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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | affects expression | ISO | RGD:1353804 | 6480464 | Estradiol affects the expression of DAB1 mRNA | CTD | PMID:22574217 | all-trans-retinoic acid | decreases expression | ISO | RGD:1353804 | 6480464 | Tretinoin results in decreased expression of DAB1 mRNA | CTD | PMID:21934132 | benzo[a]pyrene | increases expression | ISO | RGD:1558041 | 6480464 | Benzo(a)pyrene results in increased expression of DAB1 mRNA | CTD | PMID:20127859 | calciol | increases expression | ISO | RGD:1558041 | 6480464 | Cholecalciferol results in increased expression of DAB1 mRNA | CTD | PMID:17170073 | clozapine | increases expression | EXP | | 6480464 | Clozapine results in increased expression of DAB1 mRNA | CTD | PMID:19359144 | dibutyl phthalate | decreases expression | ISO | RGD:1558041 | 6480464 | Dibutyl Phthalate results in decreased expression of DAB1 mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:1558041 | 6480464 | Dibutyl Phthalate results in decreased expression of DAB1 mRNA | CTD | PMID:17361019 PMID:21266533 | fluoxetine | increases expression | EXP | | 6480464 | Fluoxetine results in increased expression of DAB1 protein | CTD | PMID:19359144 | fonofos | increases methylation | ISO | RGD:1353804 | 6480464 | Fonofos results in increased methylation of DAB1 promoter | CTD | PMID:22847954 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of DAB1 mRNA | CTD | PMID:21396975 | mercury atom | increases expression | ISO | RGD:1353804 | 6480464 | Mercury results in increased expression of DAB1 mRNA | CTD | PMID:16823088 | mercury(0) | increases expression | ISO | RGD:1353804 | 6480464 | Mercury results in increased expression of DAB1 mRNA | CTD | PMID:16823088 | nickel sulfate | increases expression | ISO | RGD:1353804 | 6480464 | nickel sulfate results in increased expression of DAB1 mRNA | CTD | PMID:16780908 | nitric oxide | decreases expression | ISO | RGD:1558041 | 6480464 | Nitric Oxide deficiency results in decreased expression of DAB1 mRNA | CTD | PMID:15878706 | olanzapine | decreases expression | EXP | | 6480464 | olanzapine results in decreased expression of DAB1 protein | CTD | PMID:19359144 | parathion | increases methylation | ISO | RGD:1353804 | 6480464 | Parathion results in increased methylation of DAB1 promoter | CTD | PMID:22847954 | pirinixic acid | multiple interactions | ISO | RGD:1558041 | 6480464 | [pirinixic acid co-treated with PPARA] results in increased expression of DAB1 mRNA | CTD | PMID:20813756 | pirinixic acid | increases expression | ISO | RGD:1558041 | 6480464 | pirinixic acid results in increased expression of DAB1 mRNA | CTD | PMID:20813756 PMID:18301758 | pirinixic acid | increases expression | ISO | RGD:1558041 | 6480464 | pirinixic acid results in increased expression of DAB1 mRNA | CTD | PMID:18301758 PMID:20813756 | pirinixic acid | decreases expression | ISO | RGD:1558041 | 6480464 | pirinixic acid results in decreased expression of DAB1 mRNA | CTD | PMID:17426115 | rosiglitazone | decreases expression | EXP | | 6480464 | rosiglitazone results in decreased expression of DAB1 mRNA | CTD | PMID:21515302 | S-butyl-DL-homocysteine (S,R)-sulfoximine | decreases expression | ISO | RGD:1558041 | 6480464 | Buthionine Sulfoximine results in decreased expression of DAB1 mRNA | CTD | PMID:15878706 | terbufos | increases methylation | ISO | RGD:1353804 | 6480464 | terbufos results in increased methylation of DAB1 promoter | CTD | PMID:22847954 | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of DAB1 mRNA | CTD | PMID:21515302 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of DAB1 protein | CTD | PMID:19359144 | valproic acid | affects expression | ISO | RGD:1558041 | 6480464 | Valproic Acid affects the expression of DAB1 mRNA | CTD | PMID:17292431 PMID:17963808 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of DAB1 mRNA | CTD | PMID:19359144 | valproic acid | affects expression | ISO | RGD:1558041 | 6480464 | Valproic Acid affects the expression of DAB1 mRNA | CTD | PMID:17963808 PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | Lissencephaly gene (LIS1) in neuronal migration and development (PID:200132) |
| Reelin signaling pathway (PID:200062) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| Pathway Interaction Database | Lissencephaly gene (LIS1) in neuronal migration and development (PID:200132) |
| Reelin signaling pathway (PID:200062) | |
References - curated| 1. |
Alvarez-Dolado M, etal., J Neurosci 1999 Aug 15;19(16):6979-93. |
| 2. |
Beffert U, etal., Neuron. 2005 Aug 18;47(4):567-79. |
| 3. |
Bock HH, etal., J Biol Chem 2003 Oct 3;278(40):38772-9. Epub 2003 Jul 25. |
| 4. |
Fatemi SH, etal., Biol Psychiatry. 2005 Apr 1;57(7):777-87. |
| 5. |
Fatemi SH, etal., Schizophr Res. 2009 Jun;111(1-3):138-52. Epub 2009 Apr 9. |
| 6. |
Garcia-Miranda P, etal., Exp Physiol. 2010 Apr;95(4):498-507. Epub 2009 Nov 27. |
| 7. |
Gong C, etal., J Neurosci. 2007 Feb 21;27(8):1803-11. |
| 8. |
Lee EJ, etal., J Comp Neurol 2004 Mar 15;470(4):372-81. |
| 9. |
Pathak A, etal., Cereb Cortex. 2010 Apr 5. |
| 10. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 11. |
RGD automated data pipeline |
| 12. |
RGD automated import pipeline for gene-chemical interactions |
| 13. |
Yokoi N, etal., Brain Res Mol Brain Res 2003 Apr 10;112(1-2):1-7. |
| 14. |
Young-Pearse TL, etal., J Neurosci. 2007 Dec 26;27(52):14459-69. |
References - uncuratedRGD Disease Portals| Dab1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Dab1 (Rattus norvegicus) |
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| DAB1 (Homo sapiens) |
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| Dab1 (Mus musculus) |
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Position Markers| D5Rat83 |
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| D5Rat96 |
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| D5Got247 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_153621 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06039098 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06039099 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06039100 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038892 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038893 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038894 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038895 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038896 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038897 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038898 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB072426 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473998 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_153621 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_705885 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_705885 | (Get FASTA) |
| GenBank Protein | BAC20288 | (Get FASTA) |
| EDL97874 | (Get FASTA) | |
| EDL97875 | (Get FASTA) | |
| EDL97876 | (Get FASTA) | |
| EDL97877 | (Get FASTA) | |
| EDL97878 | (Get FASTA) | |
| Q8CJH2 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000007410 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000009977 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000009977 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 266729 | ENTREZGENE |
| Gene3D-CATH | PH_type | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 32084 | ENTREZGENE |
| InterPro | PH_type | UniProtKB/Swiss-Prot |
| PTyr_interaction_dom | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:266729 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | PID | UniProtKB/Swiss-Prot |
| PROSITE | PID | UniProtKB/Swiss-Prot |
| SMART | PTB | UniProtKB/Swiss-Prot |
| UniGene | Rn.206534 | ENTREZGENE |
| UniProt | DAB1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2013-03-20 | Dab1 | Dab, reelin signal transducer, homolog 1 (Drosophila) | Dab1 | disabled homolog 1 (Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2004-09-10 | Dab1 | disabled homolog 1 (Drosophila) | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2003-02-27 | Dab1 | disabled homolog 1 (Drosophila) | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_regulation | mRNA level regulated by thyroid hormone | 634730 |
| gene_regulation | adaptor function stimulated by reelin | 1304297 |
| More on Dab1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 628770 |
| Created: | 2003-02-27 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.