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Gene: Cd276 (Cd276 molecule) Rattus norvegicus

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Symbol:

Cd276

Name:

Cd276 molecule

RGD ID:

727815

Description:

Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in T cell activation; T cell receptor signaling pathway; and positive regulation of type II interferon production. Predicted to act upstream of or within several processes, including positive regulation of osteoblast differentiation; regulation of T cell proliferation; and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CD276 (CD276 molecule); INTERACTS WITH 1-naphthyl isothiocyanate; 1-nitropropane; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

B7 homlog 3; B7 homolog 3; B7-H3; B7h3; B7RP-2; CD276 antigen; costimulatory molecule

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CD276 (CD276 molecule)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cd276 (CD276 antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cd276 (CD276 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CD276 (CD276 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CD276 (CD276 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cd276 (CD276 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CD276 (CD276 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CD276 (CD276 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cd276 (CD276 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Cd276 (CD276 antigen)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CD276 (CD276 molecule)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cd276 (CD276 molecule)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cd276	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	67,833,587 - 67,863,918 (-)	NCBI		GRCr8
mRatBN7.2	8	58,937,751 - 58,968,082 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	58,937,751 - 58,968,380 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	64,467,869 - 64,498,183 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	62,745,409 - 62,775,723 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	60,610,113 - 60,640,426 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	63,312,060 - 63,350,411 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	63,318,019 - 63,350,269 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	63,090,336 - 63,121,772 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	62,331,017 - 62,361,346 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	62,350,308 - 62,380,403 (-)	NCBI
Celera	8	58,396,980 - 58,427,330 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bardet-Biedl syndrome (ISO)

Bloom syndrome (ISO)

Brugada syndrome 8 (ISO)

colorectal cancer (ISO)

Experimental Liver Cirrhosis (ISO)

hepatocellular carcinoma (ISO)

long QT syndrome (ISO)

Prostatic Neoplasms (ISO)

schizophrenia (ISO)

Tay-Sachs disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

1-nitropropane (EXP)

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (EXP)

2,6-diaminotoluene (EXP)

2-acetamidofluorene (EXP)

2-bromohexadecanoic acid (ISO)

2-nitro-p-phenylenediamine (EXP)

2-nitropropane (EXP)

4,4'-diaminodiphenylmethane (EXP)

4-acetylaminofluorene (EXP)

4-hydroxyphenyl retinamide (ISO)

4-nitro-1,2-phenylenediamine (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrolein (ISO)

aflatoxin B1 (EXP)

alpha-amanitin (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cannabidiol (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

clozapine (ISO)

cocaine (EXP)

dibenzofurans (ISO)

dibutyl phthalate (EXP)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

estriol (ISO)

ethanol (ISO)

flutamide (EXP)

FR900359 (ISO)

furan (EXP)

ivermectin (ISO)

lidocaine (EXP)

methimazole (EXP)

N,N-diethyl-m-toluamide (EXP)

N-nitrosodiethylamine (EXP,ISO)

N-nitrosodimethylamine (EXP)

nickel sulfate (ISO)

orphenadrine (EXP)

ozone (ISO)

paracetamol (EXP)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

potassium dichromate (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

Soman (EXP)

succimer (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

triptonide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of inflammatory response (ISO)

negative regulation of interleukin-2 production (ISO)

negative regulation of T cell proliferation (ISO)

negative regulation of type II interferon production (ISO)

positive regulation of bone mineralization (ISO)

positive regulation of interleukin-2 production (ISO)

positive regulation of osteoblast differentiation (ISO)

positive regulation of T cell proliferation (IEA,ISO)

positive regulation of type II interferon production (IEA,ISO)

regulation of cytokine production (IBA)

regulation of immune response (ISO)

T cell activation (IEA,ISO)

T cell proliferation (ISO)

T cell receptor signaling pathway (IBA)

Cellular Component

external side of plasma membrane (IBA,ISO)

membrane (IEA)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

signaling receptor binding (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	NCBI rat LocusLink and RefSeq merged data October 15, 2003	NCBI rat LocusLink and RefSeq merged data October 15, 2003
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.	Suh WK, etal., Nat Immunol 2003 Sep;4(9):899-906.

