ATF4 (activating transcription factor 4) - Rat Genome Database

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Gene: ATF4 (activating transcription factor 4) Sus scrofa
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Symbol: ATF4
Name: activating transcription factor 4
RGD ID: 13884038
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor binding (ortholog); general transcription initiation factor binding (ortholog); INVOLVED IN cellular calcium ion homeostasis (ortholog); cellular response to amino acid starvation (ortholog); cellular response to oxidative stress (ortholog); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); borna disease (ortholog); fatty liver disease (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); dendrite membrane (ortholog); INTERACTS WITH cadmium atom; cadmium dichloride; cycloheximide
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activating transcription factor 4 (tax-responsive enhancer element B67); cAMP response element-binding protein 2; CREB2; cyclic AMP-dependent transcription factor ATF-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,738,880 - 8,745,225 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,742,964 - 8,745,752 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,042,584 - 6,044,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone mineralization  (IEA)
cellular calcium ion homeostasis  (IEA,ISO)
cellular response to amino acid starvation  (ISO)
cellular response to dopamine  (IEA)
cellular response to glucose starvation  (IEA)
cellular response to leucine starvation  (IEA)
cellular response to oxidative stress  (ISO)
cellular response to oxygen-glucose deprivation  (ISO)
circadian regulation of gene expression  (IEA)
circadian rhythm  (ISO)
embryonic hemopoiesis  (IEA)
endoplasmic reticulum unfolded protein response  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
gluconeogenesis  (IEA,ISO)
HRI-mediated signaling  (IEA)
integrated stress response signaling  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA)
L-asparagine metabolic process  (IEA)
lens fiber cell morphogenesis  (IEA)
mRNA transcription by RNA polymerase II  (IEA)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of oxidative stress-induced neuron death  (IEA)
negative regulation of potassium ion transport  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
neuron differentiation  (ISO)
PERK-mediated unfolded protein response  (IEA)
positive regulation of biomineral tissue development  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of neuron apoptotic process  (IEA)
positive regulation of sodium-dependent phosphate transport  (IEA,ISO)
positive regulation of transcription by RNA polymerase I  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (IEA)
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (IEA)
positive regulation of vascular associated smooth muscle cell apoptotic process  (IEA,ISO)
positive regulation of vascular endothelial growth factor production  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of osteoblast differentiation  (IEA)
regulation of synaptic plasticity  (IEA)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to endoplasmic reticulum stress  (ISO)
response to manganese-induced endoplasmic reticulum stress  (ISO)
response to nutrient levels  (ISO)
response to toxic substance  (ISO)
transcription by RNA polymerase II  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:19691921   PMID:22207380   PMID:34246831  


