Dr1 (down-regulator of transcription 1)

Gene: Dr1 (down-regulator of transcription 1) Rattus norvegicus

Analyze

Symbol:

Dr1

Name:

down-regulator of transcription 1

RGD ID:

1305201

Description:

Predicted to enable RNA polymerase II general transcription initiation factor activity and TBP-class protein binding activity. Predicted to be involved in several processes, including RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and regulation of tubulin deacetylation. Predicted to be located in nucleoplasm. Predicted to be part of ATAC complex; RNA polymerase II transcription regulator complex; and negative cofactor 2 complex. Orthologous to human DR1 (down-regulator of transcription 1); PARTICIPATES IN RNA polymerase II transcription initiation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

down-regulator of transcription 1, TBP-binding (negative cofactor 2); LOC100910207; LOC289881; NC2-beta; negative cofactor 2-beta; protein Dr1-like; TATA-binding protein-associated phosphoprotein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DR1 (down-regulator of transcription 1)	RGD	RGD
Mus musculus (house mouse):	Dr1 (down-regulator of transcription 1)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Dr1 (down-regulator of transcription 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DR1 (down-regulator of transcription 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DR1 (down-regulator of transcription 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dr1 (down-regulator of transcription 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DR1 (down-regulator of transcription 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DR1 (down-regulator of transcription 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dr1 (down-regulator of transcription 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DR1 (down-regulator of transcription 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dr1 (down-regulator of transcription 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dr1 (down-regulator of transcription 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NCB2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	NC2beta	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dro-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dr1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,603,203 - 1,614,556 (-)	NCBI		GRCr8
mRatBN7.2	14	1,458,223 - 1,469,578 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,458,223 - 1,469,638 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	1,339,940 - 1,351,298 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	2,641,692 - 2,653,050 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	1,338,369 - 1,349,747 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,463,651 - 2,475,004 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,463,643 - 2,474,780 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	14	1,621,026 - 1,632,378 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	2,462,579 - 2,473,932 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	2,005,938 - 2,017,291 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	2,005,938 - 2,017,291 (-)	NCBI
Celera	14	1,480,040 - 1,491,393 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

Brodifacoum (EXP)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

clozapine (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diethylstilbestrol (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

folic acid (ISO)

geraniol (ISO)

haloperidol (ISO)

hydrogen peroxide (ISO)

hypochlorous acid (ISO)

leflunomide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methyl methanesulfonate (ISO)

nefazodone (EXP)

ozone (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

rimonabant (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of cell cycle (IEA,ISO)

regulation of cell division (IEA,ISO)

regulation of DNA-templated transcription (ISO)

regulation of embryonic development (IEA,ISO)

regulation of transcription by RNA polymerase II (ISO)

regulation of tubulin deacetylation (ISO)

RNA polymerase II preinitiation complex assembly (IBA,IEA)

Cellular Component

ATAC complex (IEA,ISO)

negative cofactor 2 complex (IBA,IEA)

nucleoplasm (ISO)

nucleus (ISO)

RNA polymerase II transcription regulator complex (ISO)

Molecular Function

DNA binding (IEA)

protein binding (ISO)

protein heterodimerization activity (IEA)

RNA polymerase II general transcription initiation factor activity (IBA,IEA,ISO)

TBP-class protein binding (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription initiation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	ATAC-king the complexity of SAGA during evolution.	Spedale G, etal., Genes Dev. 2012 Mar 15;26(6):527-41. doi: 10.1101/gad.184705.111.

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:18838386	PMID:19103755	PMID:20508642	PMID:36197015

Genomics

Comparative Map Data

Dr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,603,203 - 1,614,556 (-)	NCBI		GRCr8
mRatBN7.2	14	1,458,223 - 1,469,578 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,458,223 - 1,469,638 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	1,339,940 - 1,351,298 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	2,641,692 - 2,653,050 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	1,338,369 - 1,349,747 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,463,651 - 2,475,004 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,463,643 - 2,474,780 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	14	1,621,026 - 1,632,378 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	2,462,579 - 2,473,932 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	2,005,938 - 2,017,291 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	2,005,938 - 2,017,291 (-)	NCBI
Celera	14	1,480,040 - 1,491,393 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

DR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	93,345,907 - 93,369,493 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	93,345,907 - 93,369,493 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	93,811,464 - 93,835,050 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	93,584,066 - 93,600,737 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	93,523,498 - 93,540,167	NCBI
Celera	1	92,065,544 - 92,082,224 (+)	NCBI		Celera
Cytogenetic Map	1	p22.1	NCBI
HuRef	1	91,933,028 - 91,949,702 (+)	NCBI		HuRef
CHM1_1	1	93,926,443 - 93,943,112 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	93,191,628 - 93,215,212 (+)	NCBI		T2T-CHM13v2.0

Dr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	108,416,763 - 108,428,387 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	108,416,763 - 108,428,392 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	108,268,897 - 108,280,521 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	108,268,897 - 108,280,526 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	108,697,916 - 108,709,540 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	108,509,199 - 108,520,823 (+)	NCBI		MGSCv36	mm8
Celera	5	105,388,795 - 105,400,436 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	52.82	NCBI

Dr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	1,262,633 - 1,281,870 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	1,262,633 - 1,281,870 (-)	NCBI	ChiLan1.0	ChiLan1.0

DR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	133,654,446 - 133,671,092 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	132,809,630 - 132,826,270 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	96,014,758 - 96,031,402 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	94,746,109 - 94,762,736 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	94,746,109 - 94,762,736 (+)	Ensembl	panpan1.1		panPan2

DR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	55,687,581 - 55,717,118 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	55,693,752 - 55,716,516 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	58,394,802 - 58,423,443 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	56,062,710 - 56,091,972 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	56,066,414 - 56,091,908 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	55,742,084 - 55,770,728 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	55,726,996 - 55,756,232 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	56,180,439 - 56,209,096 (-)	NCBI		UU_Cfam_GSD_1.0

Dr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	103,094,464 - 103,112,245 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936537	5,835,774 - 5,853,515 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936537	5,835,774 - 5,853,509 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	123,815,461 - 123,835,825 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	123,815,088 - 123,835,875 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	135,471,129 - 135,491,365 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	39,873,024 - 39,890,090 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	39,870,814 - 39,890,106 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	78,142,864 - 78,159,920 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	4,263,288 - 4,282,609 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	4,263,288 - 4,282,097 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dr1
22 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	653
Count of miRNA genes:	294
Interacting mature miRNAs:	382
Transcripts:	ENSRNOT00000000080
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat

Markers in Region

RH131134

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	1,458,343 - 1,458,530 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	2,463,772 - 2,463,958	NCBI	Rnor6.0
Rnor_6.0	14	1,621,146 - 1,621,332	NCBI	Rnor6.0
Rnor_5.0	14	2,462,700 - 2,462,886	UniSTS	Rnor5.0
Rnor_5.0	14	1,616,377 - 1,616,563	UniSTS	Rnor5.0
RGSC_v3.4	14	2,006,059 - 2,006,245	UniSTS	RGSC3.4
Celera	14	1,480,161 - 1,480,347	UniSTS
RH 3.4 Map	14	31.9	UniSTS
Cytogenetic Map	14	p22	UniSTS

AI179296

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	1,459,971 - 1,460,066 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	2,465,400 - 2,465,494	NCBI	Rnor6.0
Rnor_6.0	14	1,622,774 - 1,622,868	NCBI	Rnor6.0
Rnor_5.0	14	2,464,328 - 2,464,422	UniSTS	Rnor5.0
Rnor_5.0	14	1,618,005 - 1,618,099	UniSTS	Rnor5.0
RGSC_v3.4	14	2,007,687 - 2,007,781	UniSTS	RGSC3.4
Celera	14	1,481,789 - 1,481,883	UniSTS
RH 3.4 Map	14	25.3	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low		22	23	11	11	11			61	17	39	6
Below cutoff	3	19	33	29	8	29	8	10	12	17	3	4	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC103314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000000080 ⟹ ENSRNOP00000000080

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	1,458,223 - 1,469,638 (-)	Ensembl
Rnor_6.0 Ensembl	14	1,621,026 - 1,632,378 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000074874 ⟹ ENSRNOP00000064336

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	2,463,643 - 2,474,780 (-)	Ensembl

RefSeq Acc Id:

NM_001011914 ⟹ NP_001011914

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,603,203 - 1,614,556 (-)	NCBI
mRatBN7.2	14	1,458,223 - 1,469,578 (-)	NCBI
Rnor_6.0	14	2,463,651 - 2,475,004 (-)	NCBI
Rnor_5.0	14	2,462,579 - 2,473,932 (-)	NCBI
RGSC_v3.4	14	2,005,938 - 2,017,291 (-)	RGD
Celera	14	1,480,040 - 1,491,393 (-)	RGD

Sequence:

show sequence

GCCGCTTCTGCTCCCACAGCCTGCTCTCGGCCAAACGCTCGGTCGCGGCGACTGCCGCTGCGGC
TCCCGCTGTTTTCGGCCCTGTCCACTTGGTTCCCAGGCAGCCAGCGTGCGTTCAGCTGCGGCTT
CGGCAGACATGTTGTGAGGCGGCGGCGCGGGTGCCTGAAGGATGGTTTGGCCGAGGCGGCTGCA
ACCGCTGCTAGTGGCGGTGGCCGCGGGGGCTCCGGCTCTGTAGAGCCGACCCTGCTGTGGTGCG
TCCGCCCGGTACTGCGGCCGGGCGGGTACTCCTCGGTCTTGCGTGCGCCCCCGAGCCGTTTAGG
TTCGGTTAGGCGACAGCGCCAGTCCGTTTGAGGCGACACGCAAGGTGGTTCTTGAGCCCTGGGA
GTGGTGTCCCCAGAGCGAGCCCTCAGCCCCCTGACCTCTCCTTCATATCCGCACTAAAATCTCT
CACACAGTGGGTGTTCCCTGCCCTCGAGCCCGCTCCTTCCTGGTTTCTGCTGCACTCTGAGCCT
CCCGGACCCCGACATCTCTCTCCAGGGACAGCCTGTTGAGAAATCTTCGTGGAGTGGTGGACTA
GAGGGAGGACTTTAAAAGTTAGGGCTTGAAAGACAGGAAGGCACGATGGCTTCCTCGTCTGGCA
ACGACGATGATCTCACTATCCCGAGAGCTGCTATAAATAAGATGATCAAAGAGACTCTCCCTAA
TGTCAGGGTGGCCAACGATGCCCGAGAGCTCGTAGTGAACTGCTGCACTGAATTCATTCACCTT
ATATCTTCCGAAGCCAACGAGATTTGTAACAAGTCAGAAAAGAAGACAATCTCACCAGAGCATG
TCATCCAAGCACTAGAAAGTTTGGGCTTTGGCTCTTACATCAGTGAAGTAAAAGAAGTCTTACA
AGAATGCAAGACAGTAGCATTAAAAAGAAGAAAGGCCAGTTCTCGTTTGGAAAACCTTGGCATT
CCTGAAGAAGAATTATTGAGACAGCAACAGGAATTATTTGCAAAAGCTAGACAGCAACAAGCAG
AATTGGCCCAACAGGAGTGGCTTCAGATGCAGCAAGCAGCTCAGCAGGCCCAGTTGGCTGCTGC
CTCAGCCAGTGCATCCAATCAGGCCGGGTCTTCACAGGACGAAGACGACGACGACGACATCTGA
ACTTCACCTTCCGGGCTTCTGCTTCCTCTGTAAGGAAACAGTGAAAGAAGTGCATCTTGATGAA
CTTACCGTTGGTGTTTTAGAGATGTCTGCTGTCAGGCTTCAACTACTGTGCTATACATGTAAAA
CTGTCTCTTTGAACTATTGAAAATTTAAGGTTAAGTATCATATTACCTTTGAATTTGTAATGGT
GTTTCTGGAATCTTAGACCAGTGTGAACCCTTTATTTGGTCAATAAACAGTGTTACAGAAAACT
TCAGGTTTATAAAAATACAGTGAAATTTATAGAAATCTCTTAATCTGTATTTGTATTTTCTCTG
CCCTTTTAACTGAACTAAAATTGAGAATTTATATTGAGATGGGGCATGGCGTAATGCAGAATAC
ATTGAATCAGGTTGGTGAAAAGTTCAGTTCTATATAGTATCTAAATTTTTTGTCTTTTAAAGTG
AGTATATATGCAGGCAACAATTATATGCTCAGATAAATATACTTGTTTAGAGGAAATCTCAAAT
AAGACATTCATTAACTAGGAAGGAAATGTATTCTTTAGTAGTTGTGTAAATTTGGTGAGTTACG
TTTTTTATTTTGTTTCTGTTTTGTGTAGCAGTGAAGACTAGTTTATTATAGTATAATTTATCTT
GAGCTACACTATGCCATTTCAGAGACTGGCTAATCTTGAAGATTGTCACGATTCTTACTGTTTC
ACTCCAGTTGGGTAGTTGTTCATAGCATTAGTTGCTCAGTCCATTTTTTGATATGTAGGTGGGA
CTTAGGAGACAGTCGCTTGGGTTCTGTTGGTTTACCTGAGGTTCCTGGATGTTGAAGCCTGTGC
TGGAGGACATAAACAAAAGCTAGTGAGCATGCTTGCTAGGAAAAGGCCTTAAGTCCTTATTTGA
CTTGCAGTCTCCTTACTGCTTGGTGTTAGTGTAGCATTCACATTTTCTTGTGAATTTTCTTCTA
GGAGGCCTCAAGAATCCAATGCTAACTTTTGATATGACATCATTGTCCCCGTCATCATAGTTTA
GTGATAGCTTTAAAAGTTTTGTGTTTGCTTAAAGAGTGTCATAACTGACCAGCCCTATACAAAG
TGTTAACTTGCTTGTTAAAAGGGAGCAGCTTTAATTCGGTTTCAGTGCATAAGATGTAGTAGTG
TTTGTGAGAGGGATCTAATGTATTTGGTGAAATGGCATATTACTTATATTTTGGAAAGAGAAAA
ATGCCACCTAAGATAAGTCATTAAGTTCCCATGTCAGTTGCCAAGCCATTTAAATATCTGTATT
CACCAAGCCCCAGAGGAGATTCTAGCTGCTAGGATTTCAATTTCGAGAGCTAAGAAATGTTTAT
AAGTATTAGATTTCTTAATATTCATATTTTTCAGTTTTAGAAGGGAAATTTATATGCATATTAT
TATGCATTTATCAGATATTCTTCCCCCTATAACAAAAAGGGTAGCAAAAAGGGTAGTAATTTTG
CTGAATGTTTTATGTTGAAGTTATTTCAAGGCATTTCATGGGTCTGCCCATGGTGTGTTTGGAA
AACATAGAAGGAACCGTTTCCTTCAGAAAGGTTGAGCACCAAAGGCCGGTGGTTTAGTCTTTGG
AAATGAGCTAGTCGCTTTTGGCTTTTCTAATTTGTACTGTAACAGTCTTTTGTTTTGTTTTAAG
TATACGTTTCTCAAGTAAACAATTTGGATAATTTTCCATACCTTTTTTTTTCCGATGCAGACTT
CAGGTTAATTAATATTTTGCTGCATCTGATAATGTATTATATGTTGGAAGCCTAGTGACTTTTA
ATTTTGATGTTCTTGTGATTTCATATGCTGTATTCTTCAAGCAATAAAATTCTGATGTGTTTTA
AAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001011914	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83822	(Get FASTA)	NCBI Sequence Viewer
	EDL84000	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000080
	ENSRNOP00000000080.5
	ENSRNOP00055038600
	ENSRNOP00060015256
	ENSRNOP00065015690
GenBank Protein	Q5XI68	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001011914 ⟸ NM_001011914
- UniProtKB:	Q5XI68 (UniProtKB/Swiss-Prot), A6KPG5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKK TISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAK ARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEDDDDDI hide sequence

