Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of KLF16 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KLF16 mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | Estradiol results in increased expression of KLF16 mRNA | CTD | PMID:23019147 and PMID:31614463 | 17beta-estradiol | increases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | Estradiol results in increased expression of KLF16 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of KLF16 mRNA | CTD | PMID:21570461 and PMID:24058054 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KLF16 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KLF16 mRNA | CTD | PMID:19933214 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of KLF16 mRNA | CTD | PMID:20188158 | 6-propyl-2-thiouracil | increases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of KLF16 mRNA | CTD | PMID:24780913 and PMID:30047161 | acrolein | multiple interactions | ISO | KLF16 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of KLF16 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of KLF16 mRNA | CTD | PMID:32699268 | acrylamide | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of KLF16 mRNA | CTD | PMID:32763439 | alpha-pinene | multiple interactions | ISO | KLF16 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of KLF16 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of KLF16 mRNA | CTD | PMID:32699268 | amiodarone | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | Amiodarone results in increased expression of KLF16 mRNA | CTD | PMID:19774075 | amitrole | increases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of KLF16 mRNA | CTD | PMID:30047161 | aristolochic acid A | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of KLF16 mRNA | CTD | PMID:33212167 | arsane | increases methylation | ISO | KLF16 (Homo sapiens) | 6480464 | Arsenic results in increased methylation of KLF16 promoter | CTD | PMID:21291286 | arsenic atom | increases methylation | ISO | KLF16 (Homo sapiens) | 6480464 | Arsenic results in increased methylation of KLF16 promoter | CTD | PMID:21291286 | avobenzone | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | avobenzone results in increased expression of KLF16 mRNA | CTD | PMID:31016361 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of KLF16 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of KLF16 protein | CTD | PMID:32717239 | benzo[e]pyrene | increases methylation | ISO | KLF16 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of KLF16 intron | CTD | PMID:30157460 | bisphenol A | affects methylation | EXP | | 6480464 | bisphenol A affects the methylation of KLF16 promoter | CTD | PMID:27334623 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KLF16 mRNA | CTD | PMID:32156529 | bisphenol A | increases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of KLF16 mRNA | CTD | PMID:25181051 and PMID:32145629 | caffeine | affects phosphorylation | ISO | KLF16 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of KLF16 protein | CTD | PMID:35688186 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of KLF16 mRNA | CTD | PMID:37019170 | cisplatin | decreases expression | ISO | KLF16 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of KLF16 mRNA | CTD | PMID:27594783 | cyclosporin A | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of KLF16 mRNA | CTD | PMID:25562108 | decabromodiphenyl ether | increases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | decabromobiphenyl ether results in increased expression of KLF16 mRNA | CTD | PMID:23640034 | diazinon | increases methylation | ISO | KLF16 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of KLF16 gene | CTD | PMID:22964155 | dicrotophos | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of KLF16 mRNA | CTD | PMID:28302478 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KLF16 mRNA | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | KLF16 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of KLF16 protein | CTD | PMID:37730182 | gentamycin | increases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of KLF16 mRNA | CTD | PMID:33387578 | ivermectin | decreases expression | ISO | KLF16 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of KLF16 protein | CTD | PMID:32959892 | methapyrilene | increases methylation | ISO | KLF16 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of KLF16 intron | CTD | PMID:30157460 | methimazole | increases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of KLF16 mRNA | CTD | PMID:30047161 | N-methyl-4-phenylpyridinium | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of KLF16 mRNA | CTD | PMID:24810058 | ozone | multiple interactions | ISO | KLF16 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of KLF16 mRNA more ... | CTD | PMID:32699268 and PMID:35430440 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of KLF16 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of KLF16 mRNA | CTD | PMID:33387578 | paracetamol | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of KLF16 mRNA | CTD | PMID:29067470 | perfluorohexanesulfonic acid | decreases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in decreased expression of KLF16 mRNA | CTD | PMID:37995155 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of KLF16 mRNA | CTD | PMID:36331819 | resveratrol | multiple interactions | ISO | KLF16 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of KLF16 mRNA | CTD | PMID:23557933 | simvastatin | increases expression | EXP | | 6480464 | Simvastatin results in increased expression of KLF16 mRNA | CTD | PMID:19262002 | sulfadimethoxine | increases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of KLF16 mRNA | CTD | PMID:30047161 | sunitinib | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of KLF16 mRNA | CTD | PMID:31533062 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of KLF16 mRNA | CTD | PMID:31919559 | triphenyl phosphate | increases expression | ISO | Klf16 (Rattus norvegicus) | 6480464 | triphenyl phosphate results in increased expression of KLF16 mRNA | CTD | PMID:30589522 | valproic acid | increases methylation | ISO | KLF16 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of KLF16 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | KLF16 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of KLF16 mRNA | CTD | PMID:37505509 | |