CSF2 (colony stimulating factor 2) - Rat Genome Database

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Gene: CSF2 (colony stimulating factor 2) Sus scrofa
Analyze
Symbol: CSF2
Name: colony stimulating factor 2
RGD ID: 14128383
Description: ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN ERK1 and ERK2 cascade; phosphatidylinositol 3-kinase signaling; positive regulation of trophectodermal cell proliferation; PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; syndecan signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); agranulocytosis (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); granulocyte macrophage colony-stimulating factor receptor complex (ortholog); INTERACTS WITH folic acid; glycine
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: colony-stimulating factor; CSF; GM-CSF; granulocyte-macrophage colony-stimulating factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,354,724 - 134,357,155 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,354,724 - 134,357,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,706,386 - 139,708,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute myeloid leukemia  (ISO)
agranulocytosis  (ISO)
amnestic disorder  (ISO)
anemia  (ISO)
aplastic anemia  (ISO)
asthma  (ISO)
B-cell lymphoma  (ISO)
Bacteremia  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
carcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Cough  (ISO)
COVID-19  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
eyelid disease  (ISO)
familial adenomatous polyposis 1  (ISO)
Femoral Fractures  (ISO)
Gastrointestinal Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Inflammation  (ISO)
interstitial cystitis  (ISO)
juvenile myelomonocytic leukemia  (ISO)
Limb Ischemia  (ISO)
Liver Neoplasms  (ISO)
Lymphoma, AIDS-Related  (ISO)
melanoma  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Muscle Weakness  (ISO)
myocardial infarction  (ISO)
Neoplasm, Residual  (ISO)
neural tube defect  (ISO)
Neurodevelopmental Disorders  (ISO)
neutropenia  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-Hodgkin lymphoma  (ISO)
Pain  (ISO)
Parkinsonism  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary alveolar proteinosis  (ISO)
pulmonary fibrosis  (ISO)
Radiation Injuries  (ISO)
rheumatoid arthritis  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
silicosis  (ISO)
Spinal Cord Injuries  (ISO)
systemic primary carnitine deficiency disease  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
Thyroid Neoplasms  (ISO)
Venous Thrombosis  (ISO)
Viral Bronchiolitis  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
folic acid  (EXP)
glycine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell population proliferation  (IEA,ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IEA)
cellular response to lipopolysaccharide  (ISO)
dendritic cell differentiation  (IEA,ISO)
embryonic placenta development  (IEA,ISO)
epithelial fluid transport  (ISO)
ERK1 and ERK2 cascade  (IMP)
granulocyte-macrophage colony-stimulating factor signaling pathway  (IEA)
histamine secretion  (ISO)
immune response  (IEA)
macrophage activation  (ISO)
macrophage differentiation  (IEA)
monocyte differentiation  (IEA,ISO)
myeloid cell differentiation  (IBA)
myeloid dendritic cell differentiation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
negative regulation of transcription, DNA-templated  (IEA)
neutrophil differentiation  (IEA,ISO)
phosphatidylinositol 3-kinase signaling  (IMP)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of interleukin-23 production  (IEA)
positive regulation of leukocyte proliferation  (IEA)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of podosome assembly  (IEA)
positive regulation of trophectodermal cell proliferation  (IMP)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
protein kinase B signaling  (IMP)
protein phosphorylation  (IEA)
receptor signaling pathway via JAK-STAT  (IEA)
regulation of cell population proliferation  (IEA,ISO)
regulation of circadian sleep/wake cycle, sleep  (ISO)
regulation of gene expression  (IEA,ISO)
response to fluid shear stress  (ISO)
response to silicon dioxide  (ISO)
signal transduction  (IEA)
TOR signaling  (IMP)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:8595928   PMID:14556997   PMID:16792532   PMID:24520418  


Genomics

Comparative Map Data
CSF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,354,724 - 134,357,155 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,354,724 - 134,357,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,706,386 - 139,708,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CSF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,073,789 - 132,076,170 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5132,073,789 - 132,076,170 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,409,482 - 131,411,863 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,437,384 - 131,439,758 (+)NCBINCBI36hg18NCBI36
Build 345131,437,383 - 131,439,758NCBI
Celera5127,539,561 - 127,541,935 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5126,601,846 - 126,604,224 (+)NCBIHuRef
CHM1_15130,842,312 - 130,844,690 (+)NCBICHM1_1
T2T-CHM13v2.05132,593,659 - 132,596,040 (+)NCBI
Csf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,138,096 - 54,140,725 (-)NCBIGRCm39mm39
GRCm39 Ensembl1154,138,097 - 54,140,493 (-)Ensembl
GRCm381154,247,270 - 54,249,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,247,271 - 54,249,667 (-)EnsemblGRCm38mm10GRCm38
MGSCv371154,060,772 - 54,063,401 (-)NCBIGRCm37mm9NCBIm37
MGSCv361154,090,687 - 54,093,065 (-)NCBImm8
Celera1158,835,805 - 58,838,455 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Csf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21038,386,945 - 38,388,926 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1038,386,945 - 38,389,199 (-)Ensembl
Rnor_6.01039,602,089 - 39,604,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,602,089 - 39,604,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,379,120 - 39,381,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,665,850 - 39,667,831 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,679,472 - 39,681,403 (-)NCBI
Celera1037,727,629 - 37,729,611 (-)NCBICelera
Cytogenetic Map10q22NCBI
Csf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,451,965 - 3,454,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554083,452,009 - 3,454,255 (+)NCBIChiLan1.0ChiLan1.0
CSF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15133,660,775 - 133,663,146 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,660,775 - 133,663,146 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05127,496,951 - 127,499,325 (+)NCBIMhudiblu_PPA_v0panPan3
CSF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,342,880 - 20,346,959 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,344,648 - 20,346,959 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,140,218 - 19,142,512 (+)NCBI
ROS_Cfam_1.01121,128,373 - 21,132,476 (+)NCBI
ROS_Cfam_1.0 Ensembl1121,129,967 - 21,132,524 (+)Ensembl
UMICH_Zoey_3.11119,849,460 - 19,851,754 (+)NCBI
UNSW_CanFamBas_1.01119,697,439 - 19,699,733 (+)NCBI
UU_Cfam_GSD_1.01120,339,024 - 20,341,318 (+)NCBI
Csf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,079,008 - 116,081,102 (-)NCBI
SpeTri2.0NW_0049366473,081,896 - 3,083,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,906,987 - 34,911,252 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2334,908,911 - 34,911,140 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603443,046,561 - 43,048,998 (-)NCBIVero_WHO_p1.0
Csf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473340,039,414 - 40,041,294 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473340,039,127 - 40,041,294 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system hemolymphoid system respiratory system
High
Medium
Low 4
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000027098   ⟹   ENSSSCP00000020413
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2134,354,724 - 134,357,155 (+)Ensembl
RefSeq Acc Id: NM_214118   ⟹   NP_999283
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12134,354,724 - 134,357,155 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_999283   ⟸   NM_214118
- Peptide Label: precursor
- UniProtKB: Q29118 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000020413   ⟸   ENSSSCT00000027098


