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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1550853 | 6480464 | Tetrachlorodibenzodioxin affects the expression of GNB3 mRNA | CTD | PMID:21570461 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GNB3 mRNA | CTD | PMID:16483693 | barium(0) | multiple interactions | ISO | RGD:1346162 | 6480464 | [GNB3 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]; more ... | CTD | PMID:11007869 | clozapine | decreases response to substance | ISO | RGD:1346162 | 6480464 | GNB3 gene polymorphism results in decreased susceptibility to Clozapine | CTD | PMID:18855531 | clozapine | increases expression | EXP | | 6480464 | Clozapine results in increased expression of GNB3 protein | CTD | PMID:16141801 | clozapine | affects response to substance | ISO | RGD:1346162 | 6480464 | GNB3 protein affects the susceptibility to Clozapine | CTD | PMID:18855531 | clozapine | increases response to substance | ISO | RGD:1346162 | 6480464 | GNB3 gene polymorphism results in increased susceptibility to Clozapine | CTD | PMID:16139171 | cytarabine | decreases expression | ISO | RGD:1346162 | 6480464 | Cytarabine results in decreased expression of GNB3 mRNA | CTD | PMID:21198554 | methamphetamine | decreases expression | EXP | | 6480464 | Methamphetamine results in decreased expression of GNB3 protein | CTD | PMID:19826936 | nitroglycerin | affects response to substance | ISO | RGD:1346162 | 6480464 | GNB3 protein affects the susceptibility to Nitroglycerin | CTD | PMID:14586390 | nortriptyline | decreases response to substance | ISO | RGD:1346162 | 6480464 | GNB3 gene polymorphism results in decreased susceptibility to Nortriptyline | CTD | PMID:14604448 | nortriptyline | increases response to substance | ISO | RGD:1346162 | 6480464 | GNB3 protein results in increased susceptibility to Nortriptyline | CTD | PMID:14604448 | paracetamol | affects expression | ISO | RGD:1550853 | 6480464 | Acetaminophen affects the expression of GNB3 mRNA | CTD | PMID:17562736 | rosiglitazone | affects expression | ISO | RGD:1346162 | 6480464 | rosiglitazone affects the expression of GNB3 protein | CTD | PMID:19556978 | valproic acid | affects expression | ISO | RGD:1550853 | 6480464 | Valproic Acid affects the expression of GNB3 mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Alcoholism |
| Chemokine signaling pathway | |
| Cholinergic synapse | |
| Circadian entrainment | |
| Dopaminergic synapse | |
| GABAergic synapse | |
| Glutamatergic synapse | |
| Morphine addiction | |
| PI3K-Akt signaling pathway | |
| Retrograde endocannabinoid signaling | |
| Serotonergic synapse | |
| Taste transduction | |
| Pathway Interaction Database | Visual signal transduction: Cones (PID:200092) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Alcoholism |
| Chemokine signaling pathway | |
| Cholinergic synapse | |
| Circadian entrainment | |
| Dopaminergic synapse | |
| GABAergic synapse | |
| Glutamatergic synapse | |
| Morphine addiction | |
| PI3K-Akt signaling pathway | |
| Retrograde endocannabinoid signaling | |
| Serotonergic synapse | |
| Taste transduction | |
| Pathway Interaction Database | Visual signal transduction: Cones (PID:200092) |
References - curated
References - uncurated
RGD Disease Portals| Gnb3 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Gnb3 (Rattus norvegicus) |
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| GNB3 (Homo sapiens) |
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| Gnb3 (Mus musculus) |
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Position Markers| RH131999 |
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| RH136873 |
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| MARC_10541-10542:1000149110:1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_021858 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_068630 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_068630 | (Get FASTA) |
| GenBank Protein | AAA62620 | (Get FASTA) |
| AAH86422 | (Get FASTA) | |
| AAZ23826 | (Get FASTA) | |
| AAZ23827 | (Get FASTA) | |
| EDM01917 | (Get FASTA) | |
| EDM01918 | (Get FASTA) | |
| EDM01919 | (Get FASTA) | |
| P52287 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000015541 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000021480 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000021481 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 60449 | ENTREZGENE |
| Gene3D-CATH | WD40/YVTN_repeat-like | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000015541 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55628 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7193131 | IMAGE-MGC_LOAD |
| InterPro | G-protein_beta_WD-40_rep_reg | UniProtKB/Swiss-Prot |
| Gprotein_B | UniProtKB/Swiss-Prot | |
| Guanine_nucleotide-bd_bsu | UniProtKB/Swiss-Prot | |
| WD40/YVTN_repeat-like_dom | UniProtKB/Swiss-Prot | |
| WD40_repeat | UniProtKB/Swiss-Prot | |
| WD40_repeat_CS | UniProtKB/Swiss-Prot | |
| WD40_repeat_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00204239 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:60449 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:105437 | IMAGE-MGC_LOAD |
| Pfam | WD40 | UniProtKB/Swiss-Prot |
| PharmGKB | GNB3 | RGD |
| PIRSF | GN-bd_beta | UniProtKB/Swiss-Prot |
| PRINTS | GPROTEINB | UniProtKB/Swiss-Prot |
| GPROTEINBRPT | UniProtKB/Swiss-Prot | |
| PROSITE | WD_REPEATS_1 | UniProtKB/Swiss-Prot |
| WD_REPEATS_2 | UniProtKB/Swiss-Prot | |
| WD_REPEATS_REGION | UniProtKB/Swiss-Prot | |
| SMART | WD40 | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | WD40_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.27065 | ENTREZGENE |
| UniProt | GBB3_RAT | UniProtKB/Swiss-Prot |
| Q45QL4_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-09-26 | Gnb3 | guanine nucleotide binding protein (G protein), beta polypeptide 3 | Gnb3 | guanine nucleotide binding protein (G protein), beta 3 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-05-20 | Gnb3 | guanine nucleotide binding protein (G protein), beta 3 | Gnb3 | guanine nucleotide binding protein, beta 3 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-07-08 | Gnb3 | guanine nucleotide binding protein, beta 3 | LOC60449 | G protein beta-subunit gene | Symbol and Name updated | 10779 | APPROVED |
| More on Gnb3 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 708344 |
| Created: | 2003-09-23 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




