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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:perfluorodecanoic acid
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Accession:CHEBI:35546 term browser browse the term
Definition:A fluoroalkanoic acid that is perfluorinated decanoic acid.
Synonyms:exact_synonym: nonadecafluorodecanoic acid
 related_synonym: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluorodecanoic acid;   Formula=C10HF19O2;   InChI=1S/C10HF19O2/c11-2(12,1(30)31)3(13,14)4(15,16)5(17,18)6(19,20)7(21,22)8(23,24)9(25,26)10(27,28)29/h(H,30,31);   InChIKey=PCIUEQPBYFRTEM-UHFFFAOYSA-N;   Ndfda;   PFDA;   SMILES=OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F;   nonadecafluoro-n-decanoic acid;   perfluoro-n-decanoic acid
 xref: CAS:335-76-2;   Gmelin:35659
 xref_mesh: MESH:C036567
 xref: PMID:24367824;   PMID:24582365;   PMID:24630253;   Reaxys:1810811


show annotations for term's descendants           Sort by:
perfluorodecanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP perfluorodecanoic acid results in increased expression of A2M mRNA CTD PMID:23567314 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Abca1 ATP-binding cassette, sub-family A member 1 increases expression ISO perfluorodecanoic acid results in increased expression of ABCA1 mRNA CTD PMID:35337807 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 increases expression EXP perfluorodecanoic acid results in increased expression of ABCB4 mRNA CTD PMID:38181850 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of ABCC2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC2 mRNA]		 CTD PMID:27344344 PMID:38181850 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of ABCC3 mRNA
NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]		 CTD PMID:18757529 PMID:38181850 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions
increases expression		 EXP gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA] CTD PMID:18757529 PMID:27344344 PMID:38181850 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression EXP perfluorodecanoic acid results in increased expression of ABCG2 mRNA CTD PMID:38181850 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP perfluorodecanoic acid results in increased expression of ABCG8 mRNA CTD PMID:38181850 NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of ACOT1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ACOT1 mRNA]		 CTD PMID:27344344 NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression ISO perfluorodecanoic acid results in increased expression of ACOT2 mRNA CTD PMID:35337807 NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl increases activity ISO perfluorodecanoic acid results in increased activity of ACOX1 protein CTD PMID:8001245 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO perfluorodecanoic acid results in increased expression of ACSL1 mRNA CTD PMID:23567314 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088 		JBrowse link
G Ahnak2 AHNAK nucleoprotein 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of AHNAK2 mRNA CTD PMID:38568856 NCBI chr12:112,738,631...112,766,278
Ensembl chr12:112,738,628...112,766,277 		JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 decreases expression ISO perfluorodecanoic acid results in decreased expression of AKR1C2 mRNA CTD PMID:38568856 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of AKT1 protein CTD PMID:19135466 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin affects binding ISO perfluorodecanoic acid binds to ALB protein CTD PMID:1606626 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 decreases expression ISO perfluorodecanoic acid results in decreased expression of ALDH3A1 mRNA CTD PMID:38568856 NCBI chr11:61,099,336...61,109,244
Ensembl chr11:61,098,363...61,109,247 		JBrowse link
G Alyref Aly/REF export factor increases expression ISO perfluorodecanoic acid results in increased expression of ALYREF mRNA CTD PMID:38568856 NCBI chr11:120,485,330...120,489,342
Ensembl chr11:120,482,947...120,489,191 		JBrowse link
G Angptl4 angiopoietin-like 4 affects expression ISO perfluorodecanoic acid affects the expression of ANGPTL4 mRNA CTD PMID:23567314 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804 		JBrowse link
G Apoa2 apolipoprotein A-II affects expression ISO perfluorodecanoic acid affects the expression of APOA2 mRNA CTD PMID:23567314 NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948 		JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation
multiple interactions		 EXP perfluorodecanoic acid results in increased phosphorylation of ATF2 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein]		 CTD PMID:27344344 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO perfluorodecanoic acid results in increased expression of ATF3 mRNA CTD PMID:23567314 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236 		JBrowse link
G Bax BCL2-associated X protein increases expression EXP perfluorodecanoic acid results in increased expression of BAX mRNA CTD PMID:34358620 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase, type 2 increases expression ISO perfluorodecanoic acid results in increased expression of BDH2 mRNA CTD PMID:35337807 NCBI chr 3:134,986,982...135,010,187
Ensembl chr 3:134,986,982...135,010,187 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO Perfluorodecanoic acid increases expression of BIRC3 mRNA and protein in gastric adenocarcinoma cells RGD PMID:30431128 RGD:152998989 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187 		JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase affects localization EXP perfluorodecanoic acid affects the localization of BUB1B protein CTD PMID:34358620 NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072 		JBrowse link
G Casp3 caspase 3 increases expression EXP perfluorodecanoic acid results in increased expression of CASP3 mRNA CTD PMID:34358620 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cdk1 cyclin dependent kinase 1 increases phosphorylation EXP perfluorodecanoic acid results in increased phosphorylation of CDK1 protein CTD PMID:34358620 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdkn1c cyclin dependent kinase inhibitor 1C decreases expression ISO perfluorodecanoic acid results in decreased expression of CDKN1C mRNA CTD PMID:38568856 NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 increases expression ISO perfluorodecanoic acid results in increased expression of CHD4 mRNA CTD PMID:38568856 NCBI chr 6:125,073,144...125,107,554
Ensembl chr 6:125,072,944...125,107,554 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver affects expression ISO perfluorodecanoic acid affects the expression of CPT1A mRNA CTD PMID:23567314 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle increases expression EXP perfluorodecanoic acid results in increased expression of CPT1B mRNA CTD PMID:23567314 NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066 		JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) decreases expression ISO perfluorodecanoic acid results in decreased expression of CSF1 protein CTD PMID:32916415 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785 		JBrowse link
G Cstb cystatin B decreases expression ISO perfluorodecanoic acid results in decreased expression of CSTB protein CTD PMID:32916415 NCBI chr10:78,261,504...78,263,456
Ensembl chr10:78,261,503...78,263,456 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of CYP1A1 mRNA CTD PMID:23567314 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression
multiple interactions		 EXP perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA]		 CTD PMID:27344344 PMID:38181850 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
increases expression		 EXP
ISO		 NR1I3 protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP2B10 mRNA]
perfluorodecanoic acid results in increased expression of CYP2B6 mRNA		 CTD PMID:18648086 PMID:23567314 PMID:27344344 PMID:35337807 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO perfluorodecanoic acid results in decreased activity of CYP2C19 protein CTD PMID:35121066 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity ISO perfluorodecanoic acid results in decreased activity of CYP2D6 protein CTD PMID:35121066 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases expression EXP perfluorodecanoic acid results in increased expression of CYP3A11 mRNA CTD PMID:18648086 PMID:27344344 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774 		JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of CYP4A10 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A10 mRNA]		 CTD PMID:27344344 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846 		JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 multiple interactions
increases expression		 EXP PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A14 mRNA] CTD PMID:18648086 PMID:23567314 NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression
increases expression
multiple interactions		 ISO
EXP		 perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA
perfluorodecanoic acid results in increased expression of CYP7A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA]		 CTD PMID:23567314 PMID:27344344 PMID:38181850 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 decreases expression EXP perfluorodecanoic acid results in decreased expression of CYP7B1 mRNA CTD PMID:38181850 NCBI chr 3:18,126,108...18,298,054
Ensembl chr 3:18,126,114...18,297,502 		JBrowse link
G Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 decreases expression EXP perfluorodecanoic acid results in decreased expression of CYP8B1 mRNA CTD PMID:27344344 NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371 		JBrowse link
G Dbi diazepam binding inhibitor increases expression ISO perfluorodecanoic acid results in increased expression of DBI mRNA; perfluorodecanoic acid results in increased expression of DBI protein CTD PMID:8499488 NCBI chr 1:120,041,010...120,048,826
Ensembl chr 1:120,041,010...120,048,808 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO perfluorodecanoic acid results in increased expression of DDIT3 mRNA CTD PMID:23567314 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Dlg3 discs large MAGUK scaffold protein 3 increases expression ISO perfluorodecanoic acid results in increased expression of DLG3 mRNA CTD PMID:38568856 NCBI chr  X:99,811,200...99,862,016
Ensembl chr  X:99,811,328...99,862,016 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in increased expression of DRD2 mRNA CTD PMID:34371090 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Ech1 enoyl coenzyme A hydratase 1, peroxisomal increases expression ISO perfluorodecanoic acid results in increased expression of ECH1 protein CTD PMID:8160215 NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of EEF1A1 mRNA CTD PMID:38568856 NCBI chr 9:78,385,735...78,389,006
Ensembl chr 9:78,385,731...78,396,433 		JBrowse link
G Ehf ets homologous factor decreases expression ISO perfluorodecanoic acid results in decreased expression of EHF mRNA CTD PMID:38568856 NCBI chr 2:103,093,776...103,133,620
Ensembl chr 2:103,093,778...103,133,623 		JBrowse link
G Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase multiple interactions
increases expression		 EXP
ISO		 PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of EHHADH mRNA] CTD PMID:23567314 PMID:27344344 PMID:35337807 NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO perfluorodecanoic acid binds to and results in increased activity of ESR1 protein CTD PMID:21163906 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver increases expression EXP perfluorodecanoic acid results in increased expression of FABP1 mRNA CTD PMID:23567314 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO perfluorodecanoic acid results in decreased expression of FAS protein CTD PMID:32916415 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions		 ISO
EXP		 perfluorodecanoic acid results in increased expression of FASN mRNA
benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [perfluorodecanoic acid results in increased expression of FASN mRNA]
NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of FASN mRNA]		 CTD PMID:35337807 PMID:36423729 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fgf23 fibroblast growth factor 23 decreases expression ISO perfluorodecanoic acid results in decreased expression of FGF23 protein CTD PMID:32916415 NCBI chr 6:127,049,865...127,059,257
Ensembl chr 6:127,049,865...127,058,371 		JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of FGFBP1 mRNA CTD PMID:38568856 NCBI chr 5:44,136,200...44,139,173
Ensembl chr 5:44,136,200...44,139,121 		JBrowse link
G Ftcd formiminotransferase cyclodeaminase multiple interactions ISO [perfluorodecanoic acid affects the methylation of FTCD gene] which affects the expression of FTCD mRNA CTD PMID:32653021 NCBI chr10:76,411,482...76,426,172
Ensembl chr10:76,411,482...76,426,172 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO perfluorodecanoic acid results in increased expression of GCLM mRNA CTD PMID:23567314 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO perfluorodecanoic acid results in decreased expression of GDF15 protein CTD PMID:32916415 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106 		JBrowse link
G Gm40318 predicted gene, 40318 decreases expression ISO perfluorodecanoic acid results in decreased expression of S100P mRNA CTD PMID:38568856 NCBI chr 5:36,919,848...36,924,763
Ensembl chr 5:36,919,961...36,924,039 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression ISO perfluorodecanoic acid results in increased expression of GPAM mRNA CTD PMID:35337807 NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases activity
multiple interactions
decreases activity
increases expression		 EXP
ISO		 perfluorodecanoic acid results in increased activity of GPT protein
PPARA protein affects the reaction [perfluorodecanoic acid results in increased activity of GPT protein]; PPARA protein promotes the reaction [perfluorodecanoic acid results in increased expression of GPT protein]
perfluorodecanoic acid results in decreased activity of GPT protein		 CTD PMID:27344344 PMID:29156323 PMID:38181850 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) decreases expression ISO perfluorodecanoic acid results in decreased expression of GRINA mRNA CTD PMID:38568856 NCBI chr15:76,130,917...76,134,109
Ensembl chr15:76,130,964...76,134,104 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases expression ISO perfluorodecanoic acid results in decreased expression of GSK3A mRNA CTD PMID:38568856 NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO perfluorodecanoic acid results in increased expression of GSTM3 mRNA CTD PMID:35337807 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002 		JBrowse link
G H1f4 H1.4 linker histone, cluster member decreases expression ISO perfluorodecanoic acid results in decreased expression of H1-4 mRNA CTD PMID:38568856 NCBI chr13:23,805,760...23,806,541
Ensembl chr13:23,804,612...23,806,541 		JBrowse link
G H4c14 H4 clustered histone 14 increases expression ISO perfluorodecanoic acid results in increased expression of H4C3 mRNA CTD PMID:38568856 NCBI chr 3:96,170,250...96,170,633
Ensembl chr 3:96,168,998...96,170,627 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha affects expression ISO perfluorodecanoic acid affects the expression of HADHA mRNA CTD PMID:23567314 NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160 		JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO perfluorodecanoic acid results in decreased expression of HGF protein CTD PMID:32916415 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 increases expression
multiple interactions		 ISO
EXP		 perfluorodecanoic acid results in increased expression of HMGCS1 mRNA
[perfluorodecanoic acid co-treated with Oleic Acid] results in increased expression of HMGCS1 mRNA; NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of HMGCS1 mRNA]
benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [perfluorodecanoic acid results in increased expression of HMGCS1 mRNA]		 CTD PMID:35337807 PMID:36423729 NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of HMGCS2 mRNA CTD PMID:23567314 NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO perfluorodecanoic acid results in increased expression of HMOX1 mRNA CTD PMID:23567314 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hoxa5 homeobox A5 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of HOXA5 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXA5 mRNA]		 CTD PMID:32534105 NCBI chr 6:52,178,768...52,181,437
Ensembl chr 6:52,178,734...52,181,567 		JBrowse link
G Hoxb7 homeobox B7 multiple interactions
increases expression		 EXP PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXB7 mRNA] CTD PMID:32534105 NCBI chr11:96,176,431...96,180,989
Ensembl chr11:96,177,449...96,180,988 		JBrowse link
G Hoxc5 homeobox C5 multiple interactions
increases expression		 EXP PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXC5 mRNA] CTD PMID:32534105 NCBI chr15:102,922,440...102,925,861
Ensembl chr15:102,875,878...102,925,861 		JBrowse link
G Hoxd10 homeobox D10 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of HOXD10 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXD10 mRNA]		 CTD PMID:32534105 NCBI chr 2:74,514,617...74,525,450
Ensembl chr 2:74,522,268...74,525,449 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
multiple interactions		 ISO perfluorodecanoic acid results in decreased activity of HSD11B2 protein
Dithiothreitol inhibits the reaction [perfluorodecanoic acid results in decreased activity of HSD11B2 protein]; perfluorodecanoic acid inhibits the reaction [Dithiothreitol results in increased activity of HSD11B2 protein]		 CTD PMID:36878351 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity ISO perfluorodecanoic acid results in decreased activity of HSD3B1 protein CTD PMID:36122607 NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110 		JBrowse link
G Hspa5 heat shock protein 5 increases metabolic processing
increases phosphorylation		 ISO perfluorodecanoic acid results in increased metabolism of HSPA5 protein
perfluorodecanoic acid results in increased phosphorylation of HSPA5 protein		 CTD PMID:7880882 PMID:7958552 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Ier3 immediate early response 3 decreases expression ISO perfluorodecanoic acid results in decreased expression of IER3 mRNA CTD PMID:38568856 NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of IL10 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of IL10 mRNA]		 CTD PMID:27344344 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il16 interleukin 16 decreases expression ISO perfluorodecanoic acid results in decreased expression of IL16 protein CTD PMID:32916415 NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934 		JBrowse link
G Il18 interleukin 18 increases secretion
multiple interactions
increases expression		 ISO perfluorodecanoic acid results in increased secretion of IL18 protein
[perfluorodecanoic acid co-treated with Oleic Acid] results in increased expression of IL18 mRNA; [perfluorodecanoic acid co-treated with Oleic Acid] results in increased secretion of IL18 protein
perfluorodecanoic acid results in increased expression of IL18 mRNA		 CTD PMID:36423729 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion		 ISO [perfluorodecanoic acid co-treated with Oleic Acid] results in increased expression of IL1B mRNA; [perfluorodecanoic acid co-treated with Oleic Acid] results in increased secretion of IL1B protein
perfluorodecanoic acid results in increased expression of IL1B mRNA
perfluorodecanoic acid results in increased secretion of IL1B protein		 CTD PMID:36423729 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 decreases expression ISO perfluorodecanoic acid results in decreased expression of IL6 protein CTD PMID:32916415 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itga1 integrin alpha 1 affects expression ISO perfluorodecanoic acid affects the expression of ITGA1 protein CTD PMID:33677611 NCBI chr13:115,094,615...115,238,500
Ensembl chr13:115,089,632...115,238,500 		JBrowse link
G Itgb4 integrin beta 4 decreases expression ISO perfluorodecanoic acid results in decreased expression of ITGB4 mRNA CTD PMID:38568856 NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO perfluorodecanoic acid inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877 		JBrowse link
G Klf16 Kruppel-like transcription factor 16 decreases expression ISO perfluorodecanoic acid results in decreased expression of KLF16 mRNA CTD PMID:38568856 NCBI chr10:80,402,955...80,413,130
Ensembl chr10:80,402,958...80,413,155 		JBrowse link
G Krt17 keratin 17 decreases expression ISO perfluorodecanoic acid results in decreased expression of KRT17 mRNA CTD PMID:38568856 NCBI chr11:100,147,041...100,151,855
Ensembl chr11:100,147,043...100,151,855 		JBrowse link
G Krt5 keratin 5 decreases expression ISO perfluorodecanoic acid results in decreased expression of KRT5 mRNA CTD PMID:38568856 NCBI chr15:101,615,504...101,621,340
Ensembl chr15:101,615,505...101,621,333 		JBrowse link
G Lama5 laminin, alpha 5 decreases expression ISO perfluorodecanoic acid results in decreased expression of LAMA5 mRNA CTD PMID:38568856 NCBI chr 2:179,818,166...179,867,652
Ensembl chr 2:179,818,166...179,867,652 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of MAPK1 protein CTD PMID:19135466 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of MAPK3 protein CTD PMID:19135466 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of MBL2 mRNA CTD PMID:23567314 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of MICAL1 mRNA CTD PMID:38568856 NCBI chr10:41,351,693...41,363,026
Ensembl chr10:41,352,310...41,363,028 		JBrowse link
G Mir205hg Mir205 host gene decreases expression ISO perfluorodecanoic acid results in decreased expression of MIR205HG mRNA CTD PMID:38568856 NCBI chr 1:193,188,768...193,192,518
Ensembl chr 1:193,188,760...193,192,519 		JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO perfluorodecanoic acid results in decreased expression of MMP12 protein CTD PMID:32916415 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) affects expression ISO perfluorodecanoic acid affects the expression of MMP1 protein CTD PMID:33677611 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 increases expression EXP perfluorodecanoic acid results in increased expression of MOGAT1 mRNA CTD PMID:23567314 NCBI chr 1:78,487,697...78,597,882
Ensembl chr 1:78,487,628...78,514,810 		JBrowse link
G mt-Co3 cytochrome c oxidase III, mitochondrial increases expression ISO perfluorodecanoic acid results in increased expression of COX3 mRNA CTD PMID:38568856 NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390 		JBrowse link
G mt-Nd3 NADH dehydrogenase 3, mitochondrial decreases expression ISO perfluorodecanoic acid results in decreased expression of ND3 mRNA CTD PMID:38568856 NCBI chr MT:9,459...9,806
Ensembl chr MT:9,459...9,806 		JBrowse link
G mt-Nd6 NADH dehydrogenase 6, mitochondrial increases expression ISO perfluorodecanoic acid results in increased expression of ND6 mRNA CTD PMID:38568856 NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070 		JBrowse link
G mt-Rnr1 12S rRNA, mitochondrial decreases expression ISO perfluorodecanoic acid results in decreased expression of MT-RNR1 mRNA CTD PMID:38568856 NCBI chr MT:70...1,024
Ensembl chr MT:70...1,024 		JBrowse link
G mt-Rnr2 16S rRNA, mitochondrial decreases expression ISO perfluorodecanoic acid results in decreased expression of MT-RNR2 mRNA CTD PMID:38568856 NCBI chr MT:1,094...2,675
Ensembl chr MT:1,094...2,675 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO perfluorodecanoic acid results in increased expression of MTTP mRNA CTD PMID:35337807 NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing decreases expression ISO perfluorodecanoic acid results in decreased expression of NACC1 mRNA CTD PMID:38568856 NCBI chr 8:85,397,106...85,414,528
Ensembl chr 8:85,397,108...85,414,531 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression		 EXP
ISO		 NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]
perfluorodecanoic acid results in increased expression of NFE2L2 mRNA		 CTD PMID:18757529 PMID:35337807 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Niban2 niban apoptosis regulator 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of NIBAN2 mRNA CTD PMID:38568856 NCBI chr 2:32,766,146...32,815,265
Ensembl chr 2:32,766,126...32,815,266 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of FASN mRNA]; NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of HMGCS1 mRNA]; NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of SCD mRNA] CTD PMID:36423729 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression EXP perfluorodecanoic acid results in increased expression of NOS2 mRNA CTD PMID:23567314 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO perfluorodecanoic acid results in increased expression of NQO1 mRNA CTD PMID:35337807 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression
increases activity		 ISO Dactinomycin inhibits the reaction [perfluorodecanoic acid results in increased expression of NR1I2 protein]
perfluorodecanoic acid results in increased activity of NR1I2 protein
perfluorodecanoic acid results in increased expression of NR1I2 mRNA		 CTD PMID:15826607 PMID:28115241 PMID:35337807 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects response to substance
multiple interactions
increases expression
affects localization		 EXP NR1I3 protein affects the susceptibility to perfluorodecanoic acid
NR1I3 protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP2B10 mRNA]
perfluorodecanoic acid results in increased expression of NR1I3 mRNA
perfluorodecanoic acid affects the localization of NR1I3 protein		 CTD PMID:18648086 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Numbl numb-like decreases expression ISO perfluorodecanoic acid results in decreased expression of NUMBL mRNA CTD PMID:38568856 NCBI chr 7:26,957,884...26,981,570
Ensembl chr 7:26,957,858...26,981,569 		JBrowse link
G Osbpl5 oxysterol binding protein-like 5 decreases expression ISO perfluorodecanoic acid results in decreased expression of OSBPL5 mRNA CTD PMID:38568856 NCBI chr 7:143,242,499...143,310,745
Ensembl chr 7:143,242,499...143,310,722 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO perfluorodecanoic acid results in increased expression of PCK2 mRNA CTD PMID:35337807 NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 increases expression EXP perfluorodecanoic acid results in increased expression of PDK4 mRNA CTD PMID:23567314 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions
increases expression		 EXP PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of PDX1 mRNA] CTD PMID:32534105 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658 		JBrowse link
G Per1 period circadian clock 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of PER1 mRNA CTD PMID:38568856 NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786 		JBrowse link
G Phf10 PHD finger protein 10 increases expression ISO perfluorodecanoic acid results in increased expression of PHF10 mRNA CTD PMID:38568856 NCBI chr17:15,165,269...15,181,550
Ensembl chr17:15,165,271...15,181,535 		JBrowse link
G Plin2 perilipin 2 increases expression ISO perfluorodecanoic acid results in increased expression of PLIN2 mRNA CTD PMID:23567314 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297 		JBrowse link
G Pomp proteasome maturation protein increases expression ISO perfluorodecanoic acid results in increased expression of POMP mRNA CTD PMID:38568856 NCBI chr 5:147,797,438...147,812,594
Ensembl chr 5:147,797,271...147,813,266 		JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO perfluorodecanoic acid results in increased expression of POR mRNA CTD PMID:23567314 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
affects response to substance
increases activity
increases expression		 EXP
ISO		 PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased phosphorylation of RELA protein]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased activity of GPT protein]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ACOT1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A14 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXA5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXB7 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXC5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXD10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of IL10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of PDX1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A6A mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A7C mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein]; PPARA protein promotes the reaction [perfluorodecanoic acid results in increased expression of GPT protein]
PPARA protein affects the susceptibility to perfluorodecanoic acid
perfluorodecanoic acid results in increased activity of PPARA protein
perfluorodecanoic acid results in increased expression of PPARA mRNA		 CTD PMID:18648086 PMID:18703564 PMID:18757529 PMID:23391484 PMID:27344344 More... NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases activity
increases expression		 ISO perfluorodecanoic acid results in increased activity of PPARG protein
perfluorodecanoic acid results in increased expression of PPARG mRNA		 CTD PMID:23391484 PMID:24998974 PMID:35337807 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppl periplakin decreases expression ISO perfluorodecanoic acid results in decreased expression of PPL mRNA CTD PMID:38568856 NCBI chr16:4,904,155...4,950,345
Ensembl chr16:4,904,155...4,950,285 		JBrowse link
G Ppp1r37 protein phosphatase 1, regulatory subunit 37 decreases expression ISO perfluorodecanoic acid results in decreased expression of PPP1R37 mRNA CTD PMID:38568856 NCBI chr 7:19,264,725...19,298,628
Ensembl chr 7:19,264,725...19,297,001 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO perfluorodecanoic acid binds to and results in decreased activity of PTPN11 protein CTD PMID:27572461 NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460 		JBrowse link
G Rag1 recombination activating 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of RAG1 mRNA CTD PMID:38549690 NCBI chr 2:101,468,597...101,479,877
Ensembl chr 2:101,468,627...101,479,846 		JBrowse link
G Rag2 recombination activating gene 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of RAG2 mRNA CTD PMID:38549690 NCBI chr 2:101,455,057...101,462,873
Ensembl chr 2:101,455,063...101,462,874 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases phosphorylation
multiple interactions		 EXP perfluorodecanoic acid results in decreased phosphorylation of RELA protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased phosphorylation of RELA protein]		 CTD PMID:27344344 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Retn resistin decreases expression ISO perfluorodecanoic acid results in decreased expression of RETN protein CTD PMID:32916415 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110 		JBrowse link
G Rpl27a ribosomal protein L27A decreases expression ISO perfluorodecanoic acid results in decreased expression of RPL27A mRNA CTD PMID:38568856 NCBI chr 7:109,118,354...109,121,967
Ensembl chr 7:109,118,354...109,121,574 		JBrowse link
G Rpl37a ribosomal protein L37a decreases expression ISO perfluorodecanoic acid results in decreased expression of RPL37A mRNA CTD PMID:38568856 NCBI chr 1:72,750,426...72,752,972
Ensembl chr 1:72,750,449...72,752,972 		JBrowse link
G Rpl39 ribosomal protein L39 decreases expression ISO perfluorodecanoic acid results in decreased expression of RPL39 mRNA CTD PMID:38568856 NCBI chr  X:36,346,169...36,348,852
Ensembl chr  X:36,346,173...36,349,055 		JBrowse link
G Rpl7a ribosomal protein L7A decreases expression ISO perfluorodecanoic acid results in decreased expression of RPL7A mRNA CTD PMID:38568856 NCBI chr 2:26,800,697...26,803,330
Ensembl chr 2:26,800,776...26,803,330 		JBrowse link
G Rps21 ribosomal protein S21 decreases expression ISO perfluorodecanoic acid results in decreased expression of RPS21 mRNA CTD PMID:38568856 NCBI chr 2:179,899,172...179,900,237
Ensembl chr 2:179,899,170...179,900,238 		JBrowse link
G Rps23 ribosomal protein S23 decreases expression ISO perfluorodecanoic acid results in decreased expression of RPS23 mRNA CTD PMID:38568856 NCBI chr13:91,071,241...91,072,851
Ensembl chr13:91,071,077...91,073,069 		JBrowse link
G Rps29 ribosomal protein S29 decreases expression ISO perfluorodecanoic acid results in decreased expression of RPS29 mRNA CTD PMID:38568856 NCBI chr12:69,204,495...69,205,891
Ensembl chr12:69,204,496...69,205,960 		JBrowse link
G Rpsa ribosomal protein SA decreases expression ISO perfluorodecanoic acid results in decreased expression of RPSA mRNA CTD PMID:38568856 NCBI chr 9:119,956,832...119,961,435
Ensembl chr 9:119,956,755...119,961,435 		JBrowse link
G S100a2 S100 calcium binding protein A2 decreases expression ISO perfluorodecanoic acid results in decreased expression of S100A2 mRNA CTD PMID:38568856 NCBI chr 3:90,497,554...90,498,815
Ensembl chr 3:90,467,670...90,498,838 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) decreases expression ISO perfluorodecanoic acid results in decreased expression of S100A8 mRNA CTD PMID:38568856 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) decreases expression ISO perfluorodecanoic acid results in decreased expression of S100A9 mRNA CTD PMID:38568856 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028 		JBrowse link
G Saa1 serum amyloid A 1 increases expression ISO perfluorodecanoic acid results in increased expression of SAA1 mRNA CTD PMID:38568856 NCBI chr 7:46,389,921...46,392,404
Ensembl chr 7:46,389,921...46,392,404 		JBrowse link
G Saa2 serum amyloid A 2 increases expression ISO perfluorodecanoic acid results in increased expression of SAA2 mRNA CTD PMID:38568856 NCBI chr 7:46,401,257...46,403,737
Ensembl chr 7:46,401,214...46,403,737 		JBrowse link
G Sap30 sin3 associated polypeptide increases expression ISO perfluorodecanoic acid results in increased expression of SAP30 mRNA CTD PMID:38568856 NCBI chr 8:57,935,740...57,940,874
Ensembl chr 8:57,935,741...57,940,894 		JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of SCD1 mRNA
benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [perfluorodecanoic acid results in increased expression of SCD1 mRNA]		 CTD PMID:23567314 PMID:36423729 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of SCD mRNA
[perfluorodecanoic acid co-treated with Oleic Acid] results in increased expression of SCD mRNA; NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of SCD mRNA]		 CTD PMID:35337807 PMID:36423729 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303 		JBrowse link
G Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of SERPIND1 mRNA CTD PMID:23567314 NCBI chr16:17,149,235...17,161,438
Ensembl chr16:17,149,235...17,161,439 		JBrowse link
G Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of SERPINF2 mRNA CTD PMID:23567314 NCBI chr11:75,322,562...75,330,327
Ensembl chr11:75,322,558...75,330,417 		JBrowse link
G Sf3a2 splicing factor 3a, subunit 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of SF3A2 mRNA CTD PMID:38568856 NCBI chr10:80,634,569...80,640,756
Ensembl chr10:80,634,032...80,640,758 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression
multiple interactions		 EXP perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA; perfluorodecanoic acid results in decreased expression of SLC10A1 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA]		 CTD PMID:18703564 PMID:27344344 PMID:38181850 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 multiple interactions ISO [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] CTD PMID:20639259 NCBI chr19:6,585,884...6,593,100
Ensembl chr19:6,585,875...6,593,062 		JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions ISO perfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate] CTD PMID:19915082 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
decreases expression		 EXP PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A1 mRNA]
perfluorodecanoic acid results in decreased expression of SLCO1A1 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1A1 protein		 CTD PMID:18703564 PMID:27344344 PMID:38181850 NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression
multiple interactions		 EXP perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1A4 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA]		 CTD PMID:18703564 PMID:38181850 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925 		JBrowse link
G Slco1a5 solute carrier organic anion transporter family, member 1a5 multiple interactions ISO perfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate] CTD PMID:20639259 NCBI chr 6:142,179,953...142,268,707
Ensembl chr 6:142,179,953...142,268,707 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 decreases expression
multiple interactions		 EXP perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1B2 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA]		 CTD PMID:18703564 PMID:27344344 PMID:38181850 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression EXP perfluorodecanoic acid results in decreased expression of SLCO2B1 mRNA CTD PMID:38181850 NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO perfluorodecanoic acid results in decreased expression of SLPI mRNA CTD PMID:38568856 NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015 		JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G increases expression ISO perfluorodecanoic acid results in increased expression of SNRPG mRNA CTD PMID:38568856 NCBI chr 6:86,348,522...86,355,884
Ensembl chr 6:86,348,286...86,356,310 		JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression ISO perfluorodecanoic acid results in increased expression of SOD1 mRNA CTD PMID:35337807 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Spon1 spondin 1, (f-spondin) extracellular matrix protein decreases expression ISO perfluorodecanoic acid results in decreased expression of SPON1 protein CTD PMID:32916415 NCBI chr 7:113,365,235...113,642,610
Ensembl chr 7:113,365,235...113,642,605 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases activity ISO perfluorodecanoic acid results in decreased activity of SRD5A1 protein CTD PMID:38574835 NCBI chr13:69,721,568...69,759,611
Ensembl chr13:69,721,568...69,759,561 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression		 EXP benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [perfluorodecanoic acid results in increased expression of SREBF1 mRNA] CTD PMID:36423729 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srek1 splicing regulatory glutamine/lysine-rich protein 1 increases expression ISO perfluorodecanoic acid results in increased expression of SREK1 mRNA CTD PMID:38568856 NCBI chr13:103,873,291...103,911,379
Ensembl chr13:103,875,856...103,911,116 		JBrowse link
G Sult1c1 sulfotransferase family, cytosolic, 1C, member 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of SULT1C1 protein CTD PMID:8620580 NCBI chr17:54,268,643...54,297,659
Ensembl chr17:54,268,643...54,297,702 		JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of SULT1E1 mRNA CTD PMID:38568856 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453 		JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 increases expression ISO perfluorodecanoic acid results in increased expression of SULT2A1 mRNA CTD PMID:35337807 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334 		JBrowse link
G Synpo synaptopodin decreases expression ISO perfluorodecanoic acid results in decreased expression of SYNPO mRNA CTD PMID:38568856 NCBI chr18:60,727,053...60,793,241
Ensembl chr18:60,727,045...60,793,214 		JBrowse link
G Syt8 synaptotagmin VIII decreases expression ISO perfluorodecanoic acid results in decreased expression of SYT8 mRNA CTD PMID:38568856 NCBI chr 7:141,988,195...141,994,136
Ensembl chr 7:141,988,587...141,994,133 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO perfluorodecanoic acid binds to THRA protein CTD PMID:24819616 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of TIMP2 mRNA CTD PMID:38568856 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
G Tmem132a transmembrane protein 132A decreases expression ISO perfluorodecanoic acid results in decreased expression of TMEM132A mRNA CTD PMID:38568856 NCBI chr19:10,835,193...10,847,569
Ensembl chr19:10,835,186...10,847,304 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of TNF protein
gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of TNF protein]		 CTD PMID:18757529 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b decreases expression ISO perfluorodecanoic acid results in decreased expression of TNFRSF1B protein CTD PMID:32916415 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
G Tor4a torsin family 4, member A decreases expression ISO perfluorodecanoic acid results in decreased expression of TOR4A mRNA CTD PMID:38568856 NCBI chr 2:25,082,732...25,086,825
Ensembl chr 2:25,082,978...25,086,898 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of TPT1 mRNA CTD PMID:38568856 NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965 		JBrowse link
G Ttr transthyretin multiple interactions ISO perfluorodecanoic acid affects the reaction [Thyroxine binds to TTR protein] CTD PMID:27528273 NCBI chr18:20,797,266...20,807,383
Ensembl chr18:20,798,337...20,807,378 		JBrowse link
G Tuba1c tubulin, alpha 1C decreases expression ISO perfluorodecanoic acid results in decreased expression of TUBA1C mRNA CTD PMID:38568856 NCBI chr15:98,927,772...98,935,986
Ensembl chr15:98,927,772...98,935,991 		JBrowse link
G Txnip thioredoxin interacting protein increases expression
decreases expression		 ISO perfluorodecanoic acid results in increased expression of TXNIP mRNA
perfluorodecanoic acid results in decreased expression of TXNIP mRNA		 CTD PMID:23567314 PMID:38568856 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of UCP2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]		 CTD PMID:27344344 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression
multiple interactions		 EXP
ISO		 perfluorodecanoic acid results in increased expression of UGT1A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA]		 CTD PMID:27344344 PMID:35337807 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of UGT1A2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A2 mRNA]		 CTD PMID:27344344 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of UGT1A5 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA]		 CTD PMID:27344344 NCBI chr 1:88,093,734...88,147,724
Ensembl chr 1:88,093,734...88,146,719 		JBrowse link
G Ugt1a6a UDP glucuronosyltransferase 1 family, polypeptide A6A increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of UGT1A6A mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A6A mRNA]		 CTD PMID:27344344 NCBI chr 1:88,062,531...88,147,724
Ensembl chr 1:88,062,531...88,146,719 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of UGT1A7C mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A7C mRNA]		 CTD PMID:27344344 NCBI chr 1:88,022,723...88,147,724
Ensembl chr 1:88,022,784...88,147,724 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO perfluorodecanoic acid results in decreased expression of VEGFA protein CTD PMID:32916415 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B decreases expression ISO perfluorodecanoic acid results in decreased expression of ZBTB7B mRNA CTD PMID:38568856 NCBI chr 3:89,284,953...89,300,976
Ensembl chr 3:89,284,951...89,302,083 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression
multiple interactions		 EXP perfluorodecanoic acid results in increased expression of ZEB1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB1 mRNA]		 CTD PMID:32534105 NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 multiple interactions EXP PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB2 mRNA] CTD PMID:32534105 NCBI chr 2:44,873,523...45,007,378
Ensembl chr 2:44,873,644...45,007,407 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22304
    role 22290
      biological role 22289
        xenobiotic 19734
          perfluorodecanoic acid 196
Path 2
Term Annotations click to browse term
  CHEBI ontology 22304
    subatomic particle 22299
      composite particle 22299
        hadron 22299
          baryon 22299
            nucleon 22299
              atomic nucleus 22299
                atom 22299
                  main group element atom 22180
                    p-block element atom 22180
                      carbon group element atom 21982
                        carbon atom 21922
                          organic molecular entity 21922
                            heteroorganic entity 21566
                              organochalcogen compound 21048
                                organooxygen compound 20897
                                  carbon oxoacid 19647
                                    carboxylic acid 19643
                                      monocarboxylic acid 19011
                                        fatty acid 17302
                                          saturated fatty acid 17003
                                            straight-chain saturated fatty acid 16463
                                              decanoic acid 204
                                                perfluorodecanoic acid 196
paths to the root