Additional References at PubMed

PMID:11224528	PMID:12055244	PMID:12477932	PMID:15317945	PMID:15489334	PMID:16751379	PMID:18650384	PMID:23376485	PMID:23583036

Genomics

Comparative Map Data

Cd276
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	67,833,587 - 67,863,918 (-)	NCBI		GRCr8
mRatBN7.2	8	58,937,751 - 58,968,082 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	58,937,751 - 58,968,380 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	64,467,869 - 64,498,183 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	62,745,409 - 62,775,723 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	60,610,113 - 60,640,426 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	63,312,060 - 63,350,411 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	63,318,019 - 63,350,269 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	63,090,336 - 63,121,772 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	62,331,017 - 62,361,346 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	62,350,308 - 62,380,403 (-)	NCBI
Celera	8	58,396,980 - 58,427,330 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

CD276
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	73,683,944 - 73,714,514 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	73,683,966 - 73,714,514 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	73,976,724 - 74,006,855 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	71,763,675 - 71,793,912 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	50,871,499 - 50,886,666 (+)	NCBI		Celera
Cytogenetic Map	15	q24.1	NCBI
HuRef	15	50,807,950 - 50,838,454 (+)	NCBI		HuRef
CHM1_1	15	74,094,539 - 74,124,834 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	71,501,041 - 71,531,847 (+)	NCBI		T2T-CHM13v2.0

Cd276
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	58,431,581 - 58,463,437 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	58,431,581 - 58,462,720 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	58,524,300 - 58,555,033 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	58,524,298 - 58,555,437 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	58,372,107 - 58,402,840 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	58,322,437 - 58,353,170 (-)	NCBI		MGSCv36	mm8
Celera	9	55,757,882 - 55,789,079 (-)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	31.79	NCBI

Cd276
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955450	3,884,437 - 3,896,416 (-)	NCBI	ChiLan1.0	ChiLan1.0

CD276
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	62,908,395 - 62,938,658 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	67,072,806 - 67,103,139 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	52,594,719 - 52,625,047 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	71,351,368 - 71,380,383 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

CD276
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	36,975,085 - 36,990,012 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	36,975,085 - 36,988,924 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	36,898,859 - 36,926,558 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	37,169,808 - 37,197,534 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	37,168,742 - 37,197,530 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	37,122,011 - 37,149,872 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	37,147,264 - 37,174,979 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	37,403,877 - 37,431,620 (+)	NCBI		UU_Cfam_GSD_1.0

Cd276
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	115,016,966 - 115,043,981 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	32,864,781 - 32,892,095 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	32,864,778 - 32,892,044 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CD276
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	59,703,289 - 59,733,777 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	59,703,283 - 59,733,910 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CD276
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	9,772,948 - 9,794,395 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	131,824,341 - 131,840,367 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cd276
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624781	691,348 - 703,202 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	417
Count of miRNA genes:	222
Interacting mature miRNAs:	261
Transcripts:	ENSRNOT00000042681
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39752803	84752803	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	39106258	84106258	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	58991697	91341052	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	39106258	84106258	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	31543661	76543661	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	49610204	68373388	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	84106258	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	58991697	91341052	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	62848139	107848139	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	62848139	107848139	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	62970527	107970527	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	62848139	107848139	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	62848139	107848139	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	62848139	107848139	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	62848139	107848139	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	60248093	105248093	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	58991697	91341052	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	62848139	107848139	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	35464071	71842899	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	62963099	107963099	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	62982864	107982864	Rat

Markers in Region

BE098935

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	58,938,889 - 58,939,043 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	63,321,121 - 63,321,274	NCBI	Rnor6.0
Rnor_5.0	8	63,091,477 - 63,091,630	UniSTS	Rnor5.0
RGSC_v3.4	8	62,332,156 - 62,332,309	UniSTS	RGSC3.4
Celera	8	58,398,119 - 58,398,272	UniSTS
RH 3.4 Map	8	694.8	UniSTS
Cytogenetic Map	8	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_182824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001839181	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY190319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC100064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000042681 ⟹ ENSRNOP00000049249

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	58,937,751 - 58,968,094 (-)	Ensembl
Rnor_6.0 Ensembl	8	63,318,019 - 63,350,269 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112160 ⟹ ENSRNOP00000079357

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	58,938,796 - 58,968,380 (-)	Ensembl

RefSeq Acc Id:

NM_182824 ⟹ NP_877976

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	67,833,587 - 67,863,918 (-)	NCBI
mRatBN7.2	8	58,937,751 - 58,968,082 (-)	NCBI
Rnor_6.0	8	63,319,982 - 63,350,312 (-)	NCBI
Rnor_5.0	8	63,090,336 - 63,121,772 (-)	NCBI
RGSC_v3.4	8	62,331,017 - 62,361,346 (-)	RGD
Celera	8	58,396,980 - 58,427,330 (-)	RGD

Sequence:

