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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aspartame
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Accession:CHEBI:2877 term browser browse the term
Definition:A dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener.
Synonyms:exact_synonym: methyl L-alpha-aspartyl-L-phenylalaninate
 related_synonym: 1-methyl N-L-alpha-aspartyl-L-phenylalanate;   3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester;   3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid;   AminoSweet;   Asp-phe-ome;   Aspartylphenylalanine methyl ester;   E 951;   Formula=C14H18N2O5;   InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1;   InChIKey=IAOZJIPTCAWIRG-QWRGUYRKSA-N;   L-Aspartyl-L-phenylalanine methyl ester;   NutraSweet;   SMILES=C(C[C@@H](C(N[C@@H](CC1=CC=CC=C1)C(=O)OC)=O)N)(=O)O;   Sanecta;   aspartam;   aspartamo;   aspartamum
 alt_id: CHEBI:45047
 xref: Beilstein:2223850;   CAS:22839-47-0;   DrugBank:DB00168;   HMDB:HMDB0001894;   KEGG:C11045;   KEGG:D02381
 xref_mesh: MESH:D001218
 xref: PDBeChem:PME;   PMID:1771173;   PMID:2013754;   PMID:21150094;   PMID:21372000;   PMID:22354473;   PMID:24355796;   PMID:24925367;   PMID:24944748;   PMID:24965331;   PMID:25431414;   PMID:25543075;   PMID:25786106;   PMID:25951455;   PMID:25991916;   PMID:26015492;   PMID:26099025;   PMID:26159964;   PMID:26247507;   PMID:26308194;   PMID:26321723;   PMID:26377607;   PMID:26582819;   PMID:26593524;   PMID:26912665;   PMID:27015640;   PMID:27038223;   PMID:27088715;   PMID:27127997;   PMID:27216413;   PMID:27298583;   PMID:27492574;   PMID:27565676;   PMID:27614095;   PMID:27640132;   PMID:27699780;   PMID:27728881;   PMID:27840415;   PMID:27845306;   PMID:30000570;   PMID:37291632;   PMID:37297402;   PMID:37454665;   Patent:US3492131;   Reaxys:2223850;   Wikipedia:Aspartame
 cyclic_relationship: is_tautomer_of CHEBI:195544


show annotations for term's descendants           Sort by:
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCA1 mRNA CTD PMID:23783067 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCB4 mRNA CTD PMID:23783067 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Abcd1 ATP-binding cassette, sub-family D member 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of ABCD1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD1 mRNA CTD PMID:23783067 NCBI chr  X:72,760,203...72,782,140
Ensembl chr  X:72,760,203...72,782,140 		JBrowse link
G Abcd2 ATP-binding cassette, sub-family D member 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD2 mRNA CTD PMID:23783067 NCBI chr15:91,029,874...91,076,013
Ensembl chr15:91,030,074...91,076,002 		JBrowse link
G Acaa1a acetyl-Coenzyme A acyltransferase 1A multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACAA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1A mRNA CTD PMID:23783067 NCBI chr 9:119,170,113...119,179,361
Ensembl chr 9:119,168,742...119,179,365 		JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1B mRNA CTD PMID:23783067 NCBI chr 9:118,977,111...118,986,149
Ensembl chr 9:118,977,091...118,986,161 		JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACACB mRNA CTD PMID:23783067 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822 		JBrowse link
G Acads acyl-Coenzyme A dehydrogenase, short chain multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADS mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADS mRNA CTD PMID:23783067 NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405 		JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADVL mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADVL mRNA CTD PMID:23783067 NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237 		JBrowse link
G Ache acetylcholinesterase decreases activity ISO Aspartame metabolite results in decreased activity of ACHE protein CTD PMID:16129618 PMID:17580119 PMID:17673349 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Aco1 aconitase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACO1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACO1 mRNA CTD PMID:23783067 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACOT1 mRNA CTD PMID:23783067 NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ADGRE1 mRNA CTD PMID:23783067 NCBI chr17:57,665,650...57,790,527
Ensembl chr17:57,665,691...57,790,527 		JBrowse link
G Agt angiotensinogen decreases expression ISO Aspartame results in decreased expression of AGT mRNA CTD PMID:31655124 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Aspartame results in decreased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation ISO Aspartame results in increased phosphorylation of AKT1 protein CTD PMID:33992720 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ALOX15 mRNA CTD PMID:23783067 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857 		JBrowse link
G Apoe apolipoprotein E decreases expression ISO Aspartame results in decreased expression of APOE mRNA CTD PMID:31655124 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression		 ISO
EXP		 [Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein
[Fats, Unsaturated co-treated with Aspartame] affects the expression of BAX mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of BAX mRNA
Aspartame results in increased expression of BAX mRNA		 CTD PMID:23783067 PMID:25009784 PMID:32951320 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression		 ISO
EXP		 [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 mRNA; [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 protein
Aspartame results in decreased expression of BCL2 mRNA		 CTD PMID:25009784 PMID:32951320 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Cabp2 calcium binding protein 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CABP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CABP2 mRNA CTD PMID:23783067 NCBI chr19:4,131,469...4,137,340
Ensembl chr19:4,131,578...4,137,340 		JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1A mRNA CTD PMID:23783067 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875 		JBrowse link
G Cacna1i calcium channel, voltage-dependent, alpha 1I subunit multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1I mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1I mRNA CTD PMID:23783067 NCBI chr15:80,171,439...80,282,493
Ensembl chr15:80,171,439...80,282,480 		JBrowse link
G Cacna2d4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA2D4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA2D4 mRNA CTD PMID:23783067 NCBI chr 6:119,213,435...119,329,368
Ensembl chr 6:119,213,487...119,329,368 		JBrowse link
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNB2 mRNA CTD PMID:23783067 NCBI chr 2:14,608,672...14,993,622
Ensembl chr 2:14,607,899...14,992,719 		JBrowse link
G Cacng4 calcium channel, voltage-dependent, gamma subunit 4 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG4 mRNA CTD PMID:23783067 NCBI chr11:107,623,183...107,685,532
Ensembl chr11:107,623,183...107,685,383 		JBrowse link
G Cacng8 calcium channel, voltage-dependent, gamma subunit 8 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG8 mRNA CTD PMID:23783067 NCBI chr 7:3,442,558...3,464,782
Ensembl chr 7:3,439,199...3,464,164 		JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CALHM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALHM2 mRNA CTD PMID:23783067 NCBI chr19:47,120,671...47,126,733
Ensembl chr19:47,093,792...47,126,733 		JBrowse link
G Calr3 calreticulin 3 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CALR3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALR3 mRNA CTD PMID:23783067 NCBI chr 8:73,178,020...73,197,638
Ensembl chr 8:73,178,020...73,197,714 		JBrowse link
G Cant1 calcium activated nucleotidase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CANT1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CANT1 mRNA CTD PMID:23783067 NCBI chr11:118,297,115...118,309,971
Ensembl chr11:118,297,115...118,309,912 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO
EXP		 [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 protein modified form
Aspartame results in increased expression of CASP3 mRNA		 CTD PMID:25009784 PMID:32951320 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CASP9 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CASP9 mRNA CTD PMID:23783067 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 ISO
EXP		 [Aspartame co-treated with Methotrexate] results in increased activity of CAT protein
Aspartame results in decreased activity of CAT protein		 CTD PMID:25009784 PMID:32951320 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] results in increased expression of CCL2 protein; [Sodium Glutamate co-treated with Aspartame] inhibits the reaction [Fats, Unsaturated results in increased expression of CCL2 protein] CTD PMID:23783067 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cdh1 cadherin 1 decreases expression ISO Aspartame results in decreased expression of CDH1 protein CTD PMID:33992720 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A affects localization
multiple interactions		 ISO Aspartame affects the localization of CDKN1A protein
TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]		 CTD PMID:33992720 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions
decreases expression		 EXP
ISO		 [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CDKN1B mRNA
Aspartame results in decreased expression of CDKN1B protein		 CTD PMID:23783067 PMID:33992720 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cherp calcium homeostasis endoplasmic reticulum protein multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CHERP mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CHERP mRNA CTD PMID:23783067 NCBI chr 8:73,214,327...73,229,077
Ensembl chr 8:73,214,333...73,229,070 		JBrowse link
G Cmc1 C-X9-C motif containing 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CMC1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CMC1 mRNA CTD PMID:23783067 NCBI chr 9:117,893,051...117,979,264
Ensembl chr 9:117,893,590...117,979,245 		JBrowse link
G Cox11 cytochrome c oxidase assembly protein 11, copper chaperone multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX11 mRNA CTD PMID:23783067 NCBI chr11:90,529,010...90,536,803
Ensembl chr11:90,528,999...90,535,757 		JBrowse link
