Cacng4 (calcium channel, voltage-dependent, gamma subunit 4) - Rat Genome Database

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Gene: Cacng4 (calcium channel, voltage-dependent, gamma subunit 4) Mus musculus
Analyze
Symbol: Cacng4
Name: calcium channel, voltage-dependent, gamma subunit 4
RGD ID: 731428
MGI Page MGI
Description: Predicted to enable calcium channel regulator activity; ionotropic glutamate receptor binding activity; and voltage-gated calcium channel activity. Involved in regulation of AMPA receptor activity and regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within transmission of nerve impulse. Located in glutamatergic synapse and somatodendritic compartment. Part of AMPA glutamate receptor complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and respiratory system. Orthologous to human CACNG4 (calcium voltage-gated channel auxiliary subunit gamma 4); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI413107; AW491861; neuronal voltage-gated calcium channel gamma-4 subunit; TARP gamma-4; transmembrane AMPAR regulatory protein gamma-4; voltage-dependent calcium channel gamma-4 subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911107,623,183 - 107,685,532 (-)NCBIGRCm39mm39
GRCm39 Ensembl11107,623,183 - 107,685,383 (-)Ensembl
GRCm3811107,732,357 - 107,794,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11107,732,357 - 107,794,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711107,596,094 - 107,655,778 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611107,550,870 - 107,610,554 (-)NCBImm8
Celera11119,469,632 - 119,528,904 (-)NCBICelera
Cytogenetic Map11E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10734232   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15226823   PMID:15677329   PMID:16141072   PMID:16141073  
PMID:16985003   PMID:17295603   PMID:17880893   PMID:17880894   PMID:18341993   PMID:18634809   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22632720  


Genomics

Comparative Map Data
Cacng4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911107,623,183 - 107,685,532 (-)NCBIGRCm39mm39
GRCm39 Ensembl11107,623,183 - 107,685,383 (-)Ensembl
GRCm3811107,732,357 - 107,794,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11107,732,357 - 107,794,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711107,596,094 - 107,655,778 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611107,550,870 - 107,610,554 (-)NCBImm8
Celera11119,469,632 - 119,528,904 (-)NCBICelera
Cytogenetic Map11E1NCBI
CACNG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1766,964,707 - 67,033,398 (+)EnsemblGRCh38hg38GRCh38
GRCh381766,964,707 - 67,033,398 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371764,960,823 - 65,029,514 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361762,391,475 - 62,459,980 (+)NCBINCBI36hg18NCBI36
Build 341762,391,474 - 62,459,980NCBI
Celera1761,533,692 - 61,602,193 (+)NCBI
Cytogenetic Map17q24.2NCBI
HuRef1760,402,967 - 60,418,125 (+)NCBIHuRef
CHM1_11765,024,942 - 65,093,343 (+)NCBICHM1_1
Cacng4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21092,686,100 - 92,745,601 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1095,951,234 - 96,015,499 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01095,954,160 - 96,015,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01095,688,305 - 95,746,619 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,139,397 - 97,214,444 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11097,153,766 - 97,228,814 (-)NCBI
Celera1091,351,585 - 91,410,600 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Cacng4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554786,219,631 - 6,280,169 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554786,219,637 - 6,278,759 (+)NCBIChiLan1.0ChiLan1.0
CACNG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11766,159,571 - 66,176,442 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01760,900,645 - 60,969,659 (+)NCBIMhudiblu_PPA_v0panPan3
CACNG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1913,449,465 - 13,464,296 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl913,449,450 - 13,462,645 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha914,344,165 - 14,404,358 (-)NCBI
ROS_Cfam_1.0915,112,749 - 15,172,995 (-)NCBI
UMICH_Zoey_3.1914,060,134 - 14,120,341 (-)NCBI
UNSW_CanFamBas_1.0913,413,810 - 13,473,970 (+)NCBI
UU_Cfam_GSD_1.0913,415,469 - 13,475,483 (+)NCBI
Cacng4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560213,107,963 - 13,143,585 (+)NCBI
SpeTri2.0NW_0049365416,051,021 - 6,062,275 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1213,391,078 - 13,452,174 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11213,391,080 - 13,454,542 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21213,761,277 - 13,824,577 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11654,413,981 - 54,482,707 (-)NCBI
ChlSab1.1 Ensembl1654,413,965 - 54,482,561 (-)Ensembl
Vero_WHO_p1.0NW_02366607725,452,813 - 25,522,456 (-)NCBI
Cacng4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248701,359,937 - 1,419,458 (-)NCBI

Position Markers
Cacng4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811107,735,270 - 107,736,841UniSTSGRCm38
MGSCv3711107,596,584 - 107,598,155UniSTSGRCm37
Celera11119,470,122 - 119,471,693UniSTS
Cytogenetic Map11E1UniSTS
cM Map11 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177880152111880273Mouse
14746970Manh71_mmandible shape 71 (mouse)1179525431113525431Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181683655115683810Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181683655115683810Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181919441115919441Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182486872116486994Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1193048547112653728Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194172953118131898Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94546357118131898Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196285639108915558Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196919310122082543Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1197006867110713165Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198461783122082543Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198609643122082543Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199363361122082543Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100167277122082543Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100363360120996339Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101131764122082543Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101613994114581537Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101613994114581537Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101613994114581537Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101613994114581537Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102453297112493297Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103383166115130618Mouse
4141702Hmtb6_mhemostasis and thrombosis rebleeding time 6 (mouse)Not determined107725518110629004Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1418
Count of miRNA genes:598
Interacting mature miRNAs:760
Transcripts:ENSMUST00000021066, ENSMUST00000134076
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021066   ⟹   ENSMUSP00000021066
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11107,732,357 - 107,794,557 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134076
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11107,735,197 - 107,742,079 (-)Ensembl
RefSeq Acc Id: NM_019431   ⟹   NP_062304
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911107,623,183 - 107,685,532 (-)NCBI
GRCm3811107,732,357 - 107,794,706 (-)NCBI
MGSCv3711107,596,094 - 107,655,778 (-)RGD
Celera11119,469,632 - 119,528,904 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062304   ⟸   NM_019431
- UniProtKB: Q9JJV4 (UniProtKB/Swiss-Prot),   A2AAU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000021066   ⟸   ENSMUST00000021066

Promoters
RGD ID:8677140
Promoter ID:EPDNEW_M16601
Type:initiation region
Name:Cacng4_1
Description:Mus musculus calcium channel, voltage-dependent, gamma subunit4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811107,794,557 - 107,794,617EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859167 AgrOrtholog
Ensembl Genes ENSMUSG00000020723 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000021066 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021066 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_g4su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_gsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54377 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1859167 ENTREZGENE
NCBI Gene 54377 ENTREZGENE
PANTHER PTHR12107:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacng4 PhenoGen
PRINTS VDCCGAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCCGAMMA4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AAU2 ENTREZGENE, UniProtKB/TrEMBL
  CCG4_MOUSE UniProtKB/Swiss-Prot
  Q3UNE8_MOUSE UniProtKB/TrEMBL
  Q9JJV4 ENTREZGENE