SOD1 (superoxide dismutase 1) - Rat Genome Database

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Gene: SOD1 (superoxide dismutase 1) Sus scrofa
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Symbol: SOD1
Name: superoxide dismutase 1
RGD ID: 14045563
Description: ENCODES a protein that exhibits copper ion binding (ortholog); enzyme binding (ortholog); protein phosphatase 2B binding (ortholog); INVOLVED IN aging (ortholog); auditory receptor cell stereocilium organization (ortholog); cellular iron ion homeostasis (ortholog); PARTICIPATES IN amyotrophic lateral sclerosis pathway; forkhead class A signaling pathway; hypertension pathway; ASSOCIATED WITH acute kidney failure (ortholog); Alcoholic Fatty Liver (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); dense core granule (ortholog); INTERACTS WITH 6-anilino-5,8-quinolinedione; aldosterone; bisphenol A
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cu-Zn-superoxide dismutase; superoxide dismutase 1, soluble; superoxide dismutase [Cu-Zn]
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13195,326,649 - 195,337,749 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113195,326,573 - 195,335,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213205,620,994 - 205,629,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Alcoholic Fatty Liver  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
Aortic Calcification  (ISO)
aortic disease  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
cardiac arrest  (ISO)
cardiomyopathy  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystitis  (ISO)
developmental coordination disorder  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
Down syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fatigue  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
fragile X-associated tremor/ataxia syndrome  (ISO)
Gliosis  (ISO)
Hearing Loss  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Hemolysis  (ISO)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (ISO)
high grade glioma  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypotension  (ISO)
Hypothermia  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
iron deficiency anemia  (ISO)
ischemia  (ISO)
Kidney Calculi  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (ISO)
low tension glaucoma  (ISO)
macular degeneration  (ISO)
Marfan syndrome  (ISO)
MELAS syndrome  (ISO)
mental depression  (ISO)
middle cerebral artery infarction  (ISO)
motor neuron disease  (ISO)
Muscle Weakness  (ISO)
muscular atrophy  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrosis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neurologic Gait Disorders  (ISO)
newborn respiratory distress syndrome  (ISO)
non-alcoholic steatohepatitis  (ISO)
nutritional deficiency disease  (ISO)
obesity  (ISO)
ocular hypertension  (ISO)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
Paralysis  (ISO)
Parkinson's disease  (ISO)
Parkinson's disease 20  (ISO)
polycystic kidney disease  (ISO)
Presbycusis  (ISO)
prion disease  (ISO)
progressive supranuclear palsy  (ISO)
Protein Aggregation, Pathological  (ISO)
Protein Deficiency  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
Radiation Injuries, Experimental  (ISO)
renal artery obstruction  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (ISO)
retinitis pigmentosa  (ISO)
retinopathy of prematurity  (ISO)
Schistosomiasis Mansoni  (ISO)
sciatic neuropathy  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
SPASTIC TETRAPLEGIA AND AXIAL HYPOTONIA, PROGRESSIVE  (ISO)
spinal cord disease  (ISO)
Spinal Cord Injuries  (ISO)
Stroke  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Ureteral Calculi  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
anterograde axonal transport  (IEA)
auditory receptor cell stereocilium organization  (IEA,ISO)
cell aging  (IEA)
cellular iron ion homeostasis  (IEA,ISO)
cellular response to ATP  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to potassium ion  (ISO)
embryo implantation  (IEA,ISO)
glutathione metabolic process  (IEA,ISO)
heart contraction  (IEA,ISO)
hydrogen peroxide biosynthetic process  (IEA,ISO)
locomotory behavior  (IEA,ISO)
muscle cell cellular homeostasis  (IEA,ISO)
myeloid cell homeostasis  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cholesterol biosynthetic process  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO)
neurofilament cytoskeleton organization  (IEA,ISO)
ovarian follicle development  (IEA,ISO)
peripheral nervous system myelin maintenance  (IEA,ISO)
positive regulation of catalytic activity  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of superoxide anion generation  (IEA)
reactive oxygen species metabolic process  (ISO)
regulation of blood pressure  (IEA,ISO)
regulation of GTPase activity  (IEA)
regulation of mitochondrial membrane potential  (IEA)
regulation of multicellular organism growth  (IEA,ISO)
regulation of protein kinase activity  (IEA)
relaxation of vascular associated smooth muscle  (IEA,ISO)
removal of superoxide radicals  (IBA,ISO)
response to amphetamine  (ISO)
response to antibiotic  (ISO)
response to antipsychotic drug  (ISO)
response to axon injury  (IEA,ISO)
response to carbon monoxide  (ISO)
response to copper ion  (ISO)
response to ethanol  (IEA,ISO)
response to heat  (IEA,ISO)
response to hydrogen peroxide  (IEA,ISO)
response to nutrient levels  (ISO)
response to organic substance  (ISO)
response to oxidative stress  (ISO)
response to reactive oxygen species  (ISO)
response to superoxide  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
retina homeostasis  (IEA,ISO)
retrograde axonal transport  (IEA)
sensory perception of sound  (IEA,ISO)
spermatogenesis  (IEA,ISO)
superoxide anion generation  (IEA,ISO)
superoxide metabolic process  (ISO)
transmission of nerve impulse  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:3891411   PMID:6883177   PMID:14681463   PMID:15679890   PMID:17145712   PMID:20943491   PMID:23394364   PMID:28624353  


Genomics

Comparative Map Data
SOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13195,326,649 - 195,337,749 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113195,326,573 - 195,335,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213205,620,994 - 205,629,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2131,659,666 - 31,668,931 (+)EnsemblGRCh38hg38GRCh38
GRCh382131,659,693 - 31,668,931 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372133,032,006 - 33,041,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,953,806 - 31,963,115 (+)NCBINCBI36hg18NCBI36
Build 342131,953,805 - 31,963,112NCBI
Celera2118,215,252 - 18,224,561 (+)NCBI
Cytogenetic Map21q22.11ENTREZGENE
HuRef2118,441,963 - 18,451,272 (+)NCBIHuRef
CHM1_12132,593,921 - 32,603,230 (+)NCBICHM1_1
Sod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,017,650 - 90,023,221 (+)NCBIGRCm39mm39
GRCm39 Ensembl1690,017,642 - 90,023,217 (+)Ensembl
GRCm381690,220,762 - 90,226,333 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1690,220,754 - 90,226,329 (+)EnsemblGRCm38mm10GRCm38
MGSCv371690,220,987 - 90,226,569 (+)NCBIGRCm37mm9NCBIm37
MGSCv361690,109,601 - 90,115,183 (+)NCBImm8
Celera1690,416,380 - 90,421,958 (+)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.56NCBI
Sod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21129,456,673 - 29,462,249 (+)NCBI
Rnor_6.0 Ensembl1130,363,280 - 30,368,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01130,363,282 - 30,368,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01133,982,764 - 33,988,340 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41129,810,766 - 29,816,342 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11129,810,765 - 29,816,342 (-)NCBI
Celera1129,143,740 - 29,149,316 (+)NCBICelera
Cytogenetic Map11q11NCBI
Sod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540731,263,863 - 31,267,727 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540731,261,451 - 31,267,657 (+)NCBIChiLan1.0ChiLan1.0
SOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12131,411,702 - 31,419,432 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02118,029,831 - 18,037,526 (+)NCBIMhudiblu_PPA_v0panPan3
SOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13126,540,291 - 26,544,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3126,486,274 - 26,662,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3126,528,080 - 26,536,169 (+)NCBI
ROS_Cfam_1.03126,654,922 - 26,662,986 (+)NCBI
UMICH_Zoey_3.13126,600,785 - 26,608,887 (+)NCBI
UNSW_CanFamBas_1.03126,612,632 - 26,620,712 (+)NCBI
UU_Cfam_GSD_1.03127,118,829 - 27,126,937 (+)NCBI
Sod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497127,114,944 - 27,122,669 (+)NCBI
SpeTri2.0NW_00493650010,345,154 - 10,352,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1260,461,219 - 60,472,999 (-)NCBI
Vero_WHO_p1.0NW_0236660713,004,172 - 3,013,463 (-)NCBI
Sod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474520,032,003 - 20,037,958 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001190422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF396674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ010339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK236139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK240282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK346331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK351289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK392550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK392718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY610279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU210903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP325217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01050765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ913661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU944822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000029514   ⟹   ENSSSCP00000026815
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13195,326,649 - 195,337,749 (+)Ensembl
RefSeq Acc Id: NM_001190422   ⟹   NP_001177351
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113195,326,573 - 195,335,273 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001177351 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK84037 (Get FASTA)   NCBI Sequence Viewer  
  ADI47520 (Get FASTA)   NCBI Sequence Viewer  
  AHW83665 (Get FASTA)   NCBI Sequence Viewer  
  CAA09097 (Get FASTA)   NCBI Sequence Viewer  
  P04178 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001177351   ⟸   NM_001190422
- UniProtKB: P04178 (UniProtKB/Swiss-Prot),   D9D839 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000026815   ⟸   ENSSSCT00000029514
Protein Domains
Sod_Cu


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000021355 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025021718 UniProtKB/Swiss-Prot
  ENSSSCG00035056538 UniProtKB/Swiss-Prot
  ENSSSCG00045021700 UniProtKB/Swiss-Prot
  ENSSSCG00050053056 UniProtKB/Swiss-Prot
  ENSSSCG00055019424 UniProtKB/Swiss-Prot
  ENSSSCG00065066291 UniProtKB/Swiss-Prot
  ENSSSCG00070014563 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000026815 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00025012561 UniProtKB/Swiss-Prot
  ENSSSCP00035030755 UniProtKB/Swiss-Prot
  ENSSSCP00045025801 UniProtKB/Swiss-Prot
  ENSSSCP00050031075 UniProtKB/Swiss-Prot
  ENSSSCP00055030202 UniProtKB/Swiss-Prot
  ENSSSCP00065039821 UniProtKB/Swiss-Prot
  ENSSSCP00070023792 UniProtKB/TrEMBL
  ENSSSCP00070023804 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000029514 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00025029544 UniProtKB/Swiss-Prot
  ENSSSCT00035075531 UniProtKB/Swiss-Prot
  ENSSSCT00045037084 UniProtKB/Swiss-Prot
  ENSSSCT00050072256 UniProtKB/Swiss-Prot
  ENSSSCT00055038009 UniProtKB/Swiss-Prot
  ENSSSCT00065090983 UniProtKB/Swiss-Prot
  ENSSSCT00070028562 UniProtKB/TrEMBL
  ENSSSCT00070028574 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SOD-like_Cu/Zn_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu/Zn_/chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu/Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu_Zn_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397036 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene SOD1 ENTREZGENE
PANTHER PTHR10003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sod_Cu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CUZNDISMTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOD_CU_ZN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_CU_ZN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49329 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2C9F3F0_PIG UniProtKB/TrEMBL
  A0A4X1U6S5_PIG UniProtKB/TrEMBL
  D9D839 ENTREZGENE, UniProtKB/TrEMBL
  P04178 ENTREZGENE
  Q95ME5_PIG UniProtKB/TrEMBL
  SODC_PIG UniProtKB/Swiss-Prot