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Gene: Dlg3 (discs large MAGUK scaffold protein 3) Mus musculus
Symbol: Dlg3
Name: discs large MAGUK scaffold protein 3
Description: Exhibits ubiquitin protein ligase binding activity. Involved in establishment of planar polarity; establishment or maintenance of epithelial cell apical/basal polarity; and regulation of postsynaptic membrane neurotransmitter receptor levels. Localizes to several cellular components, including AMPA glutamate receptor complex; bicellular tight junction; and glutamatergic synapse. Predicted to colocalize with ionotropic glutamate receptor complex. Is expressed in central nervous system and retina. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3); INTERACTS WITH 4,4'-diaminodiphenylmethane; 4-hydroxyphenyl retinamide; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: discs large homolog 3; discs, large homolog 3; discs, large homolog 3 (Drosophila); disks large homolog 3; Dlgh3; mKIAA1232; SAP-102; SAP102; synapse-associated protein 102
Homo sapiens (human) : DLG3 (discs large MAGUK scaffold protein 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dlg3 (discs large MAGUK scaffold protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg3 (discs large MAGUK scaffold protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG3 (discs large MAGUK scaffold protein 3)
Canis lupus familiaris (dog) : DLG3 (discs large MAGUK scaffold protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg3 (discs large MAGUK scaffold protein 3)
Sus scrofa (pig) : DLG3 (discs large MAGUK scaffold protein 3)
Chlorocebus sabaeus (African green monkey) : DLG3 (discs large MAGUK scaffold protein 3)
Heterocephalus glaber (naked mole-rat) : Dlg3 (discs large MAGUK scaffold protein 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 EnsemblX100,767,722 - 100,818,410 (+)EnsemblGRCm38mm10GRCm38
GRCm38X100,767,411 - 100,818,410 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X97,963,062 - 98,013,749 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X96,970,466 - 97,021,127 (+)NCBImm8
CeleraX87,686,891 - 87,737,556 (+)NCBICelera
Cytogenetic MapXC3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Dlg3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68629
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.