Gene: Lrrk2 (leucine-rich repeat kinase 2) Rattus norvegicus
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Symbol: Lrrk2
Name: leucine-rich repeat kinase 2
Description: ENCODES a protein that exhibits actin binding (ortholog); beta-catenin destruction complex binding (ortholog); clathrin binding (ortholog); INVOLVED IN cellular response to organic cyclic compound; activation of MAPK activity (ortholog); activation of MAPKK activity (ortholog); PARTICIPATES IN Parkinson disease pathway; ASSOCIATED WITH decreased erythrocyte cell number; increased alveolar lamellar body number; increased body weight; ASSOCIATED WITH Amyotrophic Lateral Sclerosis (ortholog); amyotrophic lateral sclerosis (ortholog); Arthritis, Rheumatoid (ortholog); FOUND IN axon; cytoplasm; dendrite; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; benzo[a]pyrene
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: leucine-rich repeat serine/threonine-protein kinase 2
Orthologs:
Homo sapiens (human) : LRRK2 (leucine rich repeat kinase 2)  HGNC
Mus musculus (house mouse) : Lrrk2 (leucine-rich repeat kinase 2)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Lrrk2 (leucine rich repeat kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRRK2 (leucine rich repeat kinase 2)
Canis lupus familiaris (dog) : LRRK2 (leucine rich repeat kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrrk2 (leucine rich repeat kinase 2)
more info ...
Allele / Splice: Lrrk1em1SageLrrk2em1Sage   Lrrk2em1Sage  
Genetic Models: LE-Lrrk2em1Sage LE-Lrrk1em1Sage-/-Lrrk2em1Sage-/- LE-Lrrk1em1SageLrrk2em1Sage LE-Lrrk2em1Sage-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07132,857,311 - 133,018,549 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.07132,531,591 - 132,694,226 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.47130,105,902 - 130,267,747 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7119,264,946 - 119,423,875 (+)NCBI
Cytogenetic Map7q35NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
 
More on Lrrk2
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 1561168
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2017-07-11
Status: ACTIVE