Gene: Map3k1 (mitogen-activated protein kinase kinase kinase 1) Rattus norvegicus
Symbol: Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Description: ENCODES a protein that exhibits JUN kinase binding; JUN kinase kinase kinase activity; MAP kinase kinase kinase activity; INVOLVED IN activation of JNKK activity; activation of MAPKK activity; MAPK cascade; PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; ASSOCIATED WITH 46,XY Sex Reversal 6 (ortholog); Breast Neoplasms (ortholog); Microphthalmia, Syndromic 1 (ortholog); FOUND IN cytoplasm; cytoskeleton; membrane; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol
Type: protein-coding
Also known as: MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; Mekk1; mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Homo sapiens (human) : MAP3K1 (mitogen-activated protein kinase kinase kinase 1)  HGNC  AGR
Mus musculus (house mouse) : Map3k1 (mitogen-activated protein kinase kinase kinase 1)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Map3k1 (mitogen-activated protein kinase kinase kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP3K1 (mitogen-activated protein kinase kinase kinase 1)
Canis lupus familiaris (dog) : MAP3K1 (mitogen-activated protein kinase kinase kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map3k1 (mitogen-activated protein kinase kinase kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0243,329,516 - 43,393,203 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0262,373,717 - 62,440,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,062,252 - 43,126,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1242,987,560 - 43,051,968 (-)NCBI
Celera239,134,930 - 39,199,049 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Map3k1
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620966
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE