Gene: Dlat (dihydrolipoamide S-acetyltransferase) Rattus norvegicus
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Symbol: Dlat
Name: dihydrolipoamide S-acetyltransferase
Description: ENCODES a protein that exhibits dihydrolipoyllysine-residue acetyltransferase activity; identical protein binding (ortholog); pyruvate dehydrogenase (NAD+) activity (ortholog); INVOLVED IN acetyl-CoA biosynthetic process from pyruvate; sleep; PARTICIPATES IN citric acid cycle pathway; fumaric aciduria disease pathway; Leigh syndrome pathway; ASSOCIATED WITH Sleep Deprivation; Abnormalities, Multiple (ortholog); coronary artery disease (ortholog); FOUND IN mitochondrion; pyruvate dehydrogenase complex; myelin sheath (ortholog); INTERACTS WITH (R)-adrenaline; 17alpha-ethynylestradiol; 2,2,2-tetramine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; dihydrolipoamide acetyltransferase; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; E2; PBC; PDC-E2; PDCE2; pyruvate dehydrogenase complex component E2
Orthologs:
Homo sapiens (human) : DLAT (dihydrolipoamide S-acetyltransferase)  HGNC  AGR
Mus musculus (house mouse) : Dlat (dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex))  MGI
Chinchilla lanigera (long-tailed chinchilla) : Dlat (dihydrolipoamide S-acetyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : DLAT (dihydrolipoamide S-acetyltransferase)
Canis lupus familiaris (dog) : DLAT (dihydrolipoamide S-acetyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlat (dihydrolipoamide S-acetyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0855,062,549 - 55,087,832 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0853,659,920 - 53,685,238 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4853,989,491 - 54,014,779 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1854,008,592 - 54,033,135 (-)NCBI
Celera850,507,581 - 50,552,393 (-)NCBI
Cytogenetic Map8q23NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
 
More on Dlat
AGR Gene
NCBI Gene
Ensembl Gene
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RGD Object Information
RGD ID: 619859
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE