Ewsr1 (EWS RNA-binding protein 1) - Rat Genome Database

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Gene: Ewsr1 (EWS RNA-binding protein 1) Rattus norvegicus
Analyze
Symbol: Ewsr1
Name: EWS RNA-binding protein 1
RGD ID: 1307258
Description: Predicted to enable RNA binding activity; identical protein binding activity; and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Located in Cajal body. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ewing sarcoma breakpoint region 1; LOC100912481; LOC289752; MGC112874; RNA-binding protein EWS; RNA-binding protein EWS-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,179,413 - 84,208,149 (-)NCBIGRCr8
mRatBN7.21479,965,365 - 79,994,108 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,965,368 - 79,994,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1484,367,879 - 84,396,214 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,607,961 - 85,636,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,057,300 - 82,085,639 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,322,105 - 85,350,826 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,322,296 - 85,350,948 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl424,612,205 - 24,640,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,999,726 - 86,028,412 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,730,483 - 85,758,958 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11485,749,423 - 85,757,419 (-)NCBI
Celera1478,856,524 - 78,884,367 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
Cuprizon  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
propofol  (ISO)
quinomethionate  (ISO)
resveratrol  (ISO)
romidepsin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sunitinib  (ISO)
tetraphene  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Cajal body  (IDA)
nucleolus  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Delattre O, etal., Nature. 1992 Sep 10;359(6391):162-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein. Young PJ, etal., Brain Res Mol Brain Res 2003 Nov 6;119(1):37-49.
Additional References at PubMed
PMID:11555636   PMID:12477932   PMID:21988832   PMID:22658674   PMID:22681889   PMID:23975937   PMID:27932493   PMID:31505169  


Genomics

Comparative Map Data
Ewsr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,179,413 - 84,208,149 (-)NCBIGRCr8
mRatBN7.21479,965,365 - 79,994,108 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,965,368 - 79,994,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1484,367,879 - 84,396,214 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,607,961 - 85,636,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,057,300 - 82,085,639 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,322,105 - 85,350,826 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,322,296 - 85,350,948 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl424,612,205 - 24,640,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,999,726 - 86,028,412 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,730,483 - 85,758,958 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11485,749,423 - 85,757,419 (-)NCBI
Celera1478,856,524 - 78,884,367 (-)NCBICelera
Cytogenetic Map14q21NCBI
EWSR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,268,268 - 29,300,521 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,268,009 - 29,300,525 (+)EnsemblGRCh38hg38GRCh38
GRCh372229,664,257 - 29,696,511 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,994,017 - 28,026,515 (+)NCBINCBI36Build 36hg18NCBI36
Build 342227,988,824 - 28,020,705NCBI
Celera2213,463,861 - 13,496,373 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2212,628,341 - 12,660,759 (+)NCBIHuRef
CHM1_12229,623,296 - 29,655,935 (+)NCBICHM1_1
T2T-CHM13v2.02229,731,759 - 29,763,936 (+)NCBIT2T-CHM13v2.0
Ewsr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,019,687 - 5,049,314 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,019,689 - 5,049,266 (-)EnsemblGRCm39 Ensembl
GRCm38115,069,687 - 5,099,107 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,069,689 - 5,099,266 (-)EnsemblGRCm38mm10GRCm38
MGSCv37114,969,691 - 4,999,080 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,969,691 - 4,999,080 (-)NCBIMGSCv36mm8
Celera115,566,577 - 5,596,173 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.22NCBI
Ewsr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,571,025 - 3,601,975 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554553,571,025 - 3,599,975 (+)NCBIChiLan1.0ChiLan1.0
EWSR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22339,251,871 - 39,284,196 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12241,952,383 - 41,984,707 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02210,323,622 - 10,356,039 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12228,131,109 - 28,163,134 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,131,109 - 28,163,134 (+)Ensemblpanpan1.1panPan2
EWSR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,578,782 - 22,608,174 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,578,848 - 22,608,174 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,450,852 - 22,480,199 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02622,952,619 - 22,982,513 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2622,895,456 - 22,982,513 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,661,847 - 22,691,517 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02622,925,988 - 22,954,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02622,990,198 - 23,019,840 (+)NCBIUU_Cfam_GSD_1.0
Ewsr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,547,421 - 112,574,485 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366573,296,217 - 3,323,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EWSR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,408,649 - 46,439,453 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,408,636 - 46,439,357 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,373,476 - 49,404,048 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EWSR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,138,279 - 12,169,771 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045113,980,276 - 114,011,933 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ewsr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247475,647,741 - 5,676,859 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ewsr1
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000057382
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat

Markers in Region
BF400608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,991,747 - 79,991,876 (+)MAPPERmRatBN7.2
mRatBN7.21479,991,747 - 79,991,876 (-)MAPPERmRatBN7.2
Rnor_6.0424,614,362 - 24,614,490NCBIRnor6.0
Rnor_6.01485,348,483 - 85,348,611NCBIRnor6.0
Rnor_5.0424,537,864 - 24,537,992UniSTSRnor5.0
Rnor_5.01486,026,101 - 86,026,229UniSTSRnor5.0
RGSC_v3.41485,756,655 - 85,756,783UniSTSRGSC3.4
Celera1478,882,064 - 78,882,192UniSTS
RH 3.4 Map14566.3UniSTS
Cytogenetic Map14q21UniSTS
G06555  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,965,405 - 79,965,730 (-)MAPPERmRatBN7.2
mRatBN7.21479,965,405 - 79,965,730 (+)MAPPERmRatBN7.2
Rnor_6.0424,640,502 - 24,640,826NCBIRnor6.0
Rnor_6.01485,322,146 - 85,322,470NCBIRnor6.0
Rnor_5.01485,999,767 - 86,000,091UniSTSRnor5.0
Rnor_5.0424,564,004 - 24,564,328UniSTSRnor5.0
RGSC_v3.41485,730,320 - 85,730,644UniSTSRGSC3.4
Celera1478,856,361 - 78,856,685UniSTS
Cytogenetic Map14q21UniSTS
Ewsr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,994,724 - 80,995,517 (+)MAPPERmRatBN7.2
Rnor_6.01184,769,778 - 84,770,570NCBIRnor6.0
Rnor_5.01187,832,205 - 87,832,997UniSTSRnor5.0
RGSC_v3.41183,245,576 - 83,246,368UniSTSRGSC3.4
RGSC_v3.4424,171,846 - 24,172,741UniSTSRGSC3.4
Celera1179,829,968 - 79,830,760UniSTS
Celera422,991,908 - 22,992,803UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map14q21UniSTS
UniSTS:479109  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,965,739 - 79,967,268 (-)MAPPERmRatBN7.2
mRatBN7.21479,965,739 - 79,967,268 (+)MAPPERmRatBN7.2
Rnor_6.0424,638,964 - 24,640,492NCBIRnor6.0
Rnor_6.01485,322,480 - 85,324,008NCBIRnor6.0
Rnor_5.01486,000,101 - 86,001,629UniSTSRnor5.0
Rnor_5.0424,562,466 - 24,563,994UniSTSRnor5.0
RGSC_v3.41485,730,654 - 85,732,182UniSTSRGSC3.4
Celera1478,856,695 - 78,858,223UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 6 22 6 19 6 1 15 13 26 11
Below cutoff 33 31 31 31 8 10 53 20 15 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012634   ⟹   ENSRNOP00000012634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,965,368 - 79,994,055 (-)Ensembl
Rnor_6.0 Ensembl1485,322,310 - 85,350,786 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000057382   ⟹   ENSRNOP00000054193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,965,368 - 79,994,055 (-)Ensembl
Rnor_6.0 Ensembl424,612,205 - 24,640,686 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083464   ⟹   ENSRNOP00000069920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,965,449 - 79,994,544 (-)Ensembl
Rnor_6.0 Ensembl1485,322,296 - 85,350,948 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086607   ⟹   ENSRNOP00000074472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,965,368 - 79,994,055 (-)Ensembl
Rnor_6.0 Ensembl424,617,008 - 24,640,496 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094261   ⟹   ENSRNOP00000085477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,974,943 - 79,994,167 (-)Ensembl
RefSeq Acc Id: NM_001025632   ⟹   NP_001020803
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,179,617 - 84,208,095 (-)NCBI
mRatBN7.21479,965,569 - 79,994,051 (-)NCBI
Rnor_6.01485,322,309 - 85,350,786 (-)NCBI
Rnor_5.01485,999,726 - 86,028,412 (-)NCBI
RGSC_v3.41485,730,483 - 85,758,958 (-)RGD
Celera1478,856,524 - 78,884,367 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251201   ⟹   XP_006251263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,179,413 - 84,208,149 (-)NCBI
mRatBN7.21479,965,365 - 79,994,108 (-)NCBI
Rnor_6.01485,322,105 - 85,350,826 (-)NCBI
Rnor_5.01485,999,726 - 86,028,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251202   ⟹   XP_006251264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,179,413 - 84,208,149 (-)NCBI
mRatBN7.21479,965,365 - 79,994,108 (-)NCBI
Rnor_6.01485,322,105 - 85,350,826 (-)NCBI
Rnor_5.01485,999,726 - 86,028,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251203   ⟹   XP_006251265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,179,413 - 84,208,149 (-)NCBI
mRatBN7.21479,965,588 - 79,994,067 (-)NCBI
Rnor_6.01485,322,105 - 85,350,826 (-)NCBI
Rnor_5.01485,999,726 - 86,028,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770260   ⟹   XP_008768482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,188,849 - 84,208,149 (-)NCBI
mRatBN7.21479,976,604 - 79,994,108 (-)NCBI
Rnor_6.01485,330,755 - 85,350,826 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091737   ⟹   XP_038947665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,179,413 - 84,190,671 (-)NCBI
mRatBN7.21479,965,365 - 79,976,729 (-)NCBI
RefSeq Acc Id: XM_063272946   ⟹   XP_063129016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,179,413 - 84,196,946 (-)NCBI
RefSeq Acc Id: XM_063272947   ⟹   XP_063129017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,186,794 - 84,208,149 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001020803   ⟸   NM_001025632
- UniProtKB: B1WC50 (UniProtKB/TrEMBL),   F1MA60 (UniProtKB/TrEMBL),   A0A9K3Y8I9 (UniProtKB/TrEMBL),   F1LN98 (UniProtKB/TrEMBL),   A0A0G2K850 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251265   ⟸   XM_006251203
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K850 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251264   ⟸   XM_006251202
- Peptide Label: isoform X2
- UniProtKB: A0A140UHY3 (UniProtKB/TrEMBL),   A0A0G2JWK8 (UniProtKB/TrEMBL),   A0A8J8Y9N6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251263   ⟸   XM_006251201
- Peptide Label: isoform X1
- UniProtKB: A0A8J8Y9N6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768482   ⟸   XM_008770260
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A3F5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012634   ⟸   ENSRNOT00000012634
RefSeq Acc Id: ENSRNOP00000069920   ⟸   ENSRNOT00000083464
RefSeq Acc Id: XP_038947665   ⟸   XM_039091737
- Peptide Label: isoform X6
- UniProtKB: Q4KM41 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000074472   ⟸   ENSRNOT00000086607
RefSeq Acc Id: ENSRNOP00000054193   ⟸   ENSRNOT00000057382
RefSeq Acc Id: ENSRNOP00000085477   ⟸   ENSRNOT00000094261
RefSeq Acc Id: XP_063129016   ⟸   XM_063272946
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063129017   ⟸   XM_063272947
- Peptide Label: isoform X5
Protein Domains
RanBP2-type   RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A140UHY3-F1-model_v2 AlphaFold A0A140UHY3 1-661 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699454
Promoter ID:EPDNEW_R9978
Type:initiation region
Name:Ewsr1_1
Description:EWS RNA-binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01485,350,787 - 85,350,847EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307258 AgrOrtholog
BioCyc Gene G2FUF-15149 BioCyc
Ensembl Genes ENSRNOG00000009437 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046950 Ensembl
Ensembl Transcript ENSRNOT00000012634 ENTREZGENE
  ENSRNOT00000012634.7 UniProtKB/TrEMBL
  ENSRNOT00000057382.5 UniProtKB/TrEMBL
  ENSRNOT00000083464.2 UniProtKB/TrEMBL
  ENSRNOT00000086607.2 UniProtKB/TrEMBL
  ENSRNOT00000094261.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
  Zinc finger, RanBP2-type UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9089248 IMAGE-MGC_LOAD
InterPro EWS_RRM UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  TET_fam UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/TrEMBL
KEGG Report rno:289752 UniProtKB/TrEMBL
MGC_CLONE MGC:187859 IMAGE-MGC_LOAD
NCBI Gene 289752 ENTREZGENE
PANTHER PTHR23238 UniProtKB/TrEMBL
  PTHR23238:SF3 UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
  zf-RanBP UniProtKB/TrEMBL
PhenoGen Ewsr1 PhenoGen
PROSITE RRM UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009437 RatGTEx
  ENSRNOG00000046950 RatGTEx
SMART RRM UniProtKB/TrEMBL
  ZnF_RBZ UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
  SSF90209 UniProtKB/TrEMBL
UniProt A0A0G2JWK8 ENTREZGENE
  A0A0G2K850 ENTREZGENE, UniProtKB/TrEMBL
  A0A140UHY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3F5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8Y9N6 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y8I9 ENTREZGENE, UniProtKB/TrEMBL
  B1WC50 ENTREZGENE, UniProtKB/TrEMBL
  F1LN98 ENTREZGENE
  F1MA60 ENTREZGENE
  Q4KM41 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2JWK8 UniProtKB/TrEMBL
  F1LN98 UniProtKB/TrEMBL
  F1MA60 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ewsr1  EWS RNA-binding protein 1  LOC100912481  RNA-binding protein EWS-like  Data merged from RGD:6486611 737654 PROVISIONAL
2013-06-05 Ewsr1  EWS RNA-binding protein 1  Ewsr1  Ewing sarcoma breakpoint region 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912481  RNA-binding protein EWS-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Ewsr1  Ewing sarcoma breakpoint region 1  Ewsr1_predicted  Ewing sarcoma breakpoint region 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ewsr1_predicted  Ewing sarcoma breakpoint region 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED