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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | ISO | RGD:730920 | 6480464 | Ethinyl Estradiol affects the expression of RTN4 mRNA | CTD | PMID:17555576 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:730920 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RTN4 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:730920 | 6480464 | Tetrachlorodibenzodioxin affects the expression of RTN4 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:730919 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RTN4 mRNA | CTD | PMID:21802500 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:730920 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RTN4 mRNA | CTD | PMID:19770486 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of RTN4 mRNA | CTD | PMID:21346803 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of RTN4 mRNA | CTD | PMID:16483693 | benzene | multiple interactions | EXP | | 6480464 | [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of RTN4 mRNA | CTD | PMID:17905399 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of RTN4 mRNA | CTD | PMID:21839799 | benzo[a]pyrene | decreases expression | ISO | RGD:730919 | 6480464 | Benzo(a)pyrene results in decreased expression of RTN4 mRNA | CTD | PMID:21802500 | chlorpyrifos | decreases expression | ISO | RGD:730920 | 6480464 | Chlorpyrifos results in decreased expression of RTN4 mRNA | CTD | PMID:20350560 | choline | multiple interactions | ISO | RGD:730920 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RTN4 mRNA; more ... | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | RGD:730920 | 6480464 | Cisplatin results in decreased expression of RTN4 mRNA | CTD | PMID:21151649 | clofibrate | multiple interactions | ISO | RGD:730920 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of RTN4 mRNA; more ... | CTD | PMID:17585979 | clofibrate | increases expression | ISO | RGD:730920 | 6480464 | Clofibrate results in increased expression of RTN4 mRNA | CTD | PMID:17585979 | clozapine | increases expression | ISO | RGD:730920 | 6480464 | Clozapine results in increased expression of RTN4 mRNA | CTD | PMID:17266109 | copper atom | multiple interactions | ISO | RGD:730919 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of RTN4 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:730919 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of RTN4 mRNA | CTD | PMID:20971185 | copper(2+) sulfate | increases expression | ISO | RGD:730919 | 6480464 | Copper Sulfate results in increased expression of RTN4 mRNA | CTD | PMID:19549813 | Delta(9)-tetrahydrocannabinol | decreases expression | EXP | | 6480464 | Tetrahydrocannabinol results in decreased expression of RTN4 mRNA | CTD | PMID:17578508 | diarsenic trioxide | increases expression | ISO | RGD:730919 | 6480464 | arsenic trioxide results in increased expression of RTN4 mRNA | CTD | PMID:20458559 | dibutyl phthalate | increases expression | ISO | RGD:730920 | 6480464 | Dibutyl Phthalate results in increased expression of RTN4 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:730920 | 6480464 | Dibutyl Phthalate results in increased expression of RTN4 mRNA | CTD | PMID:17361019 PMID:21266533 | disodium selenite | increases expression | ISO | RGD:730919 | 6480464 | Sodium Selenite results in increased expression of RTN4 mRNA | CTD | PMID:18175754 | folic acid | multiple interactions | ISO | RGD:730920 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RTN4 mRNA; more ... | CTD | PMID:20938992 | gold atom | multiple interactions | ISO | RGD:730920 | 6480464 | [Gold co-treated with Polyethylene Glycols] results in increased expression of RTN4 mRNA | CTD | PMID:19695318 | gold(0) | multiple interactions | ISO | RGD:730920 | 6480464 | [Gold co-treated with Polyethylene Glycols] results in increased expression of RTN4 mRNA | CTD | PMID:19695318 | haloperidol | decreases expression | ISO | RGD:730920 | 6480464 | Haloperidol results in decreased expression of RTN4 mRNA | CTD | PMID:18797397 | L-methionine | multiple interactions | ISO | RGD:730920 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RTN4 mRNA; more ... | CTD | PMID:20938992 | lead diacetate | affects expression | EXP | | 6480464 | lead acetate affects the expression of RTN4 mRNA | CTD | PMID:21864555 | lead(0) | decreases expression | ISO | RGD:730919 | 6480464 | Lead results in decreased expression of RTN4 mRNA | CTD | PMID:22313790 | maneb | multiple interactions | ISO | RGD:730920 | 6480464 | [Maneb co-treated with Paraquat] results in increased expression of RTN4 mRNA | CTD | PMID:23017109 | manganese(II) chloride | increases expression | ISO | RGD:730920 | 6480464 | manganese chloride results in increased expression of RTN4 mRNA | CTD | PMID:17467022 | mercury atom | decreases expression | ISO | RGD:730919 | 6480464 | Mercury results in decreased expression of RTN4 mRNA | CTD | PMID:19937285 | mercury(0) | decreases expression | ISO | RGD:730919 | 6480464 | Mercury results in decreased expression of RTN4 mRNA | CTD | PMID:19937285 | methylmercury(1+) | multiple interactions | EXP | | 6480464 | [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of RTN4 mRNA | CTD | PMID:17905399 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of RTN4 mRNA | CTD | PMID:19638242 | olanzapine | decreases expression | ISO | RGD:730920 | 6480464 | olanzapine results in decreased expression of RTN4 mRNA | CTD | PMID:18797397 | paracetamol | multiple interactions | ISO | RGD:730920 | 6480464 | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RTN4 mRNA] | CTD | PMID:17585979 | paracetamol | affects expression | ISO | RGD:730920 | 6480464 | Acetaminophen affects the expression of RTN4 mRNA | CTD | PMID:17562736 | paraquat | multiple interactions | ISO | RGD:730920 | 6480464 | [Maneb co-treated with Paraquat] results in increased expression of RTN4 mRNA | CTD | PMID:23017109 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of RTN4 mRNA | CTD | PMID:16221955 | phencyclidine | increases expression | ISO | RGD:730920 | 6480464 | Phencyclidine results in increased expression of RTN4 mRNA | CTD | PMID:17266109 | phenobarbital | affects expression | ISO | RGD:730920 | 6480464 | Phenobarbital affects the expression of RTN4 mRNA | CTD | PMID:23091169 | pirinixic acid | increases expression | ISO | RGD:730920 | 6480464 | pirinixic acid results in increased expression of RTN4 mRNA | CTD | PMID:20813756 more ... | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of RTN4 mRNA | CTD | PMID:22484513 | pirinixic acid | increases expression | ISO | RGD:730920 | 6480464 | pirinixic acid results in increased expression of RTN4 mRNA | CTD | PMID:17426115 more ... | pirinixic acid | increases expression | ISO | RGD:730920 | 6480464 | pirinixic acid results in increased expression of RTN4 mRNA | CTD | PMID:20813756 more ... | pirinixic acid | increases expression | ISO | RGD:730920 | 6480464 | pirinixic acid results in increased expression of RTN4 mRNA | CTD | PMID:17426115 more ... | propiconazole | decreases expression | ISO | RGD:730920 | 6480464 | propiconazole results in decreased expression of RTN4 mRNA | CTD | PMID:21278054 | pyrogallol | increases expression | ISO | RGD:730920 | 6480464 | Pyrogallol results in increased expression of RTN4 mRNA | CTD | PMID:20362636 | succimer | multiple interactions | ISO | RGD:730920 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RTN4 mRNA | CTD | PMID:21641980 | tamoxifen | affects expression | ISO | RGD:730920 | 6480464 | Tamoxifen affects the expression of RTN4 mRNA | CTD | PMID:17555576 | tamoxifen | decreases expression | EXP | | 6480464 | Tamoxifen results in decreased expression of RTN4 mRNA | CTD | PMID:19457130 | testosterone | decreases expression | ISO | RGD:730920 | 6480464 | Testosterone results in decreased expression of RTN4 mRNA | CTD | PMID:20600201 PMID:21669218 | testosterone | decreases expression | ISO | RGD:730920 | 6480464 | Testosterone results in decreased expression of RTN4 mRNA | CTD | PMID:21669218 PMID:20600201 | tetrachloromethane | affects expression | ISO | RGD:730920 | 6480464 | Carbon Tetrachloride affects the expression of RTN4 mRNA | CTD | PMID:17484886 | trichloroethene | multiple interactions | EXP | | 6480464 | [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of RTN4 mRNA | CTD | PMID:17905399 | vancomycin | decreases expression | ISO | RGD:730920 | 6480464 | Vancomycin results in decreased expression of RTN4 mRNA | CTD | PMID:18930951 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | p75(NTR)-mediated signaling (PID:200122) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | p75(NTR)-mediated signaling (PID:200122) |
