GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mthfr | affects response to substance | ISO | Mthfr (Mus musculus) | 6480464 | CTD | MTHFR affects the susceptibility to Simvastatin | PMID:18540024 | Mthfr | increases expression | ISO | Mthfr (Mus musculus) | 6480464 | CTD | Simvastatin results in increased expression of MTHFR protein modified form | PMID:18540024 | Mthfr | increases expression | ISO | MTHFR (Homo sapiens) | 6480464 | CTD | Simvastatin results in increased expression of MTHFR protein modified form | PMID:18540024 | Mthfr | multiple interactions | ISO | Mthfr (Mus musculus) | 6480464 | CTD | MTHFR gene mutant form inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]; MTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 mRNA]; MTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 protein] | PMID:18540024 | Mthfr | multiple interactions | ISO | MTHFR (Homo sapiens) | 6480464 | CTD | Homocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]; Simvastatin promotes the reaction [Homocysteine results in increased expression of MTHFR protein] | PMID:18540024 | | ||||||||||||||||||||||
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