
cell-abiotic substrate adhesion  (ISO)
cellular response to dopamine  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to peptide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
circadian regulation of gene expression  (IBA,IEA)
circadian rhythm  (ISO)
collagen metabolic process  (ISO)
endothelial cell apoptotic process  (ISO)
endothelial cell morphogenesis  (ISO)
heart development  (ISO)
lung morphogenesis  (ISO)
lung vasculature development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of dendrite morphogenesis  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
neuron differentiation  (ISO)
positive regulation of actin filament bundle assembly  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
protein destabilization  (ISO)
regulation of angiogenesis  (ISO)
regulation of MAPK cascade  (ISO)
regulation of vasculature development  (ISO)
response to antibiotic  (ISO)
response to organic cyclic compound  (ISO)

Cellular Component
centrosome  (ISO)
cytoplasm  (IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:20477796   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ID1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,316,514 - 35,317,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,316,518 - 35,317,742 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,187,160 - 40,188,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ID1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,605,289 - 31,606,510 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2031,605,283 - 31,606,515 (+)EnsemblGRCh38hg38GRCh38
GRCh372030,193,092 - 30,194,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,656,753 - 29,657,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 342029,656,752 - 29,657,974NCBI
Celera2026,949,273 - 26,950,494 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2026,981,781 - 26,983,013 (+)NCBIHuRef
CHM1_12030,096,962 - 30,098,194 (+)NCBICHM1_1
T2T-CHM13v2.02033,329,528 - 33,330,749 (+)NCBIT2T-CHM13v2.0
Id1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,578,171 - 152,579,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,578,171 - 152,579,330 (+)EnsemblGRCm39 Ensembl
GRCm382152,736,251 - 152,737,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,736,251 - 152,737,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,562,010 - 152,563,146 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,427,715 - 152,428,851 (+)NCBIMGSCv36mm8
Celera2158,552,315 - 158,553,451 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Id1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,671,525 - 161,672,691 (+)NCBIGRCr8
mRatBN7.23141,210,666 - 141,212,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,211,267 - 141,212,419 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,116,210 - 145,117,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,700,048 - 153,701,175 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,439,728 - 151,440,855 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,214,623 - 148,216,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,215,540 - 148,216,718 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,619,728 - 154,621,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,086,162 - 143,087,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13142,991,791 - 142,992,906 (+)NCBI
Celera3139,960,608 - 139,961,735 (+)NCBICelera
Cytogenetic Map3q41NCBI
Id1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,337,757 - 29,339,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,337,969 - 29,339,178 (-)NCBIChiLan1.0ChiLan1.0
ID1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,296,445 - 37,299,392 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,290,399 - 37,292,483 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02027,895,177 - 27,896,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12028,535,470 - 28,536,726 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2028,535,582 - 28,536,311 (+)Ensemblpanpan1.1panPan2
ID1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,094,339 - 21,096,276 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,094,755 - 21,096,276 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,741,568 - 20,743,501 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,780,949 - 21,782,885 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,781,704 - 21,782,885 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,059,018 - 21,060,951 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,163,982 - 21,165,918 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,594,218 - 21,596,151 (+)NCBIUU_Cfam_GSD_1.0
Id1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,179,346 - 170,180,525 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648518,610,665 - 18,612,059 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648518,610,721 - 18,611,889 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103247994
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,008,660 - 36,009,880 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,008,636 - 36,010,017 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,944,637 - 90,945,863 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Id1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741896,932 - 898,343 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741897,038 - 898,249 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ID1
10 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system
High
Medium
Low
Below cutoff 2 1 2 1 2 3 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000064936   ⟹   ENSSSCP00000040237
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1735,316,514 - 35,317,736 (+)Ensembl
RefSeq Acc Id: NM_001244700   ⟹   NP_001231629
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11735,316,518 - 35,317,742 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001231629   ⟸   NM_001244700
- UniProtKB: B3W6M6 (UniProtKB/TrEMBL),   A0A4X1SRC9 (UniProtKB/TrEMBL),   A0A8D1K6E8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000040237   ⟸   ENSSSCT00000064936
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037016 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005024704 UniProtKB/TrEMBL
  ENSSSCG00015067046 UniProtKB/TrEMBL
  ENSSSCG00025050324 UniProtKB/TrEMBL
  ENSSSCG00030052952 UniProtKB/TrEMBL
  ENSSSCG00035062145 UniProtKB/TrEMBL
  ENSSSCG00040023225 UniProtKB/TrEMBL
  ENSSSCG00045030506 UniProtKB/TrEMBL
  ENSSSCG00050059189 UniProtKB/TrEMBL
  ENSSSCG00055019014 UniProtKB/TrEMBL
  ENSSSCG00060061222 UniProtKB/TrEMBL
  ENSSSCG00065061889 UniProtKB/TrEMBL
  ENSSSCG00070003073 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000064936 ENTREZGENE
  ENSSSCT00000064936.3 UniProtKB/TrEMBL
  ENSSSCT00005039215.1 UniProtKB/TrEMBL
  ENSSSCT00015089843.1 UniProtKB/TrEMBL
  ENSSSCT00025068678.1 UniProtKB/TrEMBL
  ENSSSCT00030073870.1 UniProtKB/TrEMBL
  ENSSSCT00035083538.1 UniProtKB/TrEMBL
  ENSSSCT00040031096.1 UniProtKB/TrEMBL
  ENSSSCT00040031134.1 UniProtKB/TrEMBL
  ENSSSCT00045051988.1 UniProtKB/TrEMBL
  ENSSSCT00050080640.1 UniProtKB/TrEMBL
  ENSSSCT00055037224.1 UniProtKB/TrEMBL
  ENSSSCT00060083550.1 UniProtKB/TrEMBL
  ENSSSCT00065084867.1 UniProtKB/TrEMBL
  ENSSSCT00070005755.1 UniProtKB/TrEMBL
  ENSSSCT00070005761.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  DNA-bd_prot-inh UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report ssc:100522839 UniProtKB/TrEMBL
NCBI Gene ID1 ENTREZGENE
PANTHER DNA-BINDING PROTEIN INHIBITOR ID-1 UniProtKB/TrEMBL
  PTHR11723 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A4X1SRC9 ENTREZGENE
  A0A8D1K6E8 ENTREZGENE, UniProtKB/TrEMBL
  B3W6M6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1SRC9 UniProtKB/TrEMBL
VGNC ID VGNC:96366 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-22 ID1  inhibitor of DNA binding 1  ID1  inhibitor of DNA binding 1, HLH protein  Symbol and/or name change 19259463 PROVISIONAL