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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3853 Species: Rattus norvegicus RGD Object: Gene Symbol: Th Name: tyrosine hydroxylase

Acc ID: CHEBI:3766 Term: clozapine Definition: A benzodiazepine that has formula C18H19ClN4. CasRN: 5786-21-0 Chemical ID: MESH:D003024

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	EXP		6480464	CTD	Clozapine results in decreased activity of TH protein	PMID:15983997
multiple interactions	ISO	RGD:11414	6480464	CTD	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]	PMID:16402076
multiple interactions	ISO	RGD:11414	6480464	CTD	[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine	PMID:16415089
increases activity	ISO	RGD:11414	6480464	CTD	Clozapine results in increased activity of TH protein	PMID:16415089
decreases expression	EXP		6480464	CTD	Clozapine results in decreased expression of TH mRNA Clozapine results in decreased expression of TH protein	PMID:12645084 PMID:15983997
increases expression	EXP		6480464	CTD	Clozapine results in increased expression of TH protein	PMID:17028028
multiple interactions	EXP		6480464	CTD	Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]	PMID:15983997
decreases expression	EXP		6480464	CTD	Clozapine results in decreased expression of TH mRNA Clozapine results in decreased expression of TH protein	PMID:15983997 PMID:12645084