Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | ISO | Syt8 (Rattus norvegicus) | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SYT8 mRNA | CTD | PMID:32741896 | 17beta-estradiol 3-benzoate | multiple interactions | ISO | Syt8 (Rattus norvegicus) | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SYT8 mRNA | CTD | PMID:32741896 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Syt8 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SYT8 mRNA | CTD | PMID:22298810 | aflatoxin B1 | increases methylation | ISO | SYT8 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SYT8 gene | CTD | PMID:27153756 | ammonium chloride | affects expression | ISO | Syt8 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of SYT8 mRNA | CTD | PMID:16483693 | atrazine | increases expression | ISO | SYT8 (Homo sapiens) | 6480464 | Atrazine results in increased expression of SYT8 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | affects methylation | ISO | SYT8 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SYT8 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | SYT8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SYT8 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | decreases methylation | ISO | SYT8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SYT8 exon | CTD | PMID:27901495 | bis(2-chloroethyl) sulfide | increases expression | EXP | | 6480464 | Mustard Gas results in increased expression of SYT8 mRNA | CTD | PMID:15674843 | bisphenol A | decreases expression | ISO | Syt8 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of SYT8 mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of SYT8 promoter | CTD | PMID:27312807 | butanal | increases expression | ISO | SYT8 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of SYT8 mRNA | CTD | PMID:26079696 | C60 fullerene | decreases expression | ISO | Syt8 (Rattus norvegicus) | 6480464 | fullerene C60 results in decreased expression of SYT8 mRNA | CTD | PMID:19167457 | cadmium atom | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SYT8 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SYT8 mRNA | CTD | PMID:37325564 | calcitriol | increases expression | ISO | SYT8 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of SYT8 mRNA | CTD | PMID:26485663 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes and Carbon results in increased expression of SYT8 mRNA | CTD | PMID:25554681 | carbonyl sulfide | increases expression | ISO | Syt8 (Rattus norvegicus) | 6480464 | carbonyl sulfide results in increased expression of SYT8 mRNA | CTD | PMID:19395590 | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of SYT8 mRNA | CTD | PMID:28472532 | cisplatin | multiple interactions | ISO | SYT8 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of SYT8 mRNA | CTD | PMID:27392435 | cisplatin | increases expression | ISO | SYT8 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of SYT8 mRNA | CTD | PMID:27392435 | diazinon | increases methylation | ISO | SYT8 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of SYT8 gene | CTD | PMID:22964155 | dimethylarsinic acid | multiple interactions | EXP | | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of SYT8 mRNA | CTD | PMID:34876320 | ethanol | multiple interactions | ISO | SYT8 (Homo sapiens) | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SYT8 mRNA | CTD | PMID:29432896 | gentamycin | decreases expression | ISO | Syt8 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of SYT8 mRNA | CTD | PMID:22061828 | mercury dichloride | increases expression | ISO | SYT8 (Homo sapiens) | 6480464 | Mercuric Chloride results in increased expression of SYT8 mRNA | CTD | PMID:27188386 | methylarsonic acid | multiple interactions | EXP | | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of SYT8 mRNA | CTD | PMID:34876320 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of SYT8 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of SYT8 mRNA | CTD | PMID:27106289 and PMID:34911549 | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of SYT8 mRNA | CTD | PMID:33026818 | paracetamol | decreases expression | ISO | Syt8 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of SYT8 mRNA | CTD | PMID:33387578 | phenobarbital | decreases expression | ISO | SYT8 (Homo sapiens) | 6480464 | Phenobarbital results in decreased expression of SYT8 mRNA | CTD | PMID:19084549 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SYT8 mRNA | CTD | PMID:19710929 | resveratrol | multiple interactions | ISO | SYT8 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of SYT8 mRNA | CTD | PMID:23557933 | sodium arsenate | multiple interactions | EXP | | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of SYT8 mRNA | CTD | PMID:34876320 | sodium arsenite | affects methylation | ISO | SYT8 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of SYT8 gene | CTD | PMID:28589171 | sodium arsenite | multiple interactions | EXP | | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of SYT8 mRNA | CTD | PMID:34876320 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of SYT8 mRNA | CTD | PMID:37682722 | sodium arsenite | increases expression | ISO | SYT8 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SYT8 mRNA | CTD | PMID:29301061 | testosterone | multiple interactions | ISO | Syt8 (Rattus norvegicus) | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SYT8 mRNA | CTD | PMID:32741896 | trichloroethene | increases expression | ISO | Syt8 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of SYT8 mRNA | CTD | PMID:33387578 | urethane | decreases expression | ISO | SYT8 (Homo sapiens) | 6480464 | Urethane results in decreased expression of SYT8 mRNA | CTD | PMID:28818685 | | 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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
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Phenotype Annotations
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. | Fukuda M, etal., J Biol Chem 1999 Oct 29;274(44):31421-7. |
| 2. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 3. | Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. | Li C, etal., Nature 1995 Jun 15;375(6532):594-9. |
| 4. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
| 5. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 6. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 7. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:9575177 | PMID:10349636 | PMID:10734137 | PMID:11011146 | PMID:11042159 | PMID:11076861 | PMID:11751263 | PMID:12477932 | PMID:15774481 | PMID:16141072 | PMID:16141073 | PMID:16386321 |
| PMID:21267068 | PMID:21677750 | PMID:21873635 |
Genomics
Comparative Map Data
| Syt8 (Mus musculus - house mouse) |
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| SYT8 (Homo sapiens - human) |
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| Syt8 (Rattus norvegicus - Norway rat) |
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| Syt8 (Chinchilla lanigera - long-tailed chinchilla) |
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| SYT8 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| SYT8 (Canis lupus familiaris - dog) |
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| Syt8 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| SYT8 (Sus scrofa - pig) |
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| SYT8 (Chlorocebus sabaeus - green monkey) |
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| Syt8 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Syt8
85 total Variants 
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