CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: clozapine
Accession: CHEBI:3766
browse the term
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Synonyms: exact_synonym: 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
related_synonym: Clozapin; Formula=C18H19ClN4; InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3; InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N; SMILES=N1=C(C2=CC=CC=C2NC3=CC=C(C=C13)Cl)N4CCN(CC4)C; clozapina; clozapinum
xref: Beilstein:0764984; CAS:5786-21-0; DrugBank:DB00363; Drug_Central:722; HMDB:HMDB0014507; KEGG:C06924; KEGG:D00283
xref_mesh: MESH:D003024
xref: PMID:18690109; PMID:18766167; PMID:20825390; PMID:24219174; Patent:FR1334944; Patent:NL293201; Patent:US3539573; Reaxys:764984; Wikipedia:Clozapine
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Aars1
alanyl-tRNA synthetase 1
increases expression
ISO
Clozapine results in increased expression of AARS1 protein
CTD
PMID:34122009
NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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Abcb11
ATP binding cassette subfamily B member 11
decreases activity
ISO
Clozapine results in decreased activity of ABCB11 protein
CTD
PMID:22646477
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions decreases activity
EXP ISO
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein] Clozapine results in decreased activity of ABCB1 protein
CTD
PMID:9111066 PMID:16810505
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
multiple interactions
EXP
Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]
CTD
PMID:9111066
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abce1
ATP binding cassette subfamily E member 1
increases expression
ISO
Clozapine results in increased expression of ABCE1 protein
CTD
PMID:34122009
NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489
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Abcg1
ATP binding cassette subfamily G member 1
increases expression
ISO
Clozapine results in increased expression of ABCG1 mRNA
CTD
PMID:17346280
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]
CTD
PMID:18834354
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Ablim2
actin binding LIM protein family, member 2
increases expression
ISO
Clozapine results in increased expression of ABLIM2 mRNA
CTD
PMID:17346280
NCBI chr14:74,865,409...74,990,334
Ensembl chr14:74,866,281...74,990,334
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Acat2
acetyl-CoA acetyltransferase 2
increases expression
ISO
Clozapine results in increased expression of ACAT2 mRNA
CTD
PMID:17052361
NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
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Acot2
acyl-CoA thioesterase 2
increases expression
ISO
Clozapine results in increased expression of ACOT2 protein
CTD
PMID:34122009
NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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Acot7
acyl-CoA thioesterase 7
decreases expression
ISO
Clozapine results in decreased expression of ACOT7 protein
CTD
PMID:34122009
NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309
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Acox1
acyl-CoA oxidase 1
multiple interactions
EXP
[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA
CTD
PMID:23226405
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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Actb
actin, beta
decreases expression
ISO
Clozapine results in decreased expression of ACTB protein
CTD
PMID:34122009
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Actbl2
actin, beta-like 2
increases expression
ISO
Clozapine results in increased expression of ACTBL2 protein
CTD
PMID:34122009
NCBI chr 2:42,858,020...42,860,767
Ensembl chr 2:42,858,020...42,860,767
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Actr3
actin related protein 3
decreases expression
ISO
Clozapine results in decreased expression of ACTR3 protein
CTD
PMID:34122009
NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
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Actr5
actin related protein 5
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein
CTD
PMID:34122009
NCBI chr 3:147,282,461...147,295,870
Ensembl chr 3:147,282,624...147,296,110
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Adam1a
ADAM metallopeptidase domain 1a
decreases expression
EXP
Clozapine results in decreased expression of ADAM1A mRNA
CTD
PMID:16715494
NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311
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Adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein
CTD
PMID:34122009
NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629
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Adcy5
adenylate cyclase 5
affects response to substance multiple interactions
ISO
ADCY5 protein affects the susceptibility to Clozapine SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]
CTD
PMID:12223546
NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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Adh5
alcohol dehydrogenase 5 (class III), chi polypeptide
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of ADH5 protein
CTD
PMID:34122009
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
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Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression multiple interactions increases expression
ISO EXP
Clozapine results in decreased expression of ADIPOQ protein Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA] Clozapine results in increased expression of ADIPOQ protein
CTD
PMID:17933447 PMID:18162013 PMID:20564506
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Adora2a
adenosine A2a receptor
decreases expression
ISO
Clozapine results in decreased expression of ADORA2A mRNA
CTD
PMID:17266109
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Adra1a
adrenoceptor alpha 1A
multiple interactions
EXP
Clozapine binds to and results in decreased activity of ADRA1A protein
CTD
PMID:16545797
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1
decreases expression
ISO
Clozapine results in decreased expression of AGPAT1 mRNA
CTD
PMID:14647396
NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278
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Agt
angiotensinogen
multiple interactions
ISO
Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]
CTD
PMID:11549694
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Aimp1
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
increases expression
ISO
Clozapine results in increased expression of AIMP1 protein
CTD
PMID:34122009
NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728
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Ak1
adenylate kinase 1
decreases expression
ISO
Clozapine results in decreased expression of AK1 protein
CTD
PMID:34122009
NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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Akt1
AKT serine/threonine kinase 1
increases expression increases phosphorylation decreases expression
ISO EXP
Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein Clozapine results in increased phosphorylation of AKT1 protein Clozapine results in decreased expression of AKT1 mRNA
CTD
PMID:15860345 PMID:19440698
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Akt2
AKT serine/threonine kinase 2
increases expression
EXP
Clozapine results in increased expression of AKT2 mRNA
CTD
PMID:15860345
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Alb
albumin
multiple interactions affects binding
EXP ISO
Clozapine results in decreased expression of and results in decreased reduction of ALB protein [[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]
CTD
PMID:31400341
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
ISO
Clozapine results in increased expression of ALDH1A1 mRNA
CTD
PMID:17266109
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldoa
aldolase, fructose-bisphosphate A
increases expression
EXP
Clozapine results in increased expression of ALDOA mRNA
CTD
PMID:15860345
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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Aldob
aldolase, fructose-bisphosphate B
increases expression decreases expression
ISO
Clozapine results in increased expression of ALDOB protein Clozapine results in decreased expression of ALDOB protein
CTD
PMID:34122009 PMID:36482696
NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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Aldoc
aldolase, fructose-bisphosphate C
decreases expression increases expression
ISO EXP
Clozapine results in decreased expression of ALDOC mRNA Clozapine results in increased expression of ALDOC mRNA
CTD
PMID:15860345 PMID:16465460
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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Alpp
alkaline phosphatase, placental
multiple interactions
ISO
Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]
CTD
PMID:16036225
NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
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Alyref
Aly/REF export factor
decreases expression
ISO
Clozapine results in decreased expression of ALYREF protein
CTD
PMID:34122009
NCBI chr10:105,871,424...105,875,076
Ensembl chr10:105,871,306...105,875,069
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Anxa1
annexin A1
decreases expression
ISO
Clozapine results in decreased expression of ANXA1 protein
CTD
PMID:34122009
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Anxa5
annexin A5
decreases expression
ISO
Clozapine results in decreased expression of ANXA5 protein
CTD
PMID:34122009
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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Anxa6
annexin A6
decreases expression
ISO
Clozapine results in decreased expression of ANXA6 protein
CTD
PMID:34122009
NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433
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Ap1s1
adaptor related protein complex 1 subunit sigma 1
decreases expression
ISO
Clozapine results in decreased expression of AP1S1 mRNA
CTD
PMID:17175557
NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
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Ap2b1
adaptor related protein complex 2 subunit beta 1
increases expression
EXP
Clozapine results in increased expression of AP2B1 mRNA
CTD
PMID:15860345
NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
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Ap3b1
adaptor related protein complex 3 subunit beta 1
increases expression
ISO
Clozapine results in increased expression of AP3B1 protein
CTD
PMID:34122009
NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935
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Apoa5
apolipoprotein A5
affects response to substance
EXP
APOA5 gene polymorphism affects the susceptibility to Clozapine
CTD
PMID:17726453
NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
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Apod
apolipoprotein D
increases expression
ISO
Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein
CTD
PMID:11158250 PMID:14647396 PMID:17266109
NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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App
amyloid beta precursor protein
increases expression
ISO
Clozapine results in increased expression of APP protein
CTD
PMID:36482696
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Arc
activity-regulated cytoskeleton-associated protein
decreases expression
EXP
Clozapine results in decreased expression of ARC mRNA
CTD
PMID:18208916
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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Arhgef9
Cdc42 guanine nucleotide exchange factor 9
decreases expression
ISO
Clozapine results in decreased expression of ARHGEF9 mRNA
CTD
PMID:17266109
NCBI chr X:59,919,560...60,077,538
Ensembl chr X:59,920,870...60,077,513
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Arl8a
ADP-ribosylation factor like GTPase 8A
decreases expression
ISO
Clozapine results in decreased expression of ARL8A protein
CTD
PMID:34122009
NCBI chr13:46,585,845...46,594,851
Ensembl chr13:46,585,845...46,594,851
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Armt1
acidic residue methyltransferase 1
increases expression
ISO
Clozapine results in increased expression of ARMT1 protein
CTD
PMID:34122009
NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302
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Arpc4
actin related protein 2/3 complex, subunit 4
affects expression
ISO
Clozapine affects the expression of ARPC4 mRNA
CTD
PMID:14647396
NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785
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Asah1
N-acylsphingosine amidohydrolase 1
increases expression
ISO
Clozapine results in increased expression of ASAH1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Clozapine results in increased expression of ASNS mRNA; Clozapine results in increased expression of ASNS protein
CTD
PMID:15342952 PMID:17175557 PMID:36482696
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Asph
aspartate-beta-hydroxylase
increases expression
ISO
Clozapine results in increased expression of ASPH protein
CTD
PMID:34122009
NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876
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Ass1
argininosuccinate synthase 1
increases expression
ISO
Clozapine results in increased expression of ASS1 protein
CTD
PMID:34122009
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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Atad3a
ATPase family, AAA domain containing 3A
decreases expression
ISO
Clozapine results in decreased expression of ATAD3A protein
CTD
PMID:34122009
NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482
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Atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
increases expression
ISO
Clozapine results in increased expression of ATP2A3 protein
CTD
PMID:34122009
NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
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Atp5f1b
ATP synthase F1 subunit beta
decreases expression
EXP
Clozapine results in decreased expression of ATP5F1B protein
CTD
PMID:19441803
NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
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Atp5pb
ATP synthase peripheral stalk-membrane subunit b
increases expression
ISO
Clozapine results in increased expression of ATP5F1 protein
CTD
PMID:34122009
NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418
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Atp6v1a
ATPase H+ transporting V1 subunit A
decreases expression
ISO
Clozapine results in decreased expression of ATP6V1A protein
CTD
PMID:34122009
NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
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Atp6v1b1
ATPase H+ transporting V1 subunit B1
decreases expression
ISO
Clozapine results in decreased expression of ATP6V1B1 protein
CTD
PMID:34122009
NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475
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Atp6v1b2
ATPase H+ transporting V1 subunit B2
decreases expression
EXP ISO
Clozapine results in decreased expression of ATP6V1B2 protein
CTD
PMID:19441803 PMID:34122009
NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745
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Atxn10
ataxin 10
increases expression
ISO
Clozapine results in increased expression of ATXN10 protein
CTD
PMID:34122009
NCBI chr 7:116,441,768...116,565,093
Ensembl chr 7:116,441,613...116,565,087
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Axin2
axin 2
decreases expression
EXP
Clozapine results in decreased expression of AXIN2 mRNA
CTD
PMID:16715494
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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Bace2
beta-secretase 2
increases expression
ISO
Clozapine results in increased expression of BACE2 protein
CTD
PMID:36482696
NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546
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Bax
BCL2 associated X, apoptosis regulator
increases expression decreases expression multiple interactions
ISO EXP
Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein Clozapine results in decreased expression of BAX protein CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]
CTD
PMID:16160616 PMID:17069804
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Baz1b
bromodomain adjacent to zinc finger domain, 1B
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein
CTD
PMID:34122009
NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
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Bcar1
BCAR1 scaffold protein, Cas family member
decreases expression
ISO
Clozapine results in decreased expression of BCAR1 protein
CTD
PMID:34122009
NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
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Bcl2
BCL2, apoptosis regulator
increases expression
EXP
Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein
CTD
PMID:15126120
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l14
Bcl2-like 14
decreases expression
ISO
Clozapine results in decreased expression of BCL2L14 protein
CTD
PMID:34122009
NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
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Bdnf
brain-derived neurotrophic factor
decreases expression increases expression
EXP
Clozapine results in decreased expression of BDNF mRNA Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein
CTD
PMID:11488957 PMID:12478621 PMID:17442489
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bet1l
Bet1 golgi vesicular membrane trafficking protein-like
decreases expression
EXP
Clozapine results in decreased expression of BET1L mRNA
CTD
PMID:15860345
NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040
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Bik
BCL2-interacting killer
multiple interactions increases expression
ISO
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]
CTD
PMID:16160616
NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
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Bptf
bromodomain PHD finger transcription factor
decreases expression
ISO
Clozapine results in decreased expression of BPTF mRNA
CTD
PMID:14647396
NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769
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Bzw1
basic leucine zipper and W2 domains 1
increases expression
ISO
Clozapine results in increased expression of BZW1 protein
CTD
PMID:34122009
NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
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Cacna1a
calcium voltage-gated channel subunit alpha1 A
decreases expression
ISO EXP
Clozapine results in decreased expression of CACNA1A mRNA
CTD
PMID:14647396 PMID:16715494
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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Calcoco1
calcium binding and coiled coil domain 1
increases expression
ISO
Clozapine results in increased expression of CALCOCO1 protein
CTD
PMID:36482696
NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422
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Calm2
calmodulin 2
increases expression
EXP
Clozapine results in increased expression of CALM2 mRNA
CTD
PMID:19289156
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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Calr
calreticulin
decreases expression
ISO
Clozapine results in decreased expression of CALR protein
CTD
PMID:34122009
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Calu
calumenin
decreases expression
ISO
Clozapine results in decreased expression of CALU protein
CTD
PMID:34122009
NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
decreases expression increases expression
ISO EXP
Clozapine results in decreased expression of CAMK2A mRNA Clozapine results in increased expression of CAMK2A mRNA Clozapine results in decreased expression of CAMK2A protein
CTD
PMID:15860345 PMID:17266109 PMID:19289156
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
decreases expression
EXP
Clozapine results in decreased expression of CAMK2B mRNA
CTD
PMID:15860345
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
decreases expression
EXP
Clozapine results in decreased expression of CAMK2D mRNA
CTD
PMID:15860345
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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Camk4
calcium/calmodulin-dependent protein kinase IV
increases expression decreases expression
EXP
Clozapine results in increased expression of CAMK4 mRNA Clozapine results in decreased expression of CAMK4 protein
CTD
PMID:15860345 PMID:19289156
NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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Camkk1
calcium/calmodulin-dependent protein kinase kinase 1
decreases expression
EXP
Clozapine results in decreased expression of CAMKK1 protein
CTD
PMID:19289156
NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498
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Camkk2
calcium/calmodulin-dependent protein kinase kinase 2
decreases expression
EXP
Clozapine results in decreased expression of CAMKK2 protein
CTD
PMID:19289156
NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
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Canx
calnexin
decreases expression
ISO
Clozapine results in decreased expression of CANX protein
CTD
PMID:34122009
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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Cars1
cysteinyl-tRNA synthetase 1
increases expression
ISO
Clozapine results in increased expression of CARS1 protein
CTD
PMID:34122009
NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
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Cartpt
CART prepropeptide
decreases expression
EXP
Clozapine results in decreased expression of CARTPT mRNA
CTD
PMID:14696011
NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
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Casp1
caspase 1
increases activity
ISO
Clozapine results in increased activity of CASP1 protein
CTD
PMID:34935985
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
increases activity multiple interactions
ISO EXP
Clozapine results in increased activity of CASP3 protein Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]
CTD
PMID:22700542 PMID:24709159
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
increases activity multiple interactions
ISO
Clozapine results in increased activity of CASP7 protein Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]
CTD
PMID:22700542
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Cat
catalase
multiple interactions
ISO
Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]]
CTD
PMID:14730115
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccar1
cell division cycle and apoptosis regulator 1
increases expression
ISO
Clozapine results in increased expression of CCAR1 protein
CTD
PMID:34122009
NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
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Ccdc47
coiled-coil domain containing 47
increases expression multiple interactions
ISO
Clozapine results in increased expression of CCDC47 protein [Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein
CTD
PMID:34122009
NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881
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Cck
cholecystokinin
multiple interactions increases expression
EXP
Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein] Clozapine results in increased expression of CCK mRNA
CTD
PMID:10974607 PMID:16567023
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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Cckbr
cholecystokinin B receptor
increases expression
ISO
Clozapine results in increased expression of CCKBR mRNA
CTD
PMID:17266109
NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
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Ccl1
C-C motif chemokine ligand 1
decreases expression
ISO
Clozapine results in decreased expression of CCL1 mRNA
CTD
PMID:17346280
NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
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Ccnd1
cyclin D1
decreases expression
EXP
Clozapine results in decreased expression of CCND1 mRNA
CTD
PMID:15860345
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd3
cyclin D3
increases expression
EXP
Clozapine results in increased expression of CCND3 mRNA
CTD
PMID:15860345
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccnl1
cyclin L1
increases expression
EXP
Clozapine results in increased expression of CCNL1 mRNA
CTD
PMID:15860345
NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368
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Cct7
chaperonin containing TCP1 subunit 7
decreases expression
ISO
Clozapine results in decreased expression of CCT7 protein
CTD
PMID:34122009
NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
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Cd276
Cd276 molecule
decreases expression
ISO
Clozapine results in decreased expression of CD276 protein
CTD
PMID:34122009
NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
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Cd63
Cd63 molecule
increases expression
ISO
Clozapine results in increased expression of CD63 protein
CTD
PMID:36482696
NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
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Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
increases expression
ISO
Clozapine results in increased expression of CDIPT protein
CTD
PMID:34122009
NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408
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Cdk4
cyclin-dependent kinase 4
increases expression
EXP
Clozapine results in increased expression of CDK4 mRNA
CTD
PMID:15860345
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdk5
cyclin-dependent kinase 5
increases expression
EXP
Clozapine results in increased expression of CDK5 mRNA
CTD
PMID:15860345
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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Cdk5r1
cyclin-dependent kinase 5 regulatory subunit 1
increases expression
ISO
Clozapine results in increased expression of CDK5R1 mRNA
CTD
PMID:17266109
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
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Cebpa
CCAAT/enhancer binding protein alpha
multiple interactions increases expression
ISO
Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein] Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein
CTD
PMID:20564506
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Cenpv
centromere protein V
increases expression
ISO
Clozapine results in increased expression of CENPV protein
CTD
PMID:34122009
NCBI chr10:47,214,479...47,228,552
Ensembl chr10:47,214,490...47,228,761
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Cfap210
cilia and flagella associated protein 210
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of CFAP210 protein
CTD
PMID:34122009
NCBI chr 3:54,520,455...54,554,677
Ensembl chr 3:54,520,458...54,554,607
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Chchd2
coiled-coil-helix-coiled-coil-helix domain containing 2
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein
CTD
PMID:34122009
NCBI chr12:26,828,738...26,834,762
Ensembl chr12:26,828,736...26,834,755
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Chd4
chromodomain helicase DNA binding protein 4
decreases expression
ISO
Clozapine results in decreased expression of CHD4 protein
CTD
PMID:34122009
NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
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Chga
chromogranin A
decreases expression increases expression
EXP
Clozapine results in decreased expression of CHGA mRNA Clozapine results in increased expression of CHGA mRNA
CTD
PMID:12437575
NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
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Chl1
cell adhesion molecule L1-like
decreases expression
ISO
Clozapine results in decreased expression of CHL1 mRNA
CTD
PMID:14647396
NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265
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Chn1
chimerin 1
decreases expression
ISO
Clozapine results in decreased expression of CHN1 mRNA
CTD
PMID:14647396
NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490
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Chordc1
cysteine and histidine rich domain containing 1
increases expression
ISO
Clozapine results in increased expression of CHORDC1 protein
CTD
PMID:34122009
NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
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Chrm1
cholinergic receptor, muscarinic 1
affects binding multiple interactions increases expression
ISO EXP
Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein] Clozapine results in increased expression of CHRM1 protein
CTD
PMID:11997696 PMID:16983399 PMID:18806925
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Ckap4
cytoskeleton-associated protein 4
increases expression
ISO
Clozapine results in increased expression of CKAP4 protein
CTD
PMID:34122009
NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914
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Clic1
chloride intracellular channel 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein
CTD
PMID:34122009
NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712
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Clic4
chloride intracellular channel 4
increases expression
ISO
Clozapine results in increased expression of CLIC4 protein
CTD
PMID:34122009
NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452
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Clock
clock circadian regulator
affects response to substance
ISO
CLOCK gene SNP affects the susceptibility to Clozapine
CTD
PMID:15331141
NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
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Clta
clathrin, light chain A
decreases expression
EXP
Clozapine results in decreased expression of CLTA mRNA
CTD
PMID:15860345
NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472
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Cltb
clathrin, light chain B
decreases expression
EXP
Clozapine results in decreased expression of CLTB mRNA
CTD
PMID:15860345
NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
decreases expression increases expression
ISO
Clozapine results in decreased expression of CNP mRNA Clozapine results in increased expression of CNP mRNA Clozapine results in decreased expression of CNP protein
CTD
PMID:17266109 PMID:34122009
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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Coil
coilin
increases expression
EXP
Clozapine results in increased expression of COIL mRNA
CTD
PMID:16715494
NCBI chr10:73,789,077...73,810,378
Ensembl chr10:73,789,488...73,810,393
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Col5a2
collagen type V alpha 2 chain
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein
CTD
PMID:34122009
NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154
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Comt
catechol-O-methyltransferase
multiple interactions increases response to substance affects response to substance
EXP ISO
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine] COMT gene polymorphism results in increased susceptibility to Clozapine COMT protein affects the susceptibility to Clozapine
CTD
PMID:15190105 PMID:17123785
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Cops3
COP9 signalosome subunit 3
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein
CTD
PMID:34122009
NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597
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Coro1b
coronin 1B
decreases expression
ISO
Clozapine results in decreased expression of CORO1B protein
CTD
PMID:34122009
NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
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Cplx2
complexin 2
decreases expression
ISO
Clozapine results in decreased expression of CPLX2 mRNA
CTD
PMID:17266109
NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855
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Cpn1
carboxypeptidase N subunit 1
increases expression
EXP
Clozapine results in increased expression of CPN1 mRNA
CTD
PMID:16715494
NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465
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Cpne1
copine 1
decreases expression
ISO
Clozapine results in decreased expression of CPNE1 protein
CTD
PMID:34122009
NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636
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Cpt2
carnitine palmitoyltransferase 2
multiple interactions
EXP
[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA
CTD
PMID:23226405
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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Creb1
cAMP responsive element binding protein 1
multiple interactions decreases phosphorylation
ISO
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein] Clozapine results in decreased phosphorylation of CREB1 protein
CTD
PMID:12871586
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Crh
corticotropin releasing hormone
decreases expression
ISO
Clozapine results in decreased expression of CRH mRNA
CTD
PMID:16205782
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Crhbp
corticotropin releasing hormone binding protein
decreases expression
EXP
Clozapine results in decreased expression of CRHBP mRNA
CTD
PMID:16715494
NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710
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Crp
C-reactive protein
increases expression
ISO
Clozapine results in increased expression of CRP protein
CTD
PMID:17685758
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Csf3
colony stimulating factor 3
multiple interactions
ISO
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]
CTD
PMID:16160616
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Csnk2a1
casein kinase 2 alpha 1
decreases expression
EXP
Clozapine results in decreased expression of CSNK2A1 mRNA
CTD
PMID:16715494
NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
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Cst3
cystatin C
increases expression
ISO
Clozapine results in increased expression of CST3 mRNA
CTD
PMID:14647396
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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Cstf1
cleavage stimulation factor subunit 1
decreases expression
ISO
Clozapine results in decreased expression of CSTF1 protein
CTD
PMID:34122009
NCBI chr 3:161,144,522...161,156,294
Ensembl chr 3:161,144,548...161,156,300
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Cstf2
cleavage stimulation factor subunit 2
decreases expression
ISO
Clozapine results in decreased expression of CSTF2 protein
CTD
PMID:34122009
NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476
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Ctbp1
C-terminal binding protein 1
increases expression
ISO
Clozapine results in increased expression of CTBP1 protein
CTD
PMID:34122009
NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821
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Ctnnb1
catenin beta 1
increases expression multiple interactions
EXP
Clozapine results in increased expression of CTNNB1 protein DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]
CTD
PMID:16144542
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Ctrl
chymotrypsin-like
increases expression
EXP
Clozapine results in increased expression of CTRL mRNA
CTD
PMID:16715494
NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
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Ctsk
cathepsin K
increases expression
EXP
Clozapine results in increased expression of CTSK mRNA
CTD
PMID:16715494
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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Cttn
cortactin
increases expression
ISO
Clozapine results in increased expression of CTTN protein
CTD
PMID:34122009
NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
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Cul2
cullin 2
increases expression
ISO
Clozapine results in increased expression of CUL2 protein
CTD
PMID:34122009
NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968
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Cul3
cullin 3
increases expression
ISO
Clozapine results in increased expression of CUL3 protein
CTD
PMID:34122009
NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
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Cxcl1
C-X-C motif chemokine ligand 1
decreases expression increases secretion multiple interactions decreases secretion
ISO EXP
Clozapine results in decreased expression of CXCL1 mRNA Clozapine results in increased secretion of CXCL1 protein belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein] Clozapine results in decreased secretion of CXCL1 protein
CTD
PMID:17346280 PMID:34935985 PMID:36482696
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl10
C-X-C motif chemokine ligand 10
decreases secretion
ISO
Clozapine results in decreased secretion of CXCL10 protein
CTD
PMID:36482696
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl3
C-X-C motif chemokine ligand 3
decreases expression decreases secretion
ISO
Clozapine results in decreased expression of CXCL1 mRNA Clozapine results in decreased secretion of CXCL1 protein
CTD
PMID:17346280 PMID:36482696
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cxhxorf49
similar to human chromosome X open reading frame 49
increases expression
ISO
Clozapine results in increased expression of CXORF49 protein
CTD
PMID:34122009
NCBI chr X:66,911,430...66,915,407
Ensembl chr X:66,911,431...66,915,293
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Cyb5b
cytochrome b5 type B
increases expression
EXP
Clozapine results in increased expression of CYB5B mRNA
CTD
PMID:19441803
NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249
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Cyb5r1
cytochrome b5 reductase 1
increases expression
ISO
Clozapine results in increased expression of CYB5R1 protein
CTD
PMID:34122009
NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases metabolic processing decreases activity
EXP ISO
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CYP1A1 protein results in increased metabolism of Clozapine Clozapine results in decreased activity of CYP1A1 protein
CTD
PMID:18493746 PMID:18809730 PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases response to substance decreases metabolic processing increases metabolic processing affects response to substance multiple interactions affects metabolic processing increases expression
ISO EXP
CYP1A2 gene SNP results in decreased susceptibility to Clozapine CYP1A2 gene SNP results in decreased metabolism of Clozapine CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine] CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine Clozapine results in increased expression of CYP1A2 mRNA
CTD
PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 PMID:15286053 PMID:15883149 PMID:15949157 PMID:16044115 PMID:18493746 PMID:18809730 PMID:23397584 PMID:27320963 More...
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases metabolic processing decreases activity
ISO
CYP1B1 protein results in increased metabolism of Clozapine Clozapine results in decreased activity of CYP1B1 protein
CTD
PMID:18809730 PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions increases metabolic processing
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine CYP2C19 protein results in increased metabolism of Clozapine
CTD
PMID:18809730 PMID:23397584 PMID:27320963
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
increases metabolic processing
ISO
CYP2C8 protein results in increased metabolism of Clozapine
CTD
PMID:18809730 PMID:27320963
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
affects metabolic processing multiple interactions increases metabolic processing
ISO
CYP2D6 protein affects the metabolism of Clozapine [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine CYP2D6 protein results in increased metabolism of Clozapine
CTD
PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
increases metabolic processing
ISO
CYP2J2 protein results in increased metabolism of Clozapine
CTD
PMID:18809730
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases metabolic processing multiple interactions affects metabolic processing
ISO
CYP3A4 protein results in increased metabolism of Clozapine [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] CYP3A4 protein affects the metabolism of Clozapine
CTD
PMID:15286053 PMID:18809730 PMID:21402137 PMID:23397584 PMID:27320963
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases metabolic processing
ISO
CYP3A5 protein results in increased metabolism of Clozapine
CTD
PMID:18809730
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Dab1
DAB adaptor protein 1
increases expression
EXP
Clozapine results in increased expression of DAB1 mRNA
CTD
PMID:19359144
NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552
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Dab2
DAB adaptor protein 2
increases expression
ISO
Clozapine results in increased expression of DAB2 protein
CTD
PMID:36482696
NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
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Daglb
diacylglycerol lipase, beta
increases expression
ISO
Clozapine results in increased expression of DAGLB protein
CTD
PMID:36482696
NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154
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Dcaf6
DDB1 and CUL4 associated factor 6
decreases expression
ISO
Clozapine results in decreased expression of DCAF6 mRNA
CTD
PMID:14647396
NCBI chr13:77,626,257...77,727,645
Ensembl chr13:77,626,307...77,727,512
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Dclk1
doublecortin-like kinase 1
increases expression
ISO EXP
Clozapine results in increased expression of DCLK1 mRNA
CTD
PMID:15860345 PMID:18797397
NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956
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Ddc
dopa decarboxylase
multiple interactions increases expression
ISO
Clozapine results in increased expression of and results in increased activity of DDC protein Clozapine results in increased expression of DDC mRNA
CTD
PMID:16415089
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Ddx46
DEAD-box helicase 46
increases expression
ISO
Clozapine results in increased expression of DDX46 protein
CTD
PMID:34122009
NCBI chr17:8,942,070...8,988,440
Ensembl chr17:8,944,454...8,988,439
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Dennd10
DENN domain containing 10
increases expression
EXP
Clozapine results in increased expression of DENND10 mRNA
CTD
PMID:16715494
NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455
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Depp1
DEPP autophagy regulator 1
increases expression
ISO
Clozapine results in increased expression of DEPP1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Dgcr6
DiGeorge syndrome critical region gene 6
decreases expression
ISO
Clozapine results in decreased expression of DGCR6 protein
CTD
PMID:34122009
NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823
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Dgka
diacylglycerol kinase, alpha
decreases expression
EXP
Clozapine results in decreased expression of DGKA mRNA
CTD
PMID:15860345
NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
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Dhcr24
24-dehydrocholesterol reductase
increases expression
ISO
Clozapine results in increased expression of DHCR24 protein
CTD
PMID:34122009
NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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Dhcr7
7-dehydrocholesterol reductase
increases expression
ISO
Clozapine results in increased expression of DHCR7 mRNA
CTD
PMID:17052361
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Dhx30
DExH-box helicase 30
increases expression
ISO
Clozapine results in increased expression of DHX30 protein
CTD
PMID:34122009
NCBI chr 8:110,064,751...110,096,954
Ensembl chr 8:110,064,752...110,097,381
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Dhx38
DEAH-box helicase 38
decreases expression
ISO
Clozapine results in decreased expression of DHX38 protein
CTD
PMID:34122009
NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140
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Disc1
DISC1 scaffold protein
decreases response to substance affects response to substance
ISO
DISC1 gene mutant form results in decreased susceptibility to Clozapine DISC1 protein affects the susceptibility to Clozapine
CTD
PMID:20531374
NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
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Dlat
dihydrolipoamide S-acetyltransferase
decreases expression increases expression
EXP ISO
Clozapine results in decreased expression of DLAT mRNA Clozapine results in increased expression of DLAT protein
CTD
PMID:15860345 PMID:34122009
NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
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Dlg2
discs large MAGUK scaffold protein 2
increases expression
ISO
Clozapine results in increased expression of DLG2 protein
CTD
PMID:34122009
NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475
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Dlst
dihydrolipoamide S-succinyltransferase
decreases expression
ISO
Clozapine results in decreased expression of DLST protein
CTD
PMID:34122009
NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
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Dnah11
dynein, axonemal, heavy chain 11
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein
CTD
PMID:34122009
NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536
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Dnaja3
DnaJ heat shock protein family (Hsp40) member A3
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein
CTD
PMID:34122009
NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
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Dnajb11
DnaJ heat shock protein family (Hsp40) member B11
increases expression
ISO
Clozapine results in increased expression of DNAJB11 protein
CTD
PMID:34122009
NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
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Dpf1
double PHD fingers 1
affects expression
ISO
Clozapine affects the expression of DPF1 mRNA
CTD
PMID:14647396
NCBI chr 1:84,602,212...84,615,954
Ensembl chr 1:84,602,336...84,615,950
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Dpp3
dipeptidylpeptidase 3
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein
CTD
PMID:34122009
NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
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Dpysl3
dihydropyrimidinase-like 3
decreases expression
ISO
Clozapine results in decreased expression of DPYSL3 protein
CTD
PMID:34122009
NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
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Dpysl4
dihydropyrimidinase-like 4
decreases expression
ISO
Clozapine results in decreased expression of DPYSL4 protein
CTD
PMID:34122009
NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914
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Dr1
down-regulator of transcription 1
decreases expression
ISO
Clozapine results in decreased expression of DR1 protein
CTD
PMID:34122009
NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638
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Drd1
dopamine receptor D1
affects binding affects response to substance decreases expression
ISO EXP
Clozapine binds to DRD1 protein DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine Clozapine analog binds to DRD1 protein Clozapine results in decreased expression of DRD1 mRNA
CTD
PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Drd2
dopamine receptor D2
multiple interactions affects response to substance increases response to substance affects binding decreases expression
ISO EXP
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine DRD2 gene SNP results in increased susceptibility to Clozapine Clozapine binds to DRD2 protein alternative form [Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA Clozapine results in decreased expression of DRD2 mRNA [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein] Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein DRD2 protein affects the susceptibility to Clozapine
CTD
PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 PMID:15716360 PMID:15781964 PMID:15830237 PMID:16033416 PMID:16144542 PMID:16278074 PMID:17266109 PMID:20375926 More...
