SAP30 (Sin3A associated protein 30) - Rat Genome Database

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Gene: SAP30 (Sin3A associated protein 30) Canis lupus familiaris
Analyze
Symbol: SAP30
Name: Sin3A associated protein 30
RGD ID: 12434582
Description: ENCODES a protein that exhibits DNA binding (inferred); metal ion binding (inferred); transcription coregulator activity (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); skeletal muscle cell differentiation (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN histone deacetylase complex (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histone deacetylase complex subunit SAP30
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12523,971,692 - 23,977,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2523,971,982 - 23,977,478 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2524,622,551 - 24,628,366 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02524,135,020 - 24,140,861 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2524,135,335 - 24,140,858 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12524,081,285 - 24,087,117 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02523,971,624 - 23,977,439 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02524,121,526 - 24,127,344 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SAP30
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12523,971,692 - 23,977,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2523,971,982 - 23,977,478 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2524,622,551 - 24,628,366 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02524,135,020 - 24,140,861 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2524,135,335 - 24,140,858 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12524,081,285 - 24,087,117 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02523,971,624 - 23,977,439 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02524,121,526 - 24,127,344 (+)NCBIUU_Cfam_GSD_1.0
SAP30
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384173,370,954 - 173,377,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4173,369,969 - 173,377,532 (+)EnsemblGRCh38hg38GRCh38
GRCh374174,292,105 - 174,298,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364174,528,668 - 174,535,258 (+)NCBINCBI36Build 36hg18NCBI36
Build 344174,666,823 - 174,673,412NCBI
Celera4171,617,185 - 171,623,780 (+)NCBICelera
Cytogenetic Map4q34.1NCBI
HuRef4170,039,929 - 170,046,600 (+)NCBIHuRef
CHM1_14174,268,541 - 174,275,140 (+)NCBICHM1_1
T2T-CHM13v2.04176,710,356 - 176,716,943 (+)NCBIT2T-CHM13v2.0
Sap30
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39857,935,740 - 57,940,874 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl857,935,741 - 57,940,894 (-)EnsemblGRCm39 Ensembl
GRCm38857,482,702 - 57,487,860 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl857,482,707 - 57,487,860 (-)EnsemblGRCm38mm10GRCm38
MGSCv37859,961,499 - 59,966,657 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36860,374,867 - 60,379,999 (-)NCBIMGSCv36mm8
Celera860,121,756 - 60,126,914 (-)NCBICelera
Cytogenetic Map8B2NCBI
cM Map829.85NCBI
Sap30
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81637,758,494 - 37,763,825 (+)NCBIGRCr8
mRatBN7.21632,747,777 - 32,753,114 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1632,747,734 - 32,753,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1636,340,519 - 36,345,780 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01639,751,855 - 39,757,120 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01635,971,643 - 35,976,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01636,115,942 - 36,121,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1636,116,258 - 36,121,097 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01635,925,181 - 35,930,571 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41636,169,061 - 36,175,458 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1632,686,875 - 32,692,135 (+)NCBICelera
Cytogenetic Map16p11NCBI
Sap30
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540333,633,236 - 33,638,983 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540333,633,028 - 33,639,271 (-)NCBIChiLan1.0ChiLan1.0
SAP30
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23171,131,113 - 171,137,985 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14171,511,697 - 171,518,922 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04165,598,765 - 165,605,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14177,836,967 - 177,843,092 (+)NCBIpanpan1.1PanPan1.1panPan2
Sap30
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494324,139,083 - 24,204,848 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365164,552,743 - 4,558,928 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365164,553,382 - 4,587,360 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAP30
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1416,673,318 - 16,681,928 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11416,625,893 - 16,681,950 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SAP30
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17119,481,790 - 119,488,348 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7119,481,772 - 119,488,354 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603799,503,539 - 99,510,212 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sap30
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247694,853,519 - 4,859,967 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247694,854,075 - 4,889,506 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SAP30
70 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 1 19 3 6 3 6 11 8 10 6
Low 4 3 3 3 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012542   ⟹   ENSCAFP00000011613
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2523,971,982 - 23,977,478 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845030259   ⟹   ENSCAFP00845023729
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2524,135,335 - 24,140,858 (+)Ensembl
RefSeq Acc Id: XM_022409695   ⟹   XP_022265403
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12523,971,692 - 23,977,481 (+)NCBI
Dog10K_Boxer_Tasha2524,622,551 - 24,628,366 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038435201   ⟹   XP_038291129
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02524,135,021 - 24,140,861 (+)NCBI
RefSeq Acc Id: XM_038435202   ⟹   XP_038291130
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02524,135,020 - 24,140,861 (+)NCBI
RefSeq Acc Id: XM_038510145   ⟹   XP_038366073
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12524,081,286 - 24,087,117 (+)NCBI
RefSeq Acc Id: XM_038510146   ⟹   XP_038366074
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12524,081,285 - 24,087,117 (+)NCBI
RefSeq Acc Id: XM_038573601   ⟹   XP_038429529
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02524,121,527 - 24,127,344 (+)NCBI
RefSeq Acc Id: XM_038573602   ⟹   XP_038429530
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02524,121,526 - 24,127,344 (+)NCBI
RefSeq Acc Id: XM_038637910   ⟹   XP_038493838
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02523,971,625 - 23,977,439 (+)NCBI
RefSeq Acc Id: XM_038637911   ⟹   XP_038493839
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02523,971,624 - 23,977,439 (+)NCBI
RefSeq Acc Id: XM_843990   ⟹   XP_849083
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12523,971,692 - 23,977,481 (+)NCBI
Dog10K_Boxer_Tasha2524,622,552 - 24,628,366 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_849083   ⟸   XM_843990
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NXI2 (UniProtKB/TrEMBL),   A0A8C0QZJ5 (UniProtKB/TrEMBL),   A0A8I3P1N2 (UniProtKB/TrEMBL),   A0A8C0TFS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022265403   ⟸   XM_022409695
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TFS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000011613   ⟸   ENSCAFT00000012542
RefSeq Acc Id: XP_038366074   ⟸   XM_038510146
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038366073   ⟸   XM_038510145
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038493839   ⟸   XM_038637911
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038493838   ⟸   XM_038637910
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038291130   ⟸   XM_038435202
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TFS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038291129   ⟸   XM_038435201
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NXI2 (UniProtKB/TrEMBL),   A0A8C0QZJ5 (UniProtKB/TrEMBL),   A0A8I3P1N2 (UniProtKB/TrEMBL),   A0A8C0TFS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038429530   ⟸   XM_038573602
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TFS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038429529   ⟸   XM_038573601
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NXI2 (UniProtKB/TrEMBL),   A0A8C0QZJ5 (UniProtKB/TrEMBL),   A0A8C0TFS6 (UniProtKB/TrEMBL),   A0A8I3P1N2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845023729   ⟸   ENSCAFT00845030259
Protein Domains
Histone deacetylase complex subunit SAP30 Sin3   Histone deacetylase complex subunit SAP30 zinc-

Promoters
RGD ID:13687758
Promoter ID:EPDNEW_C5826
Type:single initiation site
Name:SAP30_1
Description:Sin3A associated protein 30
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12523,972,046 - 23,972,106EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007853 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019296 UniProtKB/TrEMBL
  ENSCAFG00040021017 UniProtKB/TrEMBL
  ENSCAFG00845017098 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012542.5 UniProtKB/TrEMBL
  ENSCAFT00030035459.1 UniProtKB/TrEMBL
  ENSCAFT00040038962.1 UniProtKB/TrEMBL
  ENSCAFT00845030259 ENTREZGENE
  ENSCAFT00845030259.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.160.20 UniProtKB/TrEMBL
InterPro His_deAcase_SAP30/SAP30L UniProtKB/TrEMBL
  SAP30_C_sf UniProtKB/TrEMBL
  SAP30_Sin3-bd UniProtKB/TrEMBL
  SAP30_zn-finger UniProtKB/TrEMBL
NCBI Gene SAP30 ENTREZGENE
PANTHER HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30 UniProtKB/TrEMBL
  PTHR13286 UniProtKB/TrEMBL
Pfam SAP30_Sin3_bdg UniProtKB/TrEMBL
  zf-SAP30 UniProtKB/TrEMBL
UniProt A0A8C0NXI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QZJ5 ENTREZGENE
  A0A8C0TFS6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P1N2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45860 ENTREZGENE