Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (6R)-5,10-methylenetetrahydrofolic acid | increases metabolic processing | ISO | RGD:733483 | 6480464 | MTHFR protein results in increased metabolism of 5,10-methylenetetrahydrofolate | CTD | PMID:16187112 | (6R)-5,10-methylenetetrahydrofolic acid | increases reduction | ISO | RGD:733483 | 6480464 | MTHFR protein results in increased reduction of 5,10-methylenetetrahydrofolate | CTD | PMID:7647779 | 2-butoxyethanol | increases expression | ISO | RGD:1551392 | 6480464 | n-butoxyethanol results in increased expression of MTHFR mRNA | CTD | PMID:19812364 | 5-fluoro-2'-deoxyuridine | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR protein affects the susceptibility to Floxuridine | CTD | PMID:18202788 | 5-fluorouracil | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the susceptibility to Fluorouracil | CTD | PMID:16785472 more ... | 5-fluorouracil | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the susceptibility to Fluorouracil | CTD | PMID:17047490 more ... | 5-fluorouracil | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the susceptibility to Fluorouracil | CTD | PMID:16399440 more ... | 5-fluorouracil | increases response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism results in increased susceptibility to Fluorouracil | CTD | PMID:15735113 PMID:18034621 | 5-fluorouracil | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the susceptibility to Fluorouracil | CTD | PMID:16785472 more ... | 5-fluorouracil | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the susceptibility to Fluorouracil | CTD | PMID:17047490 more ... | 5-fluorouracil | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR protein affects the susceptibility to Fluorouracil | CTD | PMID:18034621 PMID:15735113 | 5-fluorouracil | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the susceptibility to Fluorouracil | CTD | PMID:16399440 more ... | 5-fluorouracil | increases metabolic processing | ISO | RGD:733483 | 6480464 | MTHFR protein results in increased metabolism of Fluorouracil | CTD | PMID:18034621 | 5-fluorouracil | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR protein affects the susceptibility to Fluorouracil analog | CTD | PMID:15608557 | 5-fluorouracil | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR protein affects the susceptibility to Fluorouracil | CTD | PMID:15735113 PMID:18034621 | 5-fluorouracil | increases response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism results in increased susceptibility to Fluorouracil | CTD | PMID:18034621 PMID:15735113 | 5-fluorouracil | multiple interactions | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin] | CTD | PMID:18633250 | 5-formyltetrahydrofolic acid | multiple interactions | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin] | CTD | PMID:18633250 | 5-methyltetrahydrofolic acid | increases chemical synthesis | ISO | RGD:733483 | 6480464 | MTHFR protein results in increased chemical synthesis of 5-methyltetrahydrofolate | CTD | PMID:7647779 PMID:9719624 | 5-methyltetrahydrofolic acid | increases chemical synthesis | ISO | RGD:733483 | 6480464 | MTHFR protein results in increased chemical synthesis of 5-methyltetrahydrofolate | CTD | PMID:9719624 PMID:7647779 | aflatoxin B1 | increases expression | ISO | RGD:1551392 | 6480464 | Aflatoxin B1 results in increased expression of MTHFR mRNA | CTD | PMID:19770486 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of MTHFR mRNA | CTD | PMID:16483693 | arsenic atom | multiple interactions | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the metabolism of and affects the susceptibility to Arsenic | CTD | PMID:17365577 PMID:17548696 | arsenic atom | multiple interactions | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the metabolism of and affects the susceptibility to Arsenic | CTD | PMID:17548696 PMID:17365577 | arsenic atom | affects methylation | ISO | RGD:733483 | 6480464 | MTHFR polymorphism affects the methylation of Arsenic | CTD | PMID:17440589 | arsenic atom | affects metabolic processing | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the metabolism of Arsenic | CTD | PMID:17637926 | arsenic atom | affects metabolic processing | ISO | RGD:733483 | 6480464 | MTHFR polymorphism affects the metabolism of Arsenic | CTD | PMID:17365577 | benazepril | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the susceptibility to benazepril | CTD | PMID:16081343 | benazepril | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene SNP affects the susceptibility to benazepril | CTD | PMID:20445573 | calcitriol | increases expression | ISO | RGD:733483 | 6480464 | Calcitriol results in increased expression of MTHFR mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:733483 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of MTHFR mRNA | CTD | PMID:21592394 | choline | multiple interactions | ISO | RGD:1551392 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFR mRNA | CTD | PMID:20938992 | clozapine | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR protein affects the susceptibility to Clozapine; more ... | CTD | PMID:20547447 | cytarabine | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR protein affects the susceptibility to Cytarabine | CTD | PMID:18202788 | folic acid | affects expression | ISO | RGD:733483 | 6480464 | Folic Acid affects the expression of MTHFR mRNA | CTD | PMID:17311948 | folic acid | multiple interactions | ISO | RGD:1551392 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFR mRNA | CTD | PMID:20938992 | folic acid | affects abundance | ISO | RGD:733483 | 6480464 | MTHFR gene SNP affects the abundance of Folic Acid | CTD | PMID:21869730 | folic acid | affects abundance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the abundance of Folic Acid | CTD | PMID:16690736 PMID:16621645 | folic acid | affects metabolic processing | ISO | RGD:733483 | 6480464 | MTHFR protein affects the metabolism of Folic Acid | CTD | PMID:20547447 | folic acid | multiple interactions | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the reaction [Folic Acid affects the methylation of CDKN2A promoter] | CTD | PMID:16646054 | folic acid | affects metabolic processing | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the metabolism of Folic Acid | CTD | PMID:20532609 | folic acid | affects abundance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the abundance of Folic Acid | CTD | PMID:16621645 PMID:16690736 | folic acid | multiple interactions | ISO | RGD:733483 | 6480464 | Folic Acid inhibits the reaction [MTHFR gene polymorphism results in increased activity of ACHE protein] | CTD | PMID:16375580 | folic acid | decreases abundance | ISO | RGD:733483 | 6480464 | MTHFR gene mutant form results in decreased abundance of Folic Acid | CTD | PMID:17115185 | folic acid | multiple interactions | ISO | RGD:733483 | 6480464 | [Folic Acid co-treated with MTHFR gene SNP] affects the methylation of MGMT promoter | CTD | PMID:17301267 | gold atom | multiple interactions | ISO | RGD:1551392 | 6480464 | [Gold co-treated with Polyethylene Glycols] results in decreased expression of MTHFR mRNA | CTD | PMID:19695318 | gold(0) | multiple interactions | ISO | RGD:1551392 | 6480464 | [Gold co-treated with Polyethylene Glycols] results in decreased expression of MTHFR mRNA | CTD | PMID:19695318 | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of MTHFR mRNA | CTD | PMID:22129741 | L-methionine | multiple interactions | ISO | RGD:1551392 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFR mRNA | CTD | PMID:20938992 | maneb | multiple interactions | ISO | RGD:1551392 | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of MTHFR mRNA | CTD | PMID:18386188 | methotrexate | affects expression | ISO | RGD:1551392 | 6480464 | Methotrexate affects the expression of MTHFR mRNA | CTD | PMID:18502557 | methotrexate | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the susceptibility to Methotrexate | CTD | PMID:21064136 PMID:19821069 | methotrexate | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR protein affects the susceptibility to Methotrexate | CTD | PMID:17502830 | methotrexate | increases response to substance | ISO | RGD:733483 | 6480464 | MTHFR polymorphism results in increased susceptibility to Methotrexate | CTD | PMID:21887680 | methotrexate | decreases metabolic processing | ISO | RGD:733483 | 6480464 | MTHFR gene SNP results in decreased metabolism of Methotrexate | CTD | PMID:19391036 | methotrexate | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene SNP affects the susceptibility to Methotrexate | CTD | PMID:17488658 | methotrexate | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the susceptibility to Methotrexate | CTD | PMID:19821069 PMID:21064136 | methotrexate | affects metabolic processing | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the metabolism of Methotrexate | CTD | PMID:15753437 | methotrexate | affects response to substance | ISO | RGD:1551392 | 6480464 | MTHFR protein affects the susceptibility to Methotrexate | CTD | PMID:18551038 | N-methyl-4-phenylpyridinium | increases expression | ISO | RGD:1551392 | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of MTHFR mRNA | CTD | PMID:22776087 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of MTHFR mRNA | CTD | PMID:22129741 | olanzapine | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR protein affects the susceptibility to olanzapine; more ... | CTD | PMID:20547447 | paracetamol | decreases expression | ISO | RGD:733483 | 6480464 | Acetaminophen results in decreased expression of MTHFR mRNA | CTD | PMID:21420995 | paraquat | multiple interactions | ISO | RGD:1551392 | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of MTHFR mRNA | CTD | PMID:18386188 | pirinixic acid | increases expression | ISO | RGD:1551392 | 6480464 | pirinixic acid results in increased expression of MTHFR mRNA | CTD | PMID:20813756 PMID:18301758 | pirinixic acid | increases expression | ISO | RGD:1551392 | 6480464 | pirinixic acid results in increased expression of MTHFR mRNA | CTD | PMID:18301758 PMID:20813756 | raloxifene | decreases expression | ISO | RGD:733483 | 6480464 | Raloxifene results in decreased expression of MTHFR mRNA | CTD | PMID:15849065 | riboflavin | affects response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism affects the susceptibility to Riboflavin | CTD | PMID:17303386 | rosiglitazone | affects response to substance | ISO | RGD:1551392 | 6480464 | MTHFR affects the susceptibility to rosiglitazone | CTD | PMID:19951259 | simvastatin | multiple interactions | ISO | RGD:733483 | 6480464 | Homocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]; more ... | CTD | PMID:18540024 | simvastatin | increases expression | ISO | RGD:1551392 | 6480464 | Simvastatin results in increased expression of MTHFR protein modified form | CTD | PMID:18540024 | simvastatin | multiple interactions | ISO | RGD:1551392 | 6480464 | MTHFR gene mutant form inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]; more ... | CTD | PMID:18540024 | simvastatin | affects response to substance | ISO | RGD:1551392 | 6480464 | MTHFR affects the susceptibility to Simvastatin | CTD | PMID:18540024 | simvastatin | increases expression | ISO | RGD:733483 | 6480464 | Simvastatin results in increased expression of MTHFR protein modified form | CTD | PMID:18540024 | sulfasalazine | increases response to substance | ISO | RGD:733483 | 6480464 | MTHFR gene polymorphism results in increased susceptibility to Sulfasalazine; more ... | CTD | PMID:19578646 | tamoxifen | decreases expression | ISO | RGD:733483 | 6480464 | Tamoxifen results in decreased expression of MTHFR mRNA | CTD | PMID:15849065 | testosterone | increases expression | ISO | RGD:733483 | 6480464 | Testosterone results in increased expression of MTHFR mRNA | CTD | PMID:21592394 | testosterone | multiple interactions | ISO | RGD:733483 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of MTHFR mRNA | CTD | PMID:21592394 | valproic acid | affects expression | ISO | RGD:1551392 | 6480464 | Valproic Acid affects the expression of MTHFR mRNA | CTD | PMID:9188671 | vigabatrin | increases response to substance | ISO | RGD:1551392 | 6480464 | MTHFR results in increased susceptibility to Vigabatrin | CTD | PMID:21490592 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| One carbon pool by folate | |
Disease Annotations
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| One carbon pool by folate | |
References - curated| 1. |
Adinolfi LE, etal., Hepatology. 2005 May;41(5):995-1003. |
| 2. |
Alroy S, etal., Isr Med Assoc J. 2007 Apr;9(4):321-5. |
| 3. |
Anbazhagan K, etal., Clin Chim Acta. 2009 Aug;406(1-2):108-12. Epub 2009 Jun 9. |
| 4. |
Bates CJ and Fuller NJ, Br J Nutr. 1986 Mar;55(2):455-64. |
| 5. |
Blaise S, etal., Pediatr Res 2005 Jun;57(6):777-82. Epub 2005 Apr 21. |
| 6. |
Blom HJ and Smulders Y, J Inherit Metab Dis. 2011 Feb;34(1):75-81. doi: 10.1007/s10545-010-9177-4. Epub 2010 Sep 4. |
| 7. |
Botto LD and Yang Q, Am J Epidemiol. 2000 May 1;151(9):862-77. |
| 8. |
Burton EG and Sallach HJ, Arch Biochem Biophys. 1975 Feb;166(2):483-94. |
| 9. |
Cai DW, etal., J Int Med Res. 2009 Nov-Dec;37(6):1882-9. |
| 10. |
Carl GF and Smith DB, Biochem Pharmacol. 1984 Nov 1;33(21):3457-63. |
| 11. |
Carl GF and Smith DB, J Nutr. 1983 Nov;113(11):2368-74. |
| 12. |
Carl GF Neurochem Res. 1986 May;11(5):671-85. |
| 13. |
Carl GF, etal., Biochem Pharmacol. 1987 Jul 1;36(13):2139-44. |
| 14. |
Carl GF, etal., Biol Psychiatry. 1978 Dec;13(6):661-9. |
| 15. |
Casas JP, etal., Lancet. 2005 Jan 15-21;365(9455):224-32. |
| 16. |
Chen G, etal., Sci China C Life Sci. 1998 Dec;41(6):636-43. |
| 17. |
Cheng FW, etal., Br J Haematol. 1975 Nov;31(3):323-36. |
| 18. |
Davis JA, etal., J Surg Res. 2004 Sep;121(1):69-75. |
| 19. |
El-Baz R, etal., J Renin Angiotensin Aldosterone Syst. 2012 May 3. |
| 20. |
Eskes TK Eur J Pediatr 1998 Apr;157 Suppl 2:S139-41. |
| 21. |
Ferrara M, etal., J Pediatr Hematol Oncol. 2009 Apr;31(4):256-8. |
| 22. |
Fung MM, etal., Nephrol Dial Transplant. 2012 Jan;27(1):197-205. Epub 2011 May 25. |
| 23. |
Galli M, etal., Br J Haematol. 2000 Mar;108(4):865-70. |
| 24. |
Garcia-Aguilar J, etal., Ann Surg. 2011 Sep;254(3):486-92; discussion 492-3. |
| 25. |
GOA data from the GO Consortium |
| 26. |
Haviv YS, etal., Nephron. 2002 Sep;92(1):120-6. |
| 27. |
Huang L, etal., Anal Biochem. 2001 Dec 15;299(2):253-9. |
| 28. |
Izmirli M, etal., Asian Pac J Cancer Prev. 2011;12(7):1833-5. |
| 29. |
Jacobs RL, etal., Diabetes. 1998 Dec;47(12):1967-70. |
| 30. |
Jamison RL, etal., Am J Kidney Dis. 2009 May;53(5):779-89. Epub 2009 Mar 9. |
| 31. |
Kaiser R, etal., J Rheumatol. 2012 Aug;39(8):1603-10. Epub 2012 Jun 15. |
| 32. |
Kiseljakovic E, etal., Bosn J Basic Med Sci. 2010 Apr;10 Suppl 1:S91-5. |
| 33. |
Klerk M, etal., JAMA. 2002 Oct 23-30;288(16):2023-31. |
| 34. |
Ko KH, etal., Anticancer Res. 2006 Nov-Dec;26(6B):4229-33. |
| 35. |
Koturbash I, etal., Mol Carcinog. 2011 Dec 27. doi: 10.1002/mc.21861. |
| 36. |
Ksiazek P, etal., Med Sci Monit. 2004 Feb;10(2):BR47-51. |
| 37. |
Kuehl K, etal., Birth Defects Res A Clin Mol Teratol. 2010 Feb;88(2):101-10. |
| 38. |
Laing ME, etal., Transplantation. 2007 Jul 15;84(1):113-6. |
| 39. |
Lee SY, etal., J Korean Med Sci. 2011 Mar;26(3):461-5. Epub 2011 Feb 25. |
| 40. |
Maeda M, etal., J Diabetes Complications. 2008 Mar-Apr;22(2):119-25. |
| 41. |
Marcucci R, etal., J Thromb Haemost. 2005 Mar;3(3):502-7. |
| 42. |
Matakidou A, etal., Br J Cancer. 2007 Jul 16;97(2):247-52. Epub 2007 May 29. |
| 43. |
Matthews RG Chem Rec 2002;2(1):4-12. |
| 44. |
MGD data from the GO Consortium |
| 45. |
Moore LE, etal., Int J Cancer. 2007 Jun 1;120(11):2452-8. |
| 46. |
Moore LE, etal., Int J Cancer. 2008 Apr 15;122(8):1710-5. |
| 47. |
Movva S, etal., Genet Test Mol Biomarkers. 2011 Apr;15(4):257-61. Epub 2010 Dec 27. |
| 48. |
Mtiraoui N, etal., Diabetes Res Clin Pract. 2007 Jan;75(1):99-106. Epub 2006 Jul 7. |
| 49. |
Muntjewerff JW, etal., Mol Psychiatry. 2006 Feb;11(2):143-9. |
| 50. |
Nair CP, etal., Metabolism. 1994 Dec;43(12):1575-8. |
| 51. |
Neugebauer S, etal., Lancet. 1997 Feb 15;349(9050):473-4. |
| 52. |
Patino-Garcia A, etal., J Pediatr. 2009 May;154(5):688-93. Epub 2009 Jan 21. |
| 53. |
Peeters AC, etal., J Vasc Surg. 2007 Apr;45(4):701-5. |
| 54. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 55. |
Poduri A, etal., Mol Cell Biochem. 2008 Jan;308(1-2):43-50. Epub 2007 Sep 25. |
| 56. |
Pollex RL, etal., Cardiovasc Diabetol. 2005 Nov 7;4:17. |
| 57. |
RGD automated data pipeline |
| 58. |
RGD automated import pipeline for gene-chemical interactions |
| 59. |
RGD Automated Pipelines |
| 60. |
Rocha V, etal., Leukemia. 2009 Mar;23(3):545-56. Epub 2008 Nov 13. |
| 61. |
Rouissi K, etal., Cancer Genet Cytogenet. 2009 Nov;195(1):43-53. |
| 62. |
Safarinejad MR, etal., Clin Oncol (R Coll Radiol). 2012 May;24(4):269-81. doi: 10.1016/j.clon.2011.03.005. Epub 2011 Apr 13. |
| 63. |
Safarinejad MR, etal., Med Oncol. 2011 Dec;28 Suppl 1:S398-412. Epub 2010 Oct 29. |
| 64. |
Sakano S, etal., BJU Int. 2010 Aug;106(3):424-30. Epub 2009 Dec 22. |
| 65. |
Sibani S, etal., Hum Mutat. 2000;15(3):280-7. |
| 66. |
Siraj AK, etal., Ann Hematol. 2007 Dec;86(12):887-95. Epub 2007 Aug 22. |
| 67. |
Soares AL, etal., Pathophysiol Haemost Thromb. 2008;36(5):275-81. Epub 2009 Dec 9. |
| 68. |
Stover PJ and Field MS, Adv Nutr. 2011 Jul;2(4):325-31. doi: 10.3945/¿an.111.000596. Epub 2011 Jun 28. |
| 69. |
Stover PJ J Nutrigenet Nutrigenomics. 2011;4(5):293-305. doi: 10.1159/000334586. Epub 2012 Feb 22. |
| 70. |
Sucker C, etal., Clin Appl Thromb Hemost. 2009 May-Jun;15(3):283-8. |
| 71. |
Suzuki T, etal., Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2742-7. |
| 72. |
Thuesen BH, etal., Allergy. 2010 Nov;65(11):1446-54. doi: 10.1111/j.1398-9995.2010.02378.x. |
| 73. |
Tripathi G, etal., Clin Appl Thromb Hemost. 2010 Apr;16(2):132-40. Epub 2009 Jun 10. |
| 74. |
Wang L, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2006 Jan;27(1):50-4. |
| 75. |
Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23. |
| 76. |
Wiltshire EJ, etal., Pediatr Diabetes. 2008 Aug;9(4 Pt 2):348-53. |
| 77. |
Yilmaz H, etal., Cell Biochem Funct. 2006 Jan-Feb;24(1):87-90. |
| 78. |
Zheng YZ, etal., Br J Haematol. 2000 Jun;109(4):870-4. |
| 79. |
Zsom M, etal., Hemodial Int. 2011 Oct;15(4):501-8. doi: 10.1111/j.1542-4758.2011.00593.x. Epub 2011 Sep 13. |
RGD Disease Portals| Mthfr has been annotated in the following RGD Disease Portals. |
|||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
Comparative Map Data| Mthfr (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| MTHFR (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Mthfr (Mus musculus) |
|
Nucleotide Sequences| Nucleotide RefSeqs | XM_001074061 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_342975 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06040922 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01040795 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473968 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U57049 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | XM_001074061 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_001074061 | ||||||||||
| Position: |
|
| RefSeq Acc Id: | XM_342975 | |||||||||||||||
| RefSeq Status: | ||||||||||||||||
| Type: | CODING | |||||||||||||||
| Protein Acc Id: | XP_342976 | |||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | XP_001074061 | (Get FASTA) |
| XP_342976 | (Get FASTA) | |
| GenBank Protein | AAB01988 | (Get FASTA) |
| EDL81091 | (Get FASTA) | |
| EDL81092 | (Get FASTA) | |
| EDL81093 | (Get FASTA) | |
| EDL81094 | (Get FASTA) | |
| EDL81095 | (Get FASTA) | |
| EDL81096 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000008553 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000011384 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000011384 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 362657 | ENTREZGENE |
| HomoloGene Group ID | 4349 | ENTREZGENE |
| InterPro | Fadh2_euk | UniProtKB/TrEMBL |
| Mehydrof_redctse | UniProtKB/TrEMBL | |
| IPI | IPI00388156 | UniProtKB/TrEMBL |
| IPI00959883 | UniProtKB/TrEMBL | |
| KEGG Report | rno:362657 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | MTHFR | UniProtKB/TrEMBL |
| PharmGKB | MTHFR | RGD |
| TIGRFAMs | fadh2_euk | UniProtKB/TrEMBL |
| UniGene | Rn.10494 | ENTREZGENE |
| UniProt | D4A7E8_RAT | UniProtKB/TrEMBL |
| Q62984_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2010-12-16 | Mthfr | methylenetetrahydrofolate reductase (NAD(P)H) | Mthfr | 5,10-methylenetetrahydrofolate reductase (NADPH) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-08-29 | Mthfr | 5,10-methylenetetrahydrofolate reductase (NADPH) | Mthfr | 5,10-methylenetetrahydrofolate reductase | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-03-17 | Mthfr | 5,10-methylenetetrahydrofolate reductase | Mthfr_predicted | 5,10-methylenetetrahydrofolate reductase (NADPH) (predicted) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-12 | Mthfr_predicted | 5,10-methylenetetrahydrofolate reductase (NADPH) (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Mthfr | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1309952 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




