clozapine - Ontology Browser - Rat Genome Database

Help | FTP Download | Citing RGD | Contact Us

Keyword

ONTOLOGY BROWSER

Term:	clozapine	go back to main search page
Accession:	CHEBI:3766	browse the term view annotations
Definition:	A benzodiazepine that has formula C18H19ClN4.
Synonyms:	exact_synonym:	8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
	related_synonym:	C18H19ClN4; CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12; Clozapin; InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3; InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N; clozapina; clozapinum
	xref_casrn:	5786-21-0
	xref:	Beilstein:0764984 "Beilstein Registry Number"; ChEMBL:102261 "ChEMBL COMPOUND"; ChemIDplus:5786-21-0 "CAS Registry Number"; DrugBank:DB00363 "DrugBank"; KEGG COMPOUND:C06924 "KEGG COMPOUND"; KEGG DRUG:D00283 "KEGG DRUG"
	xref_mesh:	MESH:D003024
	xref:	Patent:FR1334944 "Patent"; Patent:NL293201 "Patent"; Patent:US3539573 "Patent"; Wikipedia:Clozapine "Wikipedia"

Parent Terms	Term With Siblings	Child Terms
adrenergic antagonist + benzodiazepine + dopaminergic antagonist + GABA antagonist + histamine antagonist + muscarinic antagonist + N-arylpiperazine + N-methylpiperazine + second generation antipsychotic + serotonergic antagonist +	(-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (-)-cubebin (11S)-8-chloro-11-[1-(methylsulfonyl)piperidin-4-yl]-6-piperazin-1-yl-11H-benzo[5,6]cyclohepta[1,2-b]pyridine (1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin (1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin hydrochloride (2S,4S,5S)-5-[((2S)-2-\{(3R)-3-benzyl-4-[(4-methylpiperazin-1-yl)carbonyl]-2-oxopiperazin-1-yl\}hexanoyl)amino]-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide (3E)-N-(2,6-diethylphenyl)-3-\{[4-(4-methylpiperazin-1-yl)benzoyl]imino\}pyrrolo[3,4-c]pyrazole-5(3H)-carboxamide (5-\{[(2R)-1-(4-\{3-[(2-methoxybenzyl)oxy]propoxy\}phenyl)-6-oxopiperazin-2-yl]methoxy\}-1H-indol-1-yl)acetic acid (6R)-6-(\{[1-(3-hydroxypropyl)-1,7-dihydroquinolin-7-yl]oxy\}methyl)-1-(4-\{3-[(2-methoxybenzyl)oxy]propoxy\}phenyl)piperazin-2-one (S)-(-)-sulpiride (S)-carbinoxamine maleate 1,1-dimethyl-4-phenylpiperazinium iodide 1,4-benzodiazepine + 1,4-benzodiazepinone + 1-(3,4-dihydroxy-5-nitrophenyl)-3-\{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl\}propan-1-one 1-(3-(2,4-dimethylthiazol-5-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl)-3-(4-methylpiperazin-1-yl)urea 1-(3-chlorophenyl)piperazine 1-\{4-[3-(2-methoxybenzyloxy)propoxy]phenyl\}-6-(1,2,3,4-tetrahydroquinolin-7-yloxymethyl)piperazin-2-one 1-acetyl-4-(4-\{4-[(2-ethoxyphenyl)thio]-3-nitrophenyl\}pyridin-2-yl)piperazine 2'-(3-iodo-4-methoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 2'-(3-iodophenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 2'-(3-methyl-4-dimethylaminophenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 2'-(4-dimethylaminophenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 2'-(4-hydroxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 2,6-dimethylphenyl 2-\{3,5-dimethoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]phenylamino\}pyrimidin-4-yl-(2,4-dimethoxyphenyl)carbamate 2-\{(2R)-4-[2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl]-1-isobutyrylpiperazin-2-yl\}-N-[2-(4-methoxyphenyl)ethyl]acetamide 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride 3-\{6-[5-(4-methylpiperazin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl]-1H-benzimidazol-2-yl\}phenol 3-methoxy-6-[4-(3-methylphenyl)piperazin-1-yl]pyridazine 4-(4-\{[(3R)-2-oxo-2,3-dihydro-1H-indol-3-yl]methyl\}phenyl)piperazine-1-carbaldehyde 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline + 4-(4-methylpiperazin-1-yl)-N-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide 4-(\{[(4-methylpiperazin-1-yl)amino]carbothioyl\}amino)benzenesulfonamide 4-[(4-methylpiperazin-1-yl)methyl]-N-\{3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl\}benzamide 4-[2-(hydroxymethyl)pyrimidin-4-yl]-N,N-dimethylpiperazine-1-sulfonamide 4-[4-(biphenyl-2-ylmethyl)piperazin-1-yl]-N-[4-\{[1,1-dimethyl-2-(phenylthio)ethyl]amino\}-3-nitrobenzenesulfonyl]benzamide 4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide 4-methylpiperazine-1-carbaldehyde 5-(4-phenoxyphenyl)-5-(4-pyrimidin-2-ylpiperazin-1-yl)pyrimidine-2,4,6(2H,3H)-trione 6,7-dimethoxy-4-\{8-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydroisoquinolin-2-(1H)-yl\}quinazoline 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)ethyl]-9H-purine-2-carbonitrile 