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Gene Ontology AnnotationsGene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | adenosine receptor signaling pathway | | ISO | RGD:736883 | 1624291 | MGI:MGI:99402 | RGD | MGI:MGI:2387279 PMID:12223546 | adenosine receptor signaling pathway | | IEA | Ensembl:ENSMUSP00000110563 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | adenylate cyclase-activating dopamine receptor signaling pathway | | ISO | RGD:736883 | 1624291 | MGI:MGI:99578 | RGD | MGI:MGI:2387279 PMID:12223546 | adenylate cyclase-activating dopamine receptor signaling pathway | | IEA | Ensembl:ENSMUSP00000110563 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | | ISO | RGD:736883 | 1624291 | MGI:MGI:99402 | RGD | MGI:MGI:2387279 PMID:12223546 | adenylate cyclase-inhibiting dopamine receptor signaling pathway | | ISO | RGD:736883 | 1624291 | MGI:MGI:94924 | RGD | MGI:MGI:2387279 PMID:12223546 | adenylate cyclase-inhibiting dopamine receptor signaling pathway | | IEA | Ensembl:ENSMUSP00000110563 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | cAMP biosynthetic process | | IDA | | 2315006 | | RGD | | cAMP biosynthetic process | | ISO | RGD:736883 | 1624291 | MGI:MGI:2662295 | RGD | MGI:MGI:2660986 PMID:12665504 | cAMP biosynthetic process | | ISO | RGD:736883 | 1624291 | MGI:MGI:2387896 | RGD | MGI:MGI:2387279 PMID:12223546 | cAMP biosynthetic process | | IDA | | 2312685 | | RGD | | cAMP biosynthetic process | | IDA | | 2312674 | | RGD | | cAMP biosynthetic process | | IDA | | 2312641 | | RGD | | intracellular signal transduction | | IEA | InterPro:IPR001054|InterPro:IPR018297 | 1600115 | GO_REF:0000002 | InterPro | GO_REF:0000002 | locomotory behavior | | ISO | RGD:736883 | 1624291 | MGI:MGI:2662295 | RGD | MGI:MGI:2660986 PMID:12665504 | locomotory behavior | | IEA | Ensembl:ENSMUSP00000110563 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | neuromuscular process controlling balance | | ISO | RGD:736883 | 1624291 | MGI:MGI:2662295 | RGD | MGI:MGI:2660986 PMID:12665504 | neuromuscular process controlling balance | | IEA | Ensembl:ENSMUSP00000110563 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Alcoholism |
| Amphetamine addiction | |
| Bile secretion | |
| Chemokine signaling pathway | |
| Cholinergic synapse | |
| Circadian entrainment | |
| Cocaine addiction | |
| Dilated cardiomyopathy | |
| Dopaminergic synapse | |
| GABAergic synapse | |
| Gap junction | |
| Gastric acid secretion | |
| Glutamatergic synapse | |
| GnRH signaling pathway | |
| HTLV-I infection | |
| Insulin secretion | |
| Melanogenesis | |
| Morphine addiction | |
| Oocyte meiosis | |
| Pancreatic secretion | |
| Progesterone-mediated oocyte maturation | |
| Purine metabolism | |
| Retrograde endocannabinoid signaling | |
| Salivary secretion | |
| Serotonergic synapse | |
| Vascular smooth muscle contraction | |
| Pathway Interaction Database | Endothelins (PID:200005) |
| LPA receptor mediated events (PID:200013) | |
| LPA4-mediated signaling events (PID:200047) | |
References - curated| 1. |
Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16. |
| 2. |
Helies-Toussaint C, etal., Am J Physiol Renal Physiol. 2000 Jul;279(1):F185-94. |
| 3. |
Ivanov A, etal., J Physiol. 2006 Jan 1;570(Pt 1):73-84. Epub 2005 Nov 10. |
| 4. |
Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69. |
| 5. |
KEGG |
| 6. |
Merlen C, etal., FEBS Lett. 2006 Oct 16;580(24):5697-704. Epub 2006 Sep 20. |
| 7. |
MGD Curation, June 12, 2002 |
| 8. |
MGD data from the GO Consortium |
| 9. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 10. |
Noyama K and Maekawa S, Neurosci Res. 2003 Feb;45(2):141-8. |
| 11. |
Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23. |
| 12. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 13. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 14. |
Premont RT, etal., Proc Natl Acad Sci U S A 1992 Oct 15;89(20):9809-13. |
| 15. |
RGD automated data pipeline |
| 16. |
RGD automated import pipeline for gene-chemical interactions |
| 17. |
Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24. |
| 18. |
Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51. |
References - uncuratedRGD Disease Portals| Adcy5 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Adcy5 (Rattus norvegicus) |
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| ADCY5 (Homo sapiens) |
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| Adcy5 (Mus musculus) |
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Position Markers| D11Rat107 |
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| RH128707 |
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| RH143365 |
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| BE114258 |
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| BF406340 |
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| Adcy5 |
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| stSG602571 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022600 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06068923 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01069723 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01069724 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473967 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M96159 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022600 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_072122 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_072122 | (Get FASTA) |
| GenBank Protein | AAB39764 | (Get FASTA) |
| EDM11326 | (Get FASTA) | |
| Q04400 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000002229 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000046488 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000049180 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 64532 | ENTREZGENE |
| Gene3D-CATH | A/G_cyclase | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000002229 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 11213 | ENTREZGENE |
| InterPro | A/G_cyclase | UniProtKB/Swiss-Prot |
| A/G_cyclase_CS | UniProtKB/Swiss-Prot | |
| Aden_cycl-like | UniProtKB/Swiss-Prot | |
| IPI | IPI00327925 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:64532 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | DUF1053 | UniProtKB/Swiss-Prot |
| Guanylate_cyc | UniProtKB/Swiss-Prot | |
| PROSITE | GUANYLATE_CYCLASE_1 | UniProtKB/Swiss-Prot |
| GUANYLATE_CYCLASE_2 | UniProtKB/Swiss-Prot | |
| SMART | CYCc | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | A/G_cyclase | UniProtKB/Swiss-Prot |
| UniGene | Rn.6278 | ENTREZGENE |
| UniProt | ADCY5_RAT | UniProtKB/Swiss-Prot |
| G3V9G1_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-07-09 | Adcy5 | adenylate cyclase 5 | Symbol and Name updated to reflect Human and Mouse nomenclature | 1755 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_regulation | membrane-bound, calcium-inhibitable adenylyl cyclase | 724707 |
| gene_regulation | activity is stimulated by forskolin, guanosine 5'-[gamma-thio]triphosphate, and isoproterenol plus GTP | 69740 |
| More on Adcy5 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 71014 |
| Created: | 2002-07-09 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.