Lrp10 (LDL receptor related protein 10) - Rat Genome Database

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Gene: Lrp10 (LDL receptor related protein 10) Rattus norvegicus
Analyze
Symbol: Lrp10
Name: LDL receptor related protein 10
RGD ID: 1310471
Description: Predicted to enable low-density lipoprotein particle receptor activity. Predicted to act upstream of or within several processes, including endocytosis; inner ear development; and lipid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human LRP10 (LDL receptor related protein 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305880; low-density lipoprotein receptor-related protein 10; MGC124814
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81531,891,358 - 31,897,530 (+)NCBIGRCr8
mRatBN7.21527,921,335 - 27,927,507 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,920,259 - 27,927,505 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1529,760,700 - 29,766,866 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,907,921 - 30,914,087 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,158,252 - 29,164,416 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,107,706 - 33,114,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,108,671 - 33,114,829 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01536,993,402 - 36,999,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,527,394 - 32,533,554 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,543,095 - 32,549,407 (+)NCBI
Celera1527,504,042 - 27,510,199 (+)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11123907   PMID:12477932   PMID:19946888   PMID:21795542  


Genomics

Comparative Map Data
Lrp10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81531,891,358 - 31,897,530 (+)NCBIGRCr8
mRatBN7.21527,921,335 - 27,927,507 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,920,259 - 27,927,505 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1529,760,700 - 29,766,866 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,907,921 - 30,914,087 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,158,252 - 29,164,416 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,107,706 - 33,114,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,108,671 - 33,114,829 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01536,993,402 - 36,999,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,527,394 - 32,533,554 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,543,095 - 32,549,407 (+)NCBI
Celera1527,504,042 - 27,510,199 (+)NCBICelera
Cytogenetic Map15p13NCBI
LRP10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381422,871,740 - 22,881,713 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1422,871,740 - 22,881,713 (+)EnsemblGRCh38hg38GRCh38
GRCh371423,340,949 - 23,350,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,410,800 - 22,417,133 (+)NCBINCBI36Build 36hg18NCBI36
Build 341422,410,799 - 22,417,129NCBI
Celera143,203,856 - 3,210,189 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,458,163 - 3,464,496 (+)NCBIHuRef
CHM1_11423,339,612 - 23,345,945 (+)NCBICHM1_1
T2T-CHM13v2.01417,069,798 - 17,079,771 (+)NCBIT2T-CHM13v2.0
Lrp10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,701,260 - 54,707,749 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,701,594 - 54,708,954 (+)EnsemblGRCm39 Ensembl
GRCm381454,464,137 - 54,470,292 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,464,137 - 54,471,497 (+)EnsemblGRCm38mm10GRCm38
MGSCv371455,082,984 - 55,089,129 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,418,352 - 53,424,497 (+)NCBIMGSCv36mm8
Celera1452,255,675 - 52,261,785 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.8NCBI
Lrp10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,412,778 - 37,419,734 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540937,413,471 - 37,419,485 (-)NCBIChiLan1.0ChiLan1.0
LRP10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,301,134 - 24,307,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,518,027 - 23,527,555 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,688,934 - 3,698,778 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11421,788,345 - 21,794,820 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1421,788,345 - 21,795,936 (+)Ensemblpanpan1.1panPan2
LRP10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,208,710 - 3,214,888 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,208,269 - 3,382,311 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,156,639 - 3,163,231 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,315,995 - 3,322,611 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,315,969 - 3,330,486 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,007,359 - 3,013,951 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,069,144 - 3,075,732 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,331,101 - 3,337,710 (+)NCBIUU_Cfam_GSD_1.0
Lrp10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864034,961,544 - 34,967,610 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,419,259 - 1,427,497 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,421,396 - 1,427,439 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl776,149,307 - 76,158,891 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1776,149,304 - 76,159,397 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LRP10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,236,863 - 23,243,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,236,539 - 23,242,638 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605923,179,221 - 23,185,663 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,645,954 - 9,652,289 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,645,954 - 9,652,296 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrp10
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:159
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000015468
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 49 33 19 33 1 4 66 35 37 11 1
Low 6 8 8 8 7 7 8 4 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015468   ⟹   ENSRNOP00000015468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1527,920,259 - 27,927,505 (+)Ensembl
Rnor_6.0 Ensembl1533,108,671 - 33,114,829 (+)Ensembl
RefSeq Acc Id: NM_001395560   ⟹   NP_001382489
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81531,891,358 - 31,897,530 (+)NCBI
mRatBN7.21527,921,335 - 27,927,507 (+)NCBI
RefSeq Acc Id: XM_063274233   ⟹   XP_063130303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81531,891,672 - 31,897,530 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001382489 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130303 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI00652 (Get FASTA)   NCBI Sequence Viewer  
  EDM14172 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015468
  ENSRNOP00000015468.5
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000015468   ⟸   ENSRNOT00000015468
RefSeq Acc Id: NP_001382489   ⟸   NM_001395560
- Peptide Label: precursor
- UniProtKB: F7F3K1 (UniProtKB/TrEMBL),   A6KGU3 (UniProtKB/TrEMBL),   Q496Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130303   ⟸   XM_063274233
- Peptide Label: isoform X1
Protein Domains
CUB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q496Z8-F1-model_v2 AlphaFold Q496Z8 1-711 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699651
Promoter ID:EPDNEW_R10174
Type:initiation region
Name:Lrp10_1
Description:LDL receptor related protein 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01533,108,659 - 33,108,719EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310471 AgrOrtholog
BioCyc Gene G2FUF-13799 BioCyc
Ensembl Genes ENSRNOG00000011592 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015468 ENTREZGENE
  ENSRNOT00000015468.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7932904 IMAGE-MGC_LOAD
InterPro CUB UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classA_rpt UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
KEGG Report rno:305880 UniProtKB/TrEMBL
MGC_CLONE MGC:124814 IMAGE-MGC_LOAD
NCBI Gene 305880 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 10 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
PhenoGen Lrp10 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011592 RatGTEx
SMART CUB UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
Superfamily-SCOP CUB UniProtKB/TrEMBL
  LDL_rcpt_classA_cys-rich UniProtKB/TrEMBL
UniProt A6KGU3 ENTREZGENE, UniProtKB/TrEMBL
  F7F3K1 ENTREZGENE, UniProtKB/TrEMBL
  Q496Z8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-11 Lrp10  LDL receptor related protein 10  Lrp10  low-density lipoprotein receptor-related protein 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Lrp10  low-density lipoprotein receptor-related protein 10  Lrp10_predicted  low-density lipoprotein receptor-related protein 10 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lrp10_predicted  low-density lipoprotein receptor-related protein 10 (predicted)      Symbol and Name status set to approved 70820 APPROVED