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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:decanoic acid
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Accession:CHEBI:30813 term browser browse the term
Definition:A C10, straight-chain saturated fatty acid.
Synonyms:related_synonym: 1-nonanecarboxylic acid;   10:0;   C10:0;   CH3-[CH2]8-COOH;   Decanoate;   Decylic acid;   Dekansaeure;   Formula=C10H20O2;   InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12);   InChIKey=GHVNFZFCNZKVNT-UHFFFAOYSA-N;   Kaprinsaeure;   SMILES=C(CCCCCC)CCC(=O)O;   capric acid;   caprinic acid;   decoic acid;   n-Capric acid;   n-decanoic acid;   n-decoic acid;   n-decylic acid
 alt_id: CHEBI:23572;   CHEBI:41906;   CHEBI:4347
 xref: Beilstein:1754556;   CAS:334-48-5;   DrugBank:DB03600;   ECMDB:ECMDB21204;   Gmelin:69184;   HMDB:HMDB0000511;   KEGG:C01571;   KNApSAcK:C00001213;   LIPID_MAPS_instance:LMFA01010010
 xref_mesh: MESH:C031071
 xref: MetaCyc:CPD-3617;   PDBeChem:DKA;   PMID:19168249;   PMID:20661498;   PMID:24284257;   PMID:24357269;   YMDB:YMDB00677
 cyclic_relationship: is_conjugate_acid_of CHEBI:27689



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decanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO decanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:19428350 NCBI chr 2:226,975,184...226,987,591 JBrowse link
G Cldn1 claudin 1 affects localization ISO decanoic acid affects the localization of CLDN1 protein CTD PMID:16566947 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
affects binding
ISO decanoic acid results in increased activity of PPARG protein
decanoic acid binds to PPARG protein
CTD PMID:24998974 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO decanoic acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of decanoic acid CTD PMID:16051554 NCBI chr 9:88,791,216...88,808,465 JBrowse link
1,2-didecanoylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnlip pancreatic lipase increases metabolic processing ISO PNLIP protein results in increased metabolism of 1,2-didecanoylglycerol CTD PMID:9822688 NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654
JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 increases metabolic processing EXP PNLIPRP2 protein results in increased metabolism of 1,2-didecanoylglycerol CTD PMID:9822688 NCBI chr 1:257,897,766...257,916,434
Ensembl chr 1:257,897,766...257,916,434
JBrowse link
G Sprr1a small proline-rich protein 1A increases expression ISO 1,2-didecanoylglycerol results in increased expression of SPRR1A protein CTD PMID:8617999 NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063
JBrowse link
decanoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsdl2 hydroxysteroid dehydrogenase like 2 multiple interactions ISO [decanoyl-coenzyme A co-treated with NADP] binds to HSDL2 protein CTD PMID:25526675 NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions ISO [decanoyl-coenzyme A co-treated with NADP] binds to PECR protein CTD PMID:25526675 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
perfluorodecanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO perfluorodecanoic acid results in increased expression of A2M mRNA CTD PMID:23567314 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of ABCC2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC2 mRNA]
CTD PMID:27344344 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of ABCC3 mRNA
NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]
CTD PMID:18757529 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression
ISO gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA] CTD PMID:18757529 PMID:27344344 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ACOT1 mRNA] CTD PMID:27344344 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases activity EXP perfluorodecanoic acid results in increased activity of ACOX1 protein CTD PMID:8001245 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO perfluorodecanoic acid results in increased expression of ACSL1 mRNA CTD PMID:23567314 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of AKT1 protein CTD PMID:19135466 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin affects binding EXP perfluorodecanoic acid binds to ALB protein CTD PMID:1606626 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Angptl4 angiopoietin-like 4 affects expression ISO perfluorodecanoic acid affects the expression of ANGPTL4 mRNA CTD PMID:23567314 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Apoa2 apolipoprotein A2 affects expression ISO perfluorodecanoic acid affects the expression of APOA2 mRNA CTD PMID:23567314 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation
multiple interactions
ISO perfluorodecanoic acid results in increased phosphorylation of ATF2 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein]
CTD PMID:27344344 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO perfluorodecanoic acid results in increased expression of ATF3 mRNA CTD PMID:23567314 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression ISO perfluorodecanoic acid affects the expression of CPT1A mRNA CTD PMID:23567314 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO perfluorodecanoic acid results in increased expression of CPT1B mRNA CTD PMID:23567314 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of CYP1A1 mRNA CTD PMID:23567314 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA]
