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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of OXT mRNA | CTD | PMID:15834898 PMID:17351261 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of OXT mRNA | CTD | PMID:17351261 PMID:15834898 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with OXT protein] results in increased expression of SLC5A5 mRNA | CTD | PMID:16954431 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | Progesterone inhibits the reaction [Estradiol results in increased expression of OXT mRNA] | CTD | PMID:17400809 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of OXT mRNA | CTD | PMID:17010207 PMID:17400809 | 2,4-D | decreases secretion | EXP | | 6480464 | 2,4-Dichlorophenoxyacetic Acid results in decreased secretion of OXT protein | CTD | PMID:20122984 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of OXT mRNA | CTD | PMID:16483693 | ATP | multiple interactions | EXP | | 6480464 | pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein]; more ... | CTD | PMID:11102496 | ATP | increases secretion | EXP | | 6480464 | Adenosine Triphosphate results in increased secretion of OXT protein | CTD | PMID:11102496 | benzo[a]pyrene | multiple interactions | ISO | RGD:11040 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of OXT mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:11040 | 6480464 | Benzo(a)pyrene results in decreased expression of OXT mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of OXT mRNA | CTD | PMID:21839799 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of OXT mRNA | CTD | PMID:17010207 | bisphenol A | decreases expression | ISO | RGD:11040 | 6480464 | bisphenol A results in decreased expression of OXT mRNA | CTD | PMID:22707478 | calcium atom | multiple interactions | ISO | RGD:737586 | 6480464 | OXT protein promotes the reaction [TRPC3 protein results in increased transport of Calcium] | CTD | PMID:12700192 | calcium atom | multiple interactions | EXP | | 6480464 | [Thapsigargin results in increased transport of Calcium] which results in increased secretion of OXT protein | CTD | PMID:22028774 | calcium(0) | multiple interactions | ISO | RGD:737586 | 6480464 | OXT protein promotes the reaction [TRPC3 protein results in increased transport of Calcium] | CTD | PMID:12700192 | calcium(0) | multiple interactions | EXP | | 6480464 | [Thapsigargin results in increased transport of Calcium] which results in increased secretion of OXT protein | CTD | PMID:22028774 | chlorpyrifos | increases expression | ISO | RGD:11040 | 6480464 | Chlorpyrifos results in increased expression of OXT protein | CTD | PMID:19165396 | clofibrate | multiple interactions | ISO | RGD:11040 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of OXT mRNA; more ... | CTD | PMID:17585979 | clozapine | affects response to substance | ISO | RGD:737586 | 6480464 | OXT protein affects the susceptibility to Clozapine | CTD | PMID:20196918 | cortisol | affects abundance | ISO | RGD:737586 | 6480464 | OXT protein affects the abundance of Hydrocortisone | CTD | PMID:16554389 | Delta(9)-tetrahydrocannabinol | decreases expression | EXP | | 6480464 | Tetrahydrocannabinol results in decreased expression of OXT mRNA; more ... | CTD | PMID:16513365 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of OXT mRNA | CTD | PMID:17010207 | fluoxetine | decreases expression | EXP | | 6480464 | Fluoxetine results in decreased expression of OXT mRNA | CTD | PMID:17033635 | lithium atom | increases expression | EXP | | 6480464 | Lithium results in increased expression of OXT mRNA | CTD | PMID:11739594 | lithium atom | increases secretion | EXP | | 6480464 | Lithium results in increased secretion of OXT protein | CTD | PMID:11739594 | paclitaxel | increases expression | EXP | | 6480464 | Paclitaxel analog results in increased expression of OXT mRNA; more ... | CTD | PMID:15585946 | paracetamol | multiple interactions | ISO | RGD:11040 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of OXT mRNA; more ... | CTD | PMID:17585979 | phenylephrine | multiple interactions | EXP | | 6480464 | Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; more ... | CTD | PMID:11102496 | phenylephrine | increases secretion | EXP | | 6480464 | Phenylephrine results in increased secretion of OXT protein | CTD | PMID:15149956 | prazosin | increases expression | EXP | | 6480464 | Prazosin results in increased expression of OXT protein | CTD | PMID:1791990 | progesterone | multiple interactions | EXP | | 6480464 | Progesterone inhibits the reaction [Estradiol results in increased expression of OXT mRNA] | CTD | PMID:17400809 | pyridaben | decreases expression | ISO | RGD:11040 | 6480464 | pyridaben results in decreased expression of OXT mRNA | CTD | PMID:22563483 | serotonin | increases secretion | ISO | RGD:11040 | 6480464 | OXT protein results in increased secretion of Serotonin | CTD | PMID:19228979 | thapsigargin | multiple interactions | EXP | | 6480464 | [Thapsigargin results in increased transport of Calcium] which results in increased secretion of OXT protein | CTD | PMID:22028774 | valproic acid | affects expression | ISO | RGD:11040 | 6480464 | Valproic Acid affects the expression of OXT mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
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RGD Disease Portals| Oxt has been annotated in the following RGD Disease Portals. |
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Candidate Gene StatusComparative Map Data| Oxt (Rattus norvegicus) |
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| Oxt (Mus musculus) |
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Position Markers| RH142212 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012996 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06026181 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01025052 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473949 | (Get FASTA) | Search GEO for Microarray Profiles | |
| K01494 | (Get FASTA) | Search GEO for Microarray Profiles | |
| K01701 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M25649 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X12792 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X59496 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012996 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037128 | ||||||||||||||||||||
| Peptide Label: | preproprotein | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037128 | (Get FASTA) |
| GenBank Protein | AAA41773 | (Get FASTA) |
| AAA41774 | (Get FASTA) | |
| AAA98733 | (Get FASTA) | |
| CAA31281 | (Get FASTA) | |
| CAA42085 | (Get FASTA) | |
| EDL80200 | (Get FASTA) | |
| P01179 | (Get FASTA) |
Promoters| RGD ID: | 6849964 | ||||||||||
| Promoter ID: | EP07101 | ||||||||||
| Type: | single initiation site | ||||||||||
| Name: | RN_NEU1 | ||||||||||
| Description: | Preprooxytocin, OXT or OT gene | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Tissues & Cell Lines: | hypothalamus | ||||||||||
| Experiment Methods: | Nuclease protection with homologous sequence ladder | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000021225 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000028829 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000028829 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 25504 | ENTREZGENE |
| Gene3D-CATH | Neurhyp_horm | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000021225 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55494 | ENTREZGENE |
| InterPro | Neurhyp_horm | UniProtKB/Swiss-Prot |
| Neurohypophysial_hormone_CS | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:25504 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR11681 | UniProtKB/Swiss-Prot |
| Pfam | Hormone_4 | UniProtKB/Swiss-Prot |
| Hormone_5 | UniProtKB/Swiss-Prot | |
| PIRSF | Nonapeptide_hormone_precursor | UniProtKB/Swiss-Prot |
| PRINTS | NEUROPHYSIN | UniProtKB/Swiss-Prot |
| ProDom | Neurhyp_horm | UniProtKB/Swiss-Prot |
| PROSITE | NEUROHYPOPHYS_HORM | UniProtKB/Swiss-Prot |
| SMART | SM00003 | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Neurhyp_horm | UniProtKB/Swiss-Prot |
| TIGR | TC207027 | |
| UniGene | Rn.48915 | ENTREZGENE |
| UniProt | NEU1_RAT | UniProtKB/Swiss-Prot |
| Q63408_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-11-07 | Oxt | oxytocin/neurophysin 1 prepropeptide | Oxt | oxytocin, prepropeptide | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-09-24 | Oxt | oxytocin, prepropeptide | Oxt | oxytocin | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Oxt | oxcytocin | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | protein synthesized by magnocellular neurons of the supraoptic and paraventricular nuclei of the hypothalamus; synthesized in ovary, thymus, kidneys, heart and vasculature | 631223 |
| gene_mapping | maps to the Bp37 QTL region and proposed to be a candidate gene for blood pressure regulation | 631223 |
| gene_process | reduces mean arterial pressure and peripheral resistance; may play a role in body fluid hemeostasis | 631223 |
| gene_regulation | biosynthesis and secretion are regulated by thyrotropin-releasing hormone (TRH) | 634240 |
| More on Oxt | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3238 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.