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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620955
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lss
Name: lanosterol synthase
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lssincreases expressionISOLSS (Homo sapiens)6480464CTDClozapine results in increased expression of LSS mRNAPMID:15342952 PMID:17175557
Lssmultiple interactionsISOLSS (Homo sapiens)6480464CTD[Cuprizone co-treated with Clozapine] results in decreased expression of LSS proteinPMID:34122009
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