Sap30 (sin3 associated polypeptide) - Rat Genome Database

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Gene: Sap30 (sin3 associated polypeptide) Mus musculus
Analyze
Symbol: Sap30
Name: sin3 associated polypeptide
RGD ID: 1619204
MGI Page MGI
Description: Predicted to enable transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; early embryo; limb bud; and sensory organ. Orthologous to human SAP30 (Sin3A associated protein 30).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 30 kDa Sin3-associated polypeptide; 30kD; 30kDa; histone deacetylase complex subunit SAP30; sin3 associated polypeptide, 30kD; sin3 corepressor complex subunit SAP30; sin3-associated polypeptide p30; sin3-associated polypeptide, 30 kDa; Sin3-associated protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39857,935,740 - 57,940,874 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl857,935,741 - 57,940,894 (-)EnsemblGRCm39 Ensembl
GRCm38857,482,702 - 57,487,860 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl857,482,707 - 57,487,860 (-)EnsemblGRCm38mm10GRCm38
MGSCv37859,961,499 - 59,966,657 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36860,374,867 - 60,379,999 (-)NCBIMGSCv36mm8
Celera860,121,756 - 60,126,914 (-)NCBICelera
Cytogenetic Map8B2NCBI
cM Map829.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
histone deacetylase complex  (IBA,ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IDA,NAS)
Sin3-type complex  (ISO,NAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9651585   PMID:9702189   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11087671   PMID:11101889   PMID:11180952   PMID:11217851   PMID:12198164   PMID:12466851   PMID:12477932  
PMID:14522945   PMID:14610273   PMID:16141072   PMID:16141073   PMID:19889787   PMID:20059953   PMID:20478393   PMID:21267068   PMID:21490601   PMID:21676866   PMID:21731673   PMID:21873635  
PMID:22147266   PMID:22865885   PMID:22984288   PMID:26238476   PMID:28554894   PMID:32325033   PMID:34321999   PMID:37551791   PMID:38355793  


Genomics

Comparative Map Data
Sap30
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39857,935,740 - 57,940,874 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl857,935,741 - 57,940,894 (-)EnsemblGRCm39 Ensembl
GRCm38857,482,702 - 57,487,860 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl857,482,707 - 57,487,860 (-)EnsemblGRCm38mm10GRCm38
MGSCv37859,961,499 - 59,966,657 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36860,374,867 - 60,379,999 (-)NCBIMGSCv36mm8
Celera860,121,756 - 60,126,914 (-)NCBICelera
Cytogenetic Map8B2NCBI
cM Map829.85NCBI
SAP30
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384173,370,954 - 173,377,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4173,369,969 - 173,377,532 (+)EnsemblGRCh38hg38GRCh38
GRCh374174,292,105 - 174,298,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364174,528,668 - 174,535,258 (+)NCBINCBI36Build 36hg18NCBI36
Build 344174,666,823 - 174,673,412NCBI
Celera4171,617,185 - 171,623,780 (+)NCBICelera
Cytogenetic Map4q34.1NCBI
HuRef4170,039,929 - 170,046,600 (+)NCBIHuRef
CHM1_14174,268,541 - 174,275,140 (+)NCBICHM1_1
T2T-CHM13v2.04176,710,356 - 176,716,943 (+)NCBIT2T-CHM13v2.0
Sap30
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81637,758,494 - 37,763,825 (+)NCBIGRCr8
mRatBN7.21632,747,777 - 32,753,114 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1632,747,734 - 32,753,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1636,340,519 - 36,345,780 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01639,751,855 - 39,757,120 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01635,971,643 - 35,976,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01636,115,942 - 36,121,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1636,116,258 - 36,121,097 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01635,925,181 - 35,930,571 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41636,169,061 - 36,175,458 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1632,686,875 - 32,692,135 (+)NCBICelera
Cytogenetic Map16p11NCBI
Sap30
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540333,633,236 - 33,638,983 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540333,633,028 - 33,639,271 (-)NCBIChiLan1.0ChiLan1.0
SAP30
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23171,131,113 - 171,137,985 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14171,511,697 - 171,518,922 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04165,598,765 - 165,605,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14177,836,967 - 177,843,092 (+)NCBIpanpan1.1PanPan1.1panPan2
SAP30
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12523,971,692 - 23,977,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2523,971,982 - 23,977,478 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2524,622,551 - 24,628,366 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02524,135,020 - 24,140,861 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2524,135,335 - 24,140,858 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12524,081,285 - 24,087,117 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02523,971,624 - 23,977,439 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02524,121,526 - 24,127,344 (+)NCBIUU_Cfam_GSD_1.0
Sap30
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494324,139,083 - 24,204,848 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365164,552,743 - 4,558,928 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365164,553,382 - 4,587,360 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAP30
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1416,673,318 - 16,681,928 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11416,625,893 - 16,681,950 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SAP30
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17119,481,790 - 119,488,348 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7119,481,772 - 119,488,354 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603799,503,539 - 99,510,212 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sap30
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247694,853,519 - 4,859,967 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247694,854,075 - 4,889,506 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sap30
410 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:59
Interacting mature miRNAs:59
Transcripts:ENSMUST00000034022
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83429039768290537Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82658332260583322Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000034022   ⟹   ENSMUSP00000034022
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl857,935,741 - 57,940,894 (-)Ensembl
GRCm38.p6 Ensembl857,482,707 - 57,487,860 (-)Ensembl
RefSeq Acc Id: NM_021788   ⟹   NP_068560
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39857,935,740 - 57,940,874 (-)NCBI
GRCm38857,482,702 - 57,487,860 (-)ENTREZGENE
MGSCv37859,961,499 - 59,966,657 (-)RGD
Celera860,121,756 - 60,126,914 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_068560   ⟸   NM_021788
- UniProtKB: A2RSE9 (UniProtKB/Swiss-Prot),   Q99JB9 (UniProtKB/Swiss-Prot),   O88574 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000034022   ⟸   ENSMUST00000034022

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88574-F1-model_v2 AlphaFold O88574 1-220 view protein structure

Promoters
RGD ID:8667117
Promoter ID:EPDNEW_M11590
Type:initiation region
Name:Sap30_2
Description:Mus musculus sin3 associated polypeptide , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11591  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38857,487,570 - 57,487,630EPDNEW
RGD ID:8667119
Promoter ID:EPDNEW_M11591
Type:initiation region
Name:Sap30_1
Description:Mus musculus sin3 associated polypeptide , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11590  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38857,487,813 - 57,487,873EPDNEW
RGD ID:6843704
Promoter ID:MM_KWN:54469
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK141659_2500002B13RIK,   ENSMUST00000034022
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36859,965,866 - 59,967,407 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929129 AgrOrtholog
Ensembl Genes ENSMUSG00000031609 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034022 ENTREZGENE
  ENSMUST00000034022.4 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.160.20 UniProtKB/Swiss-Prot
InterPro His_deAcase_SAP30/SAP30L UniProtKB/Swiss-Prot
  SAP30_C_sf UniProtKB/Swiss-Prot
  SAP30_Sin3-bd UniProtKB/Swiss-Prot
  SAP30_zn-finger UniProtKB/Swiss-Prot
KEGG Report mmu:60406 UniProtKB/Swiss-Prot
MGD MGI:1929129 ENTREZGENE
NCBI Gene 60406 ENTREZGENE
PANTHER HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30 UniProtKB/Swiss-Prot
  PTHR13286 UniProtKB/Swiss-Prot
Pfam SAP30_Sin3_bdg UniProtKB/Swiss-Prot
  zf-SAP30 UniProtKB/Swiss-Prot
PhenoGen Sap30 PhenoGen
UniProt A2RSE9 ENTREZGENE
  O88574 ENTREZGENE
  Q99JB9 ENTREZGENE
  SAP30_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A2RSE9 UniProtKB/Swiss-Prot
  Q99JB9 UniProtKB/Swiss-Prot