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000023737 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00005044749 UniProtKB/TrEMBL
  ENSSSCG00015030234 UniProtKB/Swiss-Prot
  ENSSSCG00025043767 UniProtKB/Swiss-Prot
  ENSSSCG00030058422 UniProtKB/TrEMBL
  ENSSSCG00035036607 UniProtKB/TrEMBL
  ENSSSCG00040030479 UniProtKB/TrEMBL
  ENSSSCG00045011793 UniProtKB/TrEMBL
  ENSSSCG00055002608 UniProtKB/TrEMBL
  ENSSSCG00060046522 UniProtKB/TrEMBL
  ENSSSCG00065050499 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070018837 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000020413 UniProtKB/TrEMBL
  ENSSSCP00005045045 UniProtKB/TrEMBL
  ENSSSCP00015015867 UniProtKB/Swiss-Prot
  ENSSSCP00025025192 UniProtKB/Swiss-Prot
  ENSSSCP00030037412 UniProtKB/TrEMBL
  ENSSSCP00030037427 UniProtKB/TrEMBL
  ENSSSCP00035019404 UniProtKB/TrEMBL
  ENSSSCP00035019410 UniProtKB/TrEMBL
  ENSSSCP00040017157 UniProtKB/TrEMBL
  ENSSSCP00040017184 UniProtKB/TrEMBL
  ENSSSCP00045013743 UniProtKB/TrEMBL
  ENSSSCP00045013769 UniProtKB/TrEMBL
  ENSSSCP00055003846 UniProtKB/TrEMBL
  ENSSSCP00055003859 UniProtKB/TrEMBL
  ENSSSCP00060027075 UniProtKB/TrEMBL
  ENSSSCP00060027078 UniProtKB/TrEMBL
  ENSSSCP00065030129 UniProtKB/TrEMBL
  ENSSSCP00065030133 UniProtKB/Swiss-Prot
  ENSSSCP00070031088 UniProtKB/TrEMBL
  ENSSSCP00070031092 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000027098 UniProtKB/TrEMBL
  ENSSSCT00005072114 UniProtKB/TrEMBL
  ENSSSCT00015040085 UniProtKB/Swiss-Prot
  ENSSSCT00025059383 UniProtKB/Swiss-Prot
  ENSSSCT00030081528 UniProtKB/TrEMBL
  ENSSSCT00030081557 UniProtKB/TrEMBL
  ENSSSCT00035048520 UniProtKB/TrEMBL
  ENSSSCT00035048531 UniProtKB/TrEMBL
  ENSSSCT00040040973 UniProtKB/TrEMBL
  ENSSSCT00040041039 UniProtKB/TrEMBL
  ENSSSCT00045020004 UniProtKB/TrEMBL
  ENSSSCT00045020036 UniProtKB/TrEMBL
  ENSSSCT00055004984 UniProtKB/TrEMBL
  ENSSSCT00055005000 UniProtKB/TrEMBL
  ENSSSCT00060063151 UniProtKB/TrEMBL
  ENSSSCT00060063159 UniProtKB/TrEMBL
  ENSSSCT00065069173 UniProtKB/TrEMBL
  ENSSSCT00065069179 UniProtKB/Swiss-Prot
  ENSSSCT00070037170 UniProtKB/TrEMBL
  ENSSSCT00070037176 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GM_colony-stim-fac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397208 UniProtKB/Swiss-Prot
NCBI Gene CSF2 ENTREZGENE
PANTHER PTHR10059 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GM_CSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GMCSFACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GM_CSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CSF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1UP43_PIG UniProtKB/TrEMBL
  A0A8D0XJT3_PIG UniProtKB/TrEMBL
  A0A8D0ZNN0_PIG UniProtKB/TrEMBL
  A0A8D1E543_PIG UniProtKB/TrEMBL
  A0A8D1HAV7_PIG UniProtKB/TrEMBL
  A0A8D2BKZ3_PIG UniProtKB/TrEMBL
  CSF2_PIG UniProtKB/Swiss-Prot
  I3L8Q3_PIG UniProtKB/TrEMBL
  Q29118 ENTREZGENE
UniProt Secondary Q29046 UniProtKB/Swiss-Prot
VGNC ID VGNC:87032 ENTREZGENE