Ctsk (cathepsin K) - Rat Genome Database

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Gene: Ctsk (cathepsin K) Rattus norvegicus
Analyze
Symbol: Ctsk
Name: cathepsin K
RGD ID: 61810
Description: Predicted to enable several functions, including collagen binding activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and fibronectin binding activity. Involved in several processes, including bone resorption; cellular response to tumor necrosis factor; and cellular response to zinc ion starvation. Located in extracellular space. Biomarker of intracranial aneurysm and otitis media. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K); PARTICIPATES IN rheumatoid arthritis pathway; Toll-like receptor signaling pathway; INTERACTS WITH (S)-amphetamine; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp364  
Candidate Gene For: Bp364
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,747,548 - 185,758,512 (+)NCBIGRCr8
mRatBN7.22183,058,586 - 183,069,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,058,569 - 183,069,550 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,723,332 - 190,734,303 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,518,632 - 188,529,601 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,355,824 - 183,366,795 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,655,469 - 196,666,447 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,655,469 - 196,666,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02216,154,168 - 216,164,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,394,854 - 190,405,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,357,607 - 190,368,421 (+)NCBI
Celera2175,591,773 - 175,602,552 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (ISO)
(S)-amphetamine  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-tert-butylhydroquinone  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anagliptin  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
belinostat  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brusatol  (EXP)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
cisapride  (ISO)
clozapine  (EXP)
Cuprizon  (EXP)
cyanamide  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dimethyl fumarate  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formononetin  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
guanethidine  (EXP)
haloperidol  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mangiferin  (ISO)
mercaptopurine  (EXP)
methylglyoxal  (EXP,ISO)
methylseleninic acid  (ISO)
Morroniside  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
naringin  (ISO)
niclosamide  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP)
puerarin  (EXP)
purine-6-thiol  (EXP)
quartz  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rubiadin  (EXP)
SB 203580  (ISO)
sclareol  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetradecane  (EXP)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
xanthohumol  (ISO)
zinc atom  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression and localization of cathepsin k in adult rat sertoli cells. Anway MD, etal., Biol Reprod 2004 Mar;70(3):562-9. Epub 2003 Oct 29.
2. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2008 Sep;39(9):2603-10. Epub 2008 Jul 17.
3. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Hie M and Tsukamoto I, Int J Mol Med. 2010 Oct;26(4):611-8. doi: 10.3892/ijmm_00000506.
7. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
8. Polarization and secretion of cathepsin K precede tartrate-resistant acid phosphatase secretion to the ruffled border area during the activation of matrix-resorbing clasts. Hollberg K, etal., J Bone Miner Metab. 2005;23(6):441-9.
9. Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo. Iitsuka N, etal., Int J Mol Med. 2012 Jul;30(1):165-72. doi: 10.3892/ijmm.2012.974. Epub 2012 Apr 20.
10. Gene expression relevant to osteoclastogenesis in the synovium and bone marrow of mature rats with collagen-induced arthritis. Kishimoto Y, etal., Rheumatology (Oxford). 2004 Dec;43(12):1496-503. Epub 2004 Sep 7.
11. Patterns and localization of gene expression during intramembranous bone regeneration in the rat femoral marrow ablation model. Kuroda S, etal., Calcif Tissue Int. 2005 Oct;77(4):212-25. Epub 2005 Sep 28.
12. Osteopetrosis and osteoporosis: two sides of the same coin. Lazner F, etal., Hum Mol Genet 1999;8(10):1839-46.
13. Cathepsin gene expression profile in rat acute pneumococcal otitis media. Li-Korotky HS, etal., Laryngoscope 2004 Jun;114(6):1032-6.
14. Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats. Matsubara R, etal., PLoS One. 2012;7(10):e47930. doi: 10.1371/journal.pone.0047930. Epub 2012 Oct 24.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Mouse Genome Database (MGD) Mouse Genome Database (MGD)
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Intracellular machinery for matrix degradation in bone-resorbing osteoclasts. Vaaraniemi J, etal., J Bone Miner Res 2004 Sep;19(9):1432-40. Epub 2004 Jun 14.
26. Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones. Xia L, etal., Biol Chem. 1999 Jun;380(6):679-87.
Additional References at PubMed
PMID:11082042   PMID:12782676   PMID:15489334   PMID:17181996   PMID:17916452   PMID:18664521   PMID:18974601   PMID:19834056   PMID:22365146   PMID:22952693   PMID:24912190   PMID:25558848  
PMID:29207029   PMID:29514215  


Genomics

Comparative Map Data
Ctsk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,747,548 - 185,758,512 (+)NCBIGRCr8
mRatBN7.22183,058,586 - 183,069,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,058,569 - 183,069,550 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,723,332 - 190,734,303 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,518,632 - 188,529,601 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,355,824 - 183,366,795 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,655,469 - 196,666,447 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,655,469 - 196,666,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02216,154,168 - 216,164,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,394,854 - 190,405,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,357,607 - 190,368,421 (+)NCBI
Celera2175,591,773 - 175,602,552 (+)NCBICelera
Cytogenetic Map2q34NCBI
CTSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,796,208 - 150,808,260 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1150,794,880 - 150,809,577 (-)EnsemblGRCh38hg38GRCh38
GRCh371150,768,684 - 150,780,736 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,035,311 - 149,047,436 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,581,759 - 147,593,885NCBI
Celera1123,884,715 - 123,896,850 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,146,309 - 122,158,545 (-)NCBIHuRef
CHM1_11152,164,010 - 152,176,259 (-)NCBICHM1_1
T2T-CHM13v2.01149,919,861 - 149,931,947 (-)NCBIT2T-CHM13v2.0
Ctsk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,406,521 - 95,416,698 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,406,567 - 95,416,673 (+)EnsemblGRCm39 Ensembl
GRCm38395,499,210 - 95,509,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,499,256 - 95,509,362 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,303,208 - 95,313,284 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,584,690 - 95,594,766 (+)NCBIMGSCv36mm8
Celera396,930,391 - 96,940,481 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Ctsk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955588148,748 - 158,093 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955588149,036 - 158,093 (-)NCBIChiLan1.0ChiLan1.0
CTSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,022,154 - 99,036,182 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,777,588 - 98,789,833 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,146,555 - 126,158,662 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11129,795,966 - 129,808,316 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,795,966 - 129,808,316 (-)Ensemblpanpan1.1panPan2
CTSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,928,725 - 59,938,293 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,929,287 - 59,938,507 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,375,185 - 59,382,593 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,945,042 - 60,954,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,945,043 - 61,028,017 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,774,900 - 59,782,304 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,859,083 - 59,866,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,587,454 - 60,594,862 (-)NCBIUU_Cfam_GSD_1.0
Ctsk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,992,384 - 22,005,049 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,022,762 - 1,034,984 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,022,762 - 1,038,020 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,391,428 - 98,404,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,389,459 - 98,404,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,639,430 - 107,653,109 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,471,719 - 12,484,331 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477219,015,835 - 19,025,588 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477219,013,189 - 19,026,756 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ctsk
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:53
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000028730
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat

Markers in Region
RH130167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21120,495,578 - 20,495,786 (+)MAPPERmRatBN7.2
mRatBN7.22183,061,435 - 183,061,643 (+)MAPPERmRatBN7.2
Rnor_6.01120,612,679 - 20,612,886NCBIRnor6.0
Rnor_6.02196,658,319 - 196,658,526NCBIRnor6.0
Rnor_5.01124,260,859 - 24,261,066UniSTSRnor5.0
Rnor_5.02216,157,018 - 216,157,225UniSTSRnor5.0
Cytogenetic Map11q11UniSTS
Cytogenetic Map2q34UniSTS
RH135289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,058,968 - 183,059,184 (+)MAPPERmRatBN7.2
Rnor_6.02196,655,852 - 196,656,067NCBIRnor6.0
Rnor_5.02216,154,551 - 216,154,766UniSTSRnor5.0
RGSC_v3.42190,395,237 - 190,395,452UniSTSRGSC3.4
Celera2175,592,156 - 175,592,371UniSTS
RH 3.4 Map21213.9UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:496617  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,063,027 - 183,063,128 (+)MAPPERmRatBN7.2
Rnor_6.02196,659,911 - 196,660,011NCBIRnor6.0
Rnor_5.02216,158,610 - 216,158,710UniSTSRnor5.0
RGSC_v3.42190,399,296 - 190,399,396UniSTSRGSC3.4
Celera2175,596,215 - 175,596,315UniSTS
Cytogenetic Map2q34UniSTS
Ctsk  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,063,145 - 183,063,210 (+)MAPPERmRatBN7.2
Rnor_6.02196,660,029 - 196,660,093NCBIRnor6.0
Rnor_5.02216,158,728 - 216,158,792UniSTSRnor5.0
RGSC_v3.42190,399,414 - 190,399,478UniSTSRGSC3.4
Celera2175,596,333 - 175,596,397UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 8 13 4 6 49 28 37 11 4
Low 3 8 49 41 6 41 4 5 25 7 4 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000028730   ⟹   ENSRNOP00000028730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2183,058,569 - 183,069,550 (+)Ensembl
Rnor_6.0 Ensembl2196,655,469 - 196,666,446 (+)Ensembl
RefSeq Acc Id: NM_031560   ⟹   NP_113748
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,747,548 - 185,758,512 (+)NCBI
mRatBN7.22183,058,586 - 183,069,551 (+)NCBI
Rnor_6.02196,655,469 - 196,666,447 (+)NCBI
Rnor_5.02216,154,168 - 216,164,779 (+)NCBI
RGSC_v3.42190,394,854 - 190,405,668 (+)RGD
Celera2175,591,773 - 175,602,552 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113748 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB65743 (Get FASTA)   NCBI Sequence Viewer  
  AAH78793 (Get FASTA)   NCBI Sequence Viewer  
  EDL85704 (Get FASTA)   NCBI Sequence Viewer  
  EDL85705 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028730
  ENSRNOP00000028730.3
GenBank Protein O35186 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113748   ⟸   NM_031560
- Peptide Label: precursor
- UniProtKB: O35186 (UniProtKB/Swiss-Prot),   A6K2Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028730   ⟸   ENSRNOT00000028730
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35186-F1-model_v2 AlphaFold O35186 1-329 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691549
Promoter ID:EPDNEW_R2074
Type:initiation region
Name:Ctsk_1
Description:cathepsin K
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02196,655,485 - 196,655,545EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61810 AgrOrtholog
BioCyc Gene G2FUF-52092 BioCyc
Ensembl Genes ENSRNOG00000021155 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028730 ENTREZGENE
  ENSRNOT00000028730.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.2250 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134253 IMAGE-MGC_LOAD
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29175 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93359 IMAGE-MGC_LOAD
NCBI Gene 29175 ENTREZGENE
PANTHER CATHEPSIN K UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12411:SF55 UniProtKB/Swiss-Prot
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctsk PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021155 RatGTEx
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cysteine proteinases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC229248
UniProt A6K2Z5_RAT UniProtKB/TrEMBL
  A6K2Z6 ENTREZGENE, UniProtKB/TrEMBL
  CATK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ctsk  cathepsin K      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations in human homolog are associated with pycnodysostosis 704405
gene_function human homolog displays endoprotease activity against fibrinogen 704405