RefSeq Acc Id:

ENSRNOP00000064336 ⟸ ENSRNOT00000074874

RefSeq Acc Id:

ENSRNOP00000000080 ⟸ ENSRNOT00000000080

Protein Domains

Histone-fold Transcription factor CBF/NF-Y/archaeal histone

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XI68-F1-model_v2	AlphaFold	Q5XI68	1-176	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305201	AgrOrtholog
BioCyc Gene	G2FUF-16656	BioCyc
Ensembl Genes	ENSRNOG00000000070	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000048308	Ensembl
	ENSRNOG00055027178	UniProtKB/Swiss-Prot
	ENSRNOG00060011485	UniProtKB/Swiss-Prot
	ENSRNOG00065012558	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000000080	ENTREZGENE
	ENSRNOT00000000080.6	UniProtKB/TrEMBL
	ENSRNOT00055046979	UniProtKB/Swiss-Prot
	ENSRNOT00060019439	UniProtKB/Swiss-Prot
	ENSRNOT00065020418	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.20.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7111461	IMAGE-MGC_LOAD
InterPro	CBFA_NFYB_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Histone-fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ncb2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:289881	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:94897	IMAGE-MGC_LOAD
NCBI Gene	289881	ENTREZGENE
PANTHER	PROTEIN DR1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR46138	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	CBFD_NFYB_HMF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dr1	PhenoGen
PRINTS	CCAATSUBUNTA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000070	RatGTEx
	ENSRNOG00000048308	RatGTEx
	ENSRNOG00055027178	RatGTEx
	ENSRNOG00060011485	RatGTEx
	ENSRNOG00065012558	RatGTEx
Superfamily-SCOP	SSF47113	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2PXT6_RAT	UniProtKB/TrEMBL
	A6KPG5	ENTREZGENE, UniProtKB/TrEMBL
	NC2B_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Dr1	down-regulator of transcription 1	LOC100910207	protein Dr1-like	Data merged from RGD:6499394	737654	PROVISIONAL
2015-08-19	Dr1	down-regulator of transcription 1	Dr1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-03-04	Dr1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	Dr1	down-regulator of transcription 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-05	LOC100910207	protein Dr1-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-12-06	Dr1	down-regulator of transcription 1	Dr1_predicted	down-regulator of transcription 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Dr1_predicted	down-regulator of transcription 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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