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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-amphetamine | increases expression | EXP | | 6480464 | Dextroamphetamine results in increased expression of GRK6 mRNA | CTD | PMID:16715494 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62278 | 6480464 | Tetrachlorodibenzodioxin affects the expression of GRK6 mRNA | CTD | PMID:21570461 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of GRK6 mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:62278 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRK6 mRNA | CTD | PMID:20188158 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:62278 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of GRK6 mRNA | CTD | PMID:18648102 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GRK6 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | RGD:62278 | 6480464 | Benzo(a)pyrene results in increased expression of GRK6 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:62278 | 6480464 | Benzo(a)pyrene results in decreased expression of GRK6 mRNA | CTD | PMID:15034205 | benzo[a]pyrene | multiple interactions | ISO | RGD:62278 | 6480464 | AHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of GRK6 mRNA] | CTD | PMID:15034205 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GRK6 promoter | CTD | PMID:23359474 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GRK6 promoter | CTD | PMID:23359474 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of GRK6 mRNA | CTD | PMID:19167457 | capsaicin | multiple interactions | ISO | RGD:62278 | 6480464 | GRK6 mutant form promotes the reaction [Dextran Sulfate promotes the reaction [Capsaicin results in increased expression of FOS protein]] | CTD | PMID:18687398 | capsaicin | decreases response to substance | ISO | RGD:62278 | 6480464 | GRK6 results in decreased susceptibility to Capsaicin | CTD | PMID:18687398 | choline | multiple interactions | ISO | RGD:62278 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRK6 gene | CTD | PMID:20938992 | clozapine | decreases expression | EXP | | 6480464 | Clozapine results in decreased expression of GRK6 mRNA | CTD | PMID:16715494 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRK6 mRNA | CTD | PMID:20187946 | copper(2+) sulfate | decreases expression | ISO | RGD:1350771 | 6480464 | Copper Sulfate results in decreased expression of GRK6 mRNA | CTD | PMID:19549813 | coumestrol | increases expression | ISO | RGD:1350771 | 6480464 | Coumestrol results in increased expression of GRK6 mRNA | CTD | PMID:19167446 | dexamethasone | multiple interactions | EXP | | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of GRK6 mRNA] | CTD | PMID:20032058 | dexamethasone | decreases expression | EXP | | 6480464 | Dexamethasone results in decreased expression of GRK6 mRNA | CTD | PMID:20032058 | dextran sulfate | multiple interactions | ISO | RGD:62278 | 6480464 | GRK6 mutant form promotes the reaction [Dextran Sulfate promotes the reaction [Capsaicin results in increased expression of FOS protein]] | CTD | PMID:18687398 | dextran sulfate | decreases response to substance | ISO | RGD:62278 | 6480464 | GRK6 results in decreased susceptibility to Dextran Sulfate | CTD | PMID:18687398 | dibutyl phthalate | increases expression | ISO | RGD:62278 | 6480464 | Dibutyl Phthalate results in increased expression of GRK6 mRNA | CTD | PMID:21266533 | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GRK6 promoter | CTD | PMID:23359474 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of GRK6 mRNA | CTD | PMID:21266533 | disodium selenite | increases expression | ISO | RGD:1350771 | 6480464 | Sodium Selenite results in increased expression of GRK6 mRNA | CTD | PMID:18175754 | dopamine | multiple interactions | EXP | | 6480464 | GRK6 protein affects the reaction [Dopamine binds to DRD2 protein] | CTD | PMID:15716360 | elemental selenium | increases expression | ISO | RGD:1350771 | 6480464 | Selenium results in increased expression of GRK6 mRNA | CTD | PMID:19244175 | folic acid | multiple interactions | ISO | RGD:62278 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRK6 gene | CTD | PMID:20938992 | haloperidol | decreases expression | EXP | | 6480464 | Haloperidol results in decreased expression of GRK6 mRNA | CTD | PMID:16715494 | L-methionine | multiple interactions | ISO | RGD:62278 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRK6 gene | CTD | PMID:20938992 | lead(0) | decreases expression | ISO | RGD:1350771 | 6480464 | Lead results in decreased expression of GRK6 mRNA | CTD | PMID:19921347 | nitroglycerin | decreases expression | EXP | | 6480464 | Nitroglycerin results in decreased expression of GRK6 mRNA | CTD | PMID:12102619 | paracetamol | affects expression | ISO | RGD:62278 | 6480464 | Acetaminophen affects the expression of GRK6 mRNA | CTD | PMID:17562736 | pirinixic acid | increases expression | ISO | RGD:62278 | 6480464 | pirinixic acid results in increased expression of GRK6 mRNA | CTD | PMID:18301758 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of GRK6 mRNA | CTD | PMID:19162173 | selenium atom | increases expression | ISO | RGD:1350771 | 6480464 | Selenium results in increased expression of GRK6 mRNA | CTD | PMID:19244175 | selenomethionine | affects expression | ISO | RGD:1350771 | 6480464 | Selenomethionine affects the expression of GRK6 mRNA | CTD | PMID:17222674 | testosterone | multiple interactions | EXP | | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of GRK6 mRNA] | CTD | PMID:20032058 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Endocytosis | |
| Morphine addiction | |
| Pathway Interaction Database | CXCR4-mediated signaling events (PID:200099) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Endocytosis | |
| Morphine addiction | |
| Pathway Interaction Database | CXCR4-mediated signaling events (PID:200099) |
References - curated| 1. |
Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7. |
| 2. |
Ahmed MR, etal., Sci Transl Med. 2010 Apr 21;2(28):28ra28. |
| 3. |
Fraga S, etal., Cell Physiol Biochem. 2006;18(6):347-60. |
| 4. |
GOA data from the GO Consortium |
| 5. |
Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16. |
| 6. |
KEGG |
| 7. |
Lombardi MS, etal., FASEB J. 1999 Apr;13(6):715-25. |
| 8. |
MGD data from the GO Consortium |
| 9. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 10. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 11. |
Premont RT, etal., J Biol Chem 1999 Oct 8;274(41):29381-9. |
| 12. |
RGD automated data pipeline |
| 13. |
RGD automated import pipeline for gene-chemical interactions |
| 14. |
Sato H, etal., J Neurosci. 2011 Nov 16;31(46):16884-94. |
| 15. |
Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14. |
| 16. |
Simon V, etal., Endocrinology 2003 Jul;144(7):3058-66. |
| 17. |
Tarrant TK, etal., Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26. |
| 18. |
Willets JM, etal., J Neurochem. 2007 Dec;103(6):2268-80. Epub 2007 Oct 1. |
References - uncurated
RGD Disease Portals| Grk6 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Grk6 (Rattus norvegicus) |
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| GRK6 (Homo sapiens) |
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| Grk6 (Mus musculus) |
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Position Markers| RH141163 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001112712 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001112713 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_031657 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06090287 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01089969 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01089970 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF040750 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BQ205012 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB724577 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474032 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CV795758 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EX488847 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X97439 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X97440 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y09365 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031657 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_113845 | ||||||||||||||||||||
| Peptide Label: | isoform a | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001112712 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001106183 | ||||||||||||||||||||
| Peptide Label: | isoform c | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001112713 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001106184 | ||||||||||||||||||||
| Peptide Label: | isoform b | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001106183 | (Get FASTA) |
| NP_001106184 | (Get FASTA) | |
| NP_113845 | (Get FASTA) | |
| GenBank Protein | AAC09272 | (Get FASTA) |
| CAA66069 | (Get FASTA) | |
| CAA66070 | (Get FASTA) | |
| CAA70542 | (Get FASTA) | |
| EDL93985 | (Get FASTA) | |
| EDL93986 | (Get FASTA) | |
| P97711 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000014615 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000050134 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000047958 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 59076 | ENTREZGENE |
| Germonline | ENSRNOG00000014615 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 37570 | ENTREZGENE |
| InterPro | AGC-kinase_C | UniProtKB/Swiss-Prot |
| GPCR_kinase | UniProtKB/Swiss-Prot | |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Regulat_G_prot_signal | UniProtKB/Swiss-Prot | |
| Regulat_G_prot_signal_superfam | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_AS | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00205494 | UniProtKB/Swiss-Prot |
| IPI00559356 | UniProtKB/TrEMBL | |
| IPI00882485 | UniProtKB/TrEMBL | |
| KEGG Report | rno:59076 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | Pkinase | UniProtKB/Swiss-Prot |
| RGS | UniProtKB/Swiss-Prot | |
| PRINTS | GPCRKINASE | UniProtKB/Swiss-Prot |
| PROSITE | AGC_KINASE_CTER | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| RGS | UniProtKB/Swiss-Prot | |
| SMART | RGS | UniProtKB/Swiss-Prot |
| S_TK_X | UniProtKB/Swiss-Prot | |
| S_TKc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| Regulat_G_prot_signal_superfam | UniProtKB/Swiss-Prot | |
| UniGene | Rn.10633 | ENTREZGENE |
| UniProt | F1LNP2_RAT | UniProtKB/TrEMBL |
| GRK6_RAT | UniProtKB/Swiss-Prot | |
| P97548_RAT | UniProtKB/TrEMBL | |
| P97549_RAT | UniProtKB/TrEMBL | |
| Q792R1_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-02-18 | Grk6 | G protein-coupled receptor kinase 6 | Gprk6 | G protein-coupled receptor kinase 6 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Gprk6 | G protein-coupled receptor kinase 6 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
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| More on Grk6 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 61986 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