References - curated| 1. |
Bareyre FM, etal., J Neurosci 2002 Aug 15;22(16):7097-110. |
| 2. |
Chen MS, etal., Nature 2000 Jan 27;403(6768):434-9. |
| 3. |
Chytrova G, etal., Eur J Neurosci. 2008 Jan;27(1):1-11. Epub 2007 Dec 15. |
| 4. |
Craveiro LM, etal., Eur J Neurosci. 2008 Nov;28(9):1808-24. |
| 5. |
Dodd DA, etal., J Biol Chem. 2005 Apr 1;280(13):12494-502. Epub 2005 Jan 7. |
| 6. |
Gao Y, etal., Neurosci Lett. 2009 Jul 24;458(3):132-5. Epub 2009 Apr 18. |
| 7. |
GOA data from the GO Consortium |
| 8. |
Hasegawa Y, etal., J Neurosci. 2004 Jul 28;24(30):6826-32. |
| 9. |
Jiang W, etal., Transl Res. 2009 Jul;154(1):40-8. Epub 2009 May 19. |
| 10. |
Li L, etal., Neurosci Lett. 2007 Sep 13;424(3):145-8. Epub 2007 Aug 1. |
| 11. |
Liu X, etal., Mol Cell Neurosci. 2009 May;41(1):51-61. Epub 2009 Feb 6. |
| 12. |
Ma Z, etal., Exp Neurol. 2009 May;217(1):184-96. Epub 2009 Feb 21. |
| 13. |
MGD data from the GO Consortium |
| 14. |
Morris NJ, etal., Biochim Biophys Acta 1999 May 6;1450(1):68-76. |
| 15. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 16. |
Niederost B, etal., J Neurosci 2002 Dec 1;22(23):10368-76. |
| 17. |
Oertle T, etal., FASEB J 2003 Jul;17(10):1238-47. |
| 18. |
Oertle T, etal., J Neurosci 2003 Jul 2;23(13):5393-406. |
| 19. |
Pot C, etal., J Cell Biol 2002 Oct 14;159(1):29-35. |
| 20. |
RGD automated import pipeline for gene-chemical interactions |
| 21. |
Richard M, etal., Eur J Neurosci. 2005 Nov;22(9):2145-58. |
| 22. |
Schweigreiter R, etal., Proteomics. 2007 Dec;7(24):4457-67. |
| 23. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 24. |
Takeda Y, etal., Neurol Res. 2007 Mar;29(2):199-203. |
| 25. |
Taketomi M, etal., Neurosci Lett 2002 Oct 25;332(1):37-40. |
| 26. |
Trifunovski A, etal., Neuroreport. 2006 Jun 26;17(9):913-6. |
| 27. |
Voeltz GK, etal., Cell. 2006 Feb 10;124(3):573-86. |
| 28. |
Xiong NX, etal., Neuro Endocrinol Lett. 2008 Dec;29(6):884-8. |
| 29. |
Ye J, etal., Zhonghua Yi Xue Za Zhi 2002 Apr 10;82(7):498-500. |
References - uncurated| PubMed | 10667797 |
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| 16641100 | |
| 16697217 | |
| 17022955 | |
| 17382469 | |
| 17428512 | |
| 17630211 | |
| 17963852 | |
| 18095590 | |
| 18467652 | |
| 19125329 | |
| 19665976 | |
| 19901030 | |
| 20083601 | |
| 20374087 | |
| 20473744 | |
| 20573699 | |
| 20844138 | |
| 21418929 | |
| 21420413 | |
| 21624429 | |
| 21636572 | |
| 21643729 | |
| 21862940 | |
| 21985178 | |
| 22261619 |
RGD Disease Portals| Rtn4 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Rtn4 (Rattus norvegicus) |
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| RTN4 (Homo sapiens) |
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| Rtn4 (Mus musculus) |
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Position Markers| RH143221 |
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| RH140746 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031831 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06081578 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01081907 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01081908 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01081909 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF051335 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF132045 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF132046 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ242961 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ242962 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ242963 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY164740 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY164741 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC070879 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC086375 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC097936 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC161841 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473996 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CQ829507 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CS061814 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ213608 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228713 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234570 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ235341 | (Get FASTA) | Search GEO for Microarray Profiles | |
| HI649240 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031831 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_114019 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_114019 | (Get FASTA) |
| GenBank Protein | AAD31019 | (Get FASTA) |
| AAD31020 | (Get FASTA) | |
| AAF01564 | (Get FASTA) | |
| AAH70879 | (Get FASTA) | |
| AAH86375 | (Get FASTA) | |
| AAH97936 | (Get FASTA) | |
| AAI61841 | (Get FASTA) | |
| AAP47315 | (Get FASTA) | |
| AAP47316 | (Get FASTA) | |
| CAB71027 | (Get FASTA) | |
| CAB71028 | (Get FASTA) | |
| CAB71029 | (Get FASTA) | |
| CAH03194 | (Get FASTA) | |
| CAI79373 | (Get FASTA) | |
| CBX89235 | (Get FASTA) | |
| EDL98037 | (Get FASTA) | |
| EDL98038 | (Get FASTA) | |
| EDL98039 | (Get FASTA) | |
| Q9JK11 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000004621 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000006443 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000006957 | UniProtKB/Swiss-Prot | |
| ENSRNOP00000040760 | UniProtKB/Swiss-Prot | |
| ENSRNOP00000042870 | UniProtKB/Swiss-Prot | |
| Ensembl Transcript | ENSRNOT00000006443 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000006957 | UniProtKB/Swiss-Prot | |
| ENSRNOT00000041638 | UniProtKB/Swiss-Prot | |
| ENSRNOT00000042965 | UniProtKB/Swiss-Prot | |
| Entrez Gene | 83765 | ENTREZGENE |
| Germonline | ENSRNOG00000004621 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 10743 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7189728 | IMAGE-MGC_LOAD |
| InterPro | Reticulon | UniProtKB/Swiss-Prot |
| IPI | IPI00230986 | UniProtKB/Swiss-Prot |
| IPI00230987 | UniProtKB/Swiss-Prot | |
| IPI00231765 | UniProtKB/Swiss-Prot | |
| IPI00778998 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:83765 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:105388 | IMAGE-MGC_LOAD |
| PANTHER | Reticulon | UniProtKB/Swiss-Prot |
| Pfam | Reticulon | UniProtKB/Swiss-Prot |
| PROSITE | RETICULON | UniProtKB/Swiss-Prot |
| Transposagen | Rtn4 |
Transposagen |
| UniGene | Rn.1348 | ENTREZGENE |
| Rn.163269 | ENTREZGENE | |
| UniProt | F1LQN3_RAT | UniProtKB/TrEMBL |
| Q6IRL3_RAT | UniProtKB/TrEMBL | |
| RTN4_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-02-26 | Rtn4 | reticulon 4 | Nogo-A | Name updated | 2225 | APPROVED | |
| 2002-08-07 | Rtn4 | Nogo-A | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_cellular_localization | integral membrane protein | 628411 |
| gene_domains | contains active NiG and Nogo-66 domains | 628411 |
| gene_expression | expressed in brain, spinal cord, optic nerve, and not in sciatic nerve | 633937 |
| gene_expression | predominantly expressed in oligodendrocytes | 628411 |
| gene_function | glia derived inhibitory factor | |
| gene_process | may have a role in inhibition of CNS myelin mediated neurite growth | 628411 |
| gene_process | glia derived inhibitory factor | 628411 |
| gene_process | affects neurite outgrowth and cell spreading | 628411 |
| gene_process | inhibits neurite outgrowth in CNS myelin | 628316 |
| gene_process | may be involved in neurite outgrowth inhibitory activity | 628417 |
| gene_protein | 3 forms of protein exist- Noga A,B and C | 628411 |
| gene_regulation | inhibition of function with monoclonal Ab against protein induces regeneration of adult lesioned corticospinal tract and optic nerve fibers and also greatly increases compensatory sprouting in the adult and CST sprouts grew from the unlesioned to the cont | 628411 |
| More on Rtn4 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620989 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.