CTD PMID:27344344 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO NR1I3 protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP2B10 mRNA] CTD PMID:18648086 PMID:27344344 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO perfluorodecanoic acid results in increased expression of CYP2B6 mRNA CTD PMID:23567314 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO perfluorodecanoic acid results in increased expression of CYP3A4 mRNA CTD PMID:23567314 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP perfluorodecanoic acid inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 protein] CTD PMID:15826607 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 increases expression EXP perfluorodecanoic acid results in increased expression of CYP4A2 mRNA CTD PMID:11752103 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP perfluorodecanoic acid results in increased expression of CYP4A3 mRNA CTD PMID:11752103 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
increases expression
ISO perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA]
perfluorodecanoic acid results in increased expression of CYP7A1 mRNA
CTD PMID:23567314 PMID:27344344 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of CYP8B1 mRNA CTD PMID:27344344 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein increases expression EXP perfluorodecanoic acid results in increased expression of DBI mRNA; perfluorodecanoic acid results in increased expression of DBI protein CTD PMID:8499488 NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO perfluorodecanoic acid results in increased expression of DDIT3 mRNA CTD PMID:23567314 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [perfluorononanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in increased expression of DRD2 mRNA CTD PMID:34371090 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP perfluorodecanoic acid results in increased expression of ECH1 protein CTD PMID:8160215 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of EHHADH mRNA] CTD PMID:23567314 PMID:27344344 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO perfluorodecanoic acid binds to and results in increased activity of ESR1 protein CTD PMID:21163906 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO perfluorodecanoic acid results in increased expression of FABP1 mRNA CTD PMID:23567314 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase multiple interactions ISO [perfluorodecanoic acid affects the methylation of FTCD gene] which affects the expression of FTCD mRNA CTD PMID:32653021 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO perfluorodecanoic acid results in increased expression of GCLM mRNA CTD PMID:23567314 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
decreases activity
multiple interactions
ISO perfluorodecanoic acid results in increased activity of GPT protein
perfluorodecanoic acid results in decreased activity of GPT protein
PPARA protein affects the reaction [perfluorodecanoic acid results in increased activity of GPT protein]
CTD PMID:27344344 PMID:29156323 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha affects expression ISO perfluorodecanoic acid affects the expression of HADHA mRNA CTD PMID:23567314 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of HMGCS2 mRNA CTD PMID:23567314 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO perfluorodecanoic acid results in increased expression of HMOX1 mRNA CTD PMID:23567314 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hoxa5 homeo box A5 multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXA5 mRNA] CTD PMID:32534105 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234
JBrowse link
G Hoxb7 homeo box B7 multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXB7 mRNA] CTD PMID:32534105 NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034
JBrowse link
G Hoxc5 homeo box C5 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of HOXC5 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXC5 mRNA]
CTD PMID:32534105 NCBI chr 7:134,150,988...134,154,410
Ensembl chr 7:134,150,988...134,154,410
JBrowse link
G Hoxd10 homeo box D10 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of HOXD10 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXD10 mRNA]
CTD PMID:32534105 NCBI chr 3:59,594,516...59,597,725
Ensembl chr 3:59,594,516...59,597,725
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases metabolic processing
increases phosphorylation
EXP perfluorodecanoic acid results in increased metabolism of HSPA5 protein
perfluorodecanoic acid results in increased phosphorylation of HSPA5 protein
CTD PMID:7880882 PMID:7958552 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of IL10 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of IL10 mRNA]
CTD PMID:27344344 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Itga1 integrin subunit alpha 1 affects expression ISO perfluorodecanoic acid affects the expression of ITGA1 protein CTD PMID:33677611 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO perfluorodecanoic acid inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of MAPK1 protein CTD PMID:19135466 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of MAPK3 protein CTD PMID:19135466 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mbl2 mannose binding lectin 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of MBL2 mRNA CTD PMID:23567314 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression ISO perfluorodecanoic acid affects the expression of MMP1 protein CTD PMID:33677611 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 increases expression ISO perfluorodecanoic acid results in increased expression of MOGAT1 mRNA CTD PMID:23567314 NCBI chr 9:79,980,963...79,988,513
Ensembl chr 9:79,956,649...79,988,513
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA] CTD PMID:18757529 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO perfluorodecanoic acid results in increased expression of NOS2 mRNA CTD PMID:23567314 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
increases expression
EXP
ISO
Dactinomycin inhibits the reaction [perfluorodecanoic acid results in increased expression of NR1I2 protein]
perfluorodecanoic acid results in increased activity of NR1I2 protein
CTD PMID:15826607 PMID:28115241 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects response to substance
affects localization
increases expression
multiple interactions
ISO NR1I3 protein affects the susceptibility to perfluorodecanoic acid
perfluorodecanoic acid affects the localization of NR1I3 protein
perfluorodecanoic acid results in increased expression of NR1I3 mRNA
NR1I3 protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP2B10 mRNA]
CTD PMID:18648086 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO perfluorodecanoic acid results in increased expression of PDK4 mRNA CTD PMID:23567314 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of PDX1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of PDX1 mRNA]
CTD PMID:32534105 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Plin2 perilipin 2 increases expression ISO perfluorodecanoic acid results in increased expression of PLIN2 mRNA CTD PMID:23567314 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO perfluorodecanoic acid results in increased expression of POR mRNA CTD PMID:23567314 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity
affects response to substance
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased phosphorylation of RELA protein]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased activity of GPT protein]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ACOT1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A14 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXA5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXB7 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXC5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXD10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of IL10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of PDX1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A6A mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A7C mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein]
perfluorodecanoic acid results in increased activity of PPARA protein
PPARA protein affects the susceptibility to perfluorodecanoic acid
CTD PMID:18648086 PMID:18703564 PMID:18757529 PMID:23391484 PMID:27344344 More... NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO perfluorodecanoic acid results in increased activity of PPARG protein CTD PMID:23391484 PMID:24998974 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO perfluorodecanoic acid binds to and results in decreased activity of PTPN11 protein CTD PMID:27572461 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation
multiple interactions
ISO perfluorodecanoic acid results in decreased phosphorylation of RELA protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased phosphorylation of RELA protein]
CTD PMID:27344344 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO perfluorodecanoic acid results in increased expression of SCD1 mRNA CTD PMID:23567314 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpind1 serpin family D member 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of SERPIND1 mRNA CTD PMID:23567314 NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519
JBrowse link
G Serpinf2 serpin family F member 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of SERPINF2 mRNA CTD PMID:23567314 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions
ISO perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA; perfluorodecanoic acid results in decreased expression of SLC10A1 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA]
CTD PMID:18703564 PMID:27344344 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] CTD PMID:20639259 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP perfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate] CTD PMID:19915082 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression
multiple interactions
ISO perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1A4 protein
perfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate]
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA]
CTD PMID:18703564 PMID:20639259 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions
ISO perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1B2 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA]
CTD PMID:18703564 PMID:27344344 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP perfluorodecanoic acid results in decreased expression of SULT1A1 protein CTD PMID:8620580 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 decreases expression EXP perfluorodecanoic acid results in decreased expression of SULT1C1 protein CTD PMID:8620580 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO [perfluorononanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO perfluorodecanoic acid binds to THRA protein CTD PMID:24819616 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of TNF protein
gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of TNF protein]
CTD PMID:18757529 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ttr transthyretin multiple interactions ISO perfluorodecanoic acid affects the reaction [Thyroxine binds to TTR protein] CTD PMID:27528273 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO perfluorodecanoic acid results in increased expression of TXNIP mRNA CTD PMID:23567314 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Ucp2 uncoupling protein 2 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of UCP2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]
CTD PMID:27344344 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of UGT1A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA]
CTD PMID:27344344 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of UGT1A2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A2 mRNA]
CTD PMID:27344344 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA] CTD PMID:27344344 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB1 mRNA] CTD PMID:32534105 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 multiple interactions ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB2 mRNA] CTD PMID:32534105 NCBI chr 3:29,219,765...29,342,094
Ensembl chr 3:29,218,301...29,345,157
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        anti-inflammatory agent 15841
          decanoic acid 92
            (3S,4S)-3-hydroxy-4-methyldecanoic acid + 0
            (9R)-9-hydroxydecanoic acid + 0
            (R)-3-hydroxydecanoyl-CoA 0
            (S)-3-hydroxydecanoic acid + 0
            (S)-3-hydroxydecanoyl-CoA 0
            1-O-(alpha-D-galactosyl)-N-decanoylphytosphingosine 0
            10-hydroxycapric acid + 0
            10-oxocapric acid 0
            2-hydroxydecanoic acid + 0
            2-oxodecanoic acid 0
            3-hydroxydecanoic acid 0
            3-oxodecanoic acid + 0
            N-(decanoyl)ethanolamine 0
            N-capryl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
            N-decanoyl-(2S)-hydroxyglycine 0
            N-decanoylglycine 0
            N-decanoylsphingosine 0
            N-decanoylsphingosine 1-phosphate 0
            S-decanoyl-4'-phosphopantetheine 0
            caprate phytyl ester 0
            decanamide + 0
            decanoate ester + 3
            decanoyl group + 0
            decanoyl-CoA + 2
            decanoylcholine 0
            perfluorodecanoic acid 84
            pescaprein XXIV 0
            pescaprein XXVI 0
            propyl decanoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        monocarboxylic acid 17622
                                          fatty acid 16011
                                            saturated fatty acid 15986
                                              straight-chain saturated fatty acid 15440
                                                decanoic acid 92
                                                  (3S,4S)-3-hydroxy-4-methyldecanoic acid + 0
                                                  (9R)-9-hydroxydecanoic acid + 0
                                                  (R)-3-hydroxydecanoyl-CoA 0
                                                  (S)-3-hydroxydecanoic acid + 0
                                                  (S)-3-hydroxydecanoyl-CoA 0
                                                  1-O-(alpha-D-galactosyl)-N-decanoylphytosphingosine 0
                                                  10-hydroxycapric acid + 0
                                                  10-oxocapric acid 0
                                                  2-hydroxydecanoic acid + 0
                                                  2-oxodecanoic acid 0
                                                  3-hydroxydecanoic acid 0
                                                  3-oxodecanoic acid + 0
                                                  N-(decanoyl)ethanolamine 0
                                                  N-capryl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                  N-decanoyl-(2S)-hydroxyglycine 0
                                                  N-decanoylglycine 0
                                                  N-decanoylsphingosine 0
                                                  N-decanoylsphingosine 1-phosphate 0
                                                  S-decanoyl-4'-phosphopantetheine 0
                                                  caprate phytyl ester 0
                                                  decanamide + 0
                                                  decanoate ester + 3
                                                  decanoyl group + 0
                                                  decanoyl-CoA + 2
                                                  decanoylcholine 0
                                                  perfluorodecanoic acid 84
                                                  pescaprein XXIV 0
                                                  pescaprein XXVI 0
                                                  propyl decanoate 0
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