show sequence

CGCGGCTGCTCTACCGACGGTGGCGGCGATTGTGCTGCGCCCCGCCGCGTCCCCGAGTCCCGGG
AGTCGGCGCGGCGCGGCAGGAGCAGCCATCCGCCACGGAGAGTCCAGCTGTCAGCTGTCTCACA
GGAAGATGCTTCGAGGATGGGGTGGCCCCAGTGTGGGTGTGTCTATGGGCACGGCACTGGGAGT
GTTGTGCCTCTGCCTTACAGGAGCTGTGGAGGTCCAAGTCTCTGAAGACCCTGTGGTGGCCCTA
GTGGATACGGATGCCACCCTACGCTGCTCCTTCTCCCCAGAGCCTGGCTTCAGCCTGAGACAGC
TCAACCTCATCTGGCAGCTGACAGACACCAAACAGCTGGTGCACAGCTTCACTGAGGGCCGGGA
CCAAGGCAGTGCCTATGCCAACCGCACGGCGCTCTTCCCTGACTTGTTGGTGCAGGGCAATGCA
TCCCTGAGGCTGCAGCGTGTCCGAGTAACCGACGAGGGCAGCTACACCTGCTTTGTGAGCATCC
AGGACTTTGACAGCGCTGCTGTTAGCCTGCAGGTGGCCGCCCCCTACTCAAAGCCCAGCATGAC
CCTGGAGCCCAACAAGGACCTGCGTCCAGGGGACATGGTGACCATCACGTGCTCCAGCTACCAG
GGCTATCCCGAGGCTGAGGTGTTCTGGAAGGACGGACAGGGATTGCCCTTGACTGGCAATGTGA
CCACATCCCAGATGGCCAACGAGCGGGGCCTGTTCGATGTTCACAGTGTGCTGAGGGTGGTGCT
GGGTGCTAATGGCACCTACAGCTGCCTGGTCCGCAACCCGGTGTTGCAGCAAGATGCTCATGGC
TCGGTCACCATCACAGGGCAGCCCATGACATTCCCCCCTGAGGCTCTATGGGTGACTGTGGGGC
TCTCTGTCTGTCTTGTGATACTGCTGGTGGCCCTGGCCTTCGTGTGCTGGAGAAAGATCAAGCA
GAGCTGTGAAGAGGAGAATGCAGGTGCTGAGGACCAGGATGGGGATGGAGAAGGATCCAAGACA
GCTCTTCGGCCTCTGAAACACTCTGAAAACAAAGAAGATGACGGACAAGAAATAGCTTGACTGG
AAGCTGCTGCCCTTCCCTGGTGGGGGGGCCCACCCTCTGGCTGTATTGAGCCTCAATGTGAGCC
CTGCCCCCAATGAATGGGTTTTGTTCCACAGATCTACCCATTCTTTAGAGGACGTGGTTTACAG
GCTACCCACAGCCTTATTTTCCCAATGGACTTAATTCCCATCATCCTGAAGCCTCCTTTCTCCA
GTGACACGATACACGAACCATCCTGCGGCCTTATTTCTTACGGACTCGACACAAAGAGTTCTCC
ACCTCAGTGTCCCTCCAGAGTCATCCGGTGGCCTTGTGATACTACACGGACCTTCCTTCTGCCT
TACTTTAATAGATATACACAAACCATCCCCATGTCCTTGTGCCTCCAAAGCCATGCAGAGACTG
TATTACTGCTACTATTCTCCAAGGCACATGCTATTCAGATGAACCCCTGCCTTATTCCTCTGAA
GACAGATGCTTAGTTACCTCTTGGTTCTTTCTCCCATGGCCCTGACATATCTTAGTCACCCATC
AACGATGGGATCCCATCTCTCAGCAAGTCCTCAACCTGACTCCCCTGCCCTCATCTGGCCCTGG
CTTTGGTTTTCTCCCTCCCTAAGTGAGATGGGGCACACTCCCCATCCACACACATGGGTCACAG
CTGTGCGTGCTGGATCGCGTACATACTTGCCTTGCATGGTCTCCTCTGGCTGCCCTGGGCTGTG
CCCTTTCTCGCCTCAGGAAGCAGGTGCTGGTCGGCCTGGTTCTCAGGGCCCCTCAGGGAGTCAG
CCTTCAACCCTGTGCTTCCCGTGTTGGAAATCTTTGTTACTTTTCCTTTCTTAGTAAATTAACA
TCTGTTGAACAACCACAGCGTCCAACAGGACTTTCACAGACCCTGCCAGCTAGATTAAATAATG
ATACAGAAGTTTATTAATTATTTTAAAGCTTAGGTTTTTTTGCCGGGAGGTATCCCAAATACTC
TATCCCGACTAATCCTGGCACTATGTCCCACCACATGGCCAGGCCTACCTCTGCTCCACTCTGA
ATCATCCACCTCTGTGTCCGCCGACAAATCTCCCATGATTCAGTTCTTCTCCCAGCGTCCCTAT
CTCTGCCCGGAAGTACGACCTTTGACTTCCTGACCAACTATTGGCCGTCAACTCTTTGTTAAAG
GTGATCAGATATAATTTTGCCTTAGGCACGTGAGGAAGAAACATATTTATAAAATACGAGACCA
GAGATGGGCCATGGAAATAACACCAGATTCTGACAGCCTTTAGCCCTCTGCTGGTACAAATTAA
CAATTGAATATATAGAGACACACCTTCACACAGTGCACCCCAACAACAGGGGTGAGCATTGTGC
TGGGTACTAGGGTCCTGCTGAAATCAGAGACCTTAACTCCAGCTGGGGAATGGCCTTGCTCCCT
GCTGTGCCCACAGCTTCCAACACTGTCCCTGACCCCAGGGTAGGGGTGGAAACCTGGAGAAGGC
ACAGCCCCTTACCATACCTTGAGAACTGGGTATTTTTCAGAGTCTATATGTGTGCACTGGAAGG
CAGGTGGCCACAGCCATGCAGACCTGGGTAGGGTCAGAAGCCTATGCCACGCTGGGACCTCCTC
AACAGCTGAAGTCTGAGGACAAGAAGGGCCTTCTTACTGTGGTGCTATTCTGGAGCTGGGGTAT
ATACCTGGCTTGTCTCTGACAGCCCTGGCTTTTGGCAGAACTTCTGATGTCCTGAAGGTCTCTC
TCGCACCCCAGTACTGGAGAACCTGGGGATAATTTAAACATGGGACCCTGGCAGAAGCAGGAAG
ATCTCTGACTTACTTTGGAGTCAGCCTGGTCTACAGAGTGAGTTCCAGGACAACTGGGGCTAGA
CAGAGAAGCCATCTCAAGGGCTAAAACTAATAAACACGGGACGCTAAACTGGGAATATTTTGGG
AGAAATAAATGTCTTTTTCTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_877976	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI00065	(Get FASTA)	NCBI Sequence Viewer
	AAP04008	(Get FASTA)	NCBI Sequence Viewer
	EDL95682	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000049249.4
	ENSRNOP00000079357.1
	ENSRNOP00055037777
	ENSRNOP00060030455
	ENSRNOP00065021510
GenBank Protein	Q7TPB4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_877976 ⟸ NM_182824
- Peptide Label:	precursor
- UniProtKB:	Q7TPB4 (UniProtKB/Swiss-Prot), A0A8L2QPH5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLRGWGGPSVGVSMGTALGVLCLCLTGAVEVQVSEDPVVALVDTDATLRCSFSPEPGFSLRQLN LIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLVQGNASLRLQRVRVTDEGSYTCFVSIQD FDSAAVSLQVAAPYSKPSMTLEPNKDLRPGDMVTITCSSYQGYPEAEVFWKDGQGLPLTGNVTT SQMANERGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLS VCLVILLVALAFVCWRKIKQSCEEENAGAEDQDGDGEGSKTALRPLKHSENKEDDGQEIA hide sequence

Ensembl Acc Id:

ENSRNOP00000049249 ⟸ ENSRNOT00000042681

Ensembl Acc Id:

ENSRNOP00000079357 ⟸ ENSRNOT00000112160

Protein Domains

Ig-like Ig-like C2-type Ig-like V-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TPB4-F1-model_v2	AlphaFold	Q7TPB4	1-316	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696033

Promoter ID:

EPDNEW_R6558

Type:

initiation region

Name:

Cd276_1

Description:

Cd276 molecule

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	63,350,327 - 63,350,387	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:727815	AgrOrtholog
BioCyc Gene	G2FUF-30257	BioCyc
Ensembl Genes	ENSRNOG00000033608	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00055026667	UniProtKB/Swiss-Prot
	ENSRNOG00060021317	UniProtKB/Swiss-Prot
	ENSRNOG00065016453	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000042681.5	UniProtKB/TrEMBL
	ENSRNOT00000112160.1	UniProtKB/TrEMBL
	ENSRNOT00055046050	UniProtKB/Swiss-Prot
	ENSRNOT00060036948	UniProtKB/Swiss-Prot
	ENSRNOT00065027380	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7104832	IMAGE-MGC_LOAD
InterPro	BTN3A2-like_Ig-C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CD276_IgV	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IgSF_BTN/MOG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:315716	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112584	IMAGE-MGC_LOAD
NCBI Gene	315716	ENTREZGENE
PANTHER	BUTYROPHILIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CD276 ANTIGEN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	C2-set_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	V-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cd276	PhenoGen
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000033608	RatGTEx
	ENSRNOG00055026667	RatGTEx
	ENSRNOG00060021317	RatGTEx
	ENSRNOG00065016453	RatGTEx
SMART	IGc2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGv	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00409	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZMU5_RAT	UniProtKB/TrEMBL
	A0A8L2QPH5	ENTREZGENE, UniProtKB/TrEMBL
	A6J509_RAT	UniProtKB/TrEMBL
	CD276_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-06-27	Cd276	Cd276 molecule	Cd276	CD276 antigen	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Cd276	CD276 antigen	B7h3	B7 homlog 3	Symbol and Name updated	1299863	APPROVED
2005-07-08	B7h3	B7 homlog 3		B7-H3	Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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