Gene: Lrrk2 (leucine-rich repeat kinase 2) Rattus norvegicus
Symbol: Lrrk2
Name: leucine-rich repeat kinase 2
Description: ENCODES a protein that exhibits actin binding (ortholog); beta-catenin destruction complex binding (ortholog); clathrin binding (ortholog); INVOLVED IN cellular response to organic cyclic compound; activation of MAPK activity (ortholog); activation of MAPKK activity (ortholog); PARTICIPATES IN Parkinson disease pathway; ASSOCIATED WITH Amyotrophic Lateral Sclerosis (ortholog); Arthritis, Rheumatoid (ortholog); Colitis (ortholog); FOUND IN axon; cytoplasm; dendrite; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; benzo[a]pyrene
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: leucine-rich repeat serine/threonine-protein kinase 2
Orthologs:
Allele / Splice: Lrrk1em1SageLrrk2em1Sage   Lrrk2em1Sage  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07132,857,311 - 133,018,549 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.07132,531,591 - 132,694,226 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.47130,105,902 - 130,267,747 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7119,264,946 - 119,423,875 (+)NCBI
Cytogenetic Map7q35NCBImapview
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
 
More on Lrrk2
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 1561168
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2016-09-20
Status: ACTIVE