Cplx2 (complexin 2) - Rat Genome Database

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Gene: Cplx2 (complexin 2) Rattus norvegicus
Analyze
Symbol: Cplx2
Name: complexin 2
RGD ID: 70945
Description: Enables calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in synaptic vesicle exocytosis. Located in dendrite; neuronal cell body; and synapse. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in postsynapse and presynapse. Orthologous to human CPLX2 (complexin 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: complexin II; complexin-2; CPX II; synaphin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,224,673 - 10,297,974 (-)NCBIGRCr8
mRatBN7.21710,219,577 - 10,292,835 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,222,347 - 10,293,855 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,237,601 - 10,245,934 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01711,770,838 - 11,779,143 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,234,026 - 10,242,359 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01710,756,871 - 10,828,811 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1710,756,285 - 10,818,835 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01712,880,802 - 12,952,180 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,314,592 - 16,322,938 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,314,591 - 16,322,938 (-)NCBI
Celera1710,295,626 - 10,303,931 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-butoxyethanol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
diazinon  (ISO)
dicrotophos  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fisetin  (EXP)
folic acid  (ISO)
gamma-tocopherol  (ISO)
gentamycin  (EXP)
graphene oxide  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methylazoxymethanol  (ISO)
methylmercury chloride  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
paracetamol  (EXP)
perfluorooctanoic acid  (ISO)
phencyclidine  (ISO)
propanal  (ISO)
resveratrol  (ISO)
sarin  (EXP)
silicon dioxide  (ISO)
sulfadimethoxine  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
tocopherol  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex. Ishizuka T, etal., Neuroscience 1999 Jan;88(1):295-306.
3. Complexins: cytosolic proteins that regulate SNAP receptor function. McMahon HT, etal., Cell 1995 Oct 6;83(1):111-9.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis. Pabst S, etal., J Biol Chem 2002 Mar 8;277(10):7838-48.
8. Complexins regulate a late step in Ca2+-dependent neurotransmitter release. Reim K, etal., Cell 2001 Jan 12;104(1):71-81.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. Tokumaru H, etal., Brain Cell Biol. 2008 Dec;36(5-6):173-89. doi: 10.1007/s11068-008-9032-9. Epub 2009 Jan 9.
13. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
14. Immunohistochemical distribution of the two isoforms of synaphin/complexin involved in neurotransmitter release: localization at the distinct central nervous system regions and synaptic types. Yamada M, etal., Neuroscience. 1999;93(1):7-18.
Additional References at PubMed
PMID:7654227   PMID:9753100   PMID:10777504   PMID:15870114   PMID:15911881   PMID:16430375   PMID:16499873   PMID:17511609   PMID:19900895   PMID:19932892   PMID:20829354   PMID:21110949  
PMID:25002582   PMID:26019341   PMID:33393983   PMID:36675068  


Genomics

Comparative Map Data
Cplx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,224,673 - 10,297,974 (-)NCBIGRCr8
mRatBN7.21710,219,577 - 10,292,835 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,222,347 - 10,293,855 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,237,601 - 10,245,934 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01711,770,838 - 11,779,143 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,234,026 - 10,242,359 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01710,756,871 - 10,828,811 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1710,756,285 - 10,818,835 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01712,880,802 - 12,952,180 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,314,592 - 16,322,938 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,314,591 - 16,322,938 (-)NCBI
Celera1710,295,626 - 10,303,931 (-)NCBICelera
Cytogenetic Map17p14NCBI
CPLX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385175,796,533 - 175,884,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5175,796,310 - 175,884,021 (+)EnsemblGRCh38hg38GRCh38
GRCh375175,223,536 - 175,311,024 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365175,156,216 - 175,243,629 (+)NCBINCBI36Build 36hg18NCBI36
Build 345175,156,215 - 175,243,629NCBI
Celera5171,262,673 - 171,350,105 (+)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5170,322,487 - 170,409,702 (+)NCBIHuRef
CHM1_15174,656,299 - 174,743,770 (+)NCBICHM1_1
T2T-CHM13v2.05176,340,215 - 176,427,717 (+)NCBIT2T-CHM13v2.0
Cplx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,455,447 - 54,531,736 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,455,978 - 54,466,823 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl1354,519,162 - 54,531,730 (+)EnsemblGRCm39 Ensembl
GRCm381354,301,964 - 54,383,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,371,349 - 54,383,917 (+)EnsemblGRCm38mm10GRCm38
MGSCv371354,472,713 - 54,485,278 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,380,974 - 54,393,539 (+)NCBIMGSCv36mm8
Celera1355,439,482 - 55,451,914 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.59NCBI
Cplx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,308,517 - 28,388,742 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,308,807 - 28,388,650 (+)NCBIChiLan1.0ChiLan1.0
CPLX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24170,925,024 - 171,014,363 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15169,064,487 - 169,153,901 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05171,144,671 - 171,233,028 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15178,041,212 - 178,128,595 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5178,115,947 - 178,128,595 (+)Ensemblpanpan1.1panPan2
CPLX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1437,203,003 - 37,275,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl437,206,082 - 37,275,954 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha437,150,959 - 37,235,213 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,569,467 - 37,653,831 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1437,394,694 - 37,478,954 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,582,684 - 37,667,026 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0438,092,304 - 38,176,702 (-)NCBIUU_Cfam_GSD_1.0
Cplx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213121,252,379 - 121,335,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936597348,203 - 357,997 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936597276,540 - 356,822 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPLX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl281,732,533 - 81,813,271 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1281,732,527 - 81,813,189 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CPLX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,943,553 - 78,031,083 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2378,025,798 - 78,027,094 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666034557,841 - 646,727 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cplx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473314,089,018 - 14,097,508 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473314,085,085 - 14,170,711 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cplx2
458 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:271
Count of miRNA genes:151
Interacting mature miRNAs:166
Transcripts:ENSRNOT00000000117
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat

Markers in Region
BE106621  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21710,223,320 - 10,223,477 (+)MAPPERmRatBN7.2
Rnor_6.01710,757,746 - 10,757,902NCBIRnor6.0
Rnor_5.01712,883,599 - 12,883,755UniSTSRnor5.0
RGSC_v3.41716,314,556 - 16,314,712UniSTSRGSC3.4
Celera1710,295,590 - 10,295,746UniSTS
RH 3.4 Map1796.3UniSTS
Cytogenetic Map17p14UniSTS
BF405787  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01712,886,043 - 12,886,166NCBIRnor5.0
RGSC_v3.41716,317,001 - 16,317,123UniSTSRGSC3.4
Celera1710,298,034 - 10,298,156UniSTS
RH 3.4 Map1792.3UniSTS
Cytogenetic Map17p14UniSTS
CPLX2_9184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21710,223,167 - 10,223,764 (+)MAPPERmRatBN7.2
Rnor_6.01710,757,593 - 10,758,188NCBIRnor6.0
Rnor_5.01712,883,446 - 12,884,041UniSTSRnor5.0
RGSC_v3.41716,314,403 - 16,314,998UniSTSRGSC3.4
Celera1710,295,437 - 10,296,032UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 74 21 32 11
Low 3 43 52 41 19 41 8 11 14 8 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000117   ⟹   ENSRNOP00000000117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1710,757,782 - 10,766,253 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091046   ⟹   ENSRNOP00000072664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1710,222,347 - 10,293,855 (-)Ensembl
Rnor_6.0 Ensembl1710,756,285 - 10,818,835 (-)Ensembl
RefSeq Acc Id: NM_053878   ⟹   NP_446330
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,228,447 - 10,236,753 (-)NCBI
mRatBN7.21710,223,357 - 10,231,666 (-)NCBI
Rnor_6.01710,757,782 - 10,766,253 (-)NCBI
Rnor_5.01712,880,802 - 12,952,180 (-)NCBI
RGSC_v3.41716,314,592 - 16,322,938 (-)RGD
Celera1710,295,626 - 10,303,931 (-)RGD
Sequence:
RefSeq Acc Id: XM_017600440   ⟹   XP_017455929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,224,673 - 10,297,781 (-)NCBI
mRatBN7.21710,219,577 - 10,292,575 (-)NCBI
Rnor_6.01710,756,871 - 10,828,811 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600441   ⟹   XP_017455930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,224,673 - 10,297,639 (-)NCBI
mRatBN7.21710,219,577 - 10,292,575 (-)NCBI
Rnor_6.01710,756,871 - 10,828,811 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095303   ⟹   XP_038951231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,224,673 - 10,297,974 (-)NCBI
mRatBN7.21710,219,577 - 10,292,835 (-)NCBI
RefSeq Acc Id: XM_063276028   ⟹   XP_063132098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,224,673 - 10,231,990 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446330   ⟸   NM_053878
- UniProtKB: P84087 (UniProtKB/Swiss-Prot),   A6KB03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455930   ⟸   XM_017600441
- Peptide Label: isoform X1
- UniProtKB: P84087 (UniProtKB/Swiss-Prot),   A6KB03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455929   ⟸   XM_017600440
- Peptide Label: isoform X1
- UniProtKB: P84087 (UniProtKB/Swiss-Prot),   A6KB03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000117   ⟸   ENSRNOT00000000117
RefSeq Acc Id: ENSRNOP00000072664   ⟸   ENSRNOT00000091046
RefSeq Acc Id: XP_038951231   ⟸   XM_039095303
- Peptide Label: isoform X1
- UniProtKB: P84087 (UniProtKB/Swiss-Prot),   A6KB03 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132098   ⟸   XM_063276028
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84087-F1-model_v2 AlphaFold P84087 1-134 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700326
Promoter ID:EPDNEW_R10850
Type:multiple initiation site
Name:Cplx2_1
Description:complexin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01710,766,150 - 10,766,210EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70945 AgrOrtholog
BioCyc Gene G2FUF-10163 BioCyc
Ensembl Genes ENSRNOG00000000105 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055014037 UniProtKB/Swiss-Prot
  ENSRNOG00060017677 UniProtKB/Swiss-Prot
  ENSRNOG00065010425 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091046.2 UniProtKB/Swiss-Prot
  ENSRNOT00055024121 UniProtKB/Swiss-Prot
  ENSRNOT00060030229 UniProtKB/Swiss-Prot
  ENSRNOT00065016877 UniProtKB/Swiss-Prot
Gene3D-CATH Single Helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Synaphin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116657 ENTREZGENE
PANTHER COMPLEXIN UniProtKB/TrEMBL
  COMPLEXIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16705 UniProtKB/Swiss-Prot
Pfam Synaphin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cplx2 PhenoGen
RatGTEx ENSRNOG00000000105 RatGTEx
  ENSRNOG00055014037 RatGTEx
  ENSRNOG00060017677 RatGTEx
  ENSRNOG00065010425 RatGTEx
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KB03 ENTREZGENE, UniProtKB/TrEMBL
  CPLX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O09056 UniProtKB/Swiss-Prot
  Q13329 UniProtKB/Swiss-Prot
  Q28184 UniProtKB/Swiss-Prot
  Q64386 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Cplx2  complexin 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference