RGD Reference Report - Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies. - Rat Genome Database

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Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.

Authors: Stover, PJ 
Citation: Stover PJ J Nutrigenet Nutrigenomics. 2011;4(5):293-305. doi: 10.1159/000334586. Epub 2012 Feb 22.
RGD ID: 7242562
Pubmed: PMID:22353665   (View Abstract at PubMed)
PMCID: PMC3696357   (View Article at PubMed Central)
DOI: DOI:10.1159/000334586   (Journal Full-text)

Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and result from nutritional deficiencies and common gene variants. The mechanisms underlying folate-associated pathologies and developmental anomalies have yet to be established. This review focuses on the relationships among folate-mediated 1-carbon metabolism, chromatin methylation and human disease, and the role of gene-nutrient interactions in modifying epigenetic processes.

Objects Annotated

Genes (Rattus norvegicus)
Aldh1l1  (aldehyde dehydrogenase 1 family, member L1)
Mthfd1  (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1)
Mthfr  (methylenetetrahydrofolate reductase)
Mtr  (5-methyltetrahydrofolate-homocysteine methyltransferase)

Genes (Mus musculus)
Aldh1l1  (aldehyde dehydrogenase 1 family, member L1)
Mthfd1  (methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase)
Mthfr  (methylenetetrahydrofolate reductase)
Mtr  (5-methyltetrahydrofolate-homocysteine methyltransferase)

Genes (Homo sapiens)
ALDH1L1  (aldehyde dehydrogenase 1 family member L1)
MTHFD1  (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1)
MTHFR  (methylenetetrahydrofolate reductase)
MTR  (5-methyltetrahydrofolate-homocysteine methyltransferase)


Additional Information