Lrp4 (low density lipoprotein receptor-related protein 4) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lrp4 (low density lipoprotein receptor-related protein 4) Mus musculus
Analyze
Symbol: Lrp4
Name: low density lipoprotein receptor-related protein 4
RGD ID: 1331974
MGI Page MGI
Description: Enables coreceptor activity; protein homodimerization activity; and receptor tyrosine kinase binding activity. Involved in several processes, including positive regulation of Rac protein signal transduction; regulation of synapse organization; and synapse organization. Acts upstream of or within several processes, including Rac protein signal transduction; negative regulation of canonical Wnt signaling pathway; and regionalization. Located in neuromuscular junction and plasma membrane. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and limb bud. Used to study sclerosteosis 2. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6430526J12Rik; D230026E03; LDLR dan; low-density lipoprotein receptor-related protein 4; LRP-4; mdi; mdig; Megf7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,287,794 - 91,344,246 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,287,856 - 91,344,124 (+)EnsemblGRCm39 Ensembl
GRCm38291,457,456 - 91,513,901 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,457,511 - 91,513,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37291,297,688 - 91,354,058 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36291,258,540 - 91,314,618 (+)NCBIMGSCv36mm8
Celera292,845,990 - 92,902,350 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dichloroethane  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (EXP)
Benzo[k]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fenthion  (EXP)
folic acid  (EXP)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
maneb  (EXP)
metacetamol  (EXP)
methidathion  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
nickel atom  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
pyridaben  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISO,ISS)
dendrite  (ISO,ISS)
neuromuscular junction  (IC,IDA)
neuronal cell body  (ISO,ISS)
plasma membrane  (IBA,IDA)
plasma membrane raft  (ISO,ISS)
postsynaptic density  (ISO,ISS)
synapse  (IDA,IEP)
synaptic membrane  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal coat appearance  (IAGP)
abnormal digit morphology  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal endplate potential  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal mammary gland bud morphology  (IAGP)
abnormal miniature endplate potential  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal nursing  (IAGP)
abnormal osteocyte morphology  (IAGP)
abnormal phrenic nerve morphology  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal spine curvature  (IEA)
abnormal tail morphology  (IEA)
abnormal tooth development  (IAGP)
abnormal tooth morphology  (IEA)
abnormal ureteric bud invasion  (IAGP)
abnormal ureteric bud morphology  (IAGP)
abnormal vibrissa morphology  (IAGP)
absent kidney  (IAGP)
absent metanephric mesenchyme  (IAGP)
atelectasis  (IAGP)
brachydactyly  (IAGP)
brachypodia  (IAGP)
cyanosis  (IAGP)
decreased body size  (IAGP)
decreased bone trabecular spacing  (IAGP)
deformed nails  (IAGP)
ectopic digits  (IAGP)
failure of neuromuscular synapse postsynaptic differentiation  (IAGP)
failure of neuromuscular synapse presynaptic differentiation  (IAGP)
fused metacarpal bones  (IAGP)
fused metatarsal bones  (IAGP)
fused phalanges  (IEA)
hunched posture  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
increased bone ossification  (IAGP)
increased bone strength  (IAGP)
increased bone trabecula number  (IAGP)
increased diameter of femur  (IAGP)
increased femur compact bone thickness  (IAGP)
increased trabecular bone connectivity density  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no spontaneous movement  (IAGP)
oligodactyly  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
polydactyly  (IAGP)
polysyndactyly  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
reduced fertility  (IEA)
respiratory failure  (IAGP)
single kidney  (IAGP)
small lung  (IAGP)
supernumerary incisors  (IAGP)
syndactyly  (IAGP)
thick apical ectodermal ridge  (IAGP)
thick neurocranium  (IAGP)
ureter hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
9. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
Additional References at PubMed
PMID:8653787   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14621295   PMID:14622576   PMID:16141072   PMID:16141073   PMID:16207730  
PMID:16263759   PMID:16434236   PMID:16517118   PMID:17119023   PMID:18287559   PMID:18508042   PMID:18848351   PMID:18957220   PMID:19047013   PMID:19116665   PMID:19806668   PMID:19936252  
PMID:20018657   PMID:20381006   PMID:20383322   PMID:20454682   PMID:20484637   PMID:21267068   PMID:21337463   PMID:21531785   PMID:21731673   PMID:21873635   PMID:21969364   PMID:22038040  
PMID:22038977   PMID:22496563   PMID:22794264   PMID:22854782   PMID:23293290   PMID:23341629   PMID:23986861   PMID:24140340   PMID:24200689   PMID:24297891   PMID:24639464   PMID:25091481  
PMID:25319686   PMID:25368159   PMID:25404300   PMID:25407677   PMID:25733894   PMID:25917818   PMID:26025922   PMID:26234751   PMID:26288816   PMID:26847765   PMID:27151977   PMID:27294513  
PMID:28193701   PMID:28477420   PMID:28694256   PMID:29061639   PMID:29212737   PMID:29323161   PMID:30171091   PMID:30206360   PMID:30235284   PMID:30325689   PMID:30352686   PMID:30385274  
PMID:30842262   PMID:30940800   PMID:31268420   PMID:31585407   PMID:32325033   PMID:32457076   PMID:32558157   PMID:32571845   PMID:33292473   PMID:33302985   PMID:33987657   PMID:34090516  
PMID:34108685   PMID:34321999   PMID:34847079   PMID:35099616   PMID:35340430   PMID:36765071   PMID:36883209   PMID:36966936   PMID:37091972   PMID:38051321   PMID:38327785  


Genomics

Comparative Map Data
Lrp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,287,794 - 91,344,246 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,287,856 - 91,344,124 (+)EnsemblGRCm39 Ensembl
GRCm38291,457,456 - 91,513,901 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,457,511 - 91,513,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37291,297,688 - 91,354,058 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36291,258,540 - 91,314,618 (+)NCBIMGSCv36mm8
Celera292,845,990 - 92,902,350 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
LRP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,856,717 - 46,918,550 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1146,856,717 - 46,918,642 (-)EnsemblGRCh38hg38GRCh38
GRCh371146,878,268 - 46,940,101 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,834,994 - 46,896,652 (-)NCBINCBI36Build 36hg18NCBI36
Build 341146,834,994 - 46,874,397NCBI
Celera1147,024,050 - 47,085,802 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,584,196 - 46,645,441 (-)NCBIHuRef
CHM1_11146,876,690 - 46,938,585 (-)NCBICHM1_1
T2T-CHM13v2.01147,013,618 - 47,075,418 (-)NCBIT2T-CHM13v2.0
Lrp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,885,373 - 97,939,366 (+)NCBIGRCr8
mRatBN7.2377,429,600 - 77,483,593 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,429,798 - 77,483,593 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,903,881 - 80,957,484 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,502,902 - 89,556,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,354,307 - 87,408,281 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,362,643 - 80,416,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,362,858 - 80,416,679 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,062,818 - 87,116,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,821,638 - 75,875,100 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,718,009 - 75,771,472 (+)NCBI
Celera376,634,746 - 76,688,537 (+)NCBICelera
Cytogenetic Map3q24NCBI
Lrp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,191,338 - 1,238,227 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,191,338 - 1,238,227 (+)NCBIChiLan1.0ChiLan1.0
LRP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,062,785 - 49,123,346 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,082,564 - 49,143,094 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,808,090 - 46,868,649 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,364,195 - 47,409,143 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,366,321 - 47,411,105 (-)Ensemblpanpan1.1panPan2
LRP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,616,683 - 42,667,297 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,616,426 - 42,665,794 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,344,660 - 41,396,887 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01843,271,285 - 43,323,513 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,271,155 - 43,323,246 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,756,909 - 42,808,998 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,312,112 - 42,364,153 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,041,646 - 43,093,851 (+)NCBIUU_Cfam_GSD_1.0
Lrp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,100,527 - 20,153,707 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,211,514 - 2,263,937 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365622,211,519 - 2,262,899 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,616,131 - 15,672,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,616,137 - 15,672,876 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,979,254 - 17,017,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,393,489 - 18,474,514 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,413,513 - 18,471,444 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,697,194 - 115,757,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,708,866 - 1,757,629 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrp4
2797 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1185
Count of miRNA genes:623
Interacting mature miRNAs:777
Transcripts:ENSMUST00000028689, ENSMUST00000123897, ENSMUST00000143874, ENSMUST00000151907
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276678758103095823Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse

Markers in Region
Lrp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1UniSTS
cM Map250.0UniSTS
Lrp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003952488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004939885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_374447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB757726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF247636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF247637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL691489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX294440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY753111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN533524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000028689   ⟹   ENSMUSP00000028689
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl291,287,856 - 91,344,124 (+)Ensembl
GRCm38.p6 Ensembl291,457,511 - 91,513,779 (+)Ensembl
Ensembl Acc Id: ENSMUST00000123897
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl291,306,601 - 91,311,216 (+)Ensembl
GRCm38.p6 Ensembl291,476,256 - 91,480,871 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143874
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl291,287,856 - 91,309,632 (+)Ensembl
GRCm38.p6 Ensembl291,457,511 - 91,479,287 (+)Ensembl
Ensembl Acc Id: ENSMUST00000151907
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl291,306,664 - 91,309,187 (+)Ensembl
GRCm38.p6 Ensembl291,476,319 - 91,478,842 (+)Ensembl
RefSeq Acc Id: NM_001145857   ⟹   NP_001139329
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,287,876 - 91,309,632 (+)NCBI
GRCm38291,457,531 - 91,479,287 (+)NCBI
MGSCv37291,297,688 - 91,354,058 (+)RGD
Celera292,845,990 - 92,902,350 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_172668   ⟹   NP_766256
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,287,876 - 91,344,246 (+)NCBI
GRCm38291,457,531 - 91,513,901 (+)NCBI
MGSCv37291,297,688 - 91,354,058 (+)RGD
Celera292,845,990 - 92,902,350 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036161269   ⟹   XP_036017162
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,304,790 - 91,344,246 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003952488
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,287,794 - 91,342,198 (+)NCBI
GRCm38291,457,456 - 91,513,901 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004939885
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,304,790 - 91,343,004 (+)NCBI
Sequence:
RefSeq Acc Id: XR_374447
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,287,794 - 91,342,201 (+)NCBI
GRCm38291,457,456 - 91,513,901 (+)NCBI
Sequence:
RefSeq Acc Id: NP_766256   ⟸   NM_172668
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8CBB3 (UniProtKB/Swiss-Prot),   Q8BPX5 (UniProtKB/Swiss-Prot),   A2AGT4 (UniProtKB/Swiss-Prot),   Q8CCP5 (UniProtKB/Swiss-Prot),   Q8VI56 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001139329   ⟸   NM_001145857
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8VI56 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000028689   ⟸   ENSMUST00000028689
RefSeq Acc Id: XP_036017162   ⟸   XM_036161269
- Peptide Label: isoform X1
Protein Domains
EGF-like   LDL-receptor class A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VI56-F1-model_v2 AlphaFold Q8VI56 1-1905 view protein structure

Promoters
RGD ID:6831732
Promoter ID:MM_KWN:30479
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung
Transcripts:ENSMUST00000111341,   OTTMUST00000033533,   UC008KVW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36291,297,626 - 91,298,126 (+)MPROMDB
RGD ID:6831733
Promoter ID:MM_KWN:30480
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Transcripts:OTTMUST00000033535,   UC008KVZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36291,316,224 - 91,316,724 (+)MPROMDB
RGD ID:6877918
Promoter ID:EPDNEW_M2410
Type:multiple initiation site
Name:Lrp4_1
Description:Mus musculus low density lipoprotein receptor-related protein4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2411  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38291,457,526 - 91,457,586EPDNEW
RGD ID:6877920
Promoter ID:EPDNEW_M2411
Type:initiation region
Name:Lrp4_2
Description:Mus musculus low density lipoprotein receptor-related protein4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2410  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38291,476,364 - 91,476,424EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442252 AgrOrtholog
Ensembl Genes ENSMUSG00000027253 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028689 ENTREZGENE
  ENSMUST00000028689.4 UniProtKB/Swiss-Prot
  ENSMUST00000143874 ENTREZGENE
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot
  4.10.400.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  cEGF UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  LDL_receptor-like_sf UniProtKB/Swiss-Prot
  LDLR-related UniProtKB/Swiss-Prot
  LDLR_class-A_CS UniProtKB/Swiss-Prot
  LDLR_classB_rpt UniProtKB/Swiss-Prot
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot
KEGG Report mmu:228357 UniProtKB/Swiss-Prot
MGD MGI:2442252 ENTREZGENE
NCBI Gene 228357 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED UniProtKB/Swiss-Prot
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot
Pfam cEGF UniProtKB/Swiss-Prot
  FXa_inhibition UniProtKB/Swiss-Prot
  Ldl_recept_a UniProtKB/Swiss-Prot
  Ldl_recept_b UniProtKB/Swiss-Prot
PhenoGen Lrp4 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot
  LDLRA_2 UniProtKB/Swiss-Prot
  LDLRB UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLa UniProtKB/Swiss-Prot
  SM00135 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
  SSF57424 UniProtKB/Swiss-Prot
  YWTD domain UniProtKB/Swiss-Prot
UniProt A2AGT4 ENTREZGENE
  LRP4_MOUSE UniProtKB/Swiss-Prot
  Q8BPX5 ENTREZGENE
  Q8CBB3 ENTREZGENE
  Q8CCP5 ENTREZGENE
  Q8VI56 ENTREZGENE
  Q8VI57_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2AGT4 UniProtKB/Swiss-Prot
  Q8BPX5 UniProtKB/Swiss-Prot
  Q8CBB3 UniProtKB/Swiss-Prot
  Q8CCP5 UniProtKB/Swiss-Prot