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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of PRKCZ protein | CTD | PMID:15058486 | (S)-nicotine | increases activity | ISO | RGD:736361 | 6480464 | Nicotine results in increased activity of PRKCZ protein | CTD | PMID:17525161 | (S)-nicotine | multiple interactions | ISO | RGD:736361 | 6480464 | PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein] | CTD | PMID:17525161 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:736362 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKCZ mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:736361 | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PRKCZ mRNA] | CTD | PMID:11007951 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:736362 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKCZ mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:736361 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PRKCZ mRNA | CTD | PMID:11007951 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of PRKCZ mRNA | CTD | PMID:21346803 | 2-methoxyethanol | increases expression | EXP | | 6480464 | methyl cellosolve metabolite results in increased expression of PRKCZ protein | CTD | PMID:11794376 | 2-methylcholine | affects expression | ISO | RGD:736361 | 6480464 | beta-methylcholine affects the expression of PRKCZ mRNA | CTD | PMID:21179406 | 2-nitrotoluene | increases expression | EXP | | 6480464 | 2-nitrotoluene results in increased expression of PRKCZ mRNA | CTD | PMID:16460773 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:736362 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PRKCZ mRNA | CTD | PMID:20188158 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:736362 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of PRKCZ mRNA | CTD | PMID:18648102 | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | multiple interactions | EXP | | 6480464 | 1-Butanol inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; more ... | CTD | PMID:11978788 | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | increases activity | EXP | | 6480464 | AICA ribonucleotide results in increased activity of PRKCZ protein | CTD | PMID:11978788 | 5-fluorouracil | affects expression | ISO | RGD:736361 | 6480464 | Fluorouracil affects the expression of PRKCZ mRNA | CTD | PMID:16584549 | afimoxifene | decreases response to substance | ISO | RGD:736361 | 6480464 | PRKCZ results in decreased susceptibility to 4-hydroxytamoxifen | CTD | PMID:21233418 | aflatoxin B1 | affects expression | ISO | RGD:736361 | 6480464 | Aflatoxin B1 affects the expression of PRKCZ protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | RGD:736361 | 6480464 | Aflatoxin B1 results in decreased expression of PRKCZ mRNA | CTD | PMID:22100608 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PRKCZ mRNA | CTD | PMID:16483693 | amphetamine | affects expression | EXP | | 6480464 | Amphetamine affects the expression of PRKCZ mRNA | CTD | PMID:16101753 | benzo[a]pyrene | multiple interactions | ISO | RGD:736362 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PRKCZ mRNA | CTD | PMID:21715664 | bromochloroacetic acid | increases expression | EXP | | 6480464 | bromochloroacetic acid results in increased expression of PRKCZ mRNA | CTD | PMID:16460773 | butan-1-ol | multiple interactions | ISO | RGD:736361 | 6480464 | 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein] | CTD | PMID:15255942 | butan-1-ol | multiple interactions | EXP | | 6480464 | 1-Butanol inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] | CTD | PMID:11978788 | carbachol | multiple interactions | ISO | RGD:736361 | 6480464 | 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein] | CTD | PMID:15255942 | carbachol | increases activity | ISO | RGD:736361 | 6480464 | Carbachol results in increased activity of PRKCZ protein | CTD | PMID:15255942 | clofibrate | decreases expression | ISO | RGD:736362 | 6480464 | Clofibrate results in decreased expression of PRKCZ mRNA | CTD | PMID:17585979 | clozapine | increases expression | EXP | | 6480464 | Clozapine results in increased expression of PRKCZ mRNA | CTD | PMID:15860345 | cocaine | multiple interactions | ISO | RGD:736362 | 6480464 | [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PRKCZ mRNA | CTD | PMID:18355967 | crocidolite asbestos | increases activity | ISO | RGD:736362 | 6480464 | Asbestos, Crocidolite results in increased activity of PRKCZ protein | CTD | PMID:12626342 | crocidolite asbestos | increases expression | ISO | RGD:736362 | 6480464 | Asbestos, Crocidolite results in increased expression of PRKCZ protein | CTD | PMID:12626342 | cycloheximide | multiple interactions | ISO | RGD:736361 | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PRKCZ mRNA] | CTD | PMID:11007951 | D-glucose | multiple interactions | EXP | | 6480464 | PRKCZ protein promotes the reaction [NRG1 protein results in increased transport of Glucose] | CTD | PMID:14711829 | deoxycholic acid | decreases response to substance | ISO | RGD:736361 | 6480464 | PRKCZ protein results in decreased susceptibility to Deoxycholic Acid | CTD | PMID:12507930 | dimethylarsinic acid | increases expression | EXP | | 6480464 | Cacodylic Acid results in increased expression of PRKCZ mRNA | CTD | PMID:16122865 | disodium selenite | increases expression | ISO | RGD:736361 | 6480464 | Sodium Selenite results in increased expression of PRKCZ mRNA | CTD | PMID:18175754 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of PRKCZ mRNA | CTD | PMID:20655511 | genistein | multiple interactions | EXP | | 6480464 | Genistein inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] | CTD | PMID:11978788 | glucose | multiple interactions | EXP | | 6480464 | PRKCZ protein promotes the reaction [NRG1 protein results in increased transport of Glucose] | CTD | PMID:14711829 | haloperidol | increases expression | EXP | | 6480464 | Haloperidol results in increased expression of PRKCZ mRNA | CTD | PMID:15860345 | hydrogen peroxide | increases activity | ISO | RGD:736362 | 6480464 | Hydrogen Peroxide results in increased activity of PRKCZ protein | CTD | PMID:12626342 | hydrogen peroxide | increases expression | ISO | RGD:736362 | 6480464 | Hydrogen Peroxide results in increased expression of PRKCZ protein | CTD | PMID:12626342 | LY294002 | decreases phosphorylation | ISO | RGD:736361 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of PRKCZ protein | CTD | PMID:12970779 | LY294002 | affects localization | ISO | RGD:736361 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of PRKCZ protein | CTD | PMID:15735031 | methylazoxymethanol | increases expression | ISO | RGD:736362 | 6480464 | methylazoxymethanol results in increased expression of PRKCZ mRNA | CTD | PMID:17107856 | mitomycin C | increases cleavage | ISO | RGD:736361 | 6480464 | Mitomycin results in increased cleavage of PRKCZ protein | CTD | PMID:10960761 | N-nitrosodiethylamine | increases phosphorylation | EXP | | 6480464 | Diethylnitrosamine results in increased phosphorylation of PRKCZ protein | CTD | PMID:21056072 | N-nitrosodimethylamine | increases expression | EXP | | 6480464 | Dimethylnitrosamine results in increased expression of PRKCZ mRNA | CTD | PMID:17032414 | nickel atom | multiple interactions | ISO | RGD:736361 | 6480464 | trichostatin A inhibits the reaction [Nickel affects the expression of PRKCZ mRNA] | CTD | PMID:14575637 | nickel atom | increases expression | ISO | RGD:736361 | 6480464 | Nickel results in increased expression of PRKCZ mRNA | CTD | PMID:14575637 | paracetamol | decreases expression | ISO | RGD:736361 | 6480464 | Acetaminophen results in decreased expression of PRKCZ mRNA | CTD | PMID:21420995 | phenylephrine | affects localization | EXP | | 6480464 | Phenylephrine affects the localization of PRKCZ protein | CTD | PMID:14736339 | phenylephrine | decreases activity | EXP | | 6480464 | Phenylephrine results in decreased activity of PRKCZ protein | CTD | PMID:14736339 | phenylephrine | multiple interactions | EXP | | 6480464 | GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein] | CTD | PMID:16809552 | phorbol 12,13-dibutanoate | increases expression | ISO | RGD:736362 | 6480464 | Phorbol 12,13-Dibutyrate results in increased expression of PRKCZ protein | CTD | PMID:12626342 | phorbol 13-acetate 12-myristate | affects localization | ISO | RGD:736361 | 6480464 | Tetradecanoylphorbol Acetate affects the localization of PRKCZ protein | CTD | PMID:15976015 | phorbol 13-acetate 12-myristate | multiple interactions | EXP | | 6480464 | Tetradecanoylphorbol Acetate affects the localization of and results in increased activity of PRKCZ protein | CTD | PMID:12590138 | pirinixic acid | multiple interactions | ISO | RGD:736362 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of PRKCZ mRNA] | CTD | PMID:20059764 | pirinixic acid | decreases expression | ISO | RGD:736362 | 6480464 | pirinixic acid results in decreased expression of PRKCZ mRNA | CTD | PMID:20059764 | pirinixic acid | multiple interactions | ISO | RGD:736361 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRKCZ mRNA | CTD | PMID:19710929 | raloxifene | multiple interactions | ISO | RGD:736361 | 6480464 | [Raloxifene co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA | CTD | PMID:19059307 | riddelliine | increases expression | EXP | | 6480464 | riddelliine results in increased expression of PRKCZ mRNA | CTD | PMID:18047727 | Se-methyl-L-selenocysteine | decreases expression | ISO | RGD:736362 | 6480464 | selenomethylselenocysteine results in decreased expression of PRKCZ protein | CTD | PMID:10656618 | Se-methylselenocysteine | decreases expression | ISO | RGD:736362 | 6480464 | selenomethylselenocysteine results in decreased expression of PRKCZ protein | CTD | PMID:10656618 | selenomethionine | affects expression | ISO | RGD:736361 | 6480464 | Selenomethionine affects the expression of PRKCZ mRNA | CTD | PMID:17222674 | silver atom | decreases expression | ISO | RGD:736361 | 6480464 | Silver results in decreased expression of PRKCZ protein; more ... | CTD | PMID:21611810 | silver(0) | decreases expression | ISO | RGD:736361 | 6480464 | Silver results in decreased expression of PRKCZ protein; more ... | CTD | PMID:21611810 | tamoxifen | multiple interactions | ISO | RGD:736361 | 6480464 | [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA | CTD | PMID:19059307 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PRKCZ mRNA | CTD | PMID:16644059 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of PRKCZ mRNA | CTD | PMID:17032414 | toluene | affects expression | EXP | | 6480464 | Toluene affects the expression of PRKCZ mRNA | CTD | PMID:21827849 | trichostatin A | multiple interactions | ISO | RGD:736361 | 6480464 | trichostatin A inhibits the reaction [Nickel affects the expression of PRKCZ mRNA] | CTD | PMID:14575637 | valproic acid | affects expression | ISO | RGD:736362 | 6480464 | Valproic Acid affects the expression of PRKCZ mRNA | CTD | PMID:17292431 | vanadium atom | affects localization | ISO | RGD:736362 | 6480464 | Vanadium affects the localization of PRKCZ protein | CTD | PMID:14971662 | vanadium(0) | affects localization | ISO | RGD:736362 | 6480464 | Vanadium affects the localization of PRKCZ protein | CTD | PMID:14971662 | vancomycin | increases expression | ISO | RGD:736362 | 6480464 | Vancomycin results in increased expression of PRKCZ mRNA | CTD | PMID:18930951 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Endocytosis | |
| Hippo signaling pathway | |
| Insulin signaling pathway | |
| PI3K-Akt signaling pathway | |
| Tight junction | |
| Type II diabetes mellitus | |
| Pathway Interaction Database | amb2 Integrin signaling (PID:200127) |
| CDC42 signaling events (PID:200069) | |
| Ceramide signaling pathway (PID:200119) | |
| CXCR4-mediated signaling events (PID:200099) | |
| ErbB1 downstream signaling (PID:200133) | |
| IGF1 pathway (PID:200100) | |
| IL1-mediated signaling events (PID:200089) | |
| IL2 signaling events mediated by PI3K (PID:200118) | |
| Insulin Pathway (PID:200014) | |
| Insulin-mediated glucose transport (PID:200196) | |
| Nephrin/Neph1 signaling in the kidney podocyte (PID:200152) | |
| Neurotrophic factor-mediated Trk receptor signaling (PID:200150) | |
| Noncanonical Wnt signaling pathway (PID:200020) | |
| p75(NTR)-mediated signaling (PID:200122) | |
| Regulation of Ras family activation (PID:200212) | |
| RhoA signaling pathway (PID:200009) | |
| Role of Calcineurin-dependent NFAT signaling in lymphocytes (PID:200090) | |
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) (PID:200041) | |
| Thromboxane A2 receptor signaling (PID:200082) | |
| TNF receptor signaling pathway (PID:200102) | |
Phenotype Annotations
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| 7. |
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| 8. |
GOA data from the GO Consortium |
| 9. |
Gong J, etal., Science. 1999 Sep 3;285(5433):1565-9. |
| 10. |
Hennige AM, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):85-90. |
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Kim YB, etal., Diabetes. 2003 Aug;52(8):1935-42. |
| 15. |
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Kuroda S, etal., J Cell Biol 1999 Feb 8;144(3):403-11. |
| 17. |
Lamark T, etal., J Biol Chem. 2003 Sep 5;278(36):34568-81. Epub 2003 Jun 17. |
| 18. |
Liu LZ, etal., Cell Signal. 2010 Oct;22(10):1513-22. Epub 2010 Jun 4. |
| 19. |
Liu LZ, etal., Mol Biol Cell. 2006 May;17(5):2322-30. Epub 2006 Mar 8. |
| 20. |
Mahadev K and Vemuri MC, Arch Biochem Biophys. 1998 Aug 15;356(2):249-57. |
| 21. |
McConkey M, etal., J Biol Chem. 2004 May 14;279(20):20882-8. Epub 2004 Mar 8. |
| 22. |
MGD data from the GO Consortium |
| 23. |
Miura A, etal., Metabolism 2003 Jan;52(1):19-24. |
| 24. |
Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24. |
| 25. |
Ono Y, etal., J Biol Chem 1988 May 15;263(14):6927-32. |
| 26. |
Ono Y, etal., Proc Natl Acad Sci U S A 1989 May;86(9):3099-103. |
| 27. |
Parmentier JH, etal., Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H46-54. Epub 2005 Aug 19. |
| 28. |
Parmentier JH, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1602-13. Epub 2006 May 5. |
| 29. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 30. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 31. |
Ramstrom C, etal., Cell Signal. 2004 Dec;16(12):1417-24. |
| 32. |
RGD automated data pipeline |
| 33. |
RGD automated import pipeline for gene-chemical interactions |
| 34. |
Rosse C, etal., PLoS Biol. 2009 Nov;7(11):e1000235. Epub 2009 Nov 3. |
| 35. |
Ryu J, etal., Arch Biochem Biophys 2002 Jul 1;403(1):71-82. |
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Sarkar S, etal., Traffic. 2006 Aug;7(8):1078-91. Epub 2006 May 25. |
| 37. |
Sentex E, etal., Can J Physiol Pharmacol. 2006 Feb;84(2):227-38. |
| 38. |
Serrano P, etal., J Neurosci. 2005 Feb 23;25(8):1979-84. |
| 39. |
Shema R, etal., Science. 2007 Aug 17;317(5840):951-3. |
| 40. |
Steiler TL, etal., Endocrinology. 2003 Dec;144(12):5259-67. Epub 2003 Aug 21. |
| 41. |
Suzuki A and Ohno S, J Cell Sci. 2006 Mar 15;119(Pt 6):979-87. |
| 42. |
Tokunaga C, etal., Biochem Biophys Res Commun 1998 Mar 17;244(2):353-9. |
| 43. |
Vohra BP, etal., J Neurosci. 2007 Aug 29;27(35):9458-68. |
References - uncurated| PubMed | 10406962 |
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| 11699875 | |
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RGD Disease Portals| Prkcz has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Prkcz (Rattus norvegicus) |
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| PRKCZ (Homo sapiens) |
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| Prkcz (Mus musculus) |
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Position Markers| BF387071 |
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| AW526905 |
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| AW529459 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022507 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06041306 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01041213 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01041214 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01041215 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF149212 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF149214 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473968 | (Get FASTA) | Search GEO for Microarray Profiles | |
| J04532 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M18332 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U27191 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022507 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_071952 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_071952 | (Get FASTA) |
| GenBank Protein | AAA41878 | (Get FASTA) |
| AAA41934 | (Get FASTA) | |
| EDL81293 | (Get FASTA) | |
| EDL81294 | (Get FASTA) | |
| EDL81295 | (Get FASTA) | |
| P09217 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000015480 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000021285 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000021285 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 25522 | ENTREZGENE |
| Germonline | ENSRNOG00000015480 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55681 | ENTREZGENE |
| InterPro | AGC-kinase_C | UniProtKB/Swiss-Prot |
| DAG/PE_bd | UniProtKB/Swiss-Prot | |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| OPR_PB1 | UniProtKB/Swiss-Prot | |
| PKC_zeta | UniProtKB/Swiss-Prot | |
| Pkinase_C | UniProtKB/Swiss-Prot | |
| Prot_Kinase_C-like_PE/DAG_bd | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_AS | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00212818 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:25522 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | C1_1 | UniProtKB/Swiss-Prot |
| PB1 | UniProtKB/Swiss-Prot | |
| Pkinase | UniProtKB/Swiss-Prot | |
| Pkinase_C | UniProtKB/Swiss-Prot | |
| PIRSF | PKC_zeta | UniProtKB/Swiss-Prot |
| PRINTS | DAGPEDOMAIN | UniProtKB/Swiss-Prot |
| PROSITE | AGC_KINASE_CTER | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| ZF_DAG_PE_1 | UniProtKB/Swiss-Prot | |
| ZF_DAG_PE_2 | UniProtKB/Swiss-Prot | |
| SMART | PB1 | UniProtKB/Swiss-Prot |
| S_TK_X | UniProtKB/Swiss-Prot | |
| S_TKc | UniProtKB/Swiss-Prot | |
| SM00109 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.1109 | ENTREZGENE |
| UniProt | KPCZ_RAT | UniProtKB/Swiss-Prot |
| Q9JLP6_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2001-07-23 | Prkcz | protein kinase C, zeta | Name updated to reflect Human and Mouse nomenclature | 461 | APPROVED | ||
| 2001-07-23 | Prkcz | 14 - 3 - 3 - zeta isoform | Name withdrawn | 461 | WITHDRAWN |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed in pancreatic islets | 70640 |
| gene_process | mediates basal and IGF-1-dependent mitogenesis | 61695 |
| gene_process | mediates basal and IGF-1-dependent mitogenesis | 70640 |
| gene_process | enhances PDX-1 transcription factor binding activity after stimulation of IGF-1 in RIN 1046-38 cells | 61695 |
| gene_process | enhances PDX-1 transcription factor binding activity after stimulation of IGF-1 in RIN 1046-38 cells | 70640 |
| gene_regulation | induced by IL-1 and TNF-alpha; calcium- and diacylglycerol-insensitive | 729628 |
| More on Prkcz | |
![]() |
Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3399 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