6-[(S)-3-benzylpiperazin-1-yl]-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyrazine 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one 9-cyclopentyl-6-\{2-[3-(4-methylpiperazin-1-yl)propoxy]phenylamino\}-9H-purine-2-carbonitrile aceprometazine + aclidinium + aclidinium bromide alosetron + alosetron hydrochloride alpha-adrenergic antagonist + amisulpride amocarzine amoxapine anisotropine methylbromide aripiprazole asenapine asenapine maleate atropine + AZD4547 benzatropine + benzodiazepine alkaloid benzquinamide + beta-adrenergic antagonist + bethanidine + BGJ-398 BGT226 free base bicuculline bidenlignaside A bidenlignaside B biperiden + biperiden hydrochloride bosutinib + bretylium + bretylium tosylate bromazine + bromazine hydrochloride + buclizine buclizine dihydrochloride buspirone + carbinoxamine + carbinoxamine maleate + carphenazine + chlordiazepoxide + chlorphenamine + chlorpromazine + chlorprothixene + cinnarizine ciprofloxacin + clemastine + clemastine fumarate clomipramine clomipramine hydrochloride clopenthixol + clozapine A benzodiazepine that has formula C18H19ClN4. cyclopentolate + cyclopentolate hydrochloride + cycrimine + cycrimine hydrochloride + cyproheptadine + cyproheptadine hydrochloride sesquihydrate dapiprazole darifenacin + darifenacin hydrobromide dasatinib (anhydrous) + deptropine + deptropine citrate dicyclomine + dicyclomine hydrochloride diethylcarbamazine dihydroergocristine + diphemanil methylsulfate diphenhydramine + diphenhydramine hydrochloride diphenhydramine salicylate domperidone + domperidone maleate doxazosin + doxylamine droperidol enrofloxacin epinastine + esomeprazol + ethyl 2-[4-(2H-1,4-benzothiazin-3-yl)piperazin-1-yl]-1,3-thiazole-4-carboxylate fenoldopam flavoxate flavoxate hydrochloride flumazenil flupenthixol fluphenazine gatifloxacin + GR 127935 GR 127935 hydrochloride guanadrel guanadrel sulfate guanethidine + H1-receptor antagonist + H2-receptor antagonist + H3-receptor antagonist + haloperidol homatropine methylbromide iloperidone imatinib + ipratropium bromide + ipratropium bromide hydrate itraconazole ketanserin ketoconazole + lomefloxacin + loxapine + lurasidone lurasidone hydrochloride mesoridazine + mesoridazine besylate metergoline methiothepin methiothepin maleate methotrimeprazine methyl (6-\{[(2R)-1-(4-\{3-[(2-methoxybenzyl)oxy]propoxy\}phenyl)-6-oxopiperazin-2-yl]methoxy\}-1H-indol-1-yl)acetate methylpiperazinoforskolin methysergide metixene + metoclopramide metoclopramide dihydrochloride monohydrate metoclopramide hydrochloride + mianserin + mirtazapine N-(4-\{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl\}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide N-[(1S)-3-\{[(benzyloxy)amino]sulfonyl\}-1-(2-phenylethyl)propyl]-N-[(4-methylpiperazin-1-yl)carbonyl]-L-phenylalaninamide N-[(3E)-5-[(2R)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3(5H)-ylidene]-4-(4-methylpiperazin-1-yl)benzamide N-[(4-methylpiperazin-1-yl)carbonyl]-L-phenylalanin-(N-\{(1S)-3-phenyl-1-[2-(benzenesulfonyl)ethyl]propyl\})amide N-\{4-[4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-ylsulfanyl]phenyl\}cyclopropanecarboxamide N-\{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl\}nicotinamide N-desmethylclozapine N-methylquipazine + nafadotride NAN 190 NAN 190 hydrobromide nefazodone + nemonapride norfloxacin ofloxacin + olanzapine orphenadrine + orphenadrine citrate orphenadrine hydrochloride oxybutynin + pefloxacin + perazine periciazine perphenazine + pibenzimol + pimozide pindolol + pirenzepine + pizotifen pizotifen malate pizotifen maleate posaconazole prochlorperazine + procyclidine + profenamine + profenamine hydrochloride promazine + propiomazine + quetiapine + quinidine + rifampicin risperidone ritanserin RS 39604 RS 39604 hydrochloride SB 224289 SB 224289 hydrochloride scopolamine + scopolamine hydrobromide (anhydrous) + scopolamine hydrobromide trihydrate scopolamine methobromide SDZ 35-682 sertindole sparfloxacin spiperone spiramide sulpiride + tetrahydropalmatine thiethylperazine + thiopropazate thioproperazine thioridazine + tolterodine + trazodone + trazodone hydrochloride tridihexethyl + trifluoperazine + triflupromazine + tropanyl 3,5-dimethylbenzoate vilazodone yohimbine ziprasidone + zotepine zuclopenthixol

Contact Us | About Us | Jobs at RGD

© Bioinformatics Program, HMGC at the Medical College of Wisconsin

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.
NHLBI Logo