CSF2 (colony stimulating factor 2) - Rat Genome Database

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Gene: CSF2 (colony stimulating factor 2) Sus scrofa
Analyze
Symbol: CSF2
Name: colony stimulating factor 2
RGD ID: 14128383
Description: ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN ERK1 and ERK2 cascade; phosphatidylinositol 3-kinase signaling; positive regulation of trophectodermal cell proliferation; PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; syndecan signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); agranulocytosis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH folic acid; glycine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: colony-stimulating factor; CSF; GM-CSF; granulocyte-macrophage colony-stimulating factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,354,724 - 134,357,155 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,354,724 - 134,357,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,706,386 - 139,708,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute myeloid leukemia  (ISO)
agranulocytosis  (ISO)
amnestic disorder  (ISO)
anemia  (ISO)
aplastic anemia  (ISO)
asthma  (ISO)
B-cell lymphoma  (ISO)
Bacteremia  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
carcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Cough  (ISO)
COVID-19  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
eyelid disease  (ISO)
familial adenomatous polyposis 1  (ISO)
Femoral Fractures  (ISO)
Gastrointestinal Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Inflammation  (ISO)
interstitial cystitis  (ISO)
juvenile myelomonocytic leukemia  (ISO)
Limb Ischemia  (ISO)
Liver Neoplasms  (ISO)
Lymphoma, AIDS-Related  (ISO)
melanoma  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Muscle Weakness  (ISO)
myocardial infarction  (ISO)
Neoplasm, Residual  (ISO)
neural tube defect  (ISO)
Neurodevelopmental Disorders  (ISO)
neutropenia  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-Hodgkin lymphoma  (ISO)
Pain  (ISO)
Parkinsonism  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary alveolar proteinosis  (ISO)
pulmonary fibrosis  (ISO)
Radiation Injuries  (ISO)
rheumatoid arthritis  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
silicosis  (ISO)
Spinal Cord Injuries  (ISO)
systemic primary carnitine deficiency disease  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
Thyroid Neoplasms  (ISO)
Venous Thrombosis  (ISO)
Viral Bronchiolitis  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
folic acid  (EXP)
glycine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:8595928   PMID:14556997   PMID:16792532   PMID:24520418  


Genomics

Comparative Map Data
CSF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,354,724 - 134,357,155 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,354,724 - 134,357,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,706,386 - 139,708,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CSF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5132,073,789 - 132,076,170 (+)EnsemblGRCh38hg38GRCh38
GRCh385132,073,789 - 132,076,170 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375131,409,482 - 131,411,863 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,437,384 - 131,439,758 (+)NCBINCBI36hg18NCBI36
Build 345131,437,383 - 131,439,758NCBI
Celera5127,539,561 - 127,541,935 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5126,601,846 - 126,604,224 (+)NCBIHuRef
CHM1_15130,842,312 - 130,844,690 (+)NCBICHM1_1
Csf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,138,096 - 54,140,725 (-)NCBIGRCm39mm39
GRCm39 Ensembl1154,138,097 - 54,140,493 (-)Ensembl
GRCm381154,247,270 - 54,249,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,247,271 - 54,249,667 (-)EnsemblGRCm38mm10GRCm38
MGSCv371154,060,772 - 54,063,401 (-)NCBIGRCm37mm9NCBIm37
MGSCv361154,090,687 - 54,093,065 (-)NCBImm8
Celera1158,835,805 - 58,838,455 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Csf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21038,386,945 - 38,388,926 (-)NCBI
Rnor_6.0 Ensembl1039,602,089 - 39,604,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01039,602,089 - 39,604,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01039,379,120 - 39,381,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,665,850 - 39,667,831 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,679,472 - 39,681,403 (-)NCBI
Celera1037,727,629 - 37,729,611 (-)NCBICelera
Cytogenetic Map10q22NCBI
Csf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,451,965 - 3,454,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554083,452,009 - 3,454,255 (+)NCBIChiLan1.0ChiLan1.0
CSF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15133,660,775 - 133,663,146 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,660,775 - 133,663,146 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05127,496,951 - 127,499,325 (+)NCBIMhudiblu_PPA_v0panPan3
CSF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,342,880 - 20,346,959 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,344,648 - 20,346,959 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,140,218 - 19,142,512 (+)NCBI
ROS_Cfam_1.01121,128,373 - 21,132,476 (+)NCBI
UMICH_Zoey_3.11119,849,460 - 19,851,754 (+)NCBI
UNSW_CanFamBas_1.01119,697,439 - 19,699,733 (+)NCBI
UU_Cfam_GSD_1.01120,339,024 - 20,341,318 (+)NCBI
Csf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,079,008 - 116,081,102 (-)NCBI
SpeTri2.0NW_0049366473,081,896 - 3,083,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,906,987 - 34,911,252 (+)NCBI
ChlSab1.1 Ensembl2334,908,911 - 34,911,140 (+)Ensembl
Vero_WHO_p1.0NW_02366603443,046,561 - 43,048,998 (-)NCBI
Csf2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473340,039,127 - 40,041,294 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system hemolymphoid system respiratory system
High
Medium
Low 4
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000027098   ⟹   ENSSSCP00000020413
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2134,354,724 - 134,357,155 (+)Ensembl
RefSeq Acc Id: NM_214118   ⟹   NP_999283
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12134,354,724 - 134,357,155 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_999283   ⟸   NM_214118
- Peptide Label: precursor
- UniProtKB: Q29118 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000020413   ⟸   ENSSSCT00000027098


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000023737 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015030234 UniProtKB/Swiss-Prot
  ENSSSCG00025043767 UniProtKB/Swiss-Prot
  ENSSSCG00065050499 UniProtKB/Swiss-Prot
  ENSSSCG00070018837 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000020413 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00015015867 UniProtKB/Swiss-Prot
  ENSSSCP00025025192 UniProtKB/Swiss-Prot
  ENSSSCP00065030133 UniProtKB/Swiss-Prot
  ENSSSCP00070031088 UniProtKB/TrEMBL
  ENSSSCP00070031092 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000027098 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00015040085 UniProtKB/Swiss-Prot
  ENSSSCT00025059383 UniProtKB/Swiss-Prot
  ENSSSCT00065069179 UniProtKB/Swiss-Prot
  ENSSSCT00070037170 UniProtKB/TrEMBL
  ENSSSCT00070037176 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GM_colony-stim-fac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397208 UniProtKB/Swiss-Prot
NCBI Gene CSF2 ENTREZGENE
PANTHER PTHR10059 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GM_CSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GMCSFACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GM_CSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CSF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1UP43_PIG UniProtKB/TrEMBL
  CSF2_PIG UniProtKB/Swiss-Prot
  I3L8Q3_PIG UniProtKB/TrEMBL
  Q29118 ENTREZGENE
UniProt Secondary Q29046 UniProtKB/Swiss-Prot
VGNC ID VGNC:87032 ENTREZGENE