Gene: Mthfr (methylenetetrahydrofolate reductase) Rattus norvegicus
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Symbol: Mthfr
Name: methylenetetrahydrofolate reductase
Description: ENCODES a protein that exhibits flavin adenine dinucleotide binding; methylenetetrahydrofolate reductase (NAD(P)H) activity; NADP binding; INVOLVED IN homocysteine metabolic process; response to amino acid; response to drug; PARTICIPATES IN altered folate cycle metabolic pathway; altered folate mediated one-carbon metabolic pathway; folate cycle metabolic pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental; Hyperthyroidism; hyperthyroidism; FOUND IN cytosol; synapse; INTERACTS WITH 2-acetamidofluorene; 3-chloropropane-1,2-diol; ammonium chloride
Type: protein-coding
RefSeq Status: MODEL
Also known as: 5,10-methylenetetrahydrofolate reductase; 5,10-methylenetetrahydrofolate reductase (NADPH); LOC362657; methylenetetrahydrofolate reductase (NAD(P)H)
Orthologs:
Homo sapiens (human) : MTHFR (methylenetetrahydrofolate reductase)  HGNC  AGR
Mus musculus (house mouse) : Mthfr (5,10-methylenetetrahydrofolate reductase)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Mthfr (methylenetetrahydrofolate reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : MTHFR (methylenetetrahydrofolate reductase)
Canis lupus familiaris (dog) : MTHFR (methylenetetrahydrofolate reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mthfr (methylenetetrahydrofolate reductase)
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Allele / Splice: Mthfrem1Mcwi  
Genetic Models: SS-Mthfrem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05164,844,642 - 164,864,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,502,556 - 168,522,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,112,850 - 165,126,885 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,123,406 - 165,137,073 (+)NCBI
Celera5156,747,024 - 156,766,742 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
 
More on Mthfr
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309952
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE