Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase) - Rat Genome Database

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Gene: Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase) Rattus norvegicus
Analyze
Symbol: Cnp
Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
RGD ID: 2368
Description: Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity and cyclic nucleotide binding activity. Involved in forebrain development; regulation of mitochondrial membrane permeability; and response to lipopolysaccharide. Located in several cellular components, including mitochondrial membrane; myelin sheath abaxonal region; and myelin sheath adaxonal region. Used to study carotid stenosis. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2',3'-cyclic-nucleotide 3'-phosphodiesterase; 2'3'- Cyclic nucleotide 3'-phosphodiesterase; 2,3- Cyclic nucleotide 3-phosphodiesterase; 23- cyclic nucleotide 3-phosphodiesterase; Cnp1; CNPase; CNPF; CNPI; CNPII; cyclic nucleotide phosphodiesterase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,011,504 - 86,018,063 (+)NCBIGRCr8
mRatBN7.21085,511,164 - 85,517,723 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,511,160 - 85,517,720 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,548,000 - 90,554,559 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,026,520 - 90,033,080 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,419,429 - 85,425,988 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,490,798 - 88,497,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,490,798 - 88,497,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,284,045 - 88,290,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,519,421 - 89,525,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,533,790 - 89,540,348 (+)NCBI
Celera1084,227,529 - 84,234,088 (+)NCBICelera
RH 3.4 Map10859.8RGD
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
atrazine  (EXP)
beauvericin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
cannabidiol  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
corticotropin  (EXP)
Cuprizon  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyldithiocarbamic acid  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
haloperidol  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phencyclidine  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
rac-lactic acid  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
SR 144528  (ISO)
sunitinib  (ISO)
Temsirolimus  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
triptonide  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Ca2+-dependent permeability transition regulation in rat brain mitochondria by 2',3'-cyclic nucleotides and 2',3'-cyclic nucleotide 3'-phosphodiesterase. Azarashvili T, etal., Am J Physiol Cell Physiol. 2009 Jun;296(6):C1428-39. Epub 2009 Apr 8.
2. 2',3'-Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound, microtubule-associated protein and membrane anchor for tubulin. Bifulco M, etal., Proc Natl Acad Sci U S A 2002 Feb 19;99(4):1807-12. Epub 2002 Feb 12.
3. Age-related changes of the oligodendrocytes in rat subcortical white matter. Chen L, etal., Anat Rec (Hoboken). 2011 Mar;294(3):487-93. doi: 10.1002/ar.21332. Epub 2011 Jan 31.
4. Allopregnanolone promotes regeneration and reduces beta-amyloid burden in a preclinical model of Alzheimer's disease. Chen S, etal., PLoS One. 2011;6(8):e24293. Epub 2011 Aug 30.
5. Postmortem and imaging based analyses reveal CNS decreased myelination in restless legs syndrome. Connor JR, etal., Sleep Med. 2011 Jun;12(6):614-9. Epub 2011 May 12.
6. Passive transfer of experimental autoimmune encephalomyelitis in Wistar rats: dissociation of clinical symptoms and biochemical alterations. Degano AL and Roth GA, J Neurosci Res. 2000 Jan 15;59(2):283-90.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Georgieva L, etal., Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12469-74. Epub 2006 Aug 4.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. A myelin gene causative of a catatonia-depression syndrome upon aging. Hagemeyer N, etal., EMBO Mol Med. 2012 Apr 4. doi: 10.1002/emmm.201200230.
11. Long-term cognitive impairment and myelination deficiency in a rat model of perinatal hypoxic-ischemic brain injury. Huang Z, etal., Brain Res. 2009 Dec 8;1301:100-9. Epub 2009 Sep 10.
12. Abundant extracellular myelin in the meninges of patients with multiple sclerosis. Kooi EJ, etal., Neuropathol Appl Neurobiol. 2009 Jun;35(3):283-95. Epub 2008 Sep 17.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Concurrent administration of cilostazol with donepezil effectively improves cognitive dysfunction with increased neuroprotection after chronic cerebral hypoperfusion in rats. Lee JH, etal., Brain Res. 2007 Dec 14;1185:246-55. Epub 2007 Sep 20.
15. Expression of MBP, PLP, MAG, CNP, and GFAP in the Human Alcoholic Brain. Lewohl JM, etal., Alcohol Clin Exp Res. 2005 Sep;29(9):1698-705.
16. Induction of 2',3'-cyclic nucleotide 3'-phosphodiesterase in demyelination of BALB/c mice caused by Angiostrongylus cantonensis. Lin KY and Lai SC, J Comp Pathol. 2009 Nov;141(4):248-53. Epub 2009 Jul 9.
17. Transketolase and 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I isoforms are specifically recognized by IgG autoantibodies in multiple sclerosis patients. Lovato L, etal., Mol Cell Proteomics. 2008 Dec;7(12):2337-49. Epub 2008 Jul 31.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Peirce TR, etal., Arch Gen Psychiatry. 2006 Jan;63(1):18-24.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Postnatal inflammatory rat model for cerebral palsy: too different from humans. Roberson R, etal., Am J Obstet Gynecol. 2006 Oct;195(4):1038-44.
25. Upregulation of CSPG3 accompanies neuronal progenitor proliferation and migration in EAE. Sajad M, etal., J Mol Neurosci. 2011 Mar;43(3):531-40. Epub 2010 Nov 25.
26. Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure. Svetlov SI, etal., J Trauma. 2010 Oct;69(4):795-804.
27. Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population. Tang F, etal., Neurosci Lett. 2007 Apr 12;416(2):113-6. Epub 2007 Jan 30.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Limited remyelination in Theiler's murine encephalomyelitis due to insufficient oligodendroglial differentiation of nerve/glial antigen 2 (NG2)-positive putative oligodendroglial progenitor cells. Ulrich R, etal., Neuropathol Appl Neurobiol. 2008 Dec;34(6):603-20. Epub 2008 May 5.
30. Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the amoeboid microglial cells in the developing rat brain. Wu CY, etal., Neuroscience. 2006 Oct 13;142(2):333-41. Epub 2006 Jul 28.
31. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
32. Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis. Yao DL, etal., Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6190-4.
33. Juxtanodin: an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking. Zhang B, etal., Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11527-32. Epub 2005 Jul 28.
Additional References at PubMed
PMID:3040924   PMID:7932861   PMID:11885989   PMID:12379507   PMID:12477932   PMID:12590258   PMID:12898532   PMID:12947117   PMID:14503857   PMID:14749525   PMID:15535987   PMID:16103231  
PMID:16786579   PMID:17634366   PMID:18094118   PMID:19021295   PMID:19056867   PMID:19139271   PMID:19199708   PMID:19292454   PMID:19946888   PMID:20131911   PMID:20233944   PMID:20578039  
PMID:21525035   PMID:22068741   PMID:22313968   PMID:22871113   PMID:22926577   PMID:23376485   PMID:23533145   PMID:24101522   PMID:24808540   PMID:25277077   PMID:25931508   PMID:25936639  
PMID:28251676   PMID:29350434   PMID:29476059   PMID:30405014   PMID:31885393   PMID:32357304   PMID:34330062  


Genomics

Comparative Map Data
Cnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,011,504 - 86,018,063 (+)NCBIGRCr8
mRatBN7.21085,511,164 - 85,517,723 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,511,160 - 85,517,720 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,548,000 - 90,554,559 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,026,520 - 90,033,080 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,419,429 - 85,425,988 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,490,798 - 88,497,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,490,798 - 88,497,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,284,045 - 88,290,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,519,421 - 89,525,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,533,790 - 89,540,348 (+)NCBI
Celera1084,227,529 - 84,234,088 (+)NCBICelera
RH 3.4 Map10859.8RGD
Cytogenetic Map10q31NCBI
CNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,966,795 - 41,977,740 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,966,763 - 41,977,740 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,118,813 - 40,129,758 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,372,285 - 37,383,280 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,372,284 - 37,383,280NCBI
Celera1736,773,458 - 36,784,455 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,884,123 - 35,895,118 (+)NCBIHuRef
CHM1_11740,354,523 - 40,365,518 (+)NCBICHM1_1
T2T-CHM13v2.01742,823,292 - 42,834,237 (+)NCBIT2T-CHM13v2.0
Cnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,465,765 - 100,472,565 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,465,730 - 100,482,555 (+)EnsemblGRCm39 Ensembl
GRCm3811100,574,909 - 100,591,875 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,574,904 - 100,591,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,436,253 - 100,443,053 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,391,065 - 100,397,815 (+)NCBIMGSCv36mm8
Celera11111,195,104 - 111,201,904 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
Cnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,114,454 - 16,118,622 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,115,137 - 16,119,261 (+)NCBIChiLan1.0ChiLan1.0
CNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,008,706 - 23,017,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,898,864 - 24,907,379 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,338,085 - 15,349,089 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,560,056 - 15,569,108 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,560,056 - 15,568,916 (-)Ensemblpanpan1.1panPan2
CNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,888,350 - 20,896,139 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,886,574 - 20,896,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,349,053 - 20,356,835 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,606,902 - 21,614,689 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,594,095 - 21,614,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,392,407 - 20,400,181 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,659,216 - 20,666,990 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,762,355 - 20,770,140 (-)NCBIUU_Cfam_GSD_1.0
Cnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,233,405 - 20,240,592 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,834,540 - 16,841,810 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,834,570 - 16,841,734 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,758,083 - 20,765,553 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,758,081 - 20,765,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,048,293 - 21,055,830 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,288,583 - 64,296,940 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,289,828 - 64,296,922 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607735,106,165 - 35,114,853 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,855,992 - 1,861,053 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,856,455 - 1,861,142 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnp
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:423
Count of miRNA genes:220
Interacting mature miRNAs:272
Transcripts:ENSRNOT00000023872
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat

Markers in Region
RH129321  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,517,570 - 85,517,722 (+)MAPPERmRatBN7.2
Rnor_6.01088,497,205 - 88,497,356NCBIRnor6.0
Rnor_5.01088,290,452 - 88,290,603UniSTSRnor5.0
RGSC_v3.41089,525,826 - 89,525,977UniSTSRGSC3.4
Celera1084,233,936 - 84,234,087UniSTS
RH 3.4 Map10859.5UniSTS
Cytogenetic Map10q32.1UniSTS
RH127905  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,517,409 - 85,517,627 (+)MAPPERmRatBN7.2
Rnor_6.01088,497,044 - 88,497,261NCBIRnor6.0
Rnor_5.01088,290,291 - 88,290,508UniSTSRnor5.0
RGSC_v3.41089,525,665 - 89,525,882UniSTSRGSC3.4
Celera1084,233,775 - 84,233,992UniSTS
Cytogenetic Map10q32.1UniSTS
RH94388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,517,527 - 85,517,693 (+)MAPPERmRatBN7.2
Rnor_6.01088,497,162 - 88,497,327NCBIRnor6.0
Rnor_5.01088,290,409 - 88,290,574UniSTSRnor5.0
RGSC_v3.41089,525,783 - 89,525,948UniSTSRGSC3.4
Celera1084,233,893 - 84,234,058UniSTS
RH 3.4 Map10859.8UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 2 22 29 13 19 13 4 5 72 23 40 11 4
Low 1 21 28 28 28 4 6 12 1 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023872   ⟹   ENSRNOP00000023875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,511,160 - 85,517,720 (+)Ensembl
Rnor_6.0 Ensembl1088,490,798 - 88,497,356 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103289   ⟹   ENSRNOP00000080276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,511,160 - 85,517,717 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111402   ⟹   ENSRNOP00000077498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,512,109 - 85,517,717 (+)Ensembl
RefSeq Acc Id: NM_012809   ⟹   NP_036941
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,011,504 - 86,018,063 (+)NCBI
mRatBN7.21085,511,164 - 85,517,723 (+)NCBI
Rnor_6.01088,490,798 - 88,497,357 (+)NCBI
Rnor_5.01088,284,045 - 88,290,604 (+)NCBI
RGSC_v3.41089,519,421 - 89,525,978 (+)RGD
Celera1084,227,529 - 84,234,088 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036941   ⟸   NM_012809
- UniProtKB: Q4V796 (UniProtKB/Swiss-Prot),   Q64575 (UniProtKB/Swiss-Prot),   P13233 (UniProtKB/Swiss-Prot),   A6HJ42 (UniProtKB/TrEMBL),   A0A8I5Y1M7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023875   ⟸   ENSRNOT00000023872
RefSeq Acc Id: ENSRNOP00000077498   ⟸   ENSRNOT00000111402
RefSeq Acc Id: ENSRNOP00000080276   ⟸   ENSRNOT00000103289
Protein Domains
Cyclic nucleotide phosphodiesterase catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13233-F1-model_v2 AlphaFold P13233 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697725
Promoter ID:EPDNEW_R8250
Type:initiation region
Name:Cnp_1
Description:2',3'-cyclic nucleotide 3' phosphodiesterase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,490,789 - 88,490,849EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2368 AgrOrtholog
BioCyc Gene G2FUF-23229 BioCyc
Ensembl Genes ENSRNOG00000017496 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055033417 UniProtKB/Swiss-Prot
  ENSRNOG00060027890 UniProtKB/Swiss-Prot
  ENSRNOG00065032747 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023872.5 UniProtKB/TrEMBL
  ENSRNOT00000103289 ENTREZGENE
  ENSRNOT00000103289.1 UniProtKB/Swiss-Prot
  ENSRNOT00000111402.1 UniProtKB/TrEMBL
  ENSRNOT00055057794 UniProtKB/Swiss-Prot
  ENSRNOT00060048548 UniProtKB/Swiss-Prot
  ENSRNOT00065056380 UniProtKB/Swiss-Prot
Gene3D-CATH 2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7458826 IMAGE-MGC_LOAD
InterPro CNPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNPase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNuc_Pdiesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25275 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:116229 IMAGE-MGC_LOAD
NCBI Gene 25275 ENTREZGENE
PANTHER 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cnp PhenoGen
PIRSF CNPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017496 RatGTEx
  ENSRNOG00055033417 RatGTEx
  ENSRNOG00060027890 RatGTEx
  ENSRNOG00065032747 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55144 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204961
UniProt A0A097BVJ5_RAT UniProtKB/TrEMBL
  A0A8I5Y1M7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QCQ2_RAT UniProtKB/TrEMBL
  A6HJ42 ENTREZGENE, UniProtKB/TrEMBL
  CN37_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V796 ENTREZGENE
  Q64575 ENTREZGENE
UniProt Secondary Q4V796 UniProtKB/Swiss-Prot
  Q64575 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Cnp1  cyclic nucleotide phosphodiesterase 1  Cnp  2,3- Cyclic nucleotide 3-phosphodiesterase  Symbol and Name updated 625702 APPROVED
2002-06-10 Cnp  2,3- Cyclic nucleotide 3-phosphodiesterase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization membrane-bound microtubule-associated protein 1298767
gene_expression expressed in brain and FRTL-5 thyroid cells 1298767
gene_process promotes microtubule assembly at low mole ratios 1298767
gene_process may regulate cellular distribution of microtubules 1298767
gene_process C-terminus essential for microtubule assembly function 1298767
gene_regulation phosphorylation of protein interferes with microtubule assemby function 1298767
gene_transcript may be alternatively spliced to produce different products in nervous and lymphoid tissues 1298766