|
G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
multiple interactions |
ISO |
decanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] |
CTD |
PMID:19428350 |
|
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
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|
G |
Cldn1 |
claudin 1 |
affects localization |
ISO |
decanoic acid affects the localization of CLDN1 protein |
CTD |
PMID:16566947 |
|
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
affects binding increases activity |
ISO |
decanoic acid binds to PPARG protein decanoic acid results in increased activity of PPARG protein |
CTD |
PMID:24998974 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
decanoic acid results in increased expression of PPARGC1A mRNA |
CTD |
PMID:23056435 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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|
G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of decanoic acid |
CTD |
PMID:16051554 |
|
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
|
G |
Pnlip |
pancreatic lipase |
increases metabolic processing |
ISO |
PNLIP protein results in increased metabolism of 1,2-didecanoylglycerol |
CTD |
PMID:9822688 |
|
NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654
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|
G |
Pnliprp2 |
pancreatic lipase related protein 2 |
increases metabolic processing |
EXP |
PNLIPRP2 protein results in increased metabolism of 1,2-didecanoylglycerol |
CTD |
PMID:9822688 |
|
NCBI chr 1:257,897,766...257,916,434
Ensembl chr 1:257,897,766...257,916,434
|
|
G |
Sprr1a |
small proline-rich protein 1A |
increases expression |
ISO |
1,2-didecanoylglycerol results in increased expression of SPRR1A protein |
CTD |
PMID:8617999 |
|
NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063
|
|
|
G |
Hsdl2 |
hydroxysteroid dehydrogenase like 2 |
multiple interactions |
ISO |
[decanoyl-coenzyme A co-treated with NADP] binds to HSDL2 protein |
CTD |
PMID:25526675 |
|
NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
|
|
G |
Pecr |
peroxisomal trans-2-enoyl-CoA reductase |
multiple interactions |
ISO |
[decanoyl-coenzyme A co-treated with NADP] binds to PECR protein |
CTD |
PMID:25526675 |
|
NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
|
|
|
G |
A2m |
alpha-2-macroglobulin |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of A2M mRNA |
CTD |
PMID:23567314 |
|
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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|
G |
Abca1 |
ATP binding cassette subfamily A member 1 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of ABCA1 mRNA |
CTD |
PMID:35337807 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in increased expression of ABCC2 mRNA PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC2 mRNA] |
CTD |
PMID:27344344 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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|
G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in increased expression of ABCC3 mRNA NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA] |
CTD |
PMID:18757529 |
|
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
|
|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions increases expression |
ISO |
gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA] |
CTD |
PMID:18757529 PMID:27344344 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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|
G |
Acot1 |
acyl-CoA thioesterase 1 |
multiple interactions increases expression |
ISO |
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ACOT1 mRNA] |
CTD |
PMID:27344344 |
|
NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
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|
G |
Acot2 |
acyl-CoA thioesterase 2 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of ACOT2 mRNA |
CTD |
PMID:35337807 |
|
NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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|
G |
Acox1 |
acyl-CoA oxidase 1 |
increases activity |
EXP |
perfluorodecanoic acid results in increased activity of ACOX1 protein |
CTD |
PMID:8001245 |
|
NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
|
|
G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of ACSL1 mRNA |
CTD |
PMID:23567314 |
|
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
perfluorodecanoic acid results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:19135466 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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|
G |
Alb |
albumin |
affects binding |
EXP |
perfluorodecanoic acid binds to ALB protein |
CTD |
PMID:1606626 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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|
G |
Angptl4 |
angiopoietin-like 4 |
affects expression |
ISO |
perfluorodecanoic acid affects the expression of ANGPTL4 mRNA |
CTD |
PMID:23567314 |
|
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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|
G |
Apoa2 |
apolipoprotein A2 |
affects expression |
ISO |
perfluorodecanoic acid affects the expression of APOA2 mRNA |
CTD |
PMID:23567314 |
|
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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|
G |
Atf2 |
activating transcription factor 2 |
multiple interactions increases phosphorylation |
ISO |
PPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein] |
CTD |
PMID:27344344 |
|
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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|
G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of ATF3 mRNA |
CTD |
PMID:23567314 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of BAX mRNA |
CTD |
PMID:34358620 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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|
G |
Bdh2 |
3-hydroxybutyrate dehydrogenase 2 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of BDH2 mRNA |
CTD |
PMID:35337807 |
|
NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
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|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
increases expression |
ISO |
Perfluorodecanoic acid increases expression of BIRC3 mRNA and protein in gastric adenocarcinoma cells |
RGD |
PMID:30431128 |
RGD:152998989 |
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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|
G |
Bub1b |
BUB1 mitotic checkpoint serine/threonine kinase B |
affects localization |
ISO |
perfluorodecanoic acid affects the localization of BUB1B protein |
CTD |
PMID:34358620 |
|
NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
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|
G |
Casp3 |
caspase 3 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of CASP3 mRNA |
CTD |
PMID:34358620 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Cdk1 |
cyclin-dependent kinase 1 |
increases phosphorylation |
ISO |
perfluorodecanoic acid results in increased phosphorylation of CDK1 protein |
CTD |
PMID:34358620 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
affects expression |
ISO |
perfluorodecanoic acid affects the expression of CPT1A mRNA |
CTD |
PMID:23567314 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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|
G |
Cpt1b |
carnitine palmitoyltransferase 1B |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of CPT1B mRNA |
CTD |
PMID:23567314 |
|
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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|
G |
Csf1 |
colony stimulating factor 1 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of CSF1 protein |
CTD |
PMID:32916415 |
|
NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
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|
G |
Cstb |
cystatin B |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of CSTB protein |
CTD |
PMID:32916415 |
|
NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of CYP1A1 mRNA |
CTD |
PMID:23567314 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
decreases expression multiple interactions |
ISO |
perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA] |
CTD |
PMID:27344344 |
|
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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|
G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
NR1I3 protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP2B10 mRNA] |
CTD |
PMID:18648086 PMID:27344344 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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|
G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of CYP2B6 mRNA |
CTD |
PMID:23567314 PMID:35337807 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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|
G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
perfluorodecanoic acid results in decreased activity of CYP2C19 protein |
CTD |
PMID:35121066 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
perfluorodecanoic acid results in decreased activity of CYP2D6 protein |
CTD |
PMID:35121066 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression decreases activity |
ISO |
perfluorodecanoic acid results in increased expression of CYP3A4 mRNA perfluorodecanoic acid results in decreased activity of CYP3A4 protein |
CTD |
PMID:23567314 PMID:35121066 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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|
G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions |
EXP |
perfluorodecanoic acid inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 protein] |
CTD |
PMID:15826607 |
|
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
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|
G |
Cyp4a2 |
cytochrome P450, family 4, subfamily a, polypeptide 2 |
increases expression |
EXP |
perfluorodecanoic acid results in increased expression of CYP4A2 mRNA |
CTD |
PMID:11752103 |
|
NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
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|
G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
perfluorodecanoic acid results in increased expression of CYP4A3 mRNA |
CTD |
PMID:11752103 |
|
NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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|
G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases expression increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA perfluorodecanoic acid results in increased expression of CYP7A1 mRNA PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA] |
CTD |
PMID:23567314 PMID:27344344 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
|
|
G |
Cyp8b1 |
cytochrome P450 family 8 subfamily B member 1 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of CYP8B1 mRNA |
CTD |
PMID:27344344 |
|
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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|
G |
Dbi |
diazepam binding inhibitor |
increases expression |
EXP |
perfluorodecanoic acid results in increased expression of DBI mRNA; perfluorodecanoic acid results in increased expression of DBI protein |
CTD |
PMID:8499488 |
|
NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of DDIT3 mRNA |
CTD |
PMID:23567314 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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|
G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
ISO |
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in increased expression of DRD2 mRNA |
CTD |
PMID:34371090 |
|
NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
|
|
G |
Ech1 |
enoyl-CoA hydratase 1 |
increases expression |
EXP |
perfluorodecanoic acid results in increased expression of ECH1 protein |
CTD |
PMID:8160215 |
|
NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in increased expression of EHHADH mRNA PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of EHHADH mRNA] |
CTD |
PMID:23567314 PMID:27344344 PMID:35337807 |
|
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
perfluorodecanoic acid binds to and results in increased activity of ESR1 protein |
CTD |
PMID:21163906 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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|
G |
Fabp1 |
fatty acid binding protein 1 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of FABP1 mRNA |
CTD |
PMID:23567314 |
|
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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|
G |
Fas |
Fas cell surface death receptor |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of FAS protein |
CTD |
PMID:32916415 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Fasn |
fatty acid synthase |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of FASN mRNA |
CTD |
PMID:35337807 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
|
|
G |
Fgf23 |
fibroblast growth factor 23 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of FGF23 protein |
CTD |
PMID:32916415 |
|
NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821
|
|
G |
Ftcd |
formimidoyltransferase cyclodeaminase |
multiple interactions |
ISO |
[perfluorodecanoic acid affects the methylation of FTCD gene] which affects the expression of FTCD mRNA |
CTD |
PMID:32653021 |
|
NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of GCLM mRNA |
CTD |
PMID:23567314 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Gdf15 |
growth differentiation factor 15 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of GDF15 protein |
CTD |
PMID:32916415 |
|
NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
|
|
G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of GPAM mRNA |
CTD |
PMID:35337807 |
|
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
increases activity multiple interactions decreases activity |
ISO |
perfluorodecanoic acid results in increased activity of GPT protein PPARA protein affects the reaction [perfluorodecanoic acid results in increased activity of GPT protein] perfluorodecanoic acid results in decreased activity of GPT protein |
CTD |
PMID:27344344 PMID:29156323 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gstm5 |
glutathione S-transferase, mu 5 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of GSTM3 mRNA |
CTD |
PMID:35337807 |
|
NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
|
|
G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
affects expression |
ISO |
perfluorodecanoic acid affects the expression of HADHA mRNA |
CTD |
PMID:23567314 |
|
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
|
|
G |
Hgf |
hepatocyte growth factor |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of HGF protein |
CTD |
PMID:32916415 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
|
|
G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of HMGCS1 mRNA |
CTD |
PMID:35337807 |
|
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
|
|
G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of HMGCS2 mRNA |
CTD |
PMID:23567314 |
|
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of HMOX1 mRNA |
CTD |
PMID:23567314 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hoxa5 |
homeo box A5 |
multiple interactions increases expression |
ISO |
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXA5 mRNA] |
CTD |
PMID:32534105 |
|
NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234
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G |
Hoxb7 |
homeo box B7 |
increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in increased expression of HOXB7 mRNA PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXB7 mRNA] |
CTD |
PMID:32534105 |
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NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034
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G |
Hoxc5 |
homeo box C5 |
multiple interactions increases expression |
ISO |
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXC5 mRNA] |
CTD |
PMID:32534105 |
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NCBI chr 7:134,150,988...134,154,410
Ensembl chr 7:134,150,988...134,154,410
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G |
Hoxd10 |
homeo box D10 |
increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in increased expression of HOXD10 mRNA PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXD10 mRNA] |
CTD |
PMID:32534105 |
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NCBI chr 3:59,594,516...59,597,725
Ensembl chr 3:59,594,516...59,597,725
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases metabolic processing increases phosphorylation |
EXP |
perfluorodecanoic acid results in increased metabolism of HSPA5 protein perfluorodecanoic acid results in increased phosphorylation of HSPA5 protein |
CTD |
PMID:7880882 PMID:7958552 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Il10 |
interleukin 10 |
increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in increased expression of IL10 mRNA PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of IL10 mRNA] |
CTD |
PMID:27344344 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il16 |
interleukin 16 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of IL16 protein |
CTD |
PMID:32916415 |
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NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
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G |
Il6 |
interleukin 6 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of IL6 protein |
CTD |
PMID:32916415 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itga1 |
integrin subunit alpha 1 |
affects expression |
ISO |
perfluorodecanoic acid affects the expression of ITGA1 protein |
CTD |
PMID:33677611 |
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NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
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G |
Iyd |
iodotyrosine deiodinase |
multiple interactions |
ISO |
perfluorodecanoic acid inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] |
CTD |
PMID:33352258 |
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NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
perfluorodecanoic acid results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:19135466 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
perfluorodecanoic acid results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:19135466 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mbl2 |
mannose binding lectin 2 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of MBL2 mRNA |
CTD |
PMID:23567314 |
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NCBI chr 1:228,016,439...228,024,736
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G |
Mmp1 |
matrix metallopeptidase 1 |
affects expression |
ISO |
perfluorodecanoic acid affects the expression of MMP1 protein |
CTD |
PMID:33677611 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp12 |
matrix metallopeptidase 12 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of MMP12 protein |
CTD |
PMID:32916415 |
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NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
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G |
Mogat1 |
monoacylglycerol O-acyltransferase 1 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of MOGAT1 mRNA |
CTD |
PMID:23567314 |
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NCBI chr 9:79,980,963...79,988,513
Ensembl chr 9:79,956,649...79,988,513
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G |
Mttp |
microsomal triglyceride transfer protein |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of MTTP mRNA |
CTD |
PMID:35337807 |
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NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
ISO |
NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA] perfluorodecanoic acid results in increased expression of NFE2L2 mRNA |
CTD |
PMID:18757529 PMID:35337807 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of NOS2 mRNA |
CTD |
PMID:23567314 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of NQO1 mRNA |
CTD |
PMID:35337807 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases expression increases activity |
EXP ISO |
Dactinomycin inhibits the reaction [perfluorodecanoic acid results in increased expression of NR1I2 protein] perfluorodecanoic acid results in increased activity of NR1I2 protein perfluorodecanoic acid results in increased expression of NR1I2 mRNA |
CTD |
PMID:15826607 PMID:28115241 PMID:35337807 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
affects response to substance multiple interactions increases expression affects localization |
ISO |
NR1I3 protein affects the susceptibility to perfluorodecanoic acid NR1I3 protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP2B10 mRNA] perfluorodecanoic acid results in increased expression of NR1I3 mRNA perfluorodecanoic acid affects the localization of NR1I3 protein |
CTD |
PMID:18648086 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Pck2 |
phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of PCK2 mRNA |
CTD |
PMID:35337807 |
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NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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G |
Pdk4 |
pyruvate dehydrogenase kinase 4 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of PDK4 mRNA |
CTD |
PMID:23567314 |
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NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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G |
Pdx1 |
pancreatic and duodenal homeobox 1 |
multiple interactions increases expression |
ISO |
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of PDX1 mRNA] |
CTD |
PMID:32534105 |
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NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
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G |
Plin2 |
perilipin 2 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of PLIN2 mRNA |
CTD |
PMID:23567314 |
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NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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G |
Por |
cytochrome p450 oxidoreductase |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of POR mRNA |
CTD |
PMID:23567314 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions affects response to substance increases activity increases expression |
ISO |
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased phosphorylation of RELA protein]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased activity of GPT protein]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ACOT1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A14 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXA5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXB7 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXC5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXD10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of IL10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of PDX1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A6A mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A7C mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein] PPARA protein affects the susceptibility to perfluorodecanoic acid perfluorodecanoic acid results in increased activity of PPARA protein perfluorodecanoic acid results in increased expression of PPARA mRNA |
CTD |
PMID:18648086 PMID:18703564 PMID:18757529 PMID:23391484 PMID:27344344 PMID:32534105 PMID:35337807 More...
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases activity increases expression |
ISO |
perfluorodecanoic acid results in increased activity of PPARG protein perfluorodecanoic acid results in increased expression of PPARG mRNA |
CTD |
PMID:23391484 PMID:24998974 PMID:35337807 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptpn11 |
protein tyrosine phosphatase, non-receptor type 11 |
multiple interactions |
ISO |
perfluorodecanoic acid binds to and results in decreased activity of PTPN11 protein |
CTD |
PMID:27572461 |
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NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases phosphorylation multiple interactions |
ISO |
perfluorodecanoic acid results in decreased phosphorylation of RELA protein PPARA protein affects the reaction [perfluorodecanoic acid results in decreased phosphorylation of RELA protein] |
CTD |
PMID:27344344 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Retn |
resistin |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of RETN protein |
CTD |
PMID:32916415 |
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NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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G |
Scd |
stearoyl-CoA desaturase |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of SCD1 mRNA perfluorodecanoic acid results in increased expression of SCD mRNA |
CTD |
PMID:23567314 PMID:35337807 |
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NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Serpind1 |
serpin family D member 1 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of SERPIND1 mRNA |
CTD |
PMID:23567314 |
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NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519
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G |
Serpinf2 |
serpin family F member 2 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of SERPINF2 mRNA |
CTD |
PMID:23567314 |
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NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
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G |
Slc10a1 |
solute carrier family 10 member 1 |
decreases expression multiple interactions |
ISO |
perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA; perfluorodecanoic acid results in decreased expression of SLC10A1 protein PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA] |
CTD |
PMID:18703564 PMID:27344344 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Slc22a12 |
solute carrier family 22 member 12 |
multiple interactions |
ISO |
[Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] |
CTD |
PMID:20639259 |
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NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
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G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions |
EXP |
perfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate] |
CTD |
PMID:19915082 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
decreases expression multiple interactions |
ISO |
perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1A4 protein PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA] perfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate] |
CTD |
PMID:18703564 PMID:20639259 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
decreases expression multiple interactions |
ISO |
perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1B2 protein PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA] |
CTD |
PMID:18703564 PMID:27344344 |
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NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Sod1 |
superoxide dismutase 1 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of SOD1 mRNA |
CTD |
PMID:35337807 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Spon1 |
spondin 1 |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of SPON1 protein |
CTD |
PMID:32916415 |
|
NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
decreases expression |
EXP |
perfluorodecanoic acid results in decreased expression of SULT1A1 protein |
CTD |
PMID:8620580 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Sult1c3 |
sulfotransferase family 1C member 3 |
decreases expression |
EXP |
perfluorodecanoic acid results in decreased expression of SULT1C1 protein |
CTD |
PMID:8620580 |
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NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
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G |
Sult2a1 |
sulfotransferase family 2A member 1 |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of SULT2A1 mRNA |
CTD |
PMID:35337807 |
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NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
ISO |
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA |
CTD |
PMID:34371090 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Thra |
thyroid hormone receptor alpha |
affects binding |
ISO |
perfluorodecanoic acid binds to THRA protein |
CTD |
PMID:24819616 |
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NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in increased expression of TNF protein gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of TNF protein] |
CTD |
PMID:18757529 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of TNFRSF1B protein |
CTD |
PMID:32916415 |
|
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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G |
Ttr |
transthyretin |
multiple interactions |
ISO |
perfluorodecanoic acid affects the reaction [Thyroxine binds to TTR protein] |
CTD |
PMID:27528273 |
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NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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G |
Txnip |
thioredoxin interacting protein |
increases expression |
ISO |
perfluorodecanoic acid results in increased expression of TXNIP mRNA |
CTD |
PMID:23567314 |
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NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions increases expression |
ISO |
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA] |
CTD |
PMID:27344344 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in increased expression of UGT1A1 mRNA PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA] |
CTD |
PMID:27344344 PMID:35337807 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in increased expression of UGT1A2 mRNA PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A2 mRNA] |
CTD |
PMID:27344344 |
|
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
multiple interactions increases expression |
ISO |
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA] |
CTD |
PMID:27344344 |
|
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
perfluorodecanoic acid results in decreased expression of VEGFA protein |
CTD |
PMID:32916415 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Zeb1 |
zinc finger E-box binding homeobox 1 |
increases expression multiple interactions |
ISO |
perfluorodecanoic acid results in increased expression of ZEB1 mRNA PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB1 mRNA] |
CTD |
PMID:32534105 |
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NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
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G |
Zeb2 |
zinc finger E-box binding homeobox 2 |
multiple interactions |
ISO |
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB2 mRNA] |
CTD |
PMID:32534105 |
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NCBI chr 3:29,219,765...29,342,094
Ensembl chr 3:29,218,301...29,345,157
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