Genomics

Comparative Map Data
ATF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,738,880 - 8,745,225 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,742,964 - 8,745,752 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,042,584 - 6,044,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,520,559 - 39,522,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2239,519,695 - 39,522,683 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,916,564 - 39,918,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,246,515 - 38,248,637 (+)NCBINCBI36hg18NCBI36
Build 342238,241,068 - 38,243,191NCBI
Celera2223,718,625 - 23,720,747 (+)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2222,881,158 - 22,883,280 (+)NCBIHuRef
CHM1_12239,875,308 - 39,877,431 (+)NCBICHM1_1
T2T-CHM13v2.02239,991,189 - 39,993,317 (+)NCBI
Atf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,139,385 - 80,141,746 (+)NCBIGRCm39mm39
GRCm39 Ensembl1580,139,385 - 80,141,742 (+)Ensembl
GRCm381580,255,184 - 80,257,545 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,255,184 - 80,257,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv371580,085,614 - 80,087,971 (+)NCBIGRCm37mm9NCBIm37
MGSCv361580,082,756 - 80,084,759 (+)NCBImm8
Celera1582,372,526 - 82,374,883 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Atf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27111,804,135 - 111,806,457 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl7111,804,183 - 111,806,446 (+)Ensembl
Rnor_6.07121,480,723 - 121,482,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,480,723 - 121,482,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,468,275 - 121,470,587 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,537,718 - 118,538,994NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17118,571,947 - 118,573,223NCBI
Cytogenetic Map7q34NCBI
Atf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,406,589 - 25,412,218 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,406,589 - 25,408,727 (+)NCBIChiLan1.0ChiLan1.0
ATF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12238,246,337 - 38,249,333 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,248,094 - 38,249,249 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02220,426,743 - 20,428,892 (+)NCBIMhudiblu_PPA_v0panPan3
ATF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,528,880 - 25,531,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,528,874 - 25,530,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,464,741 - 25,466,879 (-)NCBI
ROS_Cfam_1.01026,280,612 - 26,282,756 (-)NCBI
ROS_Cfam_1.0 Ensembl1026,280,619 - 26,282,738 (-)Ensembl
UMICH_Zoey_3.11025,995,219 - 25,997,329 (-)NCBI
UNSW_CanFamBas_1.01026,314,765 - 26,316,875 (-)NCBI
UU_Cfam_GSD_1.01026,490,223 - 26,492,367 (-)NCBI
Atf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,104,066 - 9,105,487 (-)NCBI
SpeTri2.0NW_0049364922,114,478 - 2,115,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,092,046 - 22,094,184 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,091,667 - 22,095,230 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045103,557,595 - 103,561,018 (-)NCBIVero_WHO_p1.0
Atf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,822,740 - 8,825,032 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247528,822,955 - 8,825,019 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 20 3 3
Low 3 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000064502   ⟹   ENSSSCP00000057464
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl58,738,880 - 8,745,225 (-)Ensembl
RefSeq Acc Id: NM_001123078   ⟹   NP_001116550
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.158,742,970 - 8,745,036 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090887   ⟹   XP_020946546
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.158,742,964 - 8,745,752 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001116550 (Get FASTA)   NCBI Sequence Viewer  
  XP_020946546 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABK56832 (Get FASTA)   NCBI Sequence Viewer  
  ACC62401 (Get FASTA)   NCBI Sequence Viewer  
  ADP21474 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020946546   ⟸   XM_021090887
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001116550   ⟸   NM_001123078
- UniProtKB: A0N0D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000057464   ⟸   ENSSSCT00000064502
Protein Domains
bZIP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000084 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00005009045 UniProtKB/TrEMBL
  ENSSSCG00015035821 UniProtKB/TrEMBL
  ENSSSCG00025025156 UniProtKB/TrEMBL
  ENSSSCG00030005002 UniProtKB/TrEMBL
  ENSSSCG00035076393 UniProtKB/TrEMBL
  ENSSSCG00040050769 UniProtKB/TrEMBL
  ENSSSCG00045027421 UniProtKB/TrEMBL
  ENSSSCG00050076184 UniProtKB/TrEMBL
  ENSSSCG00055010007 UniProtKB/TrEMBL
  ENSSSCG00060048277 UniProtKB/TrEMBL
  ENSSSCG00065015378 UniProtKB/TrEMBL
  ENSSSCG00070027080 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000057464.1 UniProtKB/TrEMBL
  ENSSSCP00005008198.1 UniProtKB/TrEMBL
  ENSSSCP00015018932.1 UniProtKB/TrEMBL
  ENSSSCP00025014135.1 UniProtKB/TrEMBL
  ENSSSCP00030003033.1 UniProtKB/TrEMBL
  ENSSSCP00035044524.1 UniProtKB/TrEMBL
  ENSSSCP00040029168.1 UniProtKB/TrEMBL
  ENSSSCP00045032436.1 UniProtKB/TrEMBL
  ENSSSCP00050045907.1 UniProtKB/TrEMBL
  ENSSSCP00055015431.1 UniProtKB/TrEMBL
  ENSSSCP00060028072.1 UniProtKB/TrEMBL
  ENSSSCP00065008282.1 UniProtKB/TrEMBL
  ENSSSCP00070046073.1 UniProtKB/TrEMBL
  ENSSSCP00070046081.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000064502.2 UniProtKB/TrEMBL
  ENSSSCT00005013800.1 UniProtKB/TrEMBL
  ENSSSCT00015047763.1 UniProtKB/TrEMBL
  ENSSSCT00025033957.1 UniProtKB/TrEMBL
  ENSSSCT00030006802.1 UniProtKB/TrEMBL
  ENSSSCT00035104010.1 UniProtKB/TrEMBL
  ENSSSCT00040068538.1 UniProtKB/TrEMBL
  ENSSSCT00045046733.1 UniProtKB/TrEMBL
  ENSSSCT00050104604.1 UniProtKB/TrEMBL
  ENSSSCT00055019561.1 UniProtKB/TrEMBL
  ENSSSCT00060065565.1 UniProtKB/TrEMBL
  ENSSSCT00065020415.1 UniProtKB/TrEMBL
  ENSSSCT00070054332.1 UniProtKB/TrEMBL
  ENSSSCT00070054343.1 UniProtKB/TrEMBL
InterPro ATF4 UniProtKB/TrEMBL
  bZIP UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
KEGG Report ssc:100144302 UniProtKB/TrEMBL
NCBI Gene ATF4 ENTREZGENE
PANTHER PTHR13044:SF32 UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/TrEMBL
UniProt A0A287BLS7_PIG UniProtKB/TrEMBL
  A0A4X1VWR7_PIG UniProtKB/TrEMBL
  A0A4X1VXQ0_PIG UniProtKB/TrEMBL
  A0N0D5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85607 ENTREZGENE