G Cox7a1 cytochrome c oxidase subunit 7A1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX7A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX7A1 mRNA CTD PMID:23783067 NCBI chr 7:29,883,596...29,885,455
Ensembl chr 7:29,883,569...29,885,503 		JBrowse link
G Cox8b cytochrome c oxidase subunit 8B multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX8B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX8B mRNA CTD PMID:23783067 NCBI chr 7:140,478,855...140,480,359
Ensembl chr 7:140,478,858...140,480,359 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of CPT1B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1B mRNA CTD PMID:23783067 NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066 		JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1C mRNA CTD PMID:23783067 NCBI chr 7:44,607,907...44,624,304
Ensembl chr 7:44,608,796...44,624,275 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CREB1 mRNA CTD PMID:23783067 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CSF1 mRNA CTD PMID:23783067 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity ISO Aspartame results in increased activity of CYP1A1 protein CTD PMID:16937917 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity ISO Aspartame results in increased activity of CYP1A2 protein CTD PMID:16937917 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases activity ISO Aspartame results in increased activity of CYP2B2 protein CTD PMID:16937917 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Aspartame results in increased expression of and results in increased activity of CYP2E1 protein CTD PMID:16937917 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CYP4A10 mRNA CTD PMID:23783067 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846 		JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CYP4A14 mRNA CTD PMID:23783067 NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of DIABLO mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DIABLO mRNA CTD PMID:23783067 NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239 		JBrowse link
G Dnajc27 DnaJ heat shock protein family (Hsp40) member C27 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of DNAJC27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DNAJC27 mRNA CTD PMID:23783067 NCBI chr12:4,132,569...4,174,140
Ensembl chr12:4,132,583...4,160,606 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of E2F1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of E2F1 mRNA CTD PMID:23783067 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Edn2 endothelin 2 decreases expression ISO Aspartame results in decreased expression of EDN2 mRNA CTD PMID:31655124 NCBI chr 4:120,018,403...120,024,557
Ensembl chr 4:120,018,403...120,024,557 		JBrowse link
G Ednra endothelin receptor type A decreases expression ISO Aspartame results in decreased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093 		JBrowse link
G Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of EHHADH mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EHHADH mRNA CTD PMID:23783067 NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of EPHX2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EPHX2 mRNA CTD PMID:23783067 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G F2 coagulation factor II decreases activity ISO Aspartame analog results in decreased activity of F2 protein; Aspartame results in decreased activity of F2 protein CTD PMID:15572260 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Aspartame results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA CTD PMID:23783067 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Fshb follicle stimulating hormone beta decreases expression EXP Aspartame results in decreased expression of FSHB protein CTD PMID:32951320 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GADD45B mRNA CTD PMID:23783067 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038 		JBrowse link
G Gfm2 G elongation factor, mitochondrial 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of GFM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GFM2 mRNA CTD PMID:23783067 NCBI chr13:97,274,445...97,317,710
Ensembl chr13:97,274,445...97,317,703 		JBrowse link
G Gip gastric inhibitory polypeptide multiple interactions EXP Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]; Sodium Glutamate inhibits the reaction [Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]] CTD PMID:23783067 NCBI chr11:95,915,358...95,921,657
Ensembl chr11:95,915,371...95,921,657 		JBrowse link
G Gli1 GLI-Kruppel family member GLI1 affects localization
multiple interactions		 ISO Aspartame affects the localization of GLI1 protein
TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]		 CTD PMID:33992720 NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843 		JBrowse link
G Gli2 GLI-Kruppel family member GLI2 decreases expression ISO Aspartame results in decreased expression of GLI2 protein CTD PMID:33992720 NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Aspartame results in increased phosphorylation of GSK3B protein CTD PMID:33992720 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO [Aspartame co-treated with Methotrexate] results in decreased activity of GSR protein CTD PMID:25009784 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHA mRNA CTD PMID:23783067 NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHB mRNA CTD PMID:23783067 NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA CTD PMID:23783067 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC5 mRNA CTD PMID:23783067 NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HGF mRNA CTD PMID:23783067 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene increases expression EXP Aspartame results in increased expression of HRAS CTD PMID:17354619 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Hspg2 perlecan (heparan sulfate proteoglycan 2) multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HSPG2 mRNA CTD PMID:23783067 NCBI chr 4:137,196,062...137,297,941
Ensembl chr 4:137,196,080...137,297,941 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of IDH2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IDH2 mRNA CTD PMID:23783067 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Il11 interleukin 11 decreases expression ISO Aspartame results in decreased expression of IL11 mRNA CTD PMID:31655124 NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Aspartame results in increased expression of IL1B mRNA CTD PMID:31655124 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il3 interleukin 3 decreases expression ISO Aspartame results in decreased expression of IL3 mRNA CTD PMID:31655124 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103 		JBrowse link
G Il6 interleukin 6 increases secretion ISO Aspartame results in increased secretion of IL6 protein CTD PMID:20837131 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Immt inner membrane protein, mitochondrial multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of IMMT mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IMMT mRNA CTD PMID:23783067 NCBI chr 6:71,806,200...71,852,250
Ensembl chr 6:71,808,315...71,854,372 		JBrowse link
G Ins2 insulin II increases expression
multiple interactions		 ISO
EXP		 Aspartame results in increased expression of INS protein
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] results in increased expression of INS2 protein; Aspartame inhibits the reaction [Fats, Unsaturated results in increased expression of INS2 protein]		 CTD PMID:1805284 PMID:23783067 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Kdr kinase insert domain protein receptor increases secretion ISO Aspartame results in increased secretion of KDR protein CTD PMID:20837131 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Lep leptin decreases expression
multiple interactions		 ISO
EXP		 Aspartame results in decreased expression of LEP protein
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of LEP protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein]		 CTD PMID:11890951 PMID:23783067 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lhb luteinizing hormone beta decreases expression EXP Aspartame results in decreased expression of LHB protein CTD PMID:32951320 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Lipg lipase, endothelial multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LIPG mRNA CTD PMID:23783067 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334 		JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP1 mRNA CTD PMID:23783067 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017 		JBrowse link
G Lrp2 low density lipoprotein receptor-related protein 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP2 mRNA CTD PMID:23783067 NCBI chr 2:69,254,679...69,416,373
Ensembl chr 2:69,254,684...69,416,409 		JBrowse link
G Lrp4 low density lipoprotein receptor-related protein 4 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP4 mRNA CTD PMID:23783067 NCBI chr 2:91,287,794...91,344,246
Ensembl chr 2:91,287,856...91,344,124 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation ISO Aspartame results in increased phosphorylation of MAPK1 protein CTD PMID:20837131 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation ISO Aspartame results in increased phosphorylation of MAPK3 protein CTD PMID:20837131 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mcu mitochondrial calcium uniporter multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MCU mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MCU mRNA CTD PMID:23783067 NCBI chr10:59,282,806...59,453,231
Ensembl chr10:59,282,806...59,452,514 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Med23 mediator complex subunit 23 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MED23 mRNA CTD PMID:23783067 NCBI chr10:24,745,889...24,789,358
Ensembl chr10:24,745,884...24,789,579 		JBrowse link
G Mef2d myocyte enhancer factor 2D multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MEF2D mRNA CTD PMID:23783067 NCBI chr 3:88,049,248...88,079,398
Ensembl chr 3:88,049,679...88,079,393 		JBrowse link
G Micos10 mitochondrial contact site and cristae organizing system subunit 10 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MINOS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MINOS1 mRNA CTD PMID:23783067 NCBI chr 4:138,829,125...138,858,667
Ensembl chr 4:138,829,125...138,858,424 		JBrowse link
G Micu1 mitochondrial calcium uptake 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MICU1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MICU1 mRNA CTD PMID:23783067 NCBI chr10:59,538,385...59,699,956
Ensembl chr10:59,538,299...59,699,954 		JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL20 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL20 mRNA CTD PMID:23783067 NCBI chr 4:155,887,335...155,893,288
Ensembl chr 4:155,887,335...155,894,432 		JBrowse link
G Mrpl3 mitochondrial ribosomal protein L3 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL3 mRNA CTD PMID:23783067 NCBI chr 9:104,930,394...104,954,665
Ensembl chr 9:104,930,438...104,957,087 		JBrowse link
G Mrps12 mitochondrial ribosomal protein S12 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS12 mRNA CTD PMID:23783067 NCBI chr 7:28,439,066...28,441,246
Ensembl chr 7:28,439,066...28,441,245 		JBrowse link
G Mrps24 mitochondrial ribosomal protein S24 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS24 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS24 mRNA CTD PMID:23783067 NCBI chr11:5,653,982...5,657,701
Ensembl chr11:5,653,983...5,665,680 		JBrowse link
G Mrps27 mitochondrial ribosomal protein S27 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS27 mRNA CTD PMID:23783067 NCBI chr13:99,481,275...99,552,070
Ensembl chr13:99,481,294...99,552,070 		JBrowse link
G Mrps7 mitchondrial ribosomal protein S7 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS7 mRNA CTD PMID:23783067 NCBI chr11:115,494,966...115,498,862
Ensembl chr11:115,494,751...115,498,862 		JBrowse link
G Mtfp1 mitochondrial fission process 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of MTFP1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MTFP1 mRNA CTD PMID:23783067 NCBI chr11:4,041,481...4,045,431
Ensembl chr11:4,041,480...4,045,445 		JBrowse link
G Myc myelocytomatosis oncogene increases expression EXP
ISO		 Aspartame results in increased expression of MYC
Aspartame results in increased expression of MYC protein		 CTD PMID:17354619 PMID:33992720 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NCOR1 mRNA CTD PMID:23783067 NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367 		JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA12 mRNA CTD PMID:23783067 NCBI chr10:94,034,897...94,057,302
Ensembl chr10:94,034,582...94,057,305 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA5 mRNA CTD PMID:23783067 NCBI chr 6:24,518,661...24,527,689
Ensembl chr 6:24,518,665...24,528,012 		JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB10 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB10 mRNA CTD PMID:23783067 NCBI chr17:24,941,034...24,943,397
Ensembl chr17:24,941,034...24,943,452 		JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB2 mRNA CTD PMID:23783067 NCBI chr 6:39,569,499...39,576,777
Ensembl chr 6:39,569,508...39,580,316 		JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB6 mRNA CTD PMID:23783067 NCBI chr 4:40,270,591...40,279,421
Ensembl chr 4:40,270,591...40,279,421 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS1 mRNA CTD PMID:23783067 NCBI chr 1:63,182,751...63,215,981
Ensembl chr 1:63,182,755...63,215,992 		JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase core subunit S6 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS6 mRNA CTD PMID:23783067 NCBI chr13:73,467,995...73,476,574
Ensembl chr13:73,467,957...73,476,661 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFV1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFV1 mRNA CTD PMID:23783067 NCBI chr19:4,057,499...4,062,755
Ensembl chr19:4,057,384...4,062,806 		JBrowse link
G Nf1 neurofibromin 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NF1 mRNA CTD PMID:23783067 NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438 		JBrowse link
G Notch1 notch 1 multiple interactions
affects localization		 EXP
ISO		 [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA
TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form]		 CTD PMID:23783067 PMID:33992720 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA CTD PMID:23783067 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Nppb natriuretic peptide type B decreases expression ISO Aspartame results in decreased expression of NPPB mRNA CTD PMID:31655124 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Npy neuropeptide Y decreases expression ISO Aspartame results in decreased expression of NPY protein CTD PMID:11890951 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NR1I3 mRNA CTD PMID:23783067 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Onecut1 one cut domain, family member 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ONECUT1 mRNA CTD PMID:23783067 NCBI chr 9:74,769,203...74,796,930
Ensembl chr 9:74,769,203...74,799,063 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 alpha 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHA2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHA2 mRNA CTD PMID:23783067 NCBI chr 3:140,915,765...140,918,116
Ensembl chr 3:140,915,765...140,918,116 		JBrowse link
G Pdhb pyruvate dehydrogenase (lipoamide) beta multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHB mRNA CTD PMID:23783067 NCBI chr14:14,296,470...14,303,782
Ensembl chr14:14,296,748...14,303,777 		JBrowse link
G Pex1 peroxisomal biogenesis factor 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX1 mRNA CTD PMID:23783067 NCBI chr 5:3,646,066...3,687,230
Ensembl chr 5:3,646,066...3,687,232 		JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX11A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX11A mRNA CTD PMID:23783067 NCBI chr 7:79,385,705...79,392,879
Ensembl chr 7:79,385,705...79,392,879 		JBrowse link
G Pex13 peroxisomal biogenesis factor 13 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX13 mRNA CTD PMID:23783067 NCBI chr11:23,597,283...23,615,883
Ensembl chr11:23,596,479...23,615,959 		JBrowse link
G Pex5 peroxisomal biogenesis factor 5 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX5 mRNA CTD PMID:23783067 NCBI chr 6:124,373,774...124,392,878
Ensembl chr 6:124,373,775...124,392,026 		JBrowse link
G Pex7 peroxisomal biogenesis factor 7 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX7 mRNA CTD PMID:23783067 NCBI chr10:19,735,836...19,783,420
Ensembl chr10:19,729,646...19,783,435 		JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB2 mRNA CTD PMID:23783067 NCBI chr 1:130,616,780...130,656,990
Ensembl chr 1:130,616,919...130,656,990
Ensembl chr 1:130,616,919...130,656,990 		JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB4 mRNA CTD PMID:23783067 NCBI chr 9:108,817,336...108,861,302
Ensembl chr 9:108,820,846...108,861,296 		JBrowse link
G Pld2 phospholipase D2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLD2 mRNA CTD PMID:23783067 NCBI chr11:70,430,318...70,448,936
Ensembl chr11:70,430,890...70,448,936 		JBrowse link
G Plg plasminogen decreases expression ISO Aspartame results in decreased expression of PLG mRNA CTD PMID:31655124 NCBI chr17:12,597,496...12,638,271
Ensembl chr17:12,597,495...12,638,272 		JBrowse link
G Plxnd1 plexin D1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLXND1 mRNA CTD PMID:23783067 NCBI chr 6:115,931,772...115,972,300
Ensembl chr 6:115,931,772...115,971,966 		JBrowse link
G Polg polymerase (DNA directed), gamma multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of POLG mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of POLG mRNA CTD PMID:23783067 NCBI chr 7:79,095,979...79,117,659
Ensembl chr 7:79,095,979...79,116,110 		JBrowse link
G Pomc pro-opiomelanocortin-alpha increases expression ISO Aspartame results in increased expression of POMC protein alternative form CTD PMID:1805284 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 affects localization ISO Aspartame affects the localization of POU5F1 protein CTD PMID:33992720 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARA mRNA CTD PMID:23783067 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARD mRNA CTD PMID:23783067 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARG mRNA CTD PMID:23783067 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARGC1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARGC1A mRNA CTD PMID:23783067 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prdx5 peroxiredoxin 5 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of PRDX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PRDX5 mRNA CTD PMID:23783067 NCBI chr19:6,884,065...6,887,474
Ensembl chr19:6,884,065...6,887,474 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA CTD PMID:23783067 NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045 		JBrowse link
G S100a13 S100 calcium binding protein A13 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A13 mRNA CTD PMID:23783067 NCBI chr 3:90,421,542...90,431,888
Ensembl chr 3:90,421,742...90,431,888 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A8 mRNA CTD PMID:23783067 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of SDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SDHB mRNA CTD PMID:23783067 NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA CTD PMID:23783067 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt2 sirtuin 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA CTD PMID:23783067 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086 		JBrowse link
G Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 decreases activity ISO Aspartame results in decreased activity of SLC15A1 protein CTD PMID:15846457 NCBI chr14:121,697,033...121,742,666
Ensembl chr14:121,697,033...121,742,664 		JBrowse link
G Slc4a2 solute carrier family 4 (anion exchanger), member 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC4A2 mRNA CTD PMID:23783067 NCBI chr 5:24,628,834...24,645,945
Ensembl chr 5:24,628,835...24,645,948 		JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of SLC8A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA CTD PMID:23783067 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 affects localization ISO Aspartame affects the localization of SOX2 protein CTD PMID:33992720 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Srebf2 sterol regulatory element binding factor 2 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SREBF2 mRNA CTD PMID:23783067 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of STAT3 mRNA CTD PMID:23783067 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Surf1 surfeit gene 1 multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of SURF1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SURF1 mRNA CTD PMID:23783067 NCBI chr 2:26,803,390...26,806,667
Ensembl chr 2:26,803,393...26,806,542 		JBrowse link
G Tas1r1 taste receptor, type 1, member 1 increases expression
multiple interactions		 ISO Aspartame results in increased expression of TAS1R1 protein
Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form]		 CTD PMID:33992720 NCBI chr 4:152,112,371...152,122,947
Ensembl chr 4:152,112,371...152,123,025 		JBrowse link
G Tas1r2 taste receptor, type 1, member 2 multiple interactions
affects binding		 ISO Aspartame binds to and results in increased activity of TAS1R2 protein; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]; Aspartame binds to TAS1R2 protein		 CTD PMID:15353592 PMID:17168764 PMID:17935609 PMID:20173092 PMID:33992720 NCBI chr 4:139,380,849...139,397,591
Ensembl chr 4:139,380,849...139,397,591 		JBrowse link
G Tas1r3 taste receptor, type 1, member 3 affects binding
multiple interactions
decreases expression		 ISO Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]
Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
Aspartame results in decreased expression of TAS1R3 protein		 CTD PMID:17168764 PMID:17935609 PMID:33992720 NCBI chr 4:155,943,725...155,947,810
Ensembl chr 4:155,943,725...155,947,819 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of TFAM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TFAM mRNA CTD PMID:23783067 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of THBS1 mRNA CTD PMID:23783067 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] results in increased expression of TNF protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of TNF protein] CTD PMID:23783067 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions		 EXP Aspartame results in increased expression of TRP53; Aspartame results in increased expression of TRP53 mRNA
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TRP53 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TRP53 mRNA		 CTD PMID:17354619 PMID:23783067 PMID:32951320 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity ISO Aspartame results in increased activity of TRPV1 protein CTD PMID:17567713 PMID:18804451 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of TUFM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TUFM mRNA CTD PMID:23783067 NCBI chr 7:126,086,445...126,089,903
Ensembl chr 7:126,086,533...126,089,903 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of UCP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UCP2 mRNA CTD PMID:23783067 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI multiple interactions EXP [Fats, Unsaturated co-treated with Aspartame] affects the expression of UQCR11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UQCR11 mRNA CTD PMID:23783067 NCBI chr10:80,238,831...80,242,655
Ensembl chr10:80,238,831...80,242,664 		JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion ISO Aspartame results in increased secretion of VEGFA protein CTD PMID:20837131 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vim vimentin increases expression ISO Aspartame results in increased expression of VIM protein CTD PMID:33992720 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of XDH mRNA CTD PMID:23783067 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      biological role 22166
        xenobiotic 19678
          aspartame 170
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    main group molecular entity 22108
                      s-block molecular entity 21708
                        hydrogen molecular entity 21626
                          hydrides 20762
                            organic hydride 20315
                              organic fundamental parent 20315
                                hydrocarbon 19898
                                  cyclic hydrocarbon 17946
                                    monocyclic hydrocarbon 6194
                                      annulene 5847
                                        aromatic annulene 5847
                                          benzene 5847
                                            alkylbenzene 3513
                                              methylbenzene 3370
                                                toluene 3243
                                                  benzyl group 2650
                                                    phenylalanine 2650
                                                      L-phenylalanine 2375
                                                        L-phenylalanine derivative 2336
                                                          methyl L-phenylalaninate 170
                                                            aspartame 170
paths to the root