NOG (noggin) - Rat Genome Database

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Gene: NOG (noggin) Sus scrofa
Analyze
Symbol: NOG
Name: noggin
RGD ID: 14144126
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); axial mesoderm development (ortholog); axon guidance (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH acute kidney tubular necrosis (ortholog); Alzheimer's disease (ortholog); cleft lip (ortholog); FOUND IN axon (ortholog); extracellular space (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1232,891,321 - 32,892,206 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11232,891,321 - 32,892,206 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (ISO)
atrial cardiac muscle tissue morphogenesis  (IEA)
axial mesoderm development  (IEA,ISO)
axon guidance  (ISO)
BMP signaling pathway involved in heart development  (IEA)
brain development  (ISO)
cartilage development  (IEA)
cell differentiation in hindbrain  (IEA)
cellular response to BMP stimulus  (ISO)
cellular response to hypoxia  (ISO)
central nervous system development  (ISO)
dorsal/ventral pattern formation  (IBA)
embryonic digit morphogenesis  (IEA)
embryonic skeletal joint morphogenesis  (IEA)
embryonic skeletal system development  (ISO)
endocardial cushion morphogenesis  (IEA)
endoderm development  (ISO)
endoderm formation  (IEA,ISO)
epithelial to mesenchymal transition  (ISS)
face morphogenesis  (IEA,ISO)
fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation  (IEA)
forebrain development  (ISO)
heart trabecula morphogenesis  (IEA)
hippocampus development  (ISO)
in utero embryonic development  (IEA,ISO)
limb development  (ISO)
lung morphogenesis  (IEA,ISO)
membranous septum morphogenesis  (IEA)
memory  (ISO)
mesenchymal cell differentiation  (ISO)
mesoderm formation  (IEA,ISO)
middle ear morphogenesis  (IEA)
motor neuron axon guidance  (IEA,ISO)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of astrocyte differentiation  (ISO,ISS)
negative regulation of BMP signaling pathway  (IBA,ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cardiac muscle cell proliferation  (ISS)
negative regulation of cartilage development  (IEA,ISO)
negative regulation of cell migration  (IEA)
negative regulation of cytokine activity  (IEA)
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (IEA)
negative regulation of gene expression  (IEA,ISO)
negative regulation of osteoblast differentiation  (IEA)
negative regulation of pathway-restricted SMAD protein phosphorylation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
neural plate morphogenesis  (IEA,ISO)
neural tube closure  (IEA,ISO)
neural tube development  (ISO)
notochord morphogenesis  (IEA,ISO)
ossification  (ISO)
osteoblast differentiation  (IBA,ISS)
outflow tract morphogenesis  (IEA)
pattern specification process  (ISO)
pharyngeal arch artery morphogenesis  (IEA)
pituitary gland development  (IEA,ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISS)
positive regulation of cell population proliferation  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of glomerulus development  (ISS)
positive regulation of oligodendrocyte progenitor proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
prostatic bud formation  (IEA,ISO)
regulation of BMP signaling pathway  (ISO)
regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation  (IEA)
skeletal system development  (ISO)
somatic stem cell population maintenance  (IEA)
somite development  (IEA,ISO)
spinal cord development  (IEA,ISO)
ureteric bud development  (ISO)
ureteric bud formation  (IEA)
urogenital system development  (ISO)
ventricular compact myocardium morphogenesis  (IEA)
ventricular septum morphogenesis  (ISO)
visual learning  (ISO)
wound healing  (ISO,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:12097429   PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
NOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1232,891,321 - 32,892,206 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11232,891,321 - 32,892,206 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1756,593,699 - 56,595,611 (+)EnsemblGRCh38hg38GRCh38
GRCh381756,593,699 - 56,595,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371754,671,060 - 54,672,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361752,026,274 - 52,027,546 (+)NCBINCBI36hg18NCBI36
Build 341752,026,273 - 52,027,542NCBI
Celera1751,132,757 - 51,134,648 (+)NCBI
Cytogenetic Map17q22NCBI
HuRef1750,031,838 - 50,033,727 (+)NCBIHuRef
CHM1_11754,735,932 - 54,737,820 (+)NCBICHM1_1
Nog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,191,464 - 89,193,385 (-)NCBIGRCm39mm39
GRCm39 Ensembl1189,191,464 - 89,193,158 (-)Ensembl
GRCm381189,300,638 - 89,302,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,300,638 - 89,302,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371189,161,952 - 89,163,873 (-)NCBIGRCm37mm9NCBIm37
MGSCv361189,117,412 - 89,118,110 (-)NCBImm8
Celera1198,919,523 - 98,921,373 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1154.34NCBI
Nog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21074,128,712 - 74,130,339 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1074,128,712 - 74,130,339 (-)Ensembl
Rnor_6.01076,811,759 - 76,813,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1076,811,759 - 76,813,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,677,612 - 76,679,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41077,689,244 - 77,690,871 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11077,703,801 - 77,704,728 (-)NCBI
Celera1073,029,127 - 73,030,754 (-)NCBICelera
Cytogenetic Map10q26NCBI
Nog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554516,193,042 - 6,193,740 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554516,192,368 - 6,193,766 (-)NCBIChiLan1.0ChiLan1.0
NOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11755,532,208 - 55,533,782 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1755,532,394 - 55,533,092 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01750,669,186 - 50,671,081 (+)NCBIMhudiblu_PPA_v0panPan3
NOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1931,453,604 - 31,456,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha930,695,378 - 30,696,228 (+)NCBI
ROS_Cfam_1.0932,262,855 - 32,263,712 (+)NCBI
UMICH_Zoey_3.1931,048,413 - 31,049,269 (+)NCBI
UNSW_CanFamBas_1.0931,332,204 - 31,333,060 (+)NCBI
UU_Cfam_GSD_1.0931,415,982 - 31,416,833 (+)NCBI
Nog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560230,811,040 - 30,812,486 (+)NCBI
SpeTri2.0NW_0049364906,262,651 - 6,264,069 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11636,816,783 - 36,818,693 (-)NCBI
ChlSab1.1 Ensembl1636,817,476 - 36,818,174 (-)Ensembl
Vero_WHO_p1.0NW_0236660777,642,384 - 7,644,356 (-)NCBI
Nog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479511,696,102 - 11,697,367 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system musculoskeletal system nervous system reproductive system
High
Medium
Low 1 19
Below cutoff 3 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000048427   ⟹   ENSSSCP00000053671
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1232,891,321 - 32,892,206 (+)Ensembl
RefSeq Acc Id: NM_001143691   ⟹   NP_001137163
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11232,891,321 - 32,892,206 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001137163 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAY41071 (Get FASTA)   NCBI Sequence Viewer  
  ACJ72018 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001137163   ⟸   NM_001143691
- Peptide Label: precursor
- UniProtKB: B8XVN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000053671   ⟸   ENSSSCT00000048427


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000036437 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070023642 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000053671 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070039779 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000048427 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070047150 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Noggin UniProtKB/TrEMBL
KEGG Report ssc:574073 UniProtKB/TrEMBL
NCBI Gene NOG ENTREZGENE
PANTHER PTHR10494 UniProtKB/TrEMBL
PIRSF Noggin UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A4X1V9V6_PIG UniProtKB/TrEMBL
  B8XVN4 ENTREZGENE, UniProtKB/TrEMBL
  Q4U312_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90812 ENTREZGENE