Gene: Dlat (dihydrolipoamide S-acetyltransferase) Rattus norvegicus
Symbol: Dlat
Name: dihydrolipoamide S-acetyltransferase
Description: ENCODES a protein that exhibits dihydrolipoyllysine-residue acetyltransferase activity; INVOLVED IN acetyl-CoA biosynthetic process from pyruvate; sleep; PARTICIPATES IN pyruvate metabolic pathway; citric acid cycle pathway; gluconeogenesis pathway; ASSOCIATED WITH Sleep Deprivation; Prostatic Neoplasms (ortholog); Pyruvate Dehydrogenase E2 Deficiency (ortholog); FOUND IN mitochondrion; pyruvate dehydrogenase complex; myelin sheath (ortholog); INTERACTS WITH (R)-adrenaline; 17alpha-ethynylestradiol; 2,2,2-tetramine
Type: protein-coding
Also known as: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; dihydrolipoamide acetyltransferase; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; E2; PBC; PDC-E2; PDCE2; pyruvate dehydrogenase complex component E2
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.0855,062,549 - 55,087,832-NCBI
Rat Cytogenetic Map8q23 NCBI
RGSC Genome Assembly v5.0853,659,920 - 53,685,238-NCBI
RGSC Genome Assembly v3.4853,989,491 - 54,014,779-NCBI
Rat Celera Assembly850,507,581 - 50,552,393-NCBI
Genome Assembly 3.1854,008,592 - 54,033,135-NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Dlat
Entrez Gene
Ensembl Gene
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RGD Object Information
RGD ID: 619859
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2015-05-12
Status: ACTIVE