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Drd3
dopamine receptor D3
affects response to substance decreases response to substance multiple interactions
ISO
DRD3 protein affects the susceptibility to Clozapine DRD3 gene polymorphism results in decreased susceptibility to Clozapine DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
CTD
PMID:15579174 PMID:20029384
NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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Drd4
dopamine receptor D4
affects binding affects response to substance multiple interactions
ISO EXP
Clozapine binds to DRD4 protein DRD4 gene polymorphism affects the susceptibility to Clozapine Clozapine analog binds to DRD4 protein Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein] Clozapine binds to Drd4 protein
CTD RGD
PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498
RGD:7248459
NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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Drp2
dystrophin related protein 2
increases expression
EXP
Clozapine results in increased expression of DRP2 mRNA alternative form
CTD
PMID:16715494
NCBI chr X:97,607,577...97,658,117
Ensembl chr X:97,607,719...97,655,684
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Dtnbp1
dystrobrevin binding protein 1
increases response to substance affects response to substance
ISO
DTNBP1 gene polymorphism results in increased susceptibility to Clozapine DTNBP1 protein affects the susceptibility to Clozapine
CTD
PMID:19369910
NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661
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Dusp1
dual specificity phosphatase 1
decreases expression
EXP
Clozapine results in decreased expression of DUSP1 mRNA
CTD
PMID:15860345
NCBI chr10:16,680,478...16,683,275
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Dusp6
dual specificity phosphatase 6
decreases expression
EXP
Clozapine results in decreased expression of DUSP6 mRNA
CTD
PMID:15860345
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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Dvl3
dishevelled segment polarity protein 3
increases expression multiple interactions
EXP
Clozapine results in increased expression of DVL3 protein DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]
CTD
PMID:16144542
NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462
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Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
decreases expression
ISO
Clozapine results in decreased expression of DYNC1LI1 protein
CTD
PMID:34122009
NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934
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Dync1li2
dynein, cytoplasmic 1 light intermediate chain 2
decreases expression
ISO
Clozapine results in decreased expression of DYNC1LI2 protein
CTD
PMID:34122009
NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670
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Edc4
enhancer of mRNA decapping 4
increases expression
ISO
Clozapine results in increased expression of EDC4 protein
CTD
PMID:34122009
NCBI chr19:33,774,062...33,786,054
Ensembl chr19:33,774,055...33,787,758
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Eef1a2
eukaryotic translation elongation factor 1 alpha 2
increases expression
ISO
Clozapine results in increased expression of EEF1A2 protein
CTD
PMID:34122009
NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071
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Eef1d
eukaryotic translation elongation factor 1 delta
decreases expression
ISO
Clozapine results in decreased expression of EEF1D protein
CTD
PMID:34122009
NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799
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Egr1
early growth response 1
decreases expression
EXP
Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein
CTD
PMID:17028028 PMID:18208916
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Egr2
early growth response 2
affects expression decreases expression
ISO EXP
Clozapine affects the expression of EGR2 mRNA Clozapine results in decreased expression of EGR2 protein
CTD
PMID:17028028 PMID:19401217
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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Egr3
early growth response 3
affects response to substance
ISO
EGR3 protein affects the susceptibility to Clozapine
CTD
PMID:17637609
NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
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Eif2s3
eukaryotic translation initiation factor 2 subunit gamma
increases expression
ISO
Clozapine results in increased expression of EIF2S3 protein
CTD
PMID:34122009
NCBI chr X:58,916,513...58,939,923
Ensembl chr X:58,917,490...58,940,686
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Eif3c
eukaryotic translation initiation factor 3, subunit C
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of EIF3C protein
CTD
PMID:34122009
NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
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Eif3j
eukaryotic translation initiation factor 3, subunit J
increases expression
ISO
Clozapine results in increased expression of EIF3J protein
CTD
PMID:34122009
NCBI chr 3:108,985,103...109,007,341
Ensembl chr 3:108,985,118...109,007,953
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Eif3m
eukaryotic translation initiation factor 3, subunit M
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of EIF3M protein
CTD
PMID:34122009
NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392
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Eif4a3
eukaryotic translation initiation factor 4A3
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of EIF4A3 protein
CTD
PMID:34122009
NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057
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Eif4e
eukaryotic translation initiation factor 4E
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of EIF4E protein
CTD
PMID:34122009
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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Eif5b
eukaryotic translation initiation factor 5B
increases expression
ISO
Clozapine results in increased expression of EIF5B protein
CTD
PMID:34122009
NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482
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Eif6
eukaryotic translation initiation factor 6
decreases expression
ISO
Clozapine results in decreased expression of EIF6 protein
CTD
PMID:34122009
NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401
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Elk1
ETS transcription factor ELK1
decreases phosphorylation
ISO
Clozapine results in decreased phosphorylation of ELK1 protein
CTD
PMID:12871586
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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Eno1
enolase 1
increases expression
EXP
Clozapine results in increased expression of ENO1 mRNA
CTD
PMID:15860345
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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Eno3
enolase 3
increases expression
ISO
Clozapine results in increased expression of ENO3 protein
CTD
PMID:34122009
NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
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Epha7
Eph receptor A7
increases expression
ISO
Clozapine results in increased expression of EPHA7 mRNA
CTD
PMID:17266109
NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
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Ephb3
Eph receptor B3
increases expression
ISO
Clozapine results in increased expression of EPHB3 protein
CTD
PMID:34122009
NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370
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Erap1
endoplasmic reticulum aminopeptidase 1
decreases expression
ISO
Clozapine results in decreased expression of ERAP1 protein
CTD
PMID:34122009
NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447
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Erbb2
erb-b2 receptor tyrosine kinase 2
affects phosphorylation
EXP
Clozapine affects the phosphorylation of ERBB2 protein
CTD
PMID:26961615
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Erbb4
erb-b2 receptor tyrosine kinase 4
multiple interactions
EXP
Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein
CTD
PMID:26961615
NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
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Erh
ERH, mRNA splicing and mitosis factor
increases expression
ISO
Clozapine results in increased expression of ERH protein
CTD
PMID:34122009
NCBI chr 6:100,280,933...100,291,200
Ensembl chr 6:100,280,930...100,291,210
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Erp44
endoplasmic reticulum protein 44
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of ERP44 protein
CTD
PMID:34122009
NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761
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Ewsr1
EWS RNA-binding protein 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of EWSR1 protein
CTD
PMID:34122009
NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544
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Exosc4
exosome component 4
increases expression
ISO
Clozapine results in increased expression of EXOSC4 protein
CTD
PMID:34122009
NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
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Ezr
ezrin
decreases expression
ISO
Clozapine results in decreased expression of EZR protein
CTD
PMID:34122009
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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Fabp1
fatty acid binding protein 1
increases expression
ISO
Clozapine results in increased expression of FABP1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fan1
FANCD2 and FANCI associated nuclease 1
increases expression
ISO
Clozapine results in increased expression of FAN1 protein
CTD
PMID:34122009
NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977
G
Farsa
phenylalanyl-tRNA synthetase subunit alpha
increases expression
ISO
Clozapine results in increased expression of FARSA protein
CTD
PMID:34122009
NCBI chr19:23,291,409...23,300,985
Ensembl chr19:23,268,869...23,300,980
G
Farsb
phenylalanyl-tRNA synthetase subunit beta
increases expression
ISO
Clozapine results in increased expression of FARSB protein
CTD
PMID:34122009
NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045
G
Fas
Fas cell surface death receptor
multiple interactions
ISO
[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA
CTD
PMID:20564506
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Faslg
Fas ligand
multiple interactions
ISO
[Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA
CTD
PMID:16510162
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
G
Fasn
fatty acid synthase
increases expression
ISO
Clozapine results in increased expression of FASN mRNA
CTD
PMID:16027736 PMID:17052361
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
G
Fdps
farnesyl diphosphate synthase
increases expression
ISO
Clozapine results in increased expression of FDPS mRNA
CTD
PMID:17052361
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
G
Fen1
flap structure-specific endonuclease 1
increases expression
ISO
Clozapine results in increased expression of FEN1 protein
CTD
PMID:34122009
NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
G
Fgf2
fibroblast growth factor 2
increases expression
EXP
Clozapine results in increased expression of FGF2 mRNA
CTD
PMID:11264663
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Fgl1
fibrinogen-like 1
increases expression
ISO
Clozapine results in increased expression of FGL1 protein
CTD
PMID:36482696
NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093
G
Fhod1
formin homology 2 domain containing 1
decreases expression
ISO
Clozapine results in decreased expression of FHOD1 protein
CTD
PMID:34122009
NCBI chr19:33,206,492...33,225,448
Ensembl chr19:33,206,492...33,225,356
G
Fkbp8
FKBP prolyl isomerase 8
decreases expression
ISO
Clozapine results in decreased expression of FKBP8 protein
CTD
PMID:34122009
NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612
G
Flot2
flotillin 2
increases expression
ISO
Clozapine results in increased expression of FLOT2 protein
CTD
PMID:34122009
NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756
G
Fmo1
flavin containing dimethylaniline monoxygenase 1
increases metabolic processing
ISO
FMO1 protein results in increased metabolism of Clozapine
CTD
PMID:18809730
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
G
Fmo3
flavin containing dimethylaniline monoxygenase 3
increases metabolic processing
ISO
FMO3 protein results in increased metabolism of Clozapine
CTD
PMID:18809730 PMID:27320963
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
G
Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Clozapine results in increased expression of FNDC4 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions decreases expression increases expression
EXP ISO
Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA] Clozapine results in decreased expression of FOS protein Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein
CTD
PMID:10435392 PMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 PMID:12243769 PMID:12464447 PMID:17028028 PMID:18208916 PMID:18521575 PMID:19695244 PMID:28272498 More...
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
increases expression decreases expression multiple interactions
ISO EXP
Clozapine results in increased expression of FOSB protein alternative form Clozapine results in decreased expression of FOSB mRNA DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form] Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein
CTD
PMID:11259127 PMID:12093589 PMID:12243769 PMID:15579174 PMID:19695244
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
G
Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
EXP
Clozapine results in increased expression of FOSL1 mRNA
CTD
PMID:18208916
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
G
Fosl2
FOS like 2, AP-1 transcription factor subunit
increases expression
EXP
Clozapine results in increased expression of FOSL2 mRNA
CTD
PMID:12093589 PMID:12243769
NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
G
Foxp2
forkhead box P2
increases expression
ISO
Clozapine results in increased expression of FOXP2 mRNA
CTD
PMID:17266109
NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
G
Fstl1
follistatin-like 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of FSTL1 protein
CTD
PMID:34122009
NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
G
Fubp1
far upstream element binding protein 1
increases expression
ISO
Clozapine results in increased expression of FUBP1 protein
CTD
PMID:34122009
NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602
G
G6pd
glucose-6-phosphate dehydrogenase
decreases expression
ISO
Clozapine results in decreased expression of G6PD protein
CTD
PMID:34122009
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gabarapl2
GABA type A receptor associated protein like 2
increases expression
ISO
Clozapine results in increased expression of GABARAPL2 protein
CTD
PMID:36482696
NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628 Ensembl chr 8:39,910,534...39,924,628
G
Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
decreases expression
ISO
Clozapine results in decreased expression of GABBR1 mRNA
CTD
PMID:17266109
NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
increases expression
ISO
Clozapine results in increased expression of GABRA1 mRNA
CTD
PMID:17266109
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
G
Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
increases expression
EXP
Clozapine results in increased expression of GABRB3 mRNA
CTD
PMID:18923069
NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
G
Gad1
glutamate decarboxylase 1
increases expression multiple interactions decreases methylation
ISO EXP
Clozapine results in increased expression of GAD1 mRNA Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]
CTD
PMID:12887421 PMID:15061247 PMID:17942719 PMID:18757738 PMID:18923069
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
G
Gad2
glutamate decarboxylase 2
increases expression
ISO EXP
Clozapine results in increased expression of GAD2 mRNA
CTD
PMID:17266109 PMID:18923069
NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
increases expression
EXP ISO
Clozapine results in increased expression of GAPDH mRNA Clozapine results in increased expression of GAPDH protein
CTD
PMID:15860345 PMID:34122009
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
G
Gart
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
increases expression
ISO
Clozapine results in increased expression of GART protein
CTD
PMID:34122009
NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125
G
Gatm
glycine amidinotransferase
increases expression
ISO
Clozapine results in increased expression of GATM protein
CTD
PMID:34122009
NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129
G
Gcc2
GRIP and coiled-coil domain containing 2
decreases expression
ISO
Clozapine results in decreased expression of GCC2 protein
CTD
PMID:34122009
NCBI chr20:26,247,394...26,293,613
Ensembl chr20:26,247,404...26,293,613
G
Gdf15
growth differentiation factor 15
increases expression
ISO
Clozapine results in increased expression of GDF15 protein
CTD
PMID:36482696
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
G
Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression
ISO
Clozapine results in increased expression of GDPD3 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
G
Gfap
glial fibrillary acidic protein
decreases expression increases expression
EXP
Clozapine results in decreased expression of GFAP protein Clozapine results in increased expression of GFAP mRNA
CTD
PMID:18585900 PMID:19441803
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Ghitm
growth hormone inducible transmembrane protein
increases expression
ISO
Clozapine results in increased expression of GHITM protein
CTD
PMID:34122009
NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879
G
Gimap5
GTPase, IMAP family member 5
decreases expression
EXP
Clozapine results in decreased expression of GIMAP5 mRNA
CTD
PMID:16715494
NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086
G
Gip
gastric inhibitory polypeptide
increases expression
EXP
Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein
CTD
PMID:16402076
NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503
G
Gja1
gap junction protein, alpha 1
increases expression
EXP
Clozapine results in increased expression of GJA1 protein
CTD
PMID:18585900
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
G
Glp1r
glucagon-like peptide 1 receptor
multiple interactions decreases expression
EXP
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]
CTD
PMID:37087062
NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
G
Glrx3
glutaredoxin 3
increases expression
ISO
Clozapine results in increased expression of GLRX3 protein
CTD
PMID:34122009
NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
G
Glul
glutamate-ammonia ligase
decreases expression
ISO
Clozapine results in decreased expression of GLUL protein
CTD
PMID:36482696
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
G
Gna12
G protein subunit alpha 12
decreases expression increases expression
EXP ISO
Clozapine results in decreased expression of GNA12 mRNA Clozapine results in increased expression of GNA12 protein
CTD
PMID:15860345 PMID:34122009
NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255
G
Gnai1
G protein subunit alpha i1
decreases expression
EXP
Clozapine results in decreased expression of GNAI1 mRNA
CTD
PMID:15860345
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gnai2
G protein subunit alpha i2
decreases expression
EXP
Clozapine results in decreased expression of GNAI2 mRNA
CTD
PMID:15860345
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
G
Gnai3
G protein subunit alpha i3
decreases expression
EXP
Clozapine results in decreased expression of GNAI3 mRNA
CTD
PMID:15860345
NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
G
Gnas
GNAS complex locus
decreases expression increases expression multiple interactions
EXP ISO
Clozapine results in decreased expression of GNAS mRNA Clozapine results in increased expression of GNAS protein [Cuprizone co-treated with Clozapine] results in decreased expression of GNAS protein
CTD
PMID:15860345 PMID:34122009
NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
G
Gnb3
G protein subunit beta 3
decreases response to substance increases response to substance affects response to substance increases expression
ISO EXP
GNB3 gene polymorphism results in decreased susceptibility to Clozapine GNB3 gene polymorphism results in increased susceptibility to Clozapine GNB3 protein affects the susceptibility to Clozapine Clozapine results in increased expression of GNB3 protein
CTD
PMID:16139171 PMID:16141801 PMID:18855531
NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
G
Golga3
golgin A3
increases expression
ISO
Clozapine results in increased expression of GOLGA3 protein
CTD
PMID:34122009
NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509
G
Golgb1
golgin B1
increases expression
ISO
Clozapine results in increased expression of GOLGB1 protein
CTD
PMID:34122009
NCBI chr11:63,843,179...63,900,665
Ensembl chr11:63,843,986...63,900,770
G
Got2
glutamic-oxaloacetic transaminase 2
increases expression multiple interactions
EXP ISO
Clozapine results in increased expression of GOT2 mRNA [Cuprizone co-treated with Clozapine] results in increased expression of GOT2 protein
CTD
PMID:15860345 PMID:34122009
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
G
Gpd2
glycerol-3-phosphate dehydrogenase 2
decreases expression
ISO
Clozapine results in decreased expression of GPD2 protein
CTD
PMID:34122009
NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
G
Gpi
glucose-6-phosphate isomerase
increases expression
ISO
Clozapine results in increased expression of GPI protein
CTD
PMID:34122009
NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
[Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein
CTD
PMID:36482696
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gpx1
glutathione peroxidase 1
increases expression
ISO
Clozapine results in increased expression of GPX1 mRNA
CTD
PMID:14647396
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Grik2
glutamate ionotropic receptor kainate type subunit 2
increases expression
EXP
Clozapine results in increased expression of GRIK2 mRNA
CTD
PMID:18923069
NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
G
Grik5
glutamate ionotropic receptor kainate type subunit 5
affects expression decreases expression
ISO EXP
Clozapine affects the expression of GRIK5 mRNA Clozapine results in decreased expression of GRIK5 mRNA
CTD
PMID:14647396 PMID:18923069
NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125
G
Grin1
glutamate ionotropic receptor NMDA type subunit 1
decreases expression increases expression
ISO EXP
Clozapine results in decreased expression of GRIN1 mRNA Clozapine results in increased expression of GRIN1 mRNA
CTD
PMID:12020038 PMID:12608697 PMID:17266109 PMID:18923069
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
G
Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
decreases expression
EXP
Clozapine results in decreased expression of GRIN2A mRNA
CTD
PMID:12608697 PMID:18923069
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
G
Grin2b
glutamate ionotropic receptor NMDA type subunit 2B
decreases expression
EXP
Clozapine results in decreased expression of GRIN2B mRNA
CTD
PMID:18923069
NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
G
Grin2c
glutamate ionotropic receptor NMDA type subunit 2C
decreases expression
EXP
Clozapine results in decreased expression of GRIN2C mRNA
CTD
PMID:18923069
NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
G
Grk6
G protein-coupled receptor kinase 6
decreases expression
EXP
Clozapine results in decreased expression of GRK6 mRNA
CTD
PMID:16715494
NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644
G
Gsk3a
glycogen synthase kinase 3 alpha
increases expression multiple interactions
EXP
Clozapine results in increased expression of GSK3A protein DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]
CTD
PMID:16144542
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
G
Gsk3b
glycogen synthase kinase 3 beta
increases phosphorylation multiple interactions increases expression
ISO EXP
Clozapine results in increased phosphorylation of GSK3B protein DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
CTD
PMID:16144542 PMID:19359144 PMID:19440698
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gsta1
glutathione S-transferase alpha 1
decreases activity increases glutathionylation
ISO
GSTA1 protein results in decreased activity of Clozapine GSTA1 protein results in increased glutathionylation of Clozapine
CTD
PMID:20849150
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
G
Gstm1
glutathione S-transferase mu 1
decreases activity increases glutathionylation increases expression
ISO EXP
GSTM1 protein results in decreased activity of Clozapine GSTM1 protein results in increased glutathionylation of Clozapine Clozapine results in increased expression of GSTM1 mRNA
CTD
PMID:15860345 PMID:20849150
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstm2
glutathione S-transferase mu 2
decreases expression
EXP
Clozapine results in decreased expression of GSTM2 mRNA
CTD
PMID:15860345
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gstp1
glutathione S-transferase pi 1
decreases activity affects binding increases glutathionylation affects metabolic processing
ISO
Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine Clozapine metabolite binds to GSTP1 protein GSTP1 protein results in increased glutathionylation of Clozapine GSTP1 protein affects the metabolism of Clozapine metabolite
CTD
PMID:20849150 PMID:21639118 PMID:24185126
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
H1f2
H1.2 linker histone, cluster member
increases expression
ISO
Clozapine results in increased expression of H1-2 protein
CTD
PMID:34122009
NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
G
H2ac18
H2A clustered histone 18
increases expression
ISO
Clozapine results in increased expression of H2AC18 mRNA
CTD
PMID:14647396
NCBI chr 2:183,808,398...183,808,992
G
H2ac20
H2A clustered histone 20
increases expression
ISO
Clozapine results in increased expression of H2AC20 protein
CTD
PMID:34122009
NCBI chr 2:183,779,879...183,780,357
G
H2aj
H2A.J histone
increases expression
ISO
Clozapine results in increased expression of H2AJ protein
CTD
PMID:34122009
NCBI chr 4:169,675,718...169,676,202
Ensembl chr 4:169,675,752...169,677,006
G
Haao
3-hydroxyanthranilate 3,4-dioxygenase
decreases expression
ISO
Clozapine results in decreased expression of HAAO protein
CTD
PMID:36482696
NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877
G
Hacd3
3-hydroxyacyl-CoA dehydratase 3
increases expression
ISO
Clozapine results in increased expression of HACD3 protein
CTD
PMID:34122009
NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
increases expression
ISO
Clozapine results in increased expression of HADHB protein
CTD
PMID:34122009
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
G
Hars1
histidyl-tRNA synthetase 1
increases expression
ISO
Clozapine results in increased expression of HARS1 protein
CTD
PMID:34122009
NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740
G
Hat1
histone acetyltransferase 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of HAT1 protein
CTD
PMID:34122009
NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517
G
Hcls1
hematopoietic cell specific Lyn substrate 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of HCLS1 protein
CTD
PMID:34122009
NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014
G
Hdgfl2
HDGF like 2
increases expression
ISO
Clozapine results in increased expression of HDGFRP2 protein
CTD
PMID:34122009
NCBI chr 9:909,581...929,195
Ensembl chr 9:909,614...929,186
G
Higd1a
HIG1 hypoxia inducible domain family, member 1A
increases expression
ISO
Clozapine results in increased expression of HIGD1A mRNA
CTD
PMID:14647396
NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443
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Hmgb2
high mobility group box 2
increases expression
ISO
Clozapine results in increased expression of HMGB2 protein
CTD
PMID:34122009
NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions increases activity increases expression
ISO
[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides Clozapine results in increased expression of HMGCR mRNA
CTD
PMID:16027736 PMID:17052361
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
Clozapine results in increased expression of HMGCS1 mRNA
CTD
PMID:16027736 PMID:17052361
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Hmox1
heme oxygenase 1
increases expression
ISO
Clozapine results in increased expression of HMOX1 mRNA
CTD
PMID:18227147
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hnrnpd
heterogeneous nuclear ribonucleoprotein D
decreases expression
ISO
Clozapine results in decreased expression of HNRNPD protein
CTD
PMID:34122009
NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
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Hnrnph2
heterogeneous nuclear ribonucleoprotein H2
decreases expression
ISO
Clozapine results in decreased expression of HNRNPH2 protein
CTD
PMID:36482696
NCBI chr X:97,780,890...97,786,846
Ensembl chr X:97,780,785...97,787,041
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Homer1
homer scaffold protein 1
increases expression multiple interactions
EXP
Clozapine results in increased expression of HOMER1 mRNA Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]
CTD
PMID:12464447 PMID:15860345
NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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Hpcal1
hippocalcin-like 1
decreases expression
EXP
Clozapine results in decreased expression of HPCAL1 mRNA
CTD
PMID:12437575
NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687
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Hpcal4
hippocalcin-like 4
affects expression
EXP
Clozapine affects the expression of HPCAL4 mRNA
CTD
PMID:12437575
NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416
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Hpn
hepsin
increases expression
ISO
Clozapine results in increased expression of HPN mRNA
CTD
PMID:15342952
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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Hrh1
histamine receptor H 1
affects binding
ISO
Clozapine binds to HRH1 protein
CTD
PMID:16983399
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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Hrh3
histamine receptor H3
multiple interactions
EXP
Clozapine binds to Hrh3 protein; Clozapine inhibits the reaction [N-methylhistamine binds to Hrh3 protein]
RGD
PMID:10869375
RGD:632981
NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
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Hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
decreases expression
ISO
Clozapine results in decreased expression of HSD17B10 protein
CTD
PMID:34122009
NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488
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Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
increases expression
ISO
Clozapine results in increased expression of HSD17B12 protein
CTD
PMID:34122009
NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617
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Hspa9
heat shock protein family A (Hsp70) member 9
decreases expression
ISO
Clozapine results in decreased expression of HSPA9 protein
CTD
PMID:34122009
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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Htr1a
5-hydroxytryptamine receptor 1A
multiple interactions affects binding
ISO EXP
Clozapine binds to and affects the activity of HTR1A protein Clozapine binds to HTR1A protein
CTD
PMID:9723970 PMID:15482641
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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Htr1d
5-hydroxytryptamine receptor 1D
decreases expression
EXP
Clozapine results in decreased expression of HTR1D mRNA
CTD
PMID:16715494
NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619
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Htr2a
5-hydroxytryptamine receptor 2A
increases response to substance increases expression affects response to substance multiple interactions affects binding decreases activity decreases expression
ISO EXP
HTR2A gene SNP results in increased susceptibility to Clozapine Clozapine results in increased expression of HTR2A mRNA HTR2A protein affects the susceptibility to Clozapine [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein] Clozapine binds to HTR2A protein Clozapine results in decreased activity of HTR2A protein Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein] Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein
CTD
PMID:7520908 PMID:9723970 PMID:11997696 PMID:14751426 PMID:15380371 PMID:15542763 PMID:16314884 PMID:16983399 PMID:17868938 PMID:18976543 PMID:20521326 More...
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Htr2c
5-hydroxytryptamine receptor 2C
affects binding affects response to substance decreases expression
ISO EXP
Clozapine binds to HTR2C protein HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine Clozapine results in decreased expression of HTR2C mRNA
CTD
PMID:9723970 PMID:12668355 PMID:15635667 PMID:16983399 PMID:17868938 PMID:19142101 PMID:19142110 More...
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Htr3a
5-hydroxytryptamine receptor 3A
multiple interactions affects response to substance
ISO
Clozapine binds to and results in decreased activity of HTR3A protein HTR3A protein affects the susceptibility to Clozapine
CTD
PMID:19696922 PMID:20168265
NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
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Htr6
5-hydroxytryptamine receptor 6
multiple interactions affects binding
ISO
Clozapine binds to and results in decreased activity of HTR6 protein Clozapine binds to HTR6 protein [Cuprizone co-treated with Clozapine] results in increased expression of HTR6 protein
CTD
PMID:11406289 PMID:16983399 PMID:34122009
NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
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Htr7
5-hydroxytryptamine receptor 7
affects binding multiple interactions
ISO
Clozapine binds to HTR7 protein [Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD
PMID:14578406 PMID:20827463
NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
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Id2
inhibitor of DNA binding 2
increases expression
EXP
Clozapine results in increased expression of ID2 mRNA
CTD
PMID:12437575
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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Idh2
isocitrate dehydrogenase (NADP(+)) 2
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein
CTD
PMID:34122009
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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Idi1
isopentenyl-diphosphate delta isomerase 1
decreases expression
ISO
Clozapine results in decreased expression of IDI1 protein
CTD
PMID:34122009
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Ifng
interferon gamma
affects expression decreases expression
ISO
Clozapine affects the expression of IFNG protein Clozapine results in decreased expression of IFNG mRNA
CTD
PMID:17346280
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ifngr1
interferon gamma receptor 1
increases expression
ISO
Clozapine results in increased expression of IFNGR1 protein
CTD
PMID:36482696
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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Igf1
insulin-like growth factor 1
decreases expression
ISO
Clozapine results in decreased expression of IGF1 protein
CTD
PMID:11769361
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Igfbp1
insulin-like growth factor binding protein 1
increases expression
ISO
Clozapine results in increased expression of IGFBP1 protein
CTD
PMID:36482696
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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Il10
interleukin 10
decreases expression
EXP
Clozapine results in decreased expression of IL10 protein
CTD
PMID:24709159
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
increases secretion multiple interactions
EXP
Clozapine results in increased secretion of IL1B protein belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein]
CTD
PMID:34935985
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2ra
interleukin 2 receptor subunit alpha
increases secretion
ISO
Clozapine results in increased secretion of IL2RA protein
CTD
PMID:8067274
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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Il5
interleukin 5
affects expression
ISO
Clozapine affects the expression of IL5 protein
CTD
PMID:17346280
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Ilkap
ILK associated serine/threonine phosphatase
decreases expression
EXP
Clozapine results in decreased expression of ILKAP mRNA
CTD
PMID:15860345
NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892
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Inha
inhibin subunit alpha
decreases expression
EXP
Clozapine results in decreased expression of INHA mRNA
CTD
PMID:16715494
NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
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Inhbe
inhibin subunit beta E
increases expression
ISO
Clozapine results in increased expression of INHBE mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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Ins2
insulin 2
affects secretion increases expression
ISO
Clozapine affects the secretion of INS protein Clozapine results in increased expression of INS protein
CTD
PMID:11769361 PMID:16601995
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Itga6
integrin subunit alpha 6
increases expression
ISO
Clozapine results in increased expression of ITGA6 protein
CTD
PMID:34122009
NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
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Jak1
Janus kinase 1
increases expression
ISO
Clozapine results in increased expression of JAK1 protein
CTD
PMID:36482696
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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Jak2
Janus kinase 2
multiple interactions
EXP
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]
CTD
PMID:18976543
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression increases expression
EXP
Clozapine results in decreased expression of JUN mRNA Clozapine results in increased expression of JUN mRNA
CTD
PMID:12093589 PMID:15860345 PMID:18208916
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
Clozapine results in increased expression of JUNB mRNA
CTD
PMID:12093589 PMID:19695244
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Jund
JunD proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
Clozapine results in decreased expression of JUND mRNA
CTD
PMID:12093589
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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Kcna1
potassium voltage-gated channel subfamily A member 1
increases expression
ISO
Clozapine results in increased expression of KCNA1 mRNA
CTD
PMID:18797397
NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions
ISO
Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD
PMID:21158687
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Kcnip3
potassium voltage-gated channel interacting protein 3
decreases expression increases expression
ISO
Clozapine results in decreased expression of KCNIP3 mRNA Clozapine results in increased expression of KCNIP3 mRNA
CTD
PMID:17266109 PMID:18797397
NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556
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Kcnk2
potassium two pore domain channel subfamily K member 2
decreases expression
ISO
Clozapine results in decreased expression of KCNK2 mRNA
CTD
PMID:15542763
NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
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Kctd12
potassium channel tetramerization domain containing 12
decreases expression
ISO
Clozapine results in decreased expression of KCTD12 protein
CTD
PMID:34122009
NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282
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Kdr
kinase insert domain receptor
increases expression
ISO
Clozapine results in increased expression of KDR protein
CTD
PMID:34122009
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Khdrbs1
KH RNA binding domain containing, signal transduction associated 1
decreases expression
ISO
Clozapine results in decreased expression of KHDRBS1 protein
CTD
PMID:34122009
NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180
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Kif13b
kinesin family member 13B
increases expression
ISO
Clozapine results in increased expression of KIF13B protein
CTD
PMID:34122009
NCBI chr15:38,908,257...39,066,021
Ensembl chr15:38,924,624...39,084,879
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Kif5c
kinesin family member 5C
decreases expression
ISO
Clozapine results in decreased expression of KIF5C protein
CTD
PMID:34122009
NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
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Kiz
kizuna centrosomal protein
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of KIZ protein
CTD
PMID:34122009
NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190
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Klhdc2
kelch domain containing 2
decreases expression
ISO
Clozapine results in decreased expression of KLHDC2 protein
CTD
PMID:34122009
NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187
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Kmt2a
lysine methyltransferase 2A
increases expression multiple interactions decreases expression
ISO
Clozapine results in increased expression of KMT2A mRNA Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter] Clozapine results in decreased expression of KMT2A mRNA
CTD
PMID:14647396 PMID:17942719
NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
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Kpna4
karyopherin subunit alpha 4
multiple interactions increases expression
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of KPNA4 protein Clozapine results in increased expression of KPNA4 protein
CTD
PMID:34122009
NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081
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Kremen1
kringle containing transmembrane protein 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of KREMEN1 protein
CTD
PMID:34122009
NCBI chr14:80,081,870...80,147,489
Ensembl chr14:80,084,403...80,147,516
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Lactb2
lactamase, beta 2
increases expression
ISO
Clozapine results in increased expression of LACTB2 protein
CTD
PMID:34122009
NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429
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Lamp1
lysosomal-associated membrane protein 1
increases expression
ISO
Clozapine results in increased expression of LAMP1 protein
CTD
PMID:34122009
NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
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Lamtor3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
increases expression
ISO
Clozapine results in increased expression of LAMTOR3 mRNA
CTD
PMID:14647396
NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607
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Larp7
La ribonucleoprotein 7, transcriptional regulator
increases expression
ISO
Clozapine results in increased expression of LARP7 protein
CTD
PMID:34122009
NCBI chr 2:215,997,641...216,012,833
Ensembl chr 2:215,997,649...216,012,865
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Lcn1
lipocalin 1
decreases expression
ISO
Clozapine results in decreased expression of LCN1 protein
CTD
PMID:34122009
NCBI chr 3:9,532,860...9,537,859
Ensembl chr 3:9,532,915...9,536,577
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Ldhb
lactate dehydrogenase B
increases expression
EXP
Clozapine results in increased expression of LDHB mRNA
CTD
PMID:15860345
NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
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Ldlr
low density lipoprotein receptor
increases expression multiple interactions
ISO
Clozapine results in increased expression of LDLR mRNA Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]
CTD
PMID:17052361 PMID:20564506
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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Leap2
liver enriched antimicrobial peptide 2
increases expression
ISO
Clozapine results in increased expression of LEAP2 mRNA
CTD
PMID:17346280
NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244
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Lemd2
LEM domain nuclear envelope protein 2
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of LEMD2 protein
CTD
PMID:34122009
NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626
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Lep
leptin
affects response to substance increases expression
ISO EXP
LEP protein affects the susceptibility to Clozapine Clozapine results in increased expression of LEP protein
CTD
PMID:16402076 PMID:17502770
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lgals8
galectin 8
increases expression
ISO
Clozapine results in increased expression of LGALS8 protein
CTD
PMID:36482696
NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764
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Lipa
lipase A, lysosomal acid type
increases expression
ISO
Clozapine results in increased expression of LIPA protein
CTD
PMID:34122009
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
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Lmod2
leiomodin 2
increases expression
ISO
Clozapine results in increased expression of LMOD2 protein
CTD
PMID:34122009
NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120
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Lpl
lipoprotein lipase
decreases expression increases expression
ISO
Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein Clozapine results in increased expression of LPL mRNA
CTD
PMID:17266109 PMID:19682446
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Lrp10
LDL receptor related protein 10
increases expression
ISO
Clozapine results in increased expression of LRP10 protein
CTD
PMID:36482696
NCBI chr15:27,921,335...27,927,507
Ensembl chr15:27,920,259...27,927,505
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Lrpprc
leucine-rich pentatricopeptide repeat containing
increases expression
ISO
Clozapine results in increased expression of LRPPRC protein
CTD
PMID:34122009
NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293
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Lrrk2
leucine-rich repeat kinase 2
increases expression
ISO
Clozapine results in increased expression of LRRK2 protein
CTD
PMID:34122009
NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703
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Lss
lanosterol synthase
increases expression multiple interactions
ISO
Clozapine results in increased expression of LSS mRNA [Cuprizone co-treated with Clozapine] results in decreased expression of LSS protein
CTD
PMID:15342952 PMID:17175557 PMID:34122009
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Lta4h
leukotriene A4 hydrolase
decreases expression
ISO
Clozapine results in decreased expression of LTA4H protein
CTD
PMID:34122009
NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
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Magt1
magnesium transporter 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of MAGT1 protein
CTD
PMID:34122009
NCBI chr X:71,038,489...71,079,704
Ensembl chr X:71,038,489...71,079,699
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Mal
mal, T-cell differentiation protein
decreases expression
ISO
Clozapine results in decreased expression of MAL mRNA
CTD
PMID:17266109 PMID:18797397
NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
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Maob
monoamine oxidase B
increases expression
ISO
Clozapine results in increased expression of MAOB mRNA
CTD
PMID:17266109
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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Map1a
microtubule-associated protein 1A
increases expression decreases expression
EXP ISO
Clozapine results in increased expression of MAP1A mRNA Clozapine results in decreased expression of MAP1A protein
CTD
PMID:15860345 PMID:34122009
NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899
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Map1b
microtubule-associated protein 1B
decreases expression
ISO
Clozapine results in decreased expression of MAP1B protein
CTD
PMID:34122009
NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
increases lipidation multiple interactions
ISO
Clozapine results in increased lipidation of MAP1LC3B protein [Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein
CTD
PMID:36482696
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Map1s
microtubule-associated protein 1S
increases expression
ISO
Clozapine results in increased expression of MAP1S protein
CTD
PMID:34122009
NCBI chr16:18,516,759...18,527,777
Ensembl chr16:18,517,574...18,527,988
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Map2k1
mitogen activated protein kinase kinase 1
decreases expression
EXP
Clozapine results in decreased expression of MAP2K1 mRNA
CTD
PMID:15860345
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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Map2k2
mitogen activated protein kinase kinase 2
increases expression decreases expression
ISO EXP
Clozapine results in increased expression of MAP2K2 mRNA Clozapine results in decreased expression of MAP2K2 mRNA
CTD
PMID:14647396 PMID:15860345
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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Map2k5
mitogen activated protein kinase kinase 5
decreases expression
EXP
Clozapine results in decreased expression of MAP2K5 mRNA
CTD
PMID:15860345
NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
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Map3k1
mitogen-activated protein kinase kinase kinase 1
increases expression
EXP
Clozapine results in increased expression of MAP3K1 mRNA
CTD
PMID:15860345
NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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Map3k12
mitogen activated protein kinase kinase kinase 12
increases expression
EXP
Clozapine results in increased expression of MAP3K12 mRNA
CTD
PMID:15860345
NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789
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Mapk1
mitogen activated protein kinase 1
multiple interactions decreases phosphorylation decreases expression
ISO EXP
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein] Clozapine results in decreased phosphorylation of MAPK1 protein Clozapine results in decreased expression of MAPK1 mRNA
CTD
PMID:12871586 PMID:15860345
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk14
mitogen activated protein kinase 14
affects expression
EXP
Clozapine affects the expression of MAPK14 mRNA
CTD
PMID:15860345
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation multiple interactions
ISO
Clozapine results in decreased phosphorylation of MAPK3 protein Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]
CTD
PMID:12871586
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk6
mitogen-activated protein kinase 6
affects expression
EXP
Clozapine affects the expression of MAPK6 mRNA
CTD
PMID:15860345
NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
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Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
increases expression
ISO
Clozapine results in increased expression of MAPK8IP1 mRNA
CTD
PMID:17266109
NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
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Mapk9
mitogen-activated protein kinase 9
affects expression
EXP
Clozapine affects the expression of MAPK9 mRNA
CTD
PMID:15860345
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mapre1
microtubule-associated protein, RP/EB family, member 1
decreases expression multiple interactions
ISO
Clozapine results in decreased expression of MAPRE1 protein [Cuprizone co-treated with Clozapine] results in decreased expression of MAPRE1 protein
CTD
PMID:34122009
NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983
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Mas1
MAS1 proto-oncogene, G protein-coupled receptor
decreases expression
EXP
Clozapine results in decreased expression of MAS1 mRNA
CTD
PMID:16715494
NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
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Mat2a
methionine adenosyltransferase 2A
decreases expression
ISO
Clozapine results in decreased expression of MAT2A protein
CTD
PMID:34122009
NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
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Mat2b
methionine adenosyltransferase 2 non-catalytic beta subunit
decreases expression
ISO
Clozapine results in decreased expression of MAT2B protein
CTD
PMID:34122009
NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777
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Mbp
myelin basic protein
increases expression
ISO
Clozapine results in increased expression of MBP mRNA
CTD
PMID:17266109 PMID:17346280
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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Mc1r
melanocortin 1 receptor
increases expression
ISO
Clozapine results in increased expression of MC1R mRNA
CTD
PMID:17346280
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
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Mdc1
mediator of DNA damage checkpoint 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of MDC1 protein
CTD
PMID:34122009
NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
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Mdh1
malate dehydrogenase 1
decreases expression
ISO
Clozapine results in decreased expression of MDH1 protein
CTD
PMID:34122009
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
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Mfn2
mitofusin 2
decreases expression multiple interactions
EXP
Clozapine results in decreased expression of MFN2 protein PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein]
CTD
PMID:37087062
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Mlkl
mixed lineage kinase domain like pseudokinase
increases expression
ISO
Clozapine results in increased expression of MLKL protein
CTD
PMID:31220554
NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502
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Mmp10
matrix metallopeptidase 10
decreases expression
ISO
Clozapine results in decreased expression of MMP10 mRNA
CTD
PMID:17346280
NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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Mmp14
matrix metallopeptidase 14
increases expression
ISO
Clozapine results in increased expression of MMP14 protein
CTD
PMID:36482696
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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Mmp7
matrix metallopeptidase 7
decreases expression
ISO
Clozapine results in decreased expression of MMP7 mRNA
CTD
PMID:17346280
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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Mobp
myelin-associated oligodendrocyte basic protein
increases expression
ISO
Clozapine results in increased expression of MOBP mRNA
CTD
PMID:15542763 PMID:17266109
NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563
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Mpo
myeloperoxidase
affects response to substance increases oxidation multiple interactions increases activity
ISO
MPO protein affects the susceptibility to Clozapine MPO protein results in increased oxidation of Clozapine Clozapine promotes the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Clozapine promotes the reaction [MPO protein results in increased abundance of Hypochlorous Acid] Clozapine results in increased activity of MPO protein
CTD
PMID:24588327 PMID:35575633
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mpp3
MAGUK p55 scaffold protein 3
decreases expression
ISO
Clozapine results in decreased expression of MPP3 mRNA
CTD
PMID:17266109
NCBI chr10:86,945,705...86,975,261
Ensembl chr10:86,945,714...86,974,737
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Mr1
major histocompatibility complex, class I-related
affects expression
ISO
Clozapine affects the expression of MR1 mRNA
CTD
PMID:25811541
NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
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Mta2
metastasis associated 1 family, member 2
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of MTA2 protein
CTD
PMID:34122009
NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946
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Mtdh
metadherin
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of MTDH protein
CTD
PMID:34122009
NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413
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Mthfr
methylenetetrahydrofolate reductase
affects response to substance
ISO
MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine
CTD
PMID:20547447
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Myadm
myeloid-associated differentiation marker
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of MYADM protein
CTD
PMID:34122009
NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035
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Mybbp1a
MYB binding protein 1a
increases expression
ISO
Clozapine results in increased expression of MYBBP1A protein
CTD
PMID:34122009
NCBI chr10:57,056,897...57,067,258
Ensembl chr10:57,056,874...57,067,255
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Myh10
myosin heavy chain 10
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of MYH10 protein
CTD
PMID:34122009
NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165
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Myh3
myosin heavy chain 3
increases expression
ISO
Clozapine results in increased expression of MYH3 protein
CTD
PMID:34122009
NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
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Myl1
myosin, light chain 1
increases expression
ISO
Clozapine results in increased expression of MYL1 protein
CTD
PMID:34122009
NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
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Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
decreases expression
ISO
Clozapine results in decreased expression of NAA10 protein
CTD
PMID:34122009
NCBI chr X:151,656,056...151,661,304
Ensembl chr X:151,656,056...151,661,252
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Nap1l4
nucleosome assembly protein 1-like 4
increases expression
ISO
Clozapine results in increased expression of NAP1L4 protein
CTD
PMID:34122009
NCBI chr 1:198,709,697...198,746,093
Ensembl chr 1:198,709,701...198,746,020
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Nat10
N-acetyltransferase 10
decreases expression
ISO
Clozapine results in decreased expression of NAT10 protein
CTD
PMID:34122009
NCBI chr 3:90,111,643...90,149,891
Ensembl chr 3:90,111,645...90,149,927
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Ncan
neurocan
decreases expression
ISO
Clozapine results in decreased expression of NCAN mRNA
CTD
PMID:18797397
NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436
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Ncapg
non-SMC condensin I complex, subunit G
increases expression
ISO
Clozapine results in increased expression of NCAPG protein
CTD
PMID:34122009
NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902
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Ncaph
non-SMC condensin I complex, subunit H
decreases expression
ISO
Clozapine results in decreased expression of NCAPH protein
CTD
PMID:34122009 PMID:36482696
NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180
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Ncbp1
nuclear cap binding protein subunit 1
decreases expression
ISO
Clozapine results in decreased expression of NCBP1 protein
CTD
PMID:34122009
NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089
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Ncl
nucleolin
increases expression
ISO
Clozapine results in increased expression of NCL mRNA
CTD
PMID:14647396
NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
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Ncoa4
nuclear receptor coactivator 4
increases expression
ISO
Clozapine results in increased expression of NCOA4 protein
CTD
PMID:36482696
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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Ndufv2
NADH:ubiquinone oxidoreductase core subunit V2
increases expression
EXP
Clozapine results in increased expression of NDUFV2 mRNA
CTD
PMID:19441803
NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
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Nectin2
nectin cell adhesion molecule 2
decreases expression
ISO
Clozapine results in decreased expression of NECTIN2 protein
CTD
PMID:34122009
NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
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Nedd4
NEDD4 E3 ubiquitin protein ligase
decreases expression
ISO
Clozapine results in decreased expression of NEDD4 mRNA
CTD
PMID:18797397
NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
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Nes
nestin
decreases expression
ISO
Clozapine results in decreased expression of NES protein
CTD
PMID:34122009
NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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Nfe2l2
NFE2 like bZIP transcription factor 2
affects response to substance
ISO
NFE2L2 protein affects the susceptibility to Clozapine
CTD
PMID:21540358
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkb1
nuclear factor kappa B subunit 1
decreases expression
EXP
Clozapine results in decreased expression of NFKB1 protein
CTD
PMID:16500086
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Ngfr
nerve growth factor receptor
decreases expression
ISO EXP
Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form Clozapine results in decreased expression of NGFR mRNA
CTD
PMID:12111809 PMID:14598305 PMID:16513140
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Nifk
nucleolar protein interacting with the FHA domain of MKI67
decreases expression
ISO
Clozapine results in decreased expression of NIFK protein
CTD
PMID:34122009
NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896
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Nnmt
nicotinamide N-methyltransferase
increases expression
ISO
Clozapine results in increased expression of NNMT protein
CTD
PMID:34122009
NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
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Nnt
nicotinamide nucleotide transhydrogenase
decreases expression
ISO
Clozapine results in decreased expression of NNT protein
CTD
PMID:34122009
NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
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Noc2l
NOC2-like nucleolar associated transcriptional repressor
increases expression
ISO
Clozapine results in increased expression of NOC2L protein
CTD
PMID:34122009
NCBI chr 5:166,820,150...166,831,949
Ensembl chr 5:166,820,161...166,831,949
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Nomo1
Nodal modulator 1
increases expression
ISO
Clozapine results in increased expression of NOMO3 protein
CTD
PMID:34122009
NCBI chr 1:96,505,460...96,556,280
Ensembl chr 1:96,505,484...96,556,279
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Nop53
NOP53 ribosome biogenesis factor
affects expression
ISO
Clozapine affects the expression of NOP53 mRNA
CTD
PMID:14647396
NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902
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Notch2
notch receptor 2
increases expression
ISO
Clozapine results in increased expression of NOTCH2 protein
CTD
PMID:36482696
NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
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Nploc4
NPL4 homolog, ubiquitin recognition factor
decreases expression
ISO
Clozapine results in decreased expression of NPLOC4 protein
CTD
PMID:34122009
NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913
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Nptn
neuroplastin
increases expression
ISO
Clozapine results in increased expression of NPTN mRNA
CTD
PMID:18797397
NCBI chr 8:58,996,873...59,063,402
Ensembl chr 8:58,996,887...59,063,401
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Nptx2
neuronal pentraxin 2
decreases expression
EXP
Clozapine results in decreased expression of NPTX2 mRNA
CTD
PMID:18208916
NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345
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Npy
neuropeptide Y
decreases expression
EXP
Clozapine results in decreased expression of NPY mRNA
CTD
PMID:16516965
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Nqo2
N-ribosyldihydronicotinamide:quinone dehydrogenase 2
affects response to substance multiple interactions increases reduction
ISO
NQO2 gene SNP affects the susceptibility to Clozapine Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3] NQO2 protein results in increased reduction of Clozapine metabolite
CTD
PMID:14617031 PMID:29281794
NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Clozapine results in increased expression of NR0B2 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]
CTD
PMID:21402137
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions
ISO
Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]
CTD
PMID:16581232
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression decreases expression
EXP
Clozapine results in increased expression of NR4A1 mRNA Clozapine results in decreased expression of NR4A1 mRNA
CTD
PMID:10987852 PMID:11564422 PMID:19695244
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
G
Nr4a2
nuclear receptor subfamily 4, group A, member 2
increases expression
ISO
Clozapine results in increased expression of NR4A2 mRNA
CTD
PMID:17266109
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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Nrg1
neuregulin 1
increases expression affects response to substance affects expression
ISO EXP
Clozapine results in increased expression of NRG1 mRNA NRG1 protein affects the susceptibility to Clozapine Clozapine affects the expression of NRG1 protein
CTD
PMID:15706234 PMID:18184445 PMID:19502011
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
G
Nsf
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
decreases expression
ISO
Clozapine results in decreased expression of NSF protein
CTD
PMID:34122009
NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
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Ntng2
netrin G2
increases expression
EXP
Clozapine results in increased expression of NTNG2 mRNA
CTD
PMID:17507910
NCBI chr 3:12,492,574...12,551,104
Ensembl chr 3:12,492,639...12,545,890
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Nts
neurotensin
increases expression
EXP
Clozapine results in increased expression of NTS mRNA
CTD
PMID:12887421
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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Numa1
nuclear mitotic apparatus protein 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of NUMA1 protein
CTD
PMID:34122009
NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855
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Numbl
NUMB-like, endocytic adaptor protein
decreases expression
ISO
Clozapine results in decreased expression of NUMBL mRNA
CTD
PMID:18797397
NCBI chr 1:82,549,814...82,573,788
Ensembl chr 1:82,550,054...82,573,776
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Nup160
nucleoporin 160
increases expression
ISO
Clozapine results in increased expression of NUP160 protein
CTD
PMID:34122009
NCBI chr 3:76,665,786...76,729,296
Ensembl chr 3:76,665,786...76,724,565
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Nup50
nucleoporin 50
increases expression
ISO
Clozapine results in increased expression of NUP50 protein
CTD
PMID:34122009
NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905
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Nup54
nucleoporin 54
decreases expression
ISO
Clozapine results in decreased expression of NUP54 protein
CTD
PMID:34122009
NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Clozapine results in increased expression of NUPR1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Osbpl8
oxysterol binding protein-like 8
increases expression
ISO
Clozapine results in increased expression of OSBPL8 mRNA
CTD
PMID:14647396
NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888
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Oxt
oxytocin/neurophysin I prepropeptide
affects response to substance
ISO
OXT protein affects the susceptibility to Clozapine
CTD
PMID:20196918
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
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Pakap
paralemmin A kinase anchor protein
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of PALM2AKAP2 protein
CTD
PMID:34122009
NCBI chr 5:72,536,986...72,648,524 NCBI chr 5:72,313,646...72,450,645
Ensembl chr 5:72,181,718...72,648,524
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Pank3
pantothenate kinase 3
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of PANK3 protein
CTD
PMID:34122009
NCBI chr10:20,229,129...20,252,955
Ensembl chr10:20,229,129...20,252,955
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Park7
Parkinsonism associated deglycase
increases expression
ISO
Clozapine results in increased expression of PARK7 mRNA
CTD
PMID:14647396
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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Pcbp1
poly(rC) binding protein 1
increases expression
ISO
Clozapine results in increased expression of PCBP1 protein
CTD
PMID:34122009
NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500
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Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
decreases expression
ISO
Clozapine results in decreased expression of PCK2 protein
CTD
PMID:34122009
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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Pclo
piccolo (presynaptic cytomatrix protein)
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of PCLO protein
CTD
PMID:34122009
NCBI chr 4:19,691,439...20,050,015
Ensembl chr 4:19,695,315...20,049,885
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Pcm1
pericentriolar material 1
decreases expression
ISO
Clozapine results in decreased expression of PCM1 mRNA
CTD
PMID:19048012
NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091
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Pcnp
PEST proteolytic signal containing nuclear protein
increases expression
ISO
Clozapine results in increased expression of PCNP protein
CTD
PMID:34122009
NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348
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Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
affects expression
ISO
Clozapine affects the expression of PCSK1N mRNA
CTD
PMID:14647396
NCBI chr X:14,580,036...14,583,478
Ensembl chr X:14,580,038...14,583,566
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Pdcd11
programmed cell death 11
increases expression
ISO
Clozapine results in increased expression of PDCD11 protein
CTD
PMID:34122009
NCBI chr 1:245,980,840...246,021,999
Ensembl chr 1:245,980,880...246,021,999
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Pde10a
phosphodiesterase 10A
increases expression
ISO EXP
Clozapine results in increased expression of PDE10A mRNA Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein
CTD
PMID:17266109 PMID:18222493
NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
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Pde1b
phosphodiesterase 1B
increases expression
ISO
Clozapine results in increased expression of PDE1B mRNA
CTD
PMID:14647396
NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580
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Pde4a
phosphodiesterase 4A
decreases expression
EXP
Clozapine results in decreased expression of PDE4A protein
CTD
PMID:20222156
NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961
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Pde4b
phosphodiesterase 4B
decreases expression increases expression
EXP
Clozapine results in decreased expression of PDE4B protein Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein
CTD
PMID:18222493 PMID:20222156
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
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Pdia3
protein disulfide isomerase family A, member 3
decreases expression
ISO
Clozapine results in decreased expression of PDIA3 protein
CTD
PMID:34122009
NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
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Pdia4
protein disulfide isomerase family A, member 4
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of PDIA4 protein
CTD
PMID:34122009
NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
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Pdlim5
PDZ and LIM domain 5
decreases expression
ISO
Clozapine results in decreased expression of PDLIM5 protein
CTD
PMID:34122009
NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
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Pebp1
phosphatidylethanolamine binding protein 1
decreases expression
ISO
Clozapine results in decreased expression of PEBP1 protein
CTD
PMID:34122009
NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
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Penk
proenkephalin
decreases expression increases expression
EXP
Clozapine results in decreased expression of PENK mRNA Clozapine results in increased expression of PENK mRNA
CTD
PMID:1635659 PMID:12887421
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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Pfdn5
prefoldin subunit 5
increases expression
ISO
Clozapine results in increased expression of PFDN5 mRNA
CTD
PMID:14647396
NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
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Pfkp
phosphofructokinase, platelet
increases expression
EXP
Clozapine results in increased expression of PFKP mRNA
CTD
PMID:15860345
NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018
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Pgam5
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
decreases expression
ISO
Clozapine results in decreased expression of PGAM5 protein
CTD
PMID:34122009
NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420
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Pgk1
phosphoglycerate kinase 1
increases expression
EXP
Clozapine results in increased expression of PGK1 mRNA
CTD
PMID:15860345
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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Pgrmc1
progesterone receptor membrane component 1
multiple interactions
EXP
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]; PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein]
CTD
PMID:37087062
NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682
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Phactr1
phosphatase and actin regulator 1
increases expression
ISO
Clozapine results in increased expression of PHACTR1 mRNA
CTD
PMID:14647396
NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831
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Phf14
PHD finger protein 14
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of PHF14 protein
CTD
PMID:34122009
NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
decreases expression
EXP
Clozapine results in decreased expression of PIK3R3 mRNA
CTD
PMID:16715494
NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
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Pitpnb
phosphatidylinositol transfer protein, beta
increases expression
ISO
Clozapine results in increased expression of PITPNB protein
CTD
PMID:34122009
NCBI chr12:45,249,308...45,298,388
Ensembl chr12:45,249,333...45,298,314
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Pkib
cAMP-dependent protein kinase inhibitor beta
decreases expression
EXP
Clozapine results in decreased expression of PKIB mRNA
CTD
PMID:15860345
NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187
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Pkm
pyruvate kinase M1/2
increases expression
EXP
Clozapine results in increased expression of PKM mRNA
CTD
PMID:15860345
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Plcb1
phospholipase C beta 1
increases expression
ISO
Clozapine results in increased expression of PLCB1 mRNA
CTD
PMID:16465460
NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
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Plp1
proteolipid protein 1
decreases expression increases expression
ISO
Clozapine results in decreased expression of PLP1 mRNA Clozapine results in increased expression of PLP1 mRNA
CTD
PMID:17266109 PMID:18797397
NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032
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Pls3
plastin 3
decreases expression
ISO
Clozapine results in decreased expression of PLS3 protein
CTD
PMID:34122009
NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891
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Pnma1
PNMA family member 1
increases expression
ISO
Clozapine results in increased expression of PNMA1 protein
CTD
PMID:34122009
NCBI chr 6:103,782,244...103,784,029
Ensembl chr 6:103,773,889...103,784,567
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Pon3
paraoxonase 3
increases expression
ISO
Clozapine results in increased expression of PON3 protein
CTD
PMID:34122009
NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
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Ppa1
inorganic pyrophosphatase 1
increases expression
ISO
Clozapine results in increased expression of PPA1 protein
CTD
PMID:34122009
NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions increases expression
ISO
Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein] Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein
CTD
PMID:20564506
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppm1a
protein phosphatase, Mg2+/Mn2+ dependent, 1A
decreases expression
EXP
Clozapine results in decreased expression of PPM1A mRNA
CTD
PMID:15860345
NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697
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Ppm1b
protein phosphatase, Mg2+/Mn2+ dependent, 1B
decreases expression
EXP
Clozapine results in decreased expression of PPM1B mRNA
CTD
PMID:15860345
NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974
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Ppp1cb
protein phosphatase 1 catalytic subunit beta
decreases expression
EXP
Clozapine results in decreased expression of PPP1CB mRNA
CTD
PMID:15860345
NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
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Ppp1cc
protein phosphatase 1 catalytic subunit gamma
decreases expression
EXP
Clozapine results in decreased expression of PPP1CC mRNA
CTD
PMID:15860345
NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553
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Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
decreases expression
ISO
Clozapine results in decreased expression of PPP1R14B protein
CTD
PMID:34122009
NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319
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Ppp1r1a
protein phosphatase 1, regulatory (inhibitor) subunit 1A
decreases expression
EXP
Clozapine results in decreased expression of PPP1R1A mRNA
CTD
PMID:15860345
NCBI chr 7:134,654,578...134,662,236
Ensembl chr 7:134,654,579...134,662,230
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Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
multiple interactions increases phosphorylation
ISO
Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] Clozapine results in increased phosphorylation of PPP1R1B protein
CTD
PMID:11880652 PMID:12871586
NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
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Ppp1r2
protein phosphatase 1, regulatory (inhibitor) subunit 2
decreases expression
EXP
Clozapine results in decreased expression of PPP1R2 mRNA
CTD
PMID:15860345
NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463
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Ppp1r9b
protein phosphatase 1, regulatory subunit 9B
increases expression
EXP
Clozapine results in increased expression of PPP1R9B protein
CTD
PMID:16844384
NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083
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Ppp2ca
protein phosphatase 2 catalytic subunit alpha
decreases expression
EXP
Clozapine results in decreased expression of PPP2CA mRNA
CTD
PMID:15860345
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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Ppp2cb
protein phosphatase 2 catalytic subunit beta
decreases expression
EXP
Clozapine results in decreased expression of PPP2CB mRNA
CTD
PMID:15860345
NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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Ppp2r1a
protein phosphatase 2 scaffold subunit A alpha
increases expression
EXP
Clozapine results in increased expression of PPP2R1A mRNA
CTD
PMID:15860345
NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
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Ppp2r2a
protein phosphatase 2, regulatory subunit B, alpha
decreases expression
EXP
Clozapine results in decreased expression of PPP2R2A mRNA
CTD
PMID:15860345
NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924
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Ppp3ca
protein phosphatase 3 catalytic subunit alpha
multiple interactions decreases expression increases expression
EXP
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein Clozapine results in decreased expression of PPP3CA mRNA; Clozapine results in decreased expression of PPP3CA protein Clozapine results in increased expression of PPP3CA mRNA
CTD
PMID:12437575 PMID:16033416
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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Ppp4r2
protein phosphatase 4, regulatory subunit 2
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of PPP4R2 protein
CTD
PMID:34122009
NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486
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Ppp5c
protein phosphatase 5, catalytic subunit
affects expression
ISO
Clozapine affects the expression of PPP5C mRNA
CTD
PMID:14647396
NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
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Prdx1
peroxiredoxin 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of PRDX1 protein
CTD
PMID:34122009
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
increases expression
EXP
Clozapine results in increased expression of PRKACA mRNA
CTD
PMID:15860345
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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Prkacb
protein kinase cAMP-activated catalytic subunit beta
decreases expression increases expression
EXP
Clozapine results in decreased expression of PRKACB mRNA; Clozapine results in decreased expression of PRKACB protein Clozapine results in increased expression of PRKACB mRNA
CTD
PMID:11907174 PMID:15860345
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
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Prkar2a
protein kinase cAMP-dependent type II regulatory subunit alpha
multiple interactions decreases expression
EXP ISO
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein] Clozapine results in decreased expression of PRKAR2A mRNA; Clozapine results in decreased expression of PRKAR2A protein [Cuprizone co-treated with Clozapine] results in decreased expression of PRKAR2A protein
CTD
PMID:11907174 PMID:34122009
NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628
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Prkar2b
protein kinase cAMP-dependent type II regulatory subunit beta
decreases expression multiple interactions
EXP
Clozapine results in decreased expression of PRKAR2B mRNA; Clozapine results in decreased expression of PRKAR2B protein Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]
CTD
PMID:11907174 PMID:15860345
NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
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Prkcb
protein kinase C, beta
affects expression increases expression
EXP
Clozapine affects the expression of PRKCB protein Clozapine results in increased expression of PRKCB mRNA
CTD
PMID:15860345 PMID:15967061
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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Prkce
protein kinase C, epsilon
increases expression
EXP
Clozapine results in increased expression of PRKCE mRNA
CTD
PMID:15860345
NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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Prkcz
protein kinase C, zeta
increases expression
EXP
Clozapine results in increased expression of PRKCZ mRNA
CTD
PMID:15860345
NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
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Prl
prolactin
increases secretion multiple interactions increases expression
ISO EXP
Clozapine results in increased secretion of PRL protein [Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein; [Risperidone co-treated with Clozapine] results in increased expression of PRL protein Clozapine analog results in increased expression of PRL protein
CTD
PMID:11155212 PMID:11997696 PMID:15286066 PMID:18562423
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Prmt1
protein arginine methyltransferase 1
decreases expression
ISO
Clozapine results in decreased expression of PRMT1 protein
CTD
PMID:34122009
NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
increases expression
ISO
Clozapine results in increased expression of PROC protein
CTD
PMID:20126316
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Prpf38b
pre-mRNA processing factor 38B
decreases expression
ISO
Clozapine results in decreased expression of PRPF38B mRNA
CTD
PMID:14647396
NCBI chr 2:196,553,224...196,562,271
Ensembl chr 2:196,553,225...196,562,250
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Prpf6
pre-mRNA processing factor 6
decreases expression multiple interactions
ISO
Clozapine results in decreased expression of PRPF6 protein [Cuprizone co-treated with Clozapine] results in decreased expression of PRPF6 protein
CTD
PMID:34122009
NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991
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Prrc2a
proline-rich coiled-coil 2A
decreases expression
ISO
Clozapine results in decreased expression of PRRC2A mRNA
CTD
PMID:18797397
NCBI chr20:3,658,391...3,674,143
Ensembl chr20:3,658,695...3,674,130
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Psmb5
proteasome 20S subunit beta 5
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of PSMB5 protein
CTD
PMID:34122009
NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
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Psmb7
proteasome 20S subunit beta 7
decreases expression
ISO
Clozapine results in decreased expression of PSMB7 protein
CTD
PMID:34122009
NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937
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Psmc3
proteasome 26S subunit, ATPase 3
increases expression
ISO
Clozapine results in increased expression of PSMC3 protein
CTD
PMID:34122009
NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358
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Psmc5
proteasome 26S subunit, ATPase 5
increases expression
ISO
Clozapine results in increased expression of PSMC5 protein
CTD
PMID:34122009
NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
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Psmd14
proteasome 26S subunit, non-ATPase 14
increases expression
ISO
Clozapine results in increased expression of PSMD14 protein
CTD
PMID:34122009
NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
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Psmd7
proteasome 26S subunit, non-ATPase 7
increases expression
ISO
Clozapine results in increased expression of PSMD7 protein
CTD
PMID:34122009
NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588
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Ptcd3
Pentatricopeptide repeat domain 3
increases expression
ISO
Clozapine results in increased expression of PTCD3 protein
CTD
PMID:34122009
NCBI chr 4:103,922,440...103,957,445
Ensembl chr 4:103,920,566...103,957,538
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Ptgds
prostaglandin D2 synthase
decreases expression increases expression
ISO
Clozapine results in decreased expression of PTGDS mRNA Clozapine results in increased expression of PTGDS mRNA
CTD
PMID:15542763 PMID:17266109
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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Ptk2
protein tyrosine kinase 2
increases expression
ISO
Clozapine results in increased expression of PTK2 protein
CTD
PMID:34122009
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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Ptma
prothymosin alpha
increases expression
ISO
Clozapine results in increased expression of PTMA protein
CTD
PMID:34122009
NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
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Ptms
parathymosin
increases expression
ISO
Clozapine results in increased expression of PTMS mRNA
CTD
PMID:14647396
NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009
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Pvalb
parvalbumin
multiple interactions
EXP
Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA]
CTD
PMID:12589379
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
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Pwp2
PWP2, small subunit processome component
increases expression
ISO
Clozapine results in increased expression of PWP2 protein
CTD
PMID:34122009
NCBI chr20:10,499,332...10,512,965
Ensembl chr20:10,499,363...10,513,640
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Pycr1
pyrroline-5-carboxylate reductase 1
increases expression
ISO
Clozapine results in increased expression of PYCR1 protein
CTD
PMID:34122009
NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549
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Qdpr
quinoid dihydropteridine reductase
decreases expression
ISO
Clozapine results in decreased expression of QDPR protein
CTD
PMID:34122009
NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854
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Rab12
RAB12, member RAS oncogene family
decreases expression
EXP
Clozapine results in decreased expression of RAB12 mRNA
CTD
PMID:12437575
NCBI chr 9:106,480,301...106,506,895
Ensembl chr 9:106,480,301...106,506,910
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Rac1
Rac family small GTPase 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of RAC1 protein
CTD
PMID:34122009
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Rack1
receptor for activated C kinase 1
decreases expression
ISO
Clozapine results in decreased expression of RACK1 protein
CTD
PMID:34122009
NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
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Ralyl
RALY RNA binding protein-like
increases expression
ISO
Clozapine results in increased expression of RALYL protein
CTD
PMID:34122009
NCBI chr 2:87,482,747...88,274,329
Ensembl chr 2:87,482,755...88,274,452
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Ran
RAN, member RAS oncogene family
decreases expression
ISO
Clozapine results in decreased expression of RAN protein
CTD
PMID:34122009
NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
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Rap1gds1
Rap1 GTPase-GDP dissociation stimulator 1
increases expression
ISO
Clozapine results in increased expression of RAP1GDS1 protein
CTD
PMID:34122009
NCBI chr 2:227,500,366...227,645,213
Ensembl chr 2:227,500,367...227,645,169
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Rapgef4
Rap guanine nucleotide exchange factor 4
decreases expression
ISO
Clozapine results in decreased expression of RAPGEF4 mRNA
CTD
PMID:18797397
NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
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Rasgrf1
RAS protein-specific guanine nucleotide-releasing factor 1
affects expression
EXP
Clozapine affects the expression of RASGRF1 mRNA
CTD
PMID:12437575
NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269
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Rbbp4
RB binding protein 4, chromatin remodeling factor
decreases expression
ISO
Clozapine results in decreased expression of RBBP4 protein
CTD
PMID:34122009
NCBI chr 5:141,655,863...141,675,157
Ensembl chr 5:141,638,421...141,675,284
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Rela
RELA proto-oncogene, NF-kB subunit
decreases expression
EXP
Clozapine results in decreased expression of RELA protein
CTD
PMID:16500086
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Reln
reelin
decreases expression decreases methylation multiple interactions
ISO EXP
Clozapine results in decreased expression of RELN mRNA Clozapine results in decreased methylation of RELN promoter Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter] Clozapine results in decreased expression of RELN protein
CTD
PMID:17266109 PMID:18757738 PMID:19359144
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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Rfc5
replication factor C subunit 5
increases expression
ISO
Clozapine results in increased expression of RFC5 protein
CTD
PMID:34122009
NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
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Rgs4
regulator of G-protein signaling 4
increases expression
EXP ISO
Clozapine results in increased expression of RGS4 mRNA
CTD
PMID:15860345 PMID:17266109
NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
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Rgs7
regulator of G-protein signaling 7
multiple interactions increases expression
EXP
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein] Clozapine results in increased expression of RGS7 mRNA
CTD
PMID:18976543
NCBI chr13:86,979,269...87,408,834
Ensembl chr13:86,979,279...87,408,888
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Rgs8
regulator of G-protein signaling 8
increases expression
EXP
Clozapine results in increased expression of RGS8 mRNA
CTD
PMID:15860345
NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807
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Rhob
ras homolog family member B
increases expression
ISO
Clozapine results in increased expression of RHOB protein
CTD
PMID:36482696
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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Ric8a
RIC8 guanine nucleotide exchange factor A
decreases expression
ISO
Clozapine results in decreased expression of RIC8A protein
CTD
PMID:34122009
NCBI chr 1:195,935,162...195,941,469
Ensembl chr 1:195,935,349...195,941,467
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Rnf13
ring finger protein 13
increases expression
ISO
Clozapine results in increased expression of RNF13 protein
CTD
PMID:36482696
NCBI chr 2:141,927,887...142,061,801
Ensembl chr 2:141,927,909...142,061,801
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Rnf20
ring finger protein 20
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of RNF20 protein
CTD
PMID:34122009
NCBI chr 5:63,976,063...64,001,754
Ensembl chr 5:63,976,045...64,001,754
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Rorb
RAR-related orphan receptor B
decreases expression
EXP
Clozapine results in decreased expression of RORB mRNA
CTD
PMID:11564422
NCBI chr 1:216,363,629...216,544,390
Ensembl chr 1:216,363,629...216,544,390
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Rpa1
replication protein A1
decreases expression
ISO
Clozapine results in decreased expression of RPA1 protein
CTD
PMID:34122009
NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949
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Rpl11
ribosomal protein L11
increases expression
ISO
Clozapine results in increased expression of RPL11 protein
CTD
PMID:34122009
NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599
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Rpl19
ribosomal protein L19
increases expression
ISO
Clozapine results in increased expression of RPL19 protein
CTD
PMID:34122009
NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112
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Rpl30
ribosomal protein L30
increases expression
ISO
Clozapine results in increased expression of RPL30 protein
CTD
PMID:34122009
NCBI chr 7:65,648,266...65,651,401
Ensembl chr 7:65,645,991...65,651,363 Ensembl chr10:65,645,991...65,651,363 Ensembl chr10:65,645,991...65,651,363
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Rpl5
ribosomal protein L5
increases expression
ISO
Clozapine results in increased expression of RPL5 protein
CTD
PMID:34122009
NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290
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Rplp0l1
ribosomal protein lateral stalk subunit P0 like 1
decreases expression
ISO
Clozapine results in decreased expression of RPLP0P6 protein
CTD
PMID:34122009
NCBI chr 2:191,921,503...191,922,661
Ensembl chr 2:191,921,574...191,922,646
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Rplp2
ribosomal protein lateral stalk subunit P2
increases expression
ISO
Clozapine results in increased expression of RPLP2 mRNA
CTD
PMID:14647396
NCBI chr 1:196,546,086...196,548,636
Ensembl chr 1:196,546,352...196,548,645
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Rpn2
ribophorin II
decreases expression
ISO
Clozapine results in decreased expression of RPN2 protein
CTD
PMID:34122009
NCBI chr 3:145,941,787...145,989,271
Ensembl chr 3:145,941,839...145,989,543
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Rps10
ribosomal protein S10
increases expression
ISO
Clozapine results in increased expression of RPS10 mRNA
CTD
PMID:14647396
NCBI chr20:5,694,313...5,698,922
Ensembl chr20:5,694,313...5,699,044 Ensembl chr 6:5,694,313...5,699,044
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Rps11
ribosomal protein S11
decreases expression
ISO
Clozapine results in decreased expression of RPS11 protein
CTD
PMID:34122009
NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:95,605,692...95,607,874
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Rps3
ribosomal protein S3
decreases expression
ISO
Clozapine results in decreased expression of RPS3 protein
CTD
PMID:34122009
NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
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Rrbp1
ribosome binding protein 1
decreases expression
ISO
Clozapine results in decreased expression of RRBP1 protein
CTD
PMID:34122009
NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981
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Rsf1
remodeling and spacing factor 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of RSF1 protein
CTD
PMID:34122009
NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051
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Rspry1
ring finger and SPRY domain containing 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of RSPRY1 protein
CTD
PMID:34122009
NCBI chr19:10,352,449...10,403,015
Ensembl chr19:10,353,821...10,401,102
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RT1-A2
RT1 class Ia, locus A2
increases expression
ISO
Clozapine results in increased expression of HLA-E protein
CTD
PMID:36482696
NCBI chr20:4,870,939...4,910,183
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Rtcb
RNA 2',3'-cyclic phosphate and 5'-OH ligase
increases expression
ISO
Clozapine results in increased expression of RTCB protein
CTD
PMID:34122009
NCBI chr 7:17,907,668...17,927,136
Ensembl chr 7:17,907,705...17,927,132
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Rtn4
reticulon 4
increases expression
ISO
Clozapine results in increased expression of RTN4 mRNA
CTD
PMID:17266109
NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686
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Rxrg
retinoid X receptor gamma
decreases expression
EXP
Clozapine results in decreased expression of RXRG mRNA alternative form
CTD
PMID:11564422
NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
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S100a9
S100 calcium binding protein A9
decreases expression
ISO
Clozapine results in decreased expression of S100A9 mRNA
CTD
PMID:18797397
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Safb
scaffold attachment factor B
increases expression
ISO
Clozapine results in increased expression of SAFB protein
CTD
PMID:34122009
NCBI chr 9:1,417,449...1,438,408
Ensembl chr 9:1,417,525...1,438,644
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Sars1
seryl-tRNA synthetase 1
decreases expression
ISO
Clozapine results in decreased expression of SARS1 protein
CTD
PMID:34122009
NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
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Satb2
SATB homeobox 2
increases expression
ISO
Clozapine results in increased expression of SATB2 protein
CTD
PMID:34122009
NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707
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Sc5d
sterol-C5-desaturase
increases expression
ISO
Clozapine results in increased expression of SC5D mRNA
CTD
PMID:17052361
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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Scd
stearoyl-CoA desaturase
increases expression
ISO
Clozapine results in increased expression of SCD mRNA
CTD
PMID:16027736 PMID:17052361
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Sdcbp
syndecan binding protein
decreases expression increases expression
ISO
Clozapine results in decreased expression of SDCBP protein Clozapine results in increased expression of SDCBP protein
CTD
PMID:34122009 PMID:36482696
NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572
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Sec31a
SEC31 homolog A, COPII coat complex component
increases expression
ISO
Clozapine results in increased expression of SEC31A protein
CTD
PMID:34122009
NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273
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Sec61b
SEC61 translocon subunit beta
increases expression
ISO
Clozapine results in increased expression of SEC61B protein
CTD
PMID:34122009
NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804
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Sec63
SEC63 homolog, protein translocation regulator
increases expression
ISO
Clozapine results in increased expression of SEC63 protein
CTD
PMID:34122009
NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055
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Septin14
septin 14
decreases expression
ISO
Clozapine results in decreased expression of SEPTIN14 protein
CTD
PMID:34122009
NCBI chr12:26,975,283...27,005,588
Ensembl chr12:26,975,344...26,998,299
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Serinc1
serine incorporator 1
increases expression
ISO
Clozapine results in increased expression of SERINC1 protein
CTD
PMID:36482696
NCBI chr20:36,850,062...36,868,999
Ensembl chr20:36,850,076...36,896,691
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Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
increases expression
ISO
Clozapine results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Serpine2
serpin family E member 2
increases expression
EXP
Clozapine results in increased expression of SERPINE2 mRNA; Clozapine results in increased expression of SERPINE2 protein
CTD
PMID:15354176
NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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Set
Set nuclear proto-oncogene
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of SET protein
CTD
PMID:34122009
NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567
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Setx
senataxin
increases expression
ISO
Clozapine results in increased expression of SETX protein
CTD
PMID:34122009
NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803
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Sf3b3
splicing factor 3b, subunit 3
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of SF3B3 protein
CTD
PMID:34122009
NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245
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Sfpq
splicing factor proline and glutamine rich
decreases expression
ISO
Clozapine results in decreased expression of SFPQ protein
CTD
PMID:34122009
NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
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Sfxn1
sideroflexin 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of SFXN1 protein
CTD
PMID:34122009
NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
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Sgk1
serum/glucocorticoid regulated kinase 1
increases expression
ISO EXP
Clozapine results in increased expression of SGK1 mRNA
CTD
PMID:17266109 PMID:18208916
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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Sh3gl1
SH3 domain containing GRB2 like 1, endophilin A2
increases expression
ISO
Clozapine results in increased expression of SH3GL1 protein
CTD
PMID:34122009
NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716
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Sh3kbp1
SH3 domain-containing kinase-binding protein 1
increases expression
ISO
Clozapine results in increased expression of SH3KBP1 protein
CTD
PMID:34122009
NCBI chr X:34,877,862...35,223,013
Ensembl chr X:34,877,866...35,222,747
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Sh3pxd2b
SH3 and PX domains 2B
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of SH3PXD2B protein
CTD
PMID:34122009
NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170
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Sim2
SIM bHLH transcription factor 2
decreases expression
ISO
Clozapine results in decreased expression of SIM2 protein
CTD
PMID:34122009
NCBI chr11:33,414,218...33,453,663
Ensembl chr11:33,414,218...33,453,663
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Sirt2
sirtuin 2
increases expression
ISO
Clozapine results in increased expression of SIRT2 protein
CTD
PMID:36482696
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
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Skp1
S-phase kinase-associated protein 1
decreases expression
ISO
Clozapine results in decreased expression of SKP1 protein
CTD
PMID:34122009
NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388
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Slc17a6
solute carrier family 17 member 6
increases expression
ISO
Clozapine results in increased expression of SLC17A6 mRNA; Clozapine results in increased expression of SLC17A6 protein
CTD
PMID:17266109 PMID:18155072
NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542
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Slc17a7
solute carrier family 17 member 7
increases expression
ISO
Clozapine results in increased expression of SLC17A7 mRNA; Clozapine results in increased expression of SLC17A7 protein
CTD
PMID:16111724
NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
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Slc18a2
solute carrier family 18 member A2
increases expression
EXP
Clozapine results in increased expression of SLC18A2 mRNA; Clozapine results in increased expression of SLC18A2 protein
CTD
PMID:12007678
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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Slc1a1
solute carrier family 1 member 1
decreases expression
EXP
Clozapine results in decreased expression of SLC1A1 mRNA
CTD
PMID:12873733
NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
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Slc1a2
solute carrier family 1 member 2
decreases activity decreases expression
EXP
Clozapine results in decreased activity of SLC1A2 protein Clozapine results in decreased expression of SLC1A2 mRNA; Clozapine results in decreased expression of SLC1A2 protein
CTD
PMID:11443521 PMID:12873733
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Clozapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a5
solute carrier family 22 member 5
multiple interactions
ISO
Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
CTD
PMID:30465787
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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Slc25a13
solute carrier family 25 member 13
increases expression
ISO
Clozapine results in increased expression of SLC25A13 protein
CTD
PMID:34122009
NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902
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Slc25a24
solute carrier family 25 member 24
increases expression
ISO
Clozapine results in increased expression of SLC25A24 protein
CTD
PMID:34122009
NCBI chr 2:196,761,076...196,799,236
Ensembl chr 2:196,761,274...196,799,231
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Slc25a6
solute carrier family 25 member 6
increases expression
ISO
Clozapine results in increased expression of SLC25A6 protein
CTD
PMID:34122009
NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199
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Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
Clozapine results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Slc39a7
solute carrier family 39 member 7
increases expression
ISO
Clozapine results in increased expression of SLC39A7 mRNA
CTD
PMID:14647396
NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537
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Slc3a2
solute carrier family 3 member 2
increases expression
ISO
Clozapine results in increased expression of SLC3A2 protein
CTD
PMID:36482696
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc6a2
solute carrier family 6 member 2
decreases expression
EXP
Clozapine results in decreased expression of SLC6A2 mRNA
CTD
PMID:18923069
NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
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Slc6a3
solute carrier family 6 member 3
affects response to substance
ISO
SLC6A3 5' UTR affects the susceptibility to Clozapine
CTD
PMID:20580759
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Slc6a4
solute carrier family 6 member 4
multiple interactions affects response to substance increases expression
ISO EXP
[SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine SLC6A4 protein affects the susceptibility to Clozapine Clozapine results in increased expression of SLC6A4
CTD
PMID:12007678 PMID:20452607
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Smarcb1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
decreases expression
ISO
Clozapine results in decreased expression of SMARCB1 protein
CTD
PMID:34122009
NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
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Smarcc2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of SMARCC2 protein
CTD
PMID:34122009
NCBI chr 7:881,844...910,090
Ensembl chr 7:881,421...909,978
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Smc2
structural maintenance of chromosomes 2
decreases expression
ISO
Clozapine results in decreased expression of SMC2 protein
CTD
PMID:34122009
NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242
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Smc3
structural maintenance of chromosomes 3
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of SMC3 protein
CTD
PMID:34122009
NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
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Snap25
synaptosome associated protein 25
increases expression affects response to substance
EXP ISO
Clozapine results in increased expression of SNAP25 mRNA SNAP25 gene SNP affects the susceptibility to Clozapine
CTD
PMID:15823421 PMID:15860345
NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
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Snrnp200
small nuclear ribonucleoprotein U5 subunit 200
increases expression
ISO
Clozapine results in increased expression of SNRNP200 protein
CTD
PMID:34122009
NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182
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Snrpb
small nuclear ribonucleoprotein polypeptides B and B1
increases expression
ISO
Clozapine results in increased expression of SNRPB protein
CTD
PMID:34122009
NCBI chr 3:117,369,816...117,379,344
Ensembl chr 3:117,370,100...117,379,339
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Snrpd2
small nuclear ribonucleoprotein D2 polypeptide
increases expression
ISO
Clozapine results in increased expression of SNRPD2 mRNA
CTD
PMID:14647396
NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351
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Snx1
sorting nexin 1
decreases expression
ISO
Clozapine results in decreased expression of SNX1 protein
CTD
PMID:34122009
NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360
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Snx6
sorting nexin 6
increases expression
ISO
Clozapine results in increased expression of SNX6 protein
CTD
PMID:34122009
NCBI chr 6:72,230,950...72,274,157
Ensembl chr 6:72,229,870...72,315,911
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Sod1
superoxide dismutase 1
increases expression multiple interactions decreases expression
EXP ISO
Clozapine results in increased expression of SOD1 mRNA Clozapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein] Clozapine results in decreased expression of SOD1 protein
CTD
PMID:12111809 PMID:12752374 PMID:16564057 PMID:34122009
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
decreases expression
EXP
Clozapine results in decreased expression of SOD2 mRNA
CTD
PMID:15860345
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sod3
superoxide dismutase 3
increases expression
EXP
Clozapine results in increased expression of SOD3 mRNA
CTD
PMID:15860345
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
decreases expression increases expression
EXP
Clozapine results in decreased expression of SOS1 mRNA Clozapine results in increased expression of SOS1 mRNA
CTD
PMID:12437575
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
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Spp1
secreted phosphoprotein 1
decreases expression
ISO
Clozapine results in decreased expression of SPP1 mRNA
CTD
PMID:17346280
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Sptlc1
serine palmitoyltransferase, long chain base subunit 1
decreases expression
ISO
Clozapine results in decreased expression of SPTLC1 protein
CTD
PMID:34122009
NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295
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Sqstm1
sequestosome 1
increases expression
ISO
Clozapine results in increased expression of SQSTM1 protein
CTD
PMID:36482696
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Srebf1
sterol regulatory element binding transcription factor 1
increases expression multiple interactions
ISO
Clozapine results in increased expression of SREBF1 mRNA Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein] Clozapine results in increased expression of SREBF1 mRNA; Clozapine results in increased expression of SREBF1 protein
CTD
PMID:17052361 PMID:19682446 PMID:20564506
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions increases expression
ISO
Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]; Clozapine results in increased cleavage of and results in increased activity of SREBF2 protein Clozapine results in increased expression of SREBF2 mRNA
CTD
PMID:17052361
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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Srrm2
serine/arginine repetitive matrix 2
decreases expression
ISO
Clozapine results in decreased expression of SRRM2 protein
CTD
PMID:34122009
NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751
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Srsf2
serine and arginine rich splicing factor 2
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of SRSF2 protein
CTD
PMID:34122009
NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
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Srsf5
serine and arginine rich splicing factor 5
multiple interactions increases expression
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of SRSF5 protein Clozapine results in increased expression of SRSF5 protein
CTD
PMID:34122009
NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
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Srsf7
serine and arginine rich splicing factor 7
decreases expression
ISO
Clozapine results in decreased expression of SRSF7 protein
CTD
PMID:34122009
NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965
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Ssr3
signal sequence receptor subunit 3
decreases expression
ISO
Clozapine results in decreased expression of SSR3 protein
CTD
PMID:34122009
NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132
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Sst
somatostatin
multiple interactions
EXP
Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]
CTD
PMID:16567023
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
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Stim1
stromal interaction molecule 1
decreases expression
ISO
Clozapine results in decreased expression of STIM1 protein
CTD
PMID:34122009
NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363
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Stip1
stress-induced phosphoprotein 1
decreases expression
ISO
Clozapine results in decreased expression of STIP1 protein
CTD
PMID:34122009
NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476
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Strap
serine/threonine kinase receptor associated protein
decreases expression
ISO
Clozapine results in decreased expression of STRAP protein
CTD
PMID:34122009
NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828
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Strn4
striatin 4
increases expression
ISO
Clozapine results in increased expression of STRN4 mRNA
CTD
PMID:14647396
NCBI chr 1:77,482,267...77,511,862
Ensembl chr 1:77,482,094...77,511,858
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Stx1a
syntaxin 1A
increases expression
EXP
Clozapine results in increased expression of STX1A mRNA
CTD
PMID:15860345
NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
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Stx1b
syntaxin 1B
increases expression
EXP
Clozapine results in increased expression of STX1B mRNA
CTD
PMID:15860345
NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280
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Stx4
syntaxin 4
increases expression
EXP
Clozapine results in increased expression of STX4 mRNA
CTD
PMID:15860345
NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979
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Stx8
syntaxin 8
affects expression
EXP
Clozapine affects the expression of STX8 mRNA
CTD
PMID:15860345
NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993
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Stxbp1
syntaxin binding protein 1
affects expression
EXP
Clozapine affects the expression of STXBP1 mRNA
CTD
PMID:12437575
NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
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Sucla2
succinate-CoA ligase ADP-forming subunit beta
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of SUCLA2 protein
CTD
PMID:34122009
NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138
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Suclg1
succinate-CoA ligase GDP/ADP-forming subunit alpha
decreases expression
ISO
Clozapine results in decreased expression of SUCLG1 protein
CTD
PMID:34122009
NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
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Supt3h
SPT3 homolog, SAGA and STAGA complex component
increases expression
EXP
Clozapine results in increased expression of SUPT3H mRNA
CTD
PMID:16715494
NCBI chr 9:15,878,296...16,206,768
Ensembl chr 9:15,868,287...16,206,706
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Syn2
synapsin II
decreases expression increases expression
ISO EXP
Clozapine results in decreased expression of SYN2 mRNA Clozapine results in increased expression of SYN2 mRNA
CTD
PMID:15860345 PMID:17266109
NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
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Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
decreases expression
ISO
Clozapine results in decreased expression of SYNCRIP protein
CTD
PMID:34122009
NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
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Syt11
synaptotagmin 11
increases expression
EXP
Clozapine results in increased expression of SYT11 mRNA
CTD
PMID:15860345
NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
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Syt2
synaptotagmin 2
increases expression
ISO
Clozapine results in increased expression of SYT2 mRNA
CTD
PMID:17266109
NCBI chr13:46,088,046...46,197,976
Ensembl chr13:46,185,282...46,193,859
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Syt4
synaptotagmin 4
increases expression
EXP
Clozapine results in increased expression of SYT4 mRNA
CTD
PMID:15860345
NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332
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Syt5
synaptotagmin 5
decreases expression
EXP
Clozapine results in decreased expression of SYT5 mRNA
CTD
PMID:12437575
NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
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Tac1
tachykinin, precursor 1
decreases expression
ISO EXP
Clozapine results in decreased expression of TAC1 mRNA
CTD
PMID:10974607 PMID:17266109
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tagln
transgelin
decreases expression
ISO
Clozapine results in decreased expression of TAGLN mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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Tagln2
transgelin 2
decreases expression
ISO
Clozapine results in decreased expression of TAGLN2 protein
CTD
PMID:34122009
NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972
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Taok2
TAO kinase 2
increases expression
ISO
Clozapine results in increased expression of TAOK2 protein
CTD
PMID:34122009
NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
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Tatdn1
TatD DNase domain containing 1
increases expression
ISO
Clozapine results in increased expression of TATDN1 mRNA
CTD
PMID:14647396
NCBI chr 7:90,449,979...90,481,000
Ensembl chr 7:90,441,079...90,481,133
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Tbc1d15
TBC1 domain family, member 15
increases expression
ISO
Clozapine results in increased expression of TBC1D15 protein
CTD
PMID:36482696
NCBI chr 7:50,804,553...50,860,272
Ensembl chr 7:50,804,012...50,860,175
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Tbc1d8b
TBC1 domain family member 8B
increases expression
ISO
Clozapine results in increased expression of TBC1D8B protein
CTD
PMID:34122009
NCBI chr X:103,319,181...103,407,137
Ensembl chr X:103,319,340...103,407,133
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Tbcb
tubulin folding cofactor B
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of TBCB protein
CTD
PMID:34122009
NCBI chr 1:85,477,639...85,483,488
Ensembl chr 1:85,477,640...85,483,488
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Tbl3
transducin (beta)-like 3
increases expression
ISO
Clozapine results in increased expression of TBL3 protein
CTD
PMID:34122009
NCBI chr10:13,726,127...13,731,340
Ensembl chr10:13,726,129...13,731,372
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Tcaf1
TRPM8 channel-associated factor 1
decreases expression
ISO
Clozapine results in decreased expression of TCAF1 protein
CTD
PMID:34122009
NCBI chr 4:71,589,674...71,639,274
Ensembl chr 4:71,591,200...71,613,309
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Tes
testin LIM domain protein
decreases expression
ISO
Clozapine results in decreased expression of TES protein
CTD
PMID:34122009
NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829
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Tgoln2
trans-golgi network protein 2
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of TGOLN2 protein
CTD
PMID:34122009
NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
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Th
tyrosine hydroxylase
decreases activity multiple interactions increases activity decreases expression increases expression
EXP ISO
Clozapine results in decreased activity of TH protein 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine Clozapine results in decreased expression of TH mRNA; Clozapine results in decreased expression of TH protein Clozapine results in increased expression of TH protein Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]
CTD
PMID:12645084 PMID:15983997 PMID:16402076 PMID:16415089 PMID:17028028
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Thra
thyroid hormone receptor alpha
decreases expression increases expression
EXP
Clozapine results in decreased expression of THRA mRNA alternative form Clozapine results in increased expression of THRA mRNA alternative form
CTD
PMID:11564422
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Thrap3
thyroid hormone receptor associated protein 3
decreases expression
ISO
Clozapine results in decreased expression of THRAP3 protein
CTD
PMID:34122009
NCBI chr 5:138,445,284...138,487,544
Ensembl chr 5:138,445,295...138,487,477
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Thrb
thyroid hormone receptor beta
decreases expression
EXP
Clozapine results in decreased expression of THRB mRNA alternative form
CTD
PMID:11564422
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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Tln2
talin 2
decreases expression
ISO
Clozapine results in decreased expression of TLN2 protein
CTD
PMID:34122009
NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219
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Tm9sf2
transmembrane 9 superfamily member 2
decreases expression
ISO
Clozapine results in decreased expression of TM9SF2 protein
CTD
PMID:34122009
NCBI chr15:99,201,556...99,254,054
Ensembl chr15:99,201,489...99,254,049
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Tmed10
transmembrane p24 trafficking protein 10
decreases expression
ISO
Clozapine results in decreased expression of TMED10 protein
CTD
PMID:34122009
NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753
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Tmem109
transmembrane protein 109
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of TMEM109 protein
CTD
PMID:34122009
NCBI chr 1:207,519,628...207,530,245
Ensembl chr 1:207,519,624...207,530,215
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Tmpo
thymopoietin
decreases expression
ISO
Clozapine results in decreased expression of TMPO protein
CTD
PMID:34122009
NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
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Tnf
tumor necrosis factor
affects response to substance increases expression multiple interactions increases secretion
ISO EXP
TNF protein affects the susceptibility to Clozapine Clozapine results in increased expression of TNF protein belnacasan inhibits the reaction [Clozapine results in increased secretion of TNF protein]
CTD
PMID:20521320 PMID:24709159 PMID:34935985
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfsf15
TNF superfamily member 15
decreases expression
ISO
Clozapine results in decreased expression of TNFSF15 mRNA
CTD
PMID:17346280
NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228
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Tnik
TRAF2 and NCK interacting kinase
decreases expression
ISO
Clozapine results in decreased expression of TNIK mRNA
CTD
PMID:14647396
NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750
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Top1mt
DNA topoisomerase I mitochondrial
increases expression
ISO
Clozapine results in increased expression of TOP1MT protein
CTD
PMID:34122009
NCBI chr 7:107,338,092...107,368,125
Ensembl chr 7:107,342,527...107,366,049
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Tp53
tumor protein p53
increases expression multiple interactions
ISO
Clozapine results in increased expression of TP53 mRNA CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]
CTD
PMID:16160616
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpi1
triosephosphate isomerase 1
increases expression
EXP
Clozapine results in increased expression of TPI1 mRNA
CTD
PMID:15860345
NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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Tpm2
tropomyosin 2
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of TPM2 protein
CTD
PMID:34122009
NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992
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Tpm3
tropomyosin 3
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of TPM3 protein
CTD
PMID:34122009
NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
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Tpm4
tropomyosin 4
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of TPM4 protein
CTD
PMID:34122009
NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
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Tpr
translocated promoter region, nuclear basket protein
decreases expression
ISO
Clozapine results in decreased expression of TPR protein
CTD
PMID:34122009
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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Tra2b
transformer 2 beta
decreases expression
ISO
Clozapine results in decreased expression of TRA2B protein
CTD
PMID:34122009
NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249
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Trim2
tripartite motif-containing 2
decreases expression
ISO
Clozapine results in decreased expression of TRIM2 mRNA
CTD
PMID:14647396
NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927
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Trim28
tripartite motif-containing 28
decreases expression
ISO
Clozapine results in decreased expression of TRIM28 protein
CTD
PMID:34122009
NCBI chr 1:73,652,441...73,659,388
Ensembl chr 1:73,652,709...73,659,380
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Tspan3
tetraspanin 3
decreases expression increases expression
ISO
Clozapine results in decreased expression of TSPAN3 protein Clozapine results in increased expression of TSPAN3 protein
CTD
PMID:34122009 PMID:36482696
NCBI chr 8:56,546,067...56,569,815
Ensembl chr 8:56,546,069...56,569,880
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Ttbk1
tau tubulin kinase 1
increases expression
ISO
Clozapine results in increased expression of TTBK1 protein
CTD
PMID:34122009
NCBI chr 9:14,493,166...14,538,372
Ensembl chr 9:14,493,389...14,535,774
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Ttr
transthyretin
decreases expression increases expression
ISO EXP
Clozapine results in decreased expression of TTR mRNA Clozapine results in increased expression of TTR mRNA; Clozapine results in increased expression of TTR protein
CTD
PMID:15927202 PMID:17266109
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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Ttyh2
tweety family member 2
increases expression
ISO
Clozapine results in increased expression of TTYH2 protein
CTD
PMID:34122009
NCBI chr10:99,709,063...99,753,449
Ensembl chr10:99,709,007...99,753,444
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Tubal3
tubulin, alpha-like 3
increases expression
ISO
Clozapine results in increased expression of TUBAL3 protein
CTD
PMID:34122009
NCBI chr17:66,323,733...66,332,423
Ensembl chr17:66,323,733...66,335,355
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Tubb4b
tubulin, beta 4B class IVb
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of TUBB4B protein
CTD
PMID:34122009
NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296
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Tubb5
tubulin, beta 5 class I
increases expression
ISO
Clozapine results in increased expression of TUBB protein
CTD
PMID:34122009
NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
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Tubb6
tubulin, beta 6 class V
decreases expression
ISO
Clozapine results in decreased expression of TUBB6 protein
CTD
PMID:34122009
NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418
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Uap1l1
UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
increases expression
ISO
Clozapine results in increased expression of UAP1L1 protein
CTD
PMID:34122009
NCBI chr 3:8,172,335...8,180,505
Ensembl chr 3:8,173,216...8,180,443
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Uba2
ubiquitin-like modifier activating enzyme 2
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in increased expression of UBA2 protein
CTD
PMID:34122009
NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682
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Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
increases expression
ISO
Clozapine results in increased expression of UBA52 mRNA
CTD
PMID:14647396
NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
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Ube2r2
ubiquitin-conjugating enzyme E2R 2
affects expression
ISO
Clozapine affects the expression of UBE2R2 mRNA
CTD
PMID:14647396
NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513
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Ubtf
upstream binding transcription factor
decreases expression
ISO
Clozapine results in decreased expression of UBTF protein
CTD
PMID:34122009
NCBI chr10:87,258,217...87,274,291
Ensembl chr10:87,258,217...87,272,969
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
ISO
Clozapine results in increased expression of UGT1A1 mRNA
CTD
PMID:18227147
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a5
UDP glucuronosyltransferase family 1 member A5
increases glucuronidation
ISO
UGT1A4 protein SNP results in increased glucuronidation of Clozapine
CTD
PMID:15708967
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Unc13a
unc-13 homolog A
decreases expression
EXP
Clozapine results in decreased expression of UNC13A mRNA
CTD
PMID:15860345
NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872
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Unc45b
unc-45 myosin chaperone B
increases expression
ISO
Clozapine results in increased expression of UNC45B protein
CTD
PMID:34122009
NCBI chr10:67,845,464...67,873,143
Ensembl chr10:67,845,462...67,873,389
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Uqcr11
ubiquinol-cytochrome c reductase, complex III subunit XI
affects expression
ISO
Clozapine affects the expression of UQCR11 mRNA
CTD
PMID:14647396
NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750
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Usp34
ubiquitin specific peptidase 34
increases expression
ISO
Clozapine results in increased expression of USP34 protein
CTD
PMID:34122009
NCBI chr14:97,285,799...97,476,376
Ensembl chr14:97,286,018...97,476,376
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Usp5
ubiquitin specific peptidase 5
increases expression
ISO
Clozapine results in increased expression of USP5 protein
CTD
PMID:34122009
NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711
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Utp18
UTP18 small subunit processome component
increases expression
ISO
Clozapine results in increased expression of UTP18 protein
CTD
PMID:34122009
NCBI chr10:78,811,879...78,839,338
Ensembl chr10:78,811,880...78,839,627
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Vamp1
vesicle-associated membrane protein 1
increases expression
EXP
Clozapine results in increased expression of VAMP1 mRNA
CTD
PMID:15860345
NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349
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Vamp2
vesicle-associated membrane protein 2
increases expression
EXP
Clozapine results in increased expression of VAMP2 mRNA
CTD
PMID:15860345
NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809
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Vapa
VAMP associated protein A
increases expression
ISO
Clozapine results in increased expression of VAPA protein
CTD
PMID:34122009
NCBI chr 9:105,177,904...105,208,400
Ensembl chr 9:105,177,907...105,207,847
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Vapb
VAMP associated protein B and C
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of VAPB protein
CTD
PMID:34122009
NCBI chr 3:162,535,974...162,578,747
Ensembl chr 3:162,535,905...162,573,763
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Vcl
vinculin
increases expression
ISO
Clozapine results in increased expression of VCL protein
CTD
PMID:34122009
NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606
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Vdac1
voltage-dependent anion channel 1
decreases expression
ISO
Clozapine results in decreased expression of VDAC1 protein
CTD
PMID:34122009
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Vsnl1
visinin-like 1
decreases expression
EXP
Clozapine results in decreased expression of VSNL1 mRNA
CTD
PMID:12437575
NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
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Wars1
tryptophanyl-tRNA synthetase 1
multiple interactions
ISO
[Cuprizone co-treated with Clozapine] results in decreased expression of WARS1 protein
CTD
PMID:34122009
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
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Wbp1l
WW domain binding protein 1-like
decreases expression
ISO
Clozapine results in decreased expression of WBP1L mRNA
CTD
PMID:14647396
NCBI chr 1:245,472,292...245,528,627
Ensembl chr 1:245,472,296...245,528,627
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Wdr12
WD repeat domain 12
decreases expression
ISO
Clozapine results in decreased expression of WDR12 protein
CTD
PMID:34122009
NCBI chr 9:61,475,498...61,502,762
Ensembl chr 9:61,475,517...61,502,469
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Clozapine results in increased expression of WIPI1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
decreases expression
ISO
Clozapine results in decreased expression of YWHAB mRNA
CTD
PMID:17266109
NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105
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Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
increases expression
ISO
Clozapine results in increased expression of YWHAQ protein
CTD
PMID:34122009
NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
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Zc3hav1
zinc finger CCCH-type containing, antiviral 1
decreases expression
ISO
Clozapine results in decreased expression of ZC3HAV1 protein
CTD
PMID:34122009
NCBI chr 4:67,012,129...67,062,428
Ensembl chr 4:67,012,185...67,062,428
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