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Gene: Mcu (mitochondrial calcium uniporter) Mus musculus
Symbol: Mcu
Name: mitochondrial calcium uniporter
Description: ENCODES a protein that exhibits identical protein binding; calcium channel activity (ortholog); uniporter activity (ortholog); INVOLVED IN mitochondrial calcium ion transmembrane transport; positive regulation of mitochondrial calcium ion concentration; calcium import into the mitochondrion (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH abnormal circulating protein level; abnormal mitochondrial physiology; abnormal mitochondrion morphology; FOUND IN calcium channel complex; integral component of mitochondrial inner membrane (ortholog); mitochondrial inner membrane (ortholog); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2010012O16Rik; AV064928; C10orf42; calcium uniporter protein, mitochondrial; Ccdc109a; coiled-coil domain containing 109A; coiled-coil domain-containing protein 109A; D130073L02Rik; Gm64
Homo sapiens (human) : MCU (mitochondrial calcium uniporter)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mcu (mitochondrial calcium uniporter)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcu (mitochondrial calcium uniporter)
Pan paniscus (bonobo/pygmy chimpanzee) : MCU (mitochondrial calcium uniporter)
Canis lupus familiaris (dog) : MCU (mitochondrial calcium uniporter)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcu (mitochondrial calcium uniporter)
Sus scrofa (pig) : MCU (mitochondrial calcium uniporter)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381059,446,984 - 59,617,409 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371058,911,181 - 59,079,440 (-)NCBIGRCm37mm9NCBIm37
MGSCv361058,843,954 - 58,853,517 (-)NCBImm8
Celera1060,547,251 - 60,716,418 (-)NCBICelera
Cytogenetic Map10 B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Mcu
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1622994
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2019-09-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.