Nsf (N-ethylmaleimide sensitive factor, vesicle fusing ATPase) - Rat Genome Database

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Gene: Nsf (N-ethylmaleimide sensitive factor, vesicle fusing ATPase) Rattus norvegicus
Analyze
Symbol: Nsf
Name: N-ethylmaleimide sensitive factor, vesicle fusing ATPase
RGD ID: 621594
Description: Enables several functions, including ATP hydrolysis activity; enzyme binding activity; and signaling receptor binding activity. Involved in protein-containing complex disassembly; regulation of vesicle-mediated transport; and vesicle-mediated transport. Located in Golgi stack and dendritic shaft. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 96. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase); PARTICIPATES IN vasopressin signaling pathway via receptor type 2; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: N-ethylmaleimide sensitive factor; N-ethylmaleimide sensitive fusion protein; N-ethylmaleimide-sensitive factor; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; vesicle-fusing ATPase; vesicular-fusion protein NSF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81089,227,937 - 89,357,383 (-)NCBIGRCr8
mRatBN7.21088,727,912 - 88,857,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,727,912 - 88,857,386 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,766,004 - 93,896,184 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01093,231,131 - 93,359,684 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,624,517 - 88,754,710 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,879,608 - 91,986,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,878,633 - 92,008,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,645,985 - 91,751,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,974,385 - 93,082,222 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,988,754 - 93,118,400 (-)NCBI
Celera1087,428,233 - 87,533,296 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
Bisphenol B  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
caffeine  (ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clozapine  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
dizocilpine maleate  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-tocopherol  (ISO)
genistein  (EXP)
haloperidol  (EXP,ISO)
irinotecan  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
N(4)-hydroxycytidine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP)
potassium chromate  (ISO)
Propiverine  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (ISO)
rutin  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
sulfadimethoxine  (EXP)
testosterone  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
dendritic shaft  (IDA)
Golgi apparatus  (ISO)
Golgi stack  (IBA,IDA,IEA)
plasma membrane  (IEA,ISO)
postsynaptic density  (TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of SNAP-23 in trafficking of H+-ATPase in cultured inner medullary collecting duct cells. Banerjee A, etal., Am J Physiol Cell Physiol. 2001 Apr;280(4):C775-81.
2. mGluR and NMDAR activation internalize distinct populations of AMPARs. Casimiro TM, etal., Mol Cell Neurosci. 2011 Oct;48(2):161-70. doi: 10.1016/j.mcn.2011.07.007. Epub 2011 Jul 23.
3. Interaction of dopamine D1 receptor with N-ethylmaleimide-sensitive factor is important for the membrane localization of the receptor. Chen S and Liu F, J Neurosci Res. 2010 Aug 15;88(11):2504-12. doi: 10.1002/jnr.22401.
4. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Identification of Rab6 as an N-ethylmaleimide-sensitive fusion protein-binding protein. Han SY, etal., Biochem J 2000 Nov 15;352 Pt 1:165-73.
7. NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex. Hanley JG, etal., Neuron 2002 Mar 28;34(1):53-67.
8. Roles that nurses in the community can play in nursing research. Johnson MN and Okunade AO, Int Nurs Rev. 1975 Sep-Oct;22(5):147-9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons. Narisawa-Saito M, etal., J Biol Chem. 2002 Oct 25;277(43):40901-10. Epub 2002 Jul 18.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. NSF binding to GluR2 regulates synaptic transmission. Nishimune A, etal., Neuron. 1998 Jul;21(1):87-97.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
Additional References at PubMed
PMID:8082782   PMID:9267032   PMID:9334216   PMID:9697855   PMID:10196135   PMID:11577089   PMID:12554740   PMID:12832401   PMID:14755058   PMID:15613468   PMID:15797712   PMID:15858065  
PMID:15935991   PMID:15944123   PMID:16039622   PMID:16431922   PMID:16461345   PMID:16724110   PMID:16795052   PMID:17302911   PMID:17634366   PMID:17897319   PMID:18598260   PMID:21106836  
PMID:21307259   PMID:22045810   PMID:22871113   PMID:23376485   PMID:23836889   PMID:24599450   PMID:24753224   PMID:25480573   PMID:26766634   PMID:26839712   PMID:29476059   PMID:31932584  
PMID:32357304  


Genomics

Comparative Map Data
Nsf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81089,227,937 - 89,357,383 (-)NCBIGRCr8
mRatBN7.21088,727,912 - 88,857,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,727,912 - 88,857,386 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,766,004 - 93,896,184 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01093,231,131 - 93,359,684 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,624,517 - 88,754,710 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,879,608 - 91,986,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,878,633 - 92,008,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,645,985 - 91,751,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,974,385 - 93,082,222 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,988,754 - 93,118,400 (-)NCBI
Celera1087,428,233 - 87,533,296 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
NSF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381746,590,669 - 46,757,464 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1746,590,669 - 46,757,679 (+)EnsemblGRCh38hg38GRCh38
GRCh371744,668,035 - 44,834,830 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361742,023,354 - 42,190,000 (+)NCBINCBI36Build 36hg18NCBI36
Build 341742,023,397 - 42,189,993NCBI
Celera1741,231,619 - 41,284,321 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1740,092,157 - 40,095,514 (+)NCBIHuRef
HuRef1740,144,350 - 40,213,196 (+)NCBIHuRef
CHM1_11744,732,424 - 44,898,954 (+)NCBICHM1_1
T2T-CHM13v2.01747,452,259 - 47,618,933 (+)NCBIT2T-CHM13v2.0
Nsf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911103,712,608 - 103,844,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11103,712,608 - 103,844,882 (-)EnsemblGRCm39 Ensembl
GRCm3811103,821,782 - 103,954,056 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11103,821,782 - 103,954,056 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711103,683,096 - 103,815,370 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611103,637,872 - 103,770,146 (-)NCBIMGSCv36mm8
Celera11115,536,808 - 115,669,815 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.54NCBI
Nsf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547810,610,619 - 10,732,656 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547810,610,715 - 10,732,656 (+)NCBIChiLan1.0ChiLan1.0
NSF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21918,259,662 - 18,426,098 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11720,225,947 - 20,392,295 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01710,746,423 - 10,912,784 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11710,923,875 - 11,056,565 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1710,923,875 - 11,057,426 (-)Ensemblpanpan1.1panPan2
NSF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,927,149 - 10,072,656 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,927,068 - 10,071,272 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha910,225,793 - 10,371,295 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0911,518,063 - 11,663,166 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl911,517,317 - 11,663,164 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1910,528,956 - 10,674,213 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0916,847,857 - 16,992,907 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0916,795,635 - 16,941,205 (-)NCBIUU_Cfam_GSD_1.0
Nsf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560217,057,557 - 17,205,506 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365411,987,326 - 2,137,067 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365411,989,092 - 2,137,006 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1217,459,077 - 17,705,351 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11217,458,996 - 17,624,335 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21217,490,697 - 17,656,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NSF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11660,308,000 - 60,467,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1660,308,008 - 60,465,731 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607731,029,330 - 31,190,857 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248492,732,792 - 2,865,569 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248492,711,426 - 2,865,569 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nsf
912 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:115
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000006361
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat

Markers in Region
AW531537  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,814,326 - 88,814,446 (+)MAPPERmRatBN7.2
Rnor_6.01091,965,052 - 91,965,171NCBIRnor6.0
Rnor_5.01091,730,647 - 91,730,766UniSTSRnor5.0
RGSC_v3.41093,061,076 - 93,061,195UniSTSRGSC3.4
Celera1087,512,119 - 87,512,238UniSTS
RH 3.4 Map10917.0UniSTS
Cytogenetic Map10q32.1UniSTS
RH134933  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,728,846 - 88,729,060 (+)MAPPERmRatBN7.2
Rnor_6.01091,879,584 - 91,879,797NCBIRnor6.0
Rnor_5.01091,645,961 - 91,646,174UniSTSRnor5.0
RGSC_v3.41092,974,361 - 92,974,574UniSTSRGSC3.4
Celera1087,428,209 - 87,428,422UniSTS
RH 3.4 Map10922.3UniSTS
Cytogenetic Map10q32.1UniSTS
AU049932  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,827,568 - 88,827,774 (+)MAPPERmRatBN7.2
Rnor_6.01091,978,293 - 91,978,496NCBIRnor6.0
Rnor_5.01091,743,602 - 91,743,805UniSTSRnor5.0
RGSC_v3.41093,074,273 - 93,074,476UniSTSRGSC3.4
Celera1087,525,347 - 87,525,550UniSTS
Cytogenetic Map10q32.1UniSTS
NSF-1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,775,207 - 88,775,861 (+)MAPPERmRatBN7.2
Rnor_6.01091,925,940 - 91,926,593NCBIRnor6.0
Rnor_5.01091,692,223 - 91,692,876UniSTSRnor5.0
RGSC_v3.41093,021,152 - 93,021,805UniSTSRGSC3.4
Celera1087,474,297 - 87,474,950UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 44 28 19 28 74 33 37 11
Low 16 13 13 13 8 11 2 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006361   ⟹   ENSRNOP00000006361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1088,727,912 - 88,857,386 (-)Ensembl
Rnor_6.0 Ensembl1091,878,633 - 92,008,082 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087824   ⟹   ENSRNOP00000073942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1088,727,912 - 88,835,940 (-)Ensembl
Rnor_6.0 Ensembl1091,880,120 - 91,986,632 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099576   ⟹   ENSRNOP00000095949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1088,727,912 - 88,835,912 (-)Ensembl
RefSeq Acc Id: NM_021748   ⟹   NP_068516
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81089,227,937 - 89,357,383 (-)NCBI
mRatBN7.21088,727,912 - 88,857,375 (-)NCBI
Rnor_6.01091,879,608 - 91,986,242 (-)NCBI
Rnor_5.01091,645,985 - 91,751,551 (-)NCBI
RGSC_v3.41092,974,385 - 93,082,222 (-)RGD
Celera1087,428,233 - 87,533,296 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_068516   ⟸   NM_021748
- UniProtKB: Q9QUL6 (UniProtKB/Swiss-Prot),   F1LQ81 (UniProtKB/TrEMBL),   A6HJT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006361   ⟸   ENSRNOT00000006361
RefSeq Acc Id: ENSRNOP00000073942   ⟸   ENSRNOT00000087824
RefSeq Acc Id: ENSRNOP00000095949   ⟸   ENSRNOT00000099576
Protein Domains
AAA+ ATPase   CDC48   CDC48 N-terminal subdomain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUL6-F1-model_v2 AlphaFold Q9QUL6 1-744 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621594 AgrOrtholog
BioCyc Gene G2FUF-23025 BioCyc
Ensembl Genes ENSRNOG00000003905 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006361 ENTREZGENE
  ENSRNOT00000006361.7 UniProtKB/TrEMBL
  ENSRNOT00000087824.2 UniProtKB/TrEMBL
  ENSRNOT00000099576.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.330.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Asp_de-COase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cdc48_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CDC48_domain_2-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CDC4_N-term_subdom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vesicle-fus_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60355 UniProtKB/Swiss-Prot
NCBI Gene 60355 ENTREZGENE
PANTHER PTHR23078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VESICLE-FUSING ATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CDC48_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CDC48_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nsf PhenoGen
PRINTS ENDOLAPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003905 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CDC48_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CDC48_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50692 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54585 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6U1_RAT UniProtKB/TrEMBL
  A0A8I6AP08_RAT UniProtKB/TrEMBL
  A6HJT2_RAT UniProtKB/TrEMBL
  A6HJT3 ENTREZGENE, UniProtKB/TrEMBL
  F1LQ81 ENTREZGENE, UniProtKB/TrEMBL
  NSF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-07 Nsf  N-ethylmaleimide sensitive factor, vesicle fusing ATPase  Nsf  N-ethylmaleimide-sensitive factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-12 Nsf  N-ethylmaleimide-sensitive factor  Nsf  N-ethylmaleimide sensitive fusion protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nsf  N-ethylmaleimide sensitive fusion protein    N-ethylmaleimide sensitive factor  Name updated 1299863 APPROVED
2002-08-07 Nsf  N-ethylmaleimide sensitive factor      Symbol and Name status set to provisional 70820 PROVISIONAL