Numa1 (nuclear mitotic apparatus protein 1) - Rat Genome Database

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Gene: Numa1 (nuclear mitotic apparatus protein 1) Rattus norvegicus
Analyze
Symbol: Numa1
Name: nuclear mitotic apparatus protein 1
RGD ID: 1308777
Description: Enables microtubule binding activity. Involved in meiotic cell cycle. Located in several cellular components, including neuronal cell body; nuclear matrix; and spindle pole. Colocalizes with spindle microtubule. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human NUMA1 (nuclear mitotic apparatus protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,709,893 - 165,784,848 (+)NCBIGRCr8
mRatBN7.21156,297,907 - 156,372,855 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,326,259 - 156,372,855 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,310,748 - 164,357,511 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,490,844 - 171,537,603 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,367,923 - 164,414,758 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,044,544 - 167,091,453 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,051,209 - 167,091,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,235,586 - 173,280,299 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,419,804 - 159,470,987 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,498,820 - 159,550,004 (+)NCBI
Celera1154,399,899 - 154,445,842 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
amphetamine  (EXP)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Unraveling the organization of the internal nuclear matrix: RNA-dependent anchoring of NuMA to a lamin scaffold. Barboro P, etal., Exp Cell Res. 2002 Oct 1;279(2):202-18.
2. The nuclear/mitotic apparatus protein NuMA is a component of the somatodendritic microtubule arrays of the neuron. Ferhat L, etal., J Neurocytol. 1998 Dec;27(12):887-99.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. NuMA in rat testis--evidence for roles in proliferative activity and meiotic cell division. Taimen P, etal., Exp Cell Res. 2004 Aug 15;298(2):512-20.
Additional References at PubMed
PMID:1541636   PMID:7962183   PMID:10811826   PMID:11092755   PMID:11590136   PMID:11781568   PMID:11956313   PMID:12445386   PMID:12477932   PMID:14718566   PMID:16076287   PMID:17172455  
PMID:18331714   PMID:18570454   PMID:20109190   PMID:21816348   PMID:22074847   PMID:22082260   PMID:22327364   PMID:23027904   PMID:23783028   PMID:23870127   PMID:23921553   PMID:24371089  
PMID:24625528   PMID:24996901   PMID:25657325   PMID:26195665   PMID:26562023   PMID:26765568   PMID:26766442   PMID:27462074   PMID:31505169  


Genomics

Comparative Map Data
Numa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,709,893 - 165,784,848 (+)NCBIGRCr8
mRatBN7.21156,297,907 - 156,372,855 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,326,259 - 156,372,855 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,310,748 - 164,357,511 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,490,844 - 171,537,603 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,367,923 - 164,414,758 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,044,544 - 167,091,453 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,051,209 - 167,091,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,235,586 - 173,280,299 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,419,804 - 159,470,987 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,498,820 - 159,550,004 (+)NCBI
Celera1154,399,899 - 154,445,842 (+)NCBICelera
Cytogenetic Map1q32NCBI
NUMA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,002,864 - 72,080,542 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,002,864 - 72,080,693 (-)EnsemblGRCh38hg38GRCh38
GRCh371171,713,910 - 71,791,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,391,559 - 71,469,221 (-)NCBINCBI36Build 36hg18NCBI36
Build 341171,391,566 - 71,469,209NCBI
Celera1169,015,884 - 69,093,534 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1168,007,666 - 68,085,181 (-)NCBIHuRef
CHM1_11171,597,790 - 71,675,396 (-)NCBICHM1_1
T2T-CHM13v2.01171,929,780 - 72,007,446 (-)NCBIT2T-CHM13v2.0
Numa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,583,169 - 101,664,166 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,583,318 - 101,664,171 (+)EnsemblGRCm39 Ensembl
GRCm387101,933,977 - 102,014,959 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,934,111 - 102,014,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv377109,118,357 - 109,163,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367101,843,664 - 101,888,780 (+)NCBIMGSCv36mm8
Celera7102,345,277 - 102,389,657 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.7NCBI
Numa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541419,252,191 - 19,327,504 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541419,252,191 - 19,327,504 (+)NCBIChiLan1.0ChiLan1.0
NUMA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2972,952,851 - 73,030,204 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11173,995,189 - 74,072,550 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01167,083,378 - 67,160,747 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11170,307,847 - 70,384,425 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1170,307,847 - 70,384,425 (-)Ensemblpanpan1.1panPan2
NUMA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12126,000,579 - 26,076,281 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2126,037,095 - 26,075,549 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2125,807,053 - 25,845,823 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02126,209,480 - 26,285,035 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2126,246,198 - 26,285,033 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12126,037,623 - 26,076,493 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02126,216,869 - 26,292,447 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,118,493 - 26,194,367 (+)NCBIUU_Cfam_GSD_1.0
Numa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,759,062 - 59,838,501 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364981,359,285 - 1,438,382 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364981,358,598 - 1,438,041 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUMA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl96,591,945 - 6,662,085 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.196,591,943 - 6,662,966 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,353,400 - 7,424,395 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUMA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,204,968 - 63,284,673 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,202,913 - 63,273,774 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604362,614,605 - 62,694,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Numa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248174,924,827 - 4,963,436 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248174,896,066 - 4,963,440 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Numa1
445 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:366
Count of miRNA genes:163
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000000474, ENSRNOT00000055249
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1155866514158592016Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat

Markers in Region
D1Got153  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,323,989 - 156,324,231 (+)MAPPERmRatBN7.2
Rnor_6.01167,042,277 - 167,042,516NCBIRnor6.0
Rnor_5.01173,233,319 - 173,233,558UniSTSRnor5.0
RGSC_v3.41159,416,889 - 159,417,127RGDRGSC3.4
RGSC_v3.41159,416,888 - 159,417,127UniSTSRGSC3.4
RGSC_v3.11159,495,906 - 159,496,144RGD
Celera1154,397,632 - 154,397,871UniSTS
RH 3.4 Map11275.4RGD
RH 3.4 Map11275.4UniSTS
Cytogenetic Map1q32UniSTS
BF394104  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,361,028 - 156,361,274 (+)MAPPERmRatBN7.2
Rnor_6.01167,079,626 - 167,079,872NCBIRnor6.0
Rnor_5.01173,268,507 - 173,268,718NCBIRnor5.0
RGSC_v3.41159,459,685 - 159,459,930UniSTSRGSC3.4
Celera1154,433,972 - 154,434,217UniSTS
RH 3.4 Map11274.39UniSTS
Cytogenetic Map1q32UniSTS
D1Bda33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,371,888 - 156,372,124 (+)MAPPERmRatBN7.2
Rnor_6.01167,090,487 - 167,090,722NCBIRnor6.0
Rnor_5.01173,279,333 - 173,279,568UniSTSRnor5.0
RGSC_v3.41159,470,655 - 159,470,890UniSTSRGSC3.4
Celera1154,444,876 - 154,445,111UniSTS
Cytogenetic Map1q32UniSTS
AW535302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,365,780 - 156,365,955 (+)MAPPERmRatBN7.2
Rnor_6.01167,084,379 - 167,084,553NCBIRnor6.0
Rnor_5.01173,273,225 - 173,273,399UniSTSRnor5.0
RGSC_v3.41159,464,547 - 159,464,721UniSTSRGSC3.4
Celera1154,438,768 - 154,438,942UniSTS
RH 3.4 Map11277.4UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 56 40 19 40 8 11 74 35 41 11 8
Low 1 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC098753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000000474   ⟹   ENSRNOP00000000474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,326,259 - 156,372,855 (+)Ensembl
Rnor_6.0 Ensembl1167,066,516 - 167,090,296 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000055249   ⟹   ENSRNOP00000052124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,340,316 - 156,372,855 (+)Ensembl
Rnor_6.0 Ensembl1167,051,209 - 167,091,453 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094333   ⟹   ENSRNOP00000094619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,326,259 - 156,372,855 (+)Ensembl
RefSeq Acc Id: NM_001100691   ⟹   NP_001094161
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,738,252 - 165,784,848 (+)NCBI
mRatBN7.21156,326,259 - 156,372,855 (+)NCBI
Rnor_6.01167,044,544 - 167,091,453 (+)NCBI
Rnor_5.01173,235,586 - 173,280,299 (+)NCBI
Celera1154,399,899 - 154,445,842 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039113343   ⟹   XP_038969271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,709,924 - 165,784,187 (+)NCBI
mRatBN7.21156,297,907 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113344   ⟹   XP_038969272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,731,126 - 165,784,187 (+)NCBI
mRatBN7.21156,326,982 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113345   ⟹   XP_038969273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,731,126 - 165,784,187 (+)NCBI
mRatBN7.21156,326,537 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113346   ⟹   XP_038969274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,731,126 - 165,784,187 (+)NCBI
mRatBN7.21156,326,099 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113349   ⟹   XP_038969277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,710,073 - 165,784,187 (+)NCBI
mRatBN7.21156,298,117 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113350   ⟹   XP_038969278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,709,924 - 165,784,187 (+)NCBI
mRatBN7.21156,297,909 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113354   ⟹   XP_038969282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,709,924 - 165,784,187 (+)NCBI
mRatBN7.21156,297,907 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113357   ⟹   XP_038969285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,709,924 - 165,784,187 (+)NCBI
mRatBN7.21156,297,909 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_063262821   ⟹   XP_063118891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,709,893 - 165,784,187 (+)NCBI
RefSeq Acc Id: XM_063262822   ⟹   XP_063118892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,731,126 - 165,784,187 (+)NCBI
RefSeq Acc Id: XM_063262823   ⟹   XP_063118893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,731,126 - 165,784,187 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001094161   ⟸   NM_001100691
- UniProtKB: A0A8I6AMK5 (UniProtKB/TrEMBL),   F7FF45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052124   ⟸   ENSRNOT00000055249
RefSeq Acc Id: ENSRNOP00000000474   ⟸   ENSRNOT00000000474
RefSeq Acc Id: XP_038969271   ⟸   XM_039113343
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969282   ⟸   XM_039113354
- Peptide Label: isoform X3
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969278   ⟸   XM_039113350
- Peptide Label: isoform X2
- UniProtKB: F1LW91 (UniProtKB/TrEMBL),   F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969285   ⟸   XM_039113357
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AMK5 (UniProtKB/TrEMBL),   F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969277   ⟸   XM_039113349
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969274   ⟸   XM_039113346
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969273   ⟸   XM_039113345
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969272   ⟸   XM_039113344
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094619   ⟸   ENSRNOT00000094333
RefSeq Acc Id: XP_063118891   ⟸   XM_063262821
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063118892   ⟸   XM_063262822
- Peptide Label: isoform X2
- UniProtKB: F1LW91 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118893   ⟸   XM_063262823
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AMK5 (UniProtKB/TrEMBL)
Protein Domains
Nuclear mitotic apparatus protein 1 N-terminal hook

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FF45-F1-model_v2 AlphaFold F7FF45 1-2091 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308777 AgrOrtholog
BioCyc Gene G2FUF-58267 BioCyc
Ensembl Genes ENSRNOG00000000417 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000474.7 UniProtKB/TrEMBL
  ENSRNOT00000055249.3 UniProtKB/TrEMBL
  ENSRNOT00000094333 ENTREZGENE
  ENSRNOT00000094333.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7370001 IMAGE-MGC_LOAD
InterPro NuMA_LGNBD UniProtKB/TrEMBL
  NuMA_N_HOOK UniProtKB/TrEMBL
KEGG Report rno:308870 UniProtKB/TrEMBL
MGC_CLONE MGC:112774 IMAGE-MGC_LOAD
NCBI Gene 308870 ENTREZGENE
PANTHER NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED UniProtKB/TrEMBL
  PTHR18902:SF24 UniProtKB/TrEMBL
Pfam HOOK_N_NuMA UniProtKB/TrEMBL
PhenoGen Numa1 PhenoGen
RatGTEx ENSRNOG00000000417 RatGTEx
Superfamily-SCOP Hook domain UniProtKB/TrEMBL
UniProt A0A8I6AMK5 ENTREZGENE, UniProtKB/TrEMBL
  A6I6Z1_RAT UniProtKB/TrEMBL
  A6I6Z3_RAT UniProtKB/TrEMBL
  A6I6Z4_RAT UniProtKB/TrEMBL
  A6I6Z5_RAT UniProtKB/TrEMBL
  F1LW91 ENTREZGENE, UniProtKB/TrEMBL
  F7FF45 ENTREZGENE, UniProtKB/TrEMBL
  Q4G051_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Numa1  nuclear mitotic apparatus protein 1  Numa1_predicted  nuclear mitotic apparatus protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Numa1_predicted  nuclear mitotic apparatus protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED