Mtfp1 (mitochondrial fission process 1) - Rat Genome Database

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Gene: Mtfp1 (mitochondrial fission process 1) Mus musculus
Analyze
Symbol: Mtfp1
Name: mitochondrial fission process 1
RGD ID: 1621541
MGI Page MGI
Description: Acts upstream of or within apoptotic process and mitochondrion organization. Located in mitochondrion. Is expressed in pancreas epithelium. Orthologous to human MTFP1 (mitochondrial fission process 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1700020C11Rik; 2610507A21Rik; AV005788; mitochondrial 18 kDa protein; mitochondrial fission process protein 1; mitochondrial fission protein MTP18; Mtp1; Mtp18; RP23-81P12.9
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,041,481 - 4,045,431 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,041,480 - 4,045,445 (-)EnsemblGRCm39 Ensembl
GRCm38114,091,481 - 4,095,431 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,091,480 - 4,095,445 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,991,484 - 3,995,434 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,991,484 - 3,995,434 (-)NCBIMGSCv36mm8
Celera114,587,412 - 4,591,361 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients. Applebaum MA, etal., Oncotarget. 2016 Nov 22;7(47):76816-76826. doi: 10.18632/oncotarget.12713.
2. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
3. Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. Gispert S, etal., PLoS One. 2009 Jun 3;4(6):e5777. doi: 10.1371/journal.pone.0005777.
4. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15155745   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:18554416   PMID:18614015   PMID:21267068   PMID:21677750   PMID:21873635   PMID:26465331   PMID:28643438   PMID:28918902   PMID:30325740   PMID:30926747  
PMID:36333300   PMID:38042218   PMID:38123539  


Genomics

Comparative Map Data
Mtfp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,041,481 - 4,045,431 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,041,480 - 4,045,445 (-)EnsemblGRCm39 Ensembl
GRCm38114,091,481 - 4,095,431 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,091,480 - 4,095,445 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,991,484 - 3,995,434 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,991,484 - 3,995,434 (-)NCBIMGSCv36mm8
Celera114,587,412 - 4,591,361 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.87NCBI
MTFP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,425,768 - 30,429,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,425,623 - 30,429,054 (+)EnsemblGRCh38hg38GRCh38
GRCh372230,821,756 - 30,825,041 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,151,720 - 29,155,041 (+)NCBINCBI36Build 36hg18NCBI36
Celera2214,621,410 - 14,624,732 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,782,814 - 13,786,245 (+)NCBIHuRef
CHM1_12230,781,170 - 30,784,601 (+)NCBICHM1_1
T2T-CHM13v2.02230,889,111 - 30,892,397 (+)NCBIT2T-CHM13v2.0
Mtfp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,192,013 - 83,195,853 (-)NCBIGRCr8
mRatBN7.21478,968,434 - 78,972,274 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,968,442 - 78,972,274 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,409,353 - 83,412,908 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,649,432 - 84,652,987 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,095,006 - 81,098,910 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,330,223 - 84,334,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,330,218 - 84,334,066 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,011,888 - 85,015,728 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,723,113 - 84,726,953 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,742,257 - 84,746,098 (-)NCBI
Celera1477,879,437 - 77,883,277 (-)NCBICelera
Cytogenetic Map14q21NCBI
Mtfp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,660,904 - 4,664,323 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,660,847 - 4,664,323 (+)NCBIChiLan1.0ChiLan1.0
MTFP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,391,328 - 40,395,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,090,753 - 43,094,416 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,461,119 - 11,464,739 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,262,118 - 29,265,700 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,262,118 - 29,265,700 (+)Ensemblpanpan1.1panPan2
MTFP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,565,438 - 23,568,919 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,565,567 - 23,568,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,436,506 - 23,439,989 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,949,521 - 23,953,008 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,949,654 - 23,952,599 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,651,028 - 23,654,510 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,913,804 - 23,917,286 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,974,230 - 23,977,712 (+)NCBIUU_Cfam_GSD_1.0
Mtfp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,480,827 - 116,484,389 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936904245,913 - 253,216 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936904249,842 - 253,349 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTFP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,392,665 - 47,396,727 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,392,578 - 47,396,115 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,477,184 - 50,480,628 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MTFP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,305,752 - 13,309,158 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,305,888 - 13,309,164 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,837,410 - 112,840,946 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtfp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247476,744,321 - 6,751,257 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,743,221 - 6,749,375 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mtfp1
134 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:496
Count of miRNA genes:353
Interacting mature miRNAs:411
Transcripts:ENSMUST00000004868, ENSMUST00000123607
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse

Markers in Region
AV005788  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,091,508 - 4,091,637UniSTSGRCm38
MGSCv37113,991,511 - 3,991,640UniSTSGRCm37
Celera114,587,439 - 4,587,568UniSTS
Cytogenetic Map11A1UniSTS
Whitehead/MRC_RH110.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000004868   ⟹   ENSMUSP00000004868
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,041,480 - 4,045,445 (-)Ensembl
GRCm38.p6 Ensembl114,091,480 - 4,095,445 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123607
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,044,434 - 4,045,140 (-)Ensembl
GRCm38.p6 Ensembl114,094,434 - 4,095,140 (-)Ensembl
RefSeq Acc Id: NM_026443   ⟹   NP_080719
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,041,481 - 4,045,431 (-)NCBI
GRCm38114,091,481 - 4,095,431 (-)ENTREZGENE
MGSCv37113,991,484 - 3,995,434 (-)RGD
Celera114,587,412 - 4,591,361 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080719   ⟸   NM_026443
- UniProtKB: Q9CZX4 (UniProtKB/Swiss-Prot),   Q9CRB8 (UniProtKB/Swiss-Prot),   Q3TI65 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000004868   ⟸   ENSMUST00000004868

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CRB8-F1-model_v2 AlphaFold Q9CRB8 1-166 view protein structure

Promoters
RGD ID:6821963
Promoter ID:MM_KWN:6210
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000011234,   OTTMUST00000011235
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36113,995,151 - 3,995,651 (-)MPROMDB
RGD ID:8673772
Promoter ID:EPDNEW_M14917
Type:initiation region
Name:Mtfp1_1
Description:Mus musculus mitochondrial fission process 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38114,095,351 - 4,095,411EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916686 AgrOrtholog
Ensembl Genes ENSMUSG00000004748 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000004868 ENTREZGENE
  ENSMUST00000004868.6 UniProtKB/Swiss-Prot
InterPro Mitochondrial_18_kDa_protein UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report mmu:67900 UniProtKB/Swiss-Prot
MGD MGI:1916686 ENTREZGENE
NCBI Gene 67900 ENTREZGENE
PANTHER MITOCHONDRIAL FISSION PROCESS PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MTP18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mtfp1 PhenoGen
UniProt MTFP1_MOUSE UniProtKB/Swiss-Prot
  Q3TI65 ENTREZGENE, UniProtKB/TrEMBL
  Q91X54_MOUSE UniProtKB/TrEMBL
  Q9CRB8 ENTREZGENE
  Q9CZX4 ENTREZGENE
UniProt Secondary Q9CZX4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Mtfp1  mitochondrial fission process 1  1700020C11Rik  RIKEN cDNA 1700020C11 gene  Symbol and/or name change 5135510 APPROVED