Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,2',5,5'-tetrachlorobiphenyl | decreases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:36804509 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KCNIP3 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KCNIP3 mRNA | CTD | PMID:33387578 | 2-palmitoylglycerol | increases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of KCNIP3 mRNA | CTD | PMID:37199045 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of KCNIP3 mRNA | CTD | PMID:20188158 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Kcnip3 (Mus musculus) | 6480464 | [bisphenol S co-treated with Tretinoin] results in decreased expression of KCNIP3 mRNA | CTD | PMID:30951980 | 4-hydroxyphenyl retinamide | increases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | Fenretinide results in increased expression of KCNIP3 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of KCNIP3 mRNA | CTD | PMID:24780913 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of KCNIP3 mRNA | CTD | PMID:28959563 | aflatoxin B1 | increases methylation | ISO | KCNIP3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of KCNIP3 gene and Aflatoxin B1 results in increased methylation of KCNIP3 intron | CTD | PMID:27153756 and PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | KCNIP3 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of KCNIP3 intron | CTD | PMID:30157460 | all-trans-retinoic acid | multiple interactions | ISO | Kcnip3 (Mus musculus) | 6480464 | [bisphenol S co-treated with Tretinoin] results in decreased expression of KCNIP3 mRNA | CTD | PMID:30951980 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KCNIP3 mRNA | CTD | PMID:16483693 | aristolochic acid A | increases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of KCNIP3 mRNA | CTD | PMID:33212167 | arsane | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of KCNIP3 mRNA | CTD | PMID:32525701 | arsane | increases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | Arsenic results in increased expression of KCNIP3 mRNA | CTD | PMID:36861143 | arsenic atom | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of KCNIP3 mRNA | CTD | PMID:32525701 | arsenic atom | increases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | Arsenic results in increased expression of KCNIP3 mRNA | CTD | PMID:36861143 | benzo[a]pyrene | affects methylation | ISO | KCNIP3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KCNIP3 exon and Benzo(a)pyrene affects the methylation of KCNIP3 intron | CTD | PMID:27901495 and PMID:30157460 | benzo[e]pyrene | increases methylation | ISO | KCNIP3 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of KCNIP3 intron | CTD | PMID:30157460 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KCNIP3 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | ISO | Kcnip3 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of KCNIP3 promoter | CTD | PMID:27312807 | butanal | increases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of KCNIP3 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KCNIP3 mRNA | CTD | PMID:35301059 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of KCNIP3 mRNA | CTD | PMID:33453195 | cadmium dichloride | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KCNIP3 mRNA | CTD | PMID:35301059 | carbon nanotube | increases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to KCNIP3 gene] | CTD | PMID:28238834 | chloroprene | increases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | Chloroprene results in increased expression of KCNIP3 mRNA | CTD | PMID:23125180 | choline | multiple interactions | ISO | Kcnip3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KCNIP3 mRNA | CTD | PMID:20938992 | clozapine | decreases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | Clozapine results in decreased expression of KCNIP3 mRNA | CTD | PMID:18797397 | clozapine | increases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | Clozapine results in increased expression of KCNIP3 mRNA | CTD | PMID:17266109 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of KCNIP3 mRNA | CTD | PMID:20187946 | ethanol | affects expression | ISO | Kcnip3 (Mus musculus) | 6480464 | Ethanol affects the expression of KCNIP3 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Kcnip3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KCNIP3 mRNA | CTD | PMID:20938992 | genistein | decreases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | Genistein results in decreased expression of KCNIP3 mRNA | CTD | PMID:18847459 | GW 4064 | decreases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | GW 4064 results in decreased expression of KCNIP3 mRNA | CTD | PMID:26655953 | haloperidol | decreases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | Haloperidol results in decreased expression of KCNIP3 mRNA and Haloperidol results in decreased expression of KCNIP3 protein | CTD | PMID:18797397 | inulin | multiple interactions | ISO | Kcnip3 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of KCNIP3 mRNA | CTD | PMID:36331819 | L-methionine | multiple interactions | ISO | Kcnip3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KCNIP3 mRNA | CTD | PMID:20938992 | lead(0) | decreases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | Lead results in decreased expression of KCNIP3 mRNA | CTD | PMID:19921347 | lipopolysaccharide | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of KCNIP3 mRNA | CTD | PMID:35811015 | manganese atom | increases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | Manganese results in increased expression of KCNIP3 mRNA | CTD | PMID:17175027 | manganese(0) | increases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | Manganese results in increased expression of KCNIP3 mRNA | CTD | PMID:17175027 | manganese(II) chloride | increases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | manganese chloride results in increased expression of KCNIP3 mRNA | CTD | PMID:17175027 | methapyrilene | increases methylation | ISO | KCNIP3 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of KCNIP3 intron | CTD | PMID:30157460 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[SOD1 protein results in increased susceptibility to Thimerosal] which results in decreased expression of KCNIP3 protein] | CTD | PMID:30503815 | olanzapine | decreases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | olanzapine results in decreased expression of KCNIP3 mRNA and olanzapine results in decreased expression of KCNIP3 protein | CTD | PMID:18797397 | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of KCNIP3 mRNA | CTD | PMID:28623178 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of KCNIP3 mRNA | CTD | PMID:32680482 | pentanal | increases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | pentanal results in increased expression of KCNIP3 mRNA | CTD | PMID:26079696 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Kcnip3 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of KCNIP3 mRNA | CTD | PMID:36331819 | phencyclidine | increases expression | ISO | Kcnip3 (Mus musculus) | 6480464 | Phencyclidine results in increased expression of KCNIP3 mRNA | CTD | PMID:17266109 | Repaglinide | multiple interactions | EXP | | 6480464 | repaglinide inhibits the reaction [Rotenone results in decreased expression of KCNIP3 mRNA] | CTD | PMID:36538285 | resveratrol | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of KCNIP3 mRNA more ... | CTD | PMID:23557933 and PMID:30503815 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of KCNIP3 mRNA | CTD | PMID:36538285 | rotenone | multiple interactions | EXP | | 6480464 | repaglinide inhibits the reaction [Rotenone results in decreased expression of KCNIP3 mRNA] | CTD | PMID:36538285 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of KCNIP3 mRNA | CTD | PMID:35811015 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of KCNIP3 mRNA | CTD | PMID:35811015 | silicon dioxide | decreases methylation | ISO | KCNIP3 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased methylation of KCNIP3 promoter | CTD | PMID:34973136 | sodium arsenate | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of KCNIP3 mRNA | CTD | PMID:32525701 | sulforaphane | decreases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of KCNIP3 mRNA | CTD | PMID:31838189 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of KCNIP3 mRNA | CTD | PMID:12734012 | thimerosal | multiple interactions | ISO | KCNIP3 (Homo sapiens) | 6480464 | [SOD1 protein mutant form results in increased susceptibility to Thimerosal] which results in increased acetylation of and results in increased ubiquitination of KCNIP3 protein more ... | CTD | PMID:30503815 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of KCNIP3 mRNA | CTD | PMID:33387578 | valproic acid | increases methylation | ISO | KCNIP3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of KCNIP3 gene | CTD | PMID:29154799 | zoledronic acid | increases expression | ISO | KCNIP3 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of KCNIP3 mRNA | CTD | PMID:24714768 | |