GDNF (glial cell derived neurotrophic factor) - Rat Genome Database

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Gene: GDNF (glial cell derived neurotrophic factor) Sus scrofa
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Symbol: GDNF
Name: glial cell derived neurotrophic factor
RGD ID: 14146028
Description: ENCODES a protein that exhibits glial cell-derived neurotrophic factor receptor binding (ortholog); growth factor activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN branching involved in ureteric bud morphogenesis (ortholog); cell population proliferation (ortholog); cellular response to dexamethasone stimulus (ortholog); ASSOCIATED WITH acoustic neuroma (ortholog); Alzheimer's disease (ortholog); amphetamine abuse (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: glial cell line-derived neurotrophic factor; glial cell-line derived neurotrophic factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1622,936,601 - 22,965,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11622,936,602 - 22,965,929 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21624,176,604 - 24,179,641 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cell population proliferation  (ISO)
cellular response to dexamethasone stimulus  (ISO)
commissural neuron axon guidance  (IEA)
dorsal spinal cord development  (IEA)
embryonic organ development  (IEA)
enteric nervous system development  (IEA)
male gonad development  (ISO)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEA,ISO)
metanephros development  (ISO)
midbrain development  (ISO)
mRNA stabilization  (IEA)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
negative regulation of neuron apoptotic process  (IBA,ISO)
nervous system development  (ISO)
neural crest cell migration  (IEA,ISO)
neuron differentiation  (ISO)
neuron projection development  (ISO)
organ induction  (IEA,ISO)
peripheral nervous system development  (IBA,ISO)
peristalsis  (IEA,ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IBA)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEA)
positive regulation of monooxygenase activity  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of ureteric bud formation  (IEA)
postganglionic parasympathetic fiber development  (IEA)
postsynaptic membrane organization  (IEA,ISO)
regulation of dopamine uptake involved in synaptic transmission  (IEA)
regulation of gene expression  (ISO)
regulation of morphogenesis of a branching structure  (ISO)
regulation of semaphorin-plexin signaling pathway  (IEA)
regulation of ureteric bud formation  (ISO)
response to wounding  (ISO)
retina development in camera-type eye  (ISO)
signal transduction  (IEA)
sympathetic nervous system development  (IEA)
ureteric bud development  (ISO)
ureteric bud formation  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:33255323  


Genomics

Comparative Map Data
GDNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1622,936,601 - 22,965,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11622,936,602 - 22,965,929 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21624,176,604 - 24,179,641 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GDNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl537,812,677 - 37,840,041 (-)EnsemblGRCh38hg38GRCh38
GRCh38537,812,677 - 37,840,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37537,812,779 - 37,840,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36537,851,510 - 37,875,539 (-)NCBINCBI36hg18NCBI36
Build 34537,851,509 - 37,870,655NCBI
Celera537,699,155 - 37,726,173 (-)NCBI
Cytogenetic Map5p13.2NCBI
HuRef537,765,313 - 37,792,316 (-)NCBIHuRef
CHM1_1537,814,804 - 37,841,806 (-)NCBICHM1_1
Gdnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39157,839,529 - 7,867,061 (+)NCBIGRCm39mm39
GRCm39 Ensembl157,840,327 - 7,867,056 (+)Ensembl
GRCm38157,810,048 - 7,837,580 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl157,810,846 - 7,837,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37157,761,011 - 7,787,575 (+)NCBIGRCm37mm9NCBIm37
MGSCv36157,758,226 - 7,784,790 (+)NCBImm8
Celera157,656,819 - 7,683,345 (+)NCBICelera
Cytogenetic Map15A1NCBI
Gdnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2256,893,992 - 56,919,935 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl256,895,010 - 56,917,209 (+)Ensembl
Rnor_6.0256,884,181 - 56,912,964 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl256,887,987 - 56,910,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0276,896,991 - 76,922,471 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4257,399,312 - 57,424,030 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1257,327,544 - 57,352,263 (+)NCBI
Celera252,510,468 - 52,532,694 (+)NCBICelera
Cytogenetic Map2q16NCBI
Gdnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542622,386,450 - 22,412,324 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542622,386,613 - 22,412,324 (-)NCBIChiLan1.0ChiLan1.0
GDNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1577,573,466 - 77,600,478 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl577,577,313 - 77,601,362 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0572,539,374 - 72,566,918 (+)NCBIMhudiblu_PPA_v0panPan3
GDNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1470,966,694 - 70,991,860 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl470,971,432 - 70,989,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0471,483,108 - 71,516,105 (+)NCBI
UMICH_Zoey_3.1471,230,252 - 71,263,217 (+)NCBI
UNSW_CanFamBas_1.0471,343,690 - 71,376,610 (+)NCBI
UU_Cfam_GSD_1.0471,882,215 - 71,915,204 (+)NCBI
Gdnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213227,058,585 - 227,083,871 (-)NCBI
SpeTri2.0NW_0049365184,291,391 - 4,310,752 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDNF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1436,662,033 - 36,691,761 (-)NCBI
ChlSab1.1 Ensembl436,665,009 - 36,684,257 (-)Ensembl
Vero_WHO_p1.0NW_02366607127,015,956 - 27,043,442 (-)NCBI
Gdnf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475917,263,570 - 17,290,046 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system hemolymphoid system musculoskeletal system nervous system renal system reproductive system
High
Medium
Low 7 2 2 4
Below cutoff 3 8 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000044133   ⟹   ENSSSCP00000043401
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1622,936,601 - 22,965,886 (-)Ensembl
RefSeq Acc Id: XM_005672424   ⟹   XP_005672481
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11622,936,602 - 22,960,661 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021076771   ⟹   XP_020932430
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11622,936,602 - 22,965,929 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021076772   ⟹   XP_020932431
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11622,936,602 - 22,965,929 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005672481 (Get FASTA)   NCBI Sequence Viewer  
  XP_020932430 (Get FASTA)   NCBI Sequence Viewer  
  XP_020932431 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADA60979 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020932431   ⟸   XM_021076772
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020932430   ⟸   XM_021076771
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005672481   ⟸   XM_005672424
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000043401   ⟸   ENSSSCT00000044133
Protein Domains
TGF_BETA_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038727 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070007037 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000043401 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070011133 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000044133 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070013504 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  GDNF UniProtKB/TrEMBL
  GDNF_fam UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
NCBI Gene GDNF ENTREZGENE
PANTHER PTHR12173 UniProtKB/TrEMBL
  PTHR12173:SF1 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
PROSITE TGF_BETA_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A287AHR3_PIG UniProtKB/TrEMBL
  A0A2Z5U6W9_PIG UniProtKB/TrEMBL
  A0A4X1T5H8_PIG UniProtKB/TrEMBL
  D2KMN4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88406 ENTREZGENE