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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | angiogenesis | | ISO | RGD:1313728 | 1624291 | MGI:MGI:1331270|PMID:9990854 | RGD | MGI:MGI:1331270 PMID:9990854 | angiogenesis | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | axon guidance | | ISO | RGD:1313728 | 1624291 | MGI:MGI:2149059|PMID:11532925 | RGD | MGI:MGI:2149059 PMID:11532925 | axon guidance | | ISO | RGD:1313728 | 1624291 | MGI:MGI:1859095|PMID:10839360 | RGD | MGI:MGI:1859095 PMID:10839360 | axon guidance | | ISO | RGD:1313728 | 1624291 | MGI:MGI:84499|PMID:8947026 | RGD | MGI:MGI:84499 PMID:8947026 | axonal fasciculation | | ISO | RGD:1313728 | 1624291 | MGI:MGI:84499|PMID:8947026 | RGD | MGI:MGI:84499 PMID:8947026 | axonal fasciculation | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | cell migration | | ISO | RGD:1313728 | 1624291 | MGI:MGI:2388849|PMID:12408869 | RGD | MGI:MGI:2388849 PMID:12408869 | cell migration | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | cell migration | | IEA | Ensembl:ENSP00000332118 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | cell migration | | ISO | RGD:1313727 | 1624291 | PMID:15536074 | RGD | PMID:15536074 | central nervous system projection neuron axonogenesis | | ISO | RGD:1313728 | 1624291 | MGI:MGI:2675767|PMID:12971893 | RGD | MGI:MGI:2675767 PMID:12971893 | central nervous system projection neuron axonogenesis | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | corpus callosum development | | ISO | RGD:1313728 | 1624291 | MGI:MGI:84499|PMID:8947026 | RGD | MGI:MGI:84499 PMID:8947026 | corpus callosum development | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | dendritic spine development | | ISO | RGD:1313728 | 1624291 | MGI:MGI:2683349|PMID:14691139 | RGD | MGI:MGI:2683349 PMID:14691139 | dendritic spine morphogenesis | | ISO | RGD:1313728 | 1624291 | MGI:MGI:2683349|PMID:14691139 | RGD | MGI:MGI:2683349 PMID:14691139 | dendritic spine morphogenesis | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | digestive tract morphogenesis | | ISO | RGD:1313728 | 1624291 | MGI:MGI:2388849|PMID:12408869 | RGD | MGI:MGI:2388849 PMID:12408869 | digestive tract morphogenesis | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | ephrin receptor signaling pathway | | ISO | RGD:1313727 | 1624291 | PMID:15536074 | RGD | PMID:15536074 | ephrin receptor signaling pathway | | ISO | RGD:1313727 | 1624291 | PMID:8397371 | RGD | PMID:8397371 | palate development | | ISO | RGD:1313728 | 1624291 | MGI:MGI:84499|PMID:8947026 | RGD | MGI:MGI:84499 PMID:8947026 | palate development | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of synapse assembly | | ISO | RGD:1313728 | 1624291 | MGI:MGI:2683349|PMID:14691139 | RGD | MGI:MGI:2683349 PMID:14691139 | positive regulation of synapse assembly | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | protein autophosphorylation | | ISO | RGD:1313727 | 1624291 | PMID:15536074 | RGD | PMID:15536074 | protein autophosphorylation | | IEA | Ensembl:ENSP00000332118 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | protein autophosphorylation | | ISO | RGD:1313727 | 1624291 | PMID:8397371 | RGD | PMID:8397371 | regulation of axonogenesis | | ISO | RGD:1313728 | 1624291 | MGI:MGI:3759704|PMID:17719550 | RGD | MGI:MGI:3759704 PMID:17719550 | regulation of axonogenesis | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | regulation of Cdc42 GTPase activity | | ISO | RGD:1313727 | 1624291 | PMID:15536074 | RGD | PMID:15536074 | regulation of Cdc42 GTPase activity | | IEA | Ensembl:ENSP00000332118 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | regulation of cell-cell adhesion | | ISO | RGD:1313727 | 1624291 | PMID:8397371 | RGD | PMID:8397371 | regulation of cell-cell adhesion | | IEA | Ensembl:ENSP00000332118 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | regulation of Rac GTPase activity | | ISO | RGD:1313727 | 1624291 | PMID:15536074 | RGD | PMID:15536074 | regulation of Rac GTPase activity | | IEA | Ensembl:ENSP00000332118 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | retinal ganglion cell axon guidance | | ISO | RGD:1313728 | 1624291 | MGI:MGI:2675767|PMID:12971893 | RGD | MGI:MGI:2675767 PMID:12971893 | retinal ganglion cell axon guidance | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | signal transduction | | ISO | RGD:1313728 | 1624291 | MGI:MGI:2149059|PMID:11532925 | RGD | MGI:MGI:2149059 PMID:11532925 | substrate adhesion-dependent cell spreading | | ISO | RGD:1313727 | 1624291 | PMID:15536074 | RGD | PMID:15536074 | substrate adhesion-dependent cell spreading | | IEA | Ensembl:ENSP00000332118 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | thymus development | | ISO | RGD:1313728 | 1624291 | MGI:MGI:4366231|PMID:19598115 | RGD | MGI:MGI:4366231 PMID:19598115 | thymus development | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | urogenital system development | | ISO | RGD:1313728 | 1624291 | MGI:MGI:3047196|PMID:15223334 | RGD | MGI:MGI:3047196 PMID:15223334 | urogenital system development | | IEA | Ensembl:ENSMUSP00000006112 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Axon guidance |
| Pathway Interaction Database | EPHB forward signaling (PID:200052) |
| EphrinB-EPHB pathway (PID:200163) | |
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Axon guidance |
| Pathway Interaction Database | EPHB forward signaling (PID:200052) |
| EphrinB-EPHB pathway (PID:200163) | |
References - curated
References - uncurated
RGD Disease Portals| Ephb3 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Ephb3 (Rattus norvegicus) |
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| EPHB3 (Homo sapiens) |
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| Ephb3 (Mus musculus) |
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Position Markers| RH70256 |
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| Z49086 |
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| Ephb3 |
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| Ephb3 |
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| Ephb3 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_001105868 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001099338 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001099338 | (Get FASTA) |
| GenBank Protein | EDL78031 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000031801 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000039489 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000044896 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 287989 | ENTREZGENE |
| Gene3D-CATH | 0.10 | UniProtKB/TrEMBL |
| 50.50 | UniProtKB/TrEMBL | |
| HomoloGene Group ID | 20938 | ENTREZGENE |
| InterPro | Ephrin_rcpt_lig-bd | UniProtKB/TrEMBL |
| Fibronectin_type3 | UniProtKB/TrEMBL | |
| Galactose-bd-like | UniProtKB/TrEMBL | |
| Ig-like_fold | UniProtKB/TrEMBL | |
| Kinase-like_dom | UniProtKB/TrEMBL | |
| Prot_kinase_cat_dom | UniProtKB/TrEMBL | |
| Protein_kinase_ATP_BS | UniProtKB/TrEMBL | |
| SAM | UniProtKB/TrEMBL | |
| SAM/pointed | UniProtKB/TrEMBL | |
| SAM_type1 | UniProtKB/TrEMBL | |
| Ser-Thr/Tyr_kinase_cat_dom | UniProtKB/TrEMBL | |
| Tyr-kin_ephrin_A/B_rcpt-like | UniProtKB/TrEMBL | |
| Tyr_kinase_AS | UniProtKB/TrEMBL | |
| Tyr_kinase_cat_dom | UniProtKB/TrEMBL | |
| Tyr_kinase_ephrin_rcpt | UniProtKB/TrEMBL | |
| Tyr_kinase_rcpt_V_CS | UniProtKB/TrEMBL | |
| IPI | IPI00870353 | UniProtKB/TrEMBL |
| KEGG Report | rno:287989 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | Ephrin_lbd | UniProtKB/TrEMBL |
| fn3 | UniProtKB/TrEMBL | |
| GCC2_GCC3 | UniProtKB/TrEMBL | |
| Pkinase_Tyr | UniProtKB/TrEMBL | |
| SAM_1 | UniProtKB/TrEMBL | |
| PIRSF | TyrPK_ephrin_receptor | UniProtKB/TrEMBL |
| PRINTS | TYRKINASE | UniProtKB/TrEMBL |
| PROSITE | EPH_LBD | UniProtKB/TrEMBL |
| FN3 | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_ATP | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_DOM | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_TYR | UniProtKB/TrEMBL | |
| RECEPTOR_TYR_KIN_V_1 | UniProtKB/TrEMBL | |
| RECEPTOR_TYR_KIN_V_2 | UniProtKB/TrEMBL | |
| SAM_DOMAIN | UniProtKB/TrEMBL | |
| SMART | EPH_lbd | UniProtKB/TrEMBL |
| FN3 | UniProtKB/TrEMBL | |
| SAM | UniProtKB/TrEMBL | |
| TyrKc | UniProtKB/TrEMBL | |
| Superfamily-SCOP | FN_III-like | UniProtKB/TrEMBL |
| Gal_bind_like | UniProtKB/TrEMBL | |
| Kinase_like | UniProtKB/TrEMBL | |
| SAM_homology | UniProtKB/TrEMBL | |
| UniGene | Rn.131133 | ENTREZGENE |
| UniProt | D3ZH39_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-04-30 | Ephb3 | Eph receptor B3 | Ephb3_predicted | Eph receptor B3 (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Ephb3_predicted | Eph receptor B3 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Ephb3 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1305602 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




