Tes (testin LIM domain protein) - Rat Genome Database

Name: Tes
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Tes (testin LIM domain protein) Rattus norvegicus

Analyze

Symbol:

Tes

Name:

testin LIM domain protein

RGD ID:

1566346

Description:

Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of cell population proliferation. Predicted to be located in cytosol; focal adhesion; and plasma membrane. Predicted to be part of protein-containing complex. Orthologous to human TES (testin LIM domain protein); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC500040; similar to Testis derived transcript; testin; testis derived transcript

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TES (testin LIM domain protein)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):	Tes (testin LIM domain protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tes (testin LIM domain protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TES (testin LIM domain protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TES (testin LIM domain protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tes (testin LIM domain protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TES (testin LIM domain protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TES (testin LIM domain protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tes (testin LIM domain protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tes (testin LIM domain protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TES (testin LIM domain protein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tes (testis derived transcript (3 LIM domains))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tes	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tes-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tes	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	46,331,257 - 46,369,782 (+)	NCBI		GRCr8
mRatBN7.2	4	45,365,304 - 45,403,829 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	45,365,285 - 45,403,829 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	50,366,261 - 50,412,536 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	46,287,252 - 46,333,519 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	44,704,633 - 44,743,227 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	44,321,883 - 44,360,407 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	44,321,883 - 44,360,405 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	44,929,781 - 44,968,305 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	42,680,722 - 42,719,246 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	40,655,536 - 40,694,015 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

glioblastoma (ISO)

hereditary breast ovarian cancer syndrome (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2-acetamidofluorene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrolein (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amphetamine (EXP)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

clozapine (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

dichloroacetic acid (ISO)

dioxygen (EXP)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

enzyme inhibitor (ISO)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

glutathione (EXP)

hydroquinone O-beta-D-glucopyranoside (ISO)

indole-3-methanol (EXP)

iron atom (ISO)

iron(0) (ISO)

ivermectin (ISO)

ketamine (EXP)

mercury atom (ISO)

mercury dibromide (ISO)

mercury(0) (ISO)

methapyrilene (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodimethylamine (EXP)

nickel dichloride (EXP,ISO)

nickel sulfate (ISO)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

resveratrol (EXP,ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

Soman (EXP)

sunitinib (ISO)

tamoxifen (ISO)

tebufenpyrad (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cell population proliferation (ISO,ISS)

Cellular Component

cell junction (ISO)

cytoplasm (ISO,ISS)

cytosol (ISO)

focal adhesion (IEA,ISO)

plasma membrane (ISO)

protein-containing complex (ISO)

Molecular Function

protein binding (IPI,ISO)

zinc ion binding (IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.	Boeda B, etal., J Biol Chem. 2011 Apr 1;286(13):11543-54. doi: 10.1074/jbc.M110.171264. Epub 2011 Jan 29.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11420696	PMID:12477932	PMID:12917688	PMID:15489334	PMID:15656790	PMID:21423176	PMID:21630459	PMID:22658674	PMID:25468996

Genomics

Comparative Map Data

Tes
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	46,331,257 - 46,369,782 (+)	NCBI		GRCr8
mRatBN7.2	4	45,365,304 - 45,403,829 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	45,365,285 - 45,403,829 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	50,366,261 - 50,412,536 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	46,287,252 - 46,333,519 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	44,704,633 - 44,743,227 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	44,321,883 - 44,360,407 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	44,321,883 - 44,360,405 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	44,929,781 - 44,968,305 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	42,680,722 - 42,719,246 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	40,655,536 - 40,694,015 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

TES
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	116,210,539 - 116,258,783 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	116,210,506 - 116,258,783 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	115,850,593 - 115,898,837 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	115,637,817 - 115,686,073 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	110,657,947 - 110,706,196 (+)	NCBI		Celera
Cytogenetic Map	7	q31.2	NCBI
HuRef	7	110,216,624 - 110,264,907 (+)	NCBI		HuRef
CHM1_1	7	115,783,744 - 115,832,054 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	117,525,529 - 117,573,770 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	115,245,942 - 115,294,229 (+)	NCBI

Tes
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	17,065,148 - 17,105,824 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	17,065,148 - 17,105,827 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	17,065,149 - 17,105,825 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	17,065,149 - 17,105,828 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	17,015,149 - 17,055,825 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	17,015,200 - 17,055,825 (+)	NCBI		MGSCv36	mm8
Celera	6	17,137,949 - 17,178,804 (+)	NCBI		Celera
Cytogenetic Map	6	A2	NCBI
cM Map	6	7.67	NCBI

Tes
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	22,014,444 - 22,035,636 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	21,992,708 - 22,035,441 (+)	NCBI	ChiLan1.0	ChiLan1.0

TES
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	153,035,730 - 153,084,220 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	5,044,942 - 5,094,479 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	108,176,519 - 108,224,816 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	120,873,407 - 120,922,333 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	120,873,762 - 120,922,333 (+)	Ensembl	panpan1.1		panPan2

TES
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	55,217,768 - 55,240,668 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	55,177,375 - 55,240,668 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	54,588,694 - 54,636,021 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	55,231,813 - 55,279,332 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	55,231,648 - 55,279,332 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	55,263,314 - 55,310,657 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	54,952,074 - 54,999,418 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	55,322,418 - 55,369,952 (+)	NCBI		UU_Cfam_GSD_1.0

Tes
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	43,893,609 - 43,933,961 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936589	2,755,903 - 2,796,308 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936589	2,755,905 - 2,796,244 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TES
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	29,895,882 - 29,936,233 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	29,895,878 - 29,936,248 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	31,991,868 - 32,012,667 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TES
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	84,913,067 - 84,963,290 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	84,913,093 - 84,963,303 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	18,799,132 - 18,844,419 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tes
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624827	3,206,196 - 3,249,025 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624827	3,208,246 - 3,248,942 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tes
153 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	102
Count of miRNA genes:	86
Interacting mature miRNAs:	93
Transcripts:	ENSRNOT00000049102
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	57114705	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5219178	56647776	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	10084089	55084089	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	10084089	55084089	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	10084089	55084089	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	10084089	55084089	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	10084089	55084089	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	10084089	55084089	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	14678065	59678065	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	17933508	62933508	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	21333343	62278020	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	26907285	75585128	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	26907285	75585128	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	29494195	81006281	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	32583980	114627242	Rat
11530004	Niddm71	Non-insulin dependent diabetes mellitus QTL 71		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	4	32584199	52754138	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	34430484	82490359	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	36303261	103194984	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	39505275	73892441	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	39524264	74726312	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	39524264	116179656	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	40433388	85433388	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	40433414	85433414	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	43457976	88457976	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat

Markers in Region

RH142926

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	45,398,333 - 45,398,633 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	44,354,912 - 44,355,211	NCBI	Rnor6.0
Rnor_5.0	4	44,962,810 - 44,963,109	UniSTS	Rnor5.0
RGSC_v3.4	4	42,713,751 - 42,714,050	UniSTS	RGSC3.4
Celera	4	40,688,520 - 40,688,819	UniSTS
RH 3.4 Map	4	299.1	UniSTS
Cytogenetic Map	4	q21	UniSTS

RH139200

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	45,403,405 - 45,403,612 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	44,359,984 - 44,360,190	NCBI	Rnor6.0
Rnor_5.0	4	44,967,882 - 44,968,088	UniSTS	Rnor5.0
RGSC_v3.4	4	42,718,823 - 42,719,029	UniSTS	RGSC3.4
Celera	4	40,693,592 - 40,693,798	UniSTS
RH 3.4 Map	4	285.0	UniSTS
Cytogenetic Map	4	q21	UniSTS

AI236772

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	45,403,394 - 45,403,612 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	44,359,973 - 44,360,190	NCBI	Rnor6.0
Rnor_5.0	4	44,967,871 - 44,968,088	UniSTS	Rnor5.0
RGSC_v3.4	4	42,718,812 - 42,719,029	UniSTS	RGSC3.4
Celera	4	40,693,581 - 40,693,798	UniSTS
RH 3.4 Map	4	285.0	UniSTS
Cytogenetic Map	4	q21	UniSTS

Tes

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	45,395,165 - 45,395,377 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	44,351,744 - 44,351,955	NCBI	Rnor6.0
Rnor_5.0	4	44,959,642 - 44,959,853	UniSTS	Rnor5.0
RGSC_v3.4	4	42,710,583 - 42,710,794	UniSTS	RGSC3.4
Celera	4	40,685,352 - 40,685,563	UniSTS
Cytogenetic Map	4	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	20	35	19	19	19			58	34	41	11
Low		23	22	22		22	8	10	16	1			8
Below cutoff								1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001039344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC126115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC127142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC129069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DP000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ339047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000091095 ⟹ ENSRNOP00000070338

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	45,365,285 - 45,403,829 (+)	Ensembl
Rnor_6.0 Ensembl	4	44,321,883 - 44,360,405 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094881 ⟹ ENSRNOP00000096525

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	45,384,770 - 45,403,829 (+)	Ensembl

RefSeq Acc Id:

NM_001039344 ⟹ NP_001034433

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	46,331,257 - 46,369,782 (+)	NCBI
mRatBN7.2	4	45,365,304 - 45,403,829 (+)	NCBI
Rnor_6.0	4	44,321,883 - 44,360,407 (+)	NCBI
Rnor_5.0	4	44,929,781 - 44,968,305 (+)	NCBI
RGSC_v3.4	4	42,680,722 - 42,719,246 (+)	RGD
Celera	4	40,655,536 - 40,694,015 (+)	RGD

Sequence:

show sequence

CGGCCGCGGCGCTGGAGTTCCCGCAGCGGAGATCCGGGACGCGGGACTGAGCCCATCCGACGCC
CAGCATGGACCTGGAAACCAAAATGAAGAAGATGGGCTTAGGTCACGAGCAAGGATTTGGAGCC
CCCTGTCTAAAATGCAAAGAGAACTGTGAAGGGTTTGAACTACACTTCTGGAGGAAAATATGTC
GTAACTGCAAATGTGGTCAAGAAGAGCATGACGTCCTCCTGAGCACTGAGGAGGACCGGAAGGT
GGGGAGACTCTTTGAAGACACCAAGTACACCACCCTGATCGCCAAGCTGAAGTCAGATGGAATC
CCCATGTATAAACGCAATGTTATGATATTGACCAATCCAGTGGCTGCCAAGAAGAACGTCTCCA
TCAACACCGTTACCTATGAGTGGGCTCCCCCGGTTCAGAACCAGGCACTGGCCAGGCAGTACAT
GCAGATGCTCCCTAAAGAGAAGCAGCCAGTGGCGGGTTCAGAGGGGGCGCAGTACCGGAAGAAG
CAGCTGGCGAAGCAGCTCCCTGCACATGACCAGGACCCTTCTAAGTGCCACGAGCTGTCTCCCA
AAGAGGTGAAGGAGATGGAACAGTTCGTGAAGAAATATAAGAGTGAAGCTCTGGGCGTGGGCGA
CGTGAAGCTTCCTTCCGAGATGAATGCTCAAGGTGACAAGGTGCACAACCCTGCCGGAGACAGA
AACACCCCAGCAGCAGTGGGTTCCAAGGACAAGTCTGCAGAAGCCAAGAAGACCCAATATTCCT
GTTACTGCTGCAAAAACACCATGAGGGAAGGAGACCCAGCCATCTATGCTGAAAGAGCTGGCTA
CGACAAACTCTGGCACCCGGCATGTTTTATCTGCAGCACCTGTGGTGAACTCTTGGTCGACATG
ATTTACTTCTGGAAGAATGGGAAGCTGTACTGTGGCAGACATTACTGTGACAGCGAGAAGCCCC
GCTGTGCTGGCTGTGATGAGCTGATATTCAGCAATGAGTATACCCAGGCAGAAAACCAGAATTG
GCATCTGAAGCACTTCTGCTGCTTTGACTGCGACAACATCCTGGCCGGAAAAATATACGTGATG
GTCCGTGACAAGCCTGTGTGCAAGCCGTGCTATGTGAAGAACCATGCTGTGGTGTGTCAAGGGT
GCCACAATGCCATCGACCCGGAAGTGCAGCGAGTGACGTACAATAACTTCAGCTGGCACGCGTC
CACGGAGTGCTTCCTCTGCTCCTGCTGCAGCAAGTGCCTGATCGGGCAGAAGTTCATGCCTGTG
GAAGGGATGGTTTTCTGTTCTGTGGAGTGTAAGAAGATGATGTCCTGAGTGAACACCAAGCAGT
ATTGAGCCATAGCTGTCTACAGTGGCCTGCATTTCATGATAAACTGCAGTTTAAAAAAAAAATA
AAAAATAAAAGGAAAAAAAAAAGCTACATAACGAACCGGAAGATTTTGTCCAATATTTTTCTCT
TTTTAACCATTATGAATTTTGTCTGTCTTATTTTTAAATGACTGCTTTAAGCGCATGATTTAAA
AAAAACAGTAAAGAATTATAGCTTTTATTTCTGCACATTAAATATTTGAGTTGGAAGCTTGAAT
TTAATCAATCCTTATAACCGCATACTCCTAGTGCTAGATATATTATATATATATATATATATAA
AATCACTTAAAATTAGTGTCCTGGGAGAGATGAACATTTTAACTTCCATGCTTGTCCCCCATGG
GAAATGTAAAGGAAGTTACAACCGCCTGTCGAGCGGTTTGATGATGGTGACGTCAGCTCAGTGA
GGAGTTCCTTGTGGCAGGCAGTGTGGTCCACGTTGGGTGTTCCAGTGCCTAAGCCTTTGCATCC
CCCATGGAGGCAGAGGGGCCTCTCCCTCCTGCATCTCTCTCTGGTTACTTTACCTCTCAGTATC
CTCTTTTGTCATCTAGCGACCTCCATCTGTGGCCTTGAATATTTTATATGTATGTGGTTAGGAC
AATATGTGCACTTTGCTCTTAGAGATTTTTTTTTTTTGTTTTTTTGTCCAGAAGATAAAAGTAG
GCCATTCATTTAATTTTTTTGAAACCCAAAGAATATATAGGTTTTGTACCCAGGGAATTATAAC
TCATGCTGATGTCACCTTAATGCCATGCCTTGACTCAGTTGTTTGCATGATTTCCAATGTTACC
AGATGGATACTCTCTTGTGCTACCTCTGAGCTTGCTATAGACACAAAGGCTGTCTTCTTTGCCT
GTGCACGCGCATCCTTGGGTATTTTTTAATGTTTTCCGTGTATGCTTTCATACATAACTATGCA
CTATAAATATTAAATGGAATGACTTATATGATATTGAAAATAAAGCCTCTTTCACTTTAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001034433	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI29070	(Get FASTA)	NCBI Sequence Viewer
	ABC68418	(Get FASTA)	NCBI Sequence Viewer
	ABC87757	(Get FASTA)	NCBI Sequence Viewer
	EDM15102	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070338
	ENSRNOP00000070338.1
	ENSRNOP00000096525.1
	ENSRNOP00055024694
	ENSRNOP00060000298
	ENSRNOP00065008891
GenBank Protein	Q2LAP6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001034433 ⟸ NM_001039344

- UniProtKB:

Q2LAP6 (UniProtKB/Swiss-Prot), A6IE14 (UniProtKB/TrEMBL), A0A8I6AV73 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDLETKMKKMGLGHEQGFGAPCLKCKENCEGFELHFWRKICRNCKCGQEEHDVLLSTEEDRKVG
RLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQ
MLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPKEVKEMEQFVKKYKSEALGVGDV
KLPSEMNAQGDKVHNPAGDRNTPAAVGSKDKSAEAKKTQYSCYCCKNTMREGDPAIYAERAGYD
KLWHPACFICSTCGELLVDMIYFWKNGKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWH
LKHFCCFDCDNILAGKIYVMVRDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHAST
ECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKMMS

hide sequence

RefSeq Acc Id:

ENSRNOP00000070338 ⟸ ENSRNOT00000091095

RefSeq Acc Id:

ENSRNOP00000096525 ⟸ ENSRNOT00000094881

Protein Domains

LIM zinc-binding PET

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q2LAP6-F1-model_v2	AlphaFold	Q2LAP6	1-419	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692890

Promoter ID:

EPDNEW_R3414

Type:

initiation region

Name:

Tes_1

Description:

testin LIM domain protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	44,321,861 - 44,321,921	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566346	AgrOrtholog
BioCyc Gene	G2FUF-45582	BioCyc
Ensembl Genes	ENSRNOG00000051952	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055018107	UniProtKB/Swiss-Prot
	ENSRNOG00060000797	UniProtKB/Swiss-Prot
	ENSRNOG00065007755	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000091095	ENTREZGENE
	ENSRNOT00000091095.2	UniProtKB/Swiss-Prot
	ENSRNOT00000094881.1	UniProtKB/TrEMBL
	ENSRNOT00055030700	UniProtKB/Swiss-Prot
	ENSRNOT00060000976	UniProtKB/Swiss-Prot
	ENSRNOT00065012162	UniProtKB/Swiss-Prot
Gene3D-CATH	Cysteine Rich Protein	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7100907	IMAGE-MGC_LOAD
InterPro	LIM1_Testin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LIM2_Testin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LIM3_Testin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PET_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PET_testin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pk/Esn/Tes	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_LIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:500040	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:156466	IMAGE-MGC_LOAD
NCBI Gene	500040	ENTREZGENE
PANTHER	LIM DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR24211:SF1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	LIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PET	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tes	PhenoGen
PROSITE	LIM_DOMAIN_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LIM_DOMAIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PET	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000051952	RatGTEx
	ENSRNOG00055018107	RatGTEx
	ENSRNOG00060000797	RatGTEx
	ENSRNOG00065007755	RatGTEx
SMART	LIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AV73	ENTREZGENE, UniProtKB/TrEMBL
	A6IE14	ENTREZGENE, UniProtKB/TrEMBL
	Q2LAP6	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-03-16	Tes	testin LIM domain protein	Tes	testis derived transcript	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Tes	testis derived transcript	LOC500040	similar to Testis derived transcript	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC500040	similar to Testis